메뉴 건너뛰기




Volumn 18, Issue 6, 2017, Pages 335-346

Adult hippocampal neurogenesis and cognitive flexibility-linking memory and mood

Author keywords

[No Author keywords available]

Indexed keywords

ANXIETY; BRAIN DISEASE; BRAIN FUNCTION; COGNITION; COGNITIVE FLEXIBILITY; DENTATE GYRUS; ENDOPHENOTYPE; HIPPOCAMPUS; HUMAN; LEARNING; MEMORY; MOOD; MOOD DISORDER; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NEUROENDOCRINE SYSTEM; NONHUMAN; PATTERN SEPARATION; PRIORITY JOURNAL; REVIEW; AFFECT; ANIMAL; GROWTH, DEVELOPMENT AND AGING; MOUSE; PHYSIOLOGY; RAT;

EID: 85019068608     PISSN: 1471003X     EISSN: 14710048     Source Type: Journal    
DOI: 10.1038/nrn.2017.45     Document Type: Review
Times cited : (723)

References (189)
  • 1
    • 0037106145 scopus 로고    scopus 로고
    • Adult neurogenesis and neural stem cells of the central nervous system in mammals
    • Taupin, P. & Gage, F. H. Adult neurogenesis and neural stem cells of the central nervous system in mammals. J. Neurosci. Res. 69, 745-749 (2002).
    • (2002) J. Neurosci. Res. , vol.69 , pp. 745-749
    • Taupin, P.1    Gage, F.H.2
  • 2
    • 84878831768 scopus 로고    scopus 로고
    • Dynamics of hippocampal neurogenesis in adult humans
    • Spalding, K. L., et al. Dynamics of hippocampal neurogenesis in adult humans. Cell 153, 1219-1227 (2013).
    • (2013) Cell , vol.153 , pp. 1219-1227
    • Spalding, K.L.1
  • 3
    • 46849111377 scopus 로고    scopus 로고
    • Finite scale of spatial representation in the hippocampus
    • Kjelstrup, K. B., et al. Finite scale of spatial representation in the hippocampus. Science 321, 140-143 (2008).
    • (2008) Science , vol.321 , pp. 140-143
    • Kjelstrup, K.B.1
  • 4
    • 57649230076 scopus 로고    scopus 로고
    • Genomic anatomy of the hippocampus
    • Thompson, C. L., et al. Genomic anatomy of the hippocampus. Neuron 60, 1010-1021 (2008).
    • (2008) Neuron , vol.60 , pp. 1010-1021
    • Thompson, C.L.1
  • 5
    • 73549123839 scopus 로고    scopus 로고
    • Are the dorsal and ventral hippocampus functionally distinct structures?
    • Fanselow, M. S. & Dong, H. W. Are the dorsal and ventral hippocampus functionally distinct structures? Neuron 65, 7-19 (2010).
    • (2010) Neuron , vol.65 , pp. 7-19
    • Fanselow, M.S.1    Dong, H.W.2
  • 6
    • 84908654563 scopus 로고    scopus 로고
    • Functional organization of the hippocampal longitudinal axis
    • Strange, B. A., Witter, M. P., Lein, E. S. & Moser, E. I. Functional organization of the hippocampal longitudinal axis. Nat. Rev. Neurosci. 15, 655-669 (2014).
    • (2014) Nat. Rev. Neurosci. , vol.15 , pp. 655-669
    • Strange, B.A.1    Witter, M.P.2    Lein, E.S.3    Moser, E.I.4
  • 7
    • 84876424951 scopus 로고    scopus 로고
    • Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus
    • Kheirbek, M. A., et al. Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus. Neuron 77, 955-968 (2013).
    • (2013) Neuron , vol.77 , pp. 955-968
    • Kheirbek, M.A.1
  • 8
    • 0034636105 scopus 로고    scopus 로고
    • Navigation-related structural change in the hippocampi of taxi drivers
    • Maguire, E. A., et al. Navigation-related structural change in the hippocampi of taxi drivers. Proc. Natl Acad. Sci. USA 97, 4398-4403 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 4398-4403
    • Maguire, E.A.1
  • 9
    • 0031841906 scopus 로고    scopus 로고
    • Functional differentiation along the anterior-posterior axis of the hippocampus in monkeys
    • Colombo, M., Fernandez, T., Nakamura, K. & Gross, C. G. Functional differentiation along the anterior-posterior axis of the hippocampus in monkeys. J. Neurophysiol. 80, 1002-1005 (1998).
    • (1998) J. Neurophysiol. , vol.80 , pp. 1002-1005
    • Colombo, M.1    Fernandez, T.2    Nakamura, K.3    Gross, C.G.4
  • 10
    • 84891820788 scopus 로고    scopus 로고
    • Amygdala inputs to the ventral hippocampus bidirectionally modulate social behavior
    • Felix-Ortiz, A. C. & Tye, K. M. Amygdala inputs to the ventral hippocampus bidirectionally modulate social behavior. J. Neurosci. 34, 586-595 (2014).
    • (2014) J. Neurosci. , vol.34 , pp. 586-595
    • Felix-Ortiz, A.C.1    Tye, K.M.2
  • 11
    • 0013838985 scopus 로고
    • Dorsal and ventral hippocampus lesions and maze learning: Influence of preoperative environment
    • Hughes, K. R. Dorsal and ventral hippocampus lesions and maze learning: influence of preoperative environment. Can. J. Psychol. 19, 325-332 (1965).
    • (1965) Can. J. Psychol. , vol.19 , pp. 325-332
    • Hughes, K.R.1
  • 12
    • 0015862974 scopus 로고
    • Effects of dorsal and ventral hippocampal lesions on spontaneous alternation, learned alternation and probability learning in rats
    • Stevens, R. & Cowey, A. Effects of dorsal and ventral hippocampal lesions on spontaneous alternation, learned alternation and probability learning in rats. Brain Res. 52, 203-224 (1973).
    • (1973) Brain Res. , vol.52 , pp. 203-224
    • Stevens, R.1    Cowey, A.2
  • 13
    • 0025597946 scopus 로고
    • Hippocampal pathway to the amygdala and stress ulcer development
    • Henke, P. G. Hippocampal pathway to the amygdala and stress ulcer development. Brain Res. Bull. 25, 691-695 (1990).
    • (1990) Brain Res. Bull. , vol.25 , pp. 691-695
    • Henke, P.G.1
  • 14
    • 0027200693 scopus 로고
    • Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions
    • Moser, E., Moser, M. B. & Andersen, P. Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions. J. Neurosci. 13, 3916-3925 (1993).
    • (1993) J. Neurosci. , vol.13 , pp. 3916-3925
    • Moser, E.1    Moser, M.B.2    Andersen, P.3
  • 15
    • 84939892801 scopus 로고    scopus 로고
    • Benzodiazepines and the potential trophic effect of antidepressants on dentate gyrus cells in mood disorders
    • Boldrini, M., et al. Benzodiazepines and the potential trophic effect of antidepressants on dentate gyrus cells in mood disorders. Int. J. Neuropsychopharmacol. 17, 1923-1933 (2014).
    • (2014) Int. J. Neuropsychopharmacol. , vol.17 , pp. 1923-1933
    • Boldrini, M.1
  • 16
    • 84876065317 scopus 로고    scopus 로고
    • Neural mechanisms underlying heterogeneity in the presentation of anxious temperament
    • Shackman, A. J., et al. Neural mechanisms underlying heterogeneity in the presentation of anxious temperament. Proc. Natl Acad. Sci. USA 110, 6145-6150 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 6145-6150
    • Shackman, A.J.1
  • 17
    • 84912531587 scopus 로고    scopus 로고
    • A ventral view on antidepressant action: Roles for adult hippocampal neurogenesis along the dorsoventral axis
    • O'Leary, O. F. & Cryan, J. F. A ventral view on antidepressant action: roles for adult hippocampal neurogenesis along the dorsoventral axis. Trends Pharmacol. Sci. 35, 675-687 (2014).
    • (2014) Trends Pharmacol Sci. , vol.35 , pp. 675-687
    • O'Leary, O.F.1    Cryan, J.F.2
  • 18
    • 79955112100 scopus 로고    scopus 로고
    • Topographic differences in adult neurogenesis in the mouse hippocampus: A stereology-based study using endogenous markers
    • Jinno, S. Topographic differences in adult neurogenesis in the mouse hippocampus: A stereology-based study using endogenous markers. Hippocampus 21, 467-480 (2011).
    • (2011) Hippocampus , vol.21 , pp. 467-480
    • Jinno, S.1
  • 19
    • 63849241816 scopus 로고    scopus 로고
    • Anatomical gradients of adult neurogenesis and activity: Young neurons in the ventral dentate gyrus are activated by water maze training
    • Snyder, J. S., Radik, R., Wojtowicz, J. M. & Cameron, H. A. Anatomical gradients of adult neurogenesis and activity: young neurons in the ventral dentate gyrus are activated by water maze training. Hippocampus 19, 360-370 (2009).
    • (2009) Hippocampus , vol.19 , pp. 360-370
    • Snyder, J.S.1    Radik, R.2    Wojtowicz, J.M.3    Cameron, H.A.4
  • 20
    • 84882915515 scopus 로고    scopus 로고
    • Region-dependent and stage-specific effects of stress, environmental enrichment, and antidepressant treatment on hippocampal neurogenesis
    • Tanti, A., et al. Region-dependent and stage-specific effects of stress, environmental enrichment, and antidepressant treatment on hippocampal neurogenesis. Hippocampus 23, 797-811 (2013).
    • (2013) Hippocampus , vol.23 , pp. 797-811
    • Tanti, A.1
  • 21
    • 79957628653 scopus 로고    scopus 로고
    • The timing for neuronal maturation in the adult hippocampus is modulated by local network activity
    • Piatti, V. C., et al. The timing for neuronal maturation in the adult hippocampus is modulated by local network activity. J. Neurosci. 31, 7715-7728 (2011).
    • (2011) J. Neurosci. , vol.31 , pp. 7715-7728
    • Piatti, V.C.1
  • 22
    • 84862003651 scopus 로고    scopus 로고
    • Differential environmental regulation of neurogenesis along the septo-temporal axis of the hippocampus
    • Tanti, A., Rainer, Q., Minier, F., Surget, A. & Belzung, C. Differential environmental regulation of neurogenesis along the septo-temporal axis of the hippocampus. Neuropharmacology.63, 374-384 (2012).
    • (2012) Neuropharmacology. , vol.63 , pp. 374-384
    • Tanti, A.1    Rainer, Q.2    Minier, F.3    Surget, A.4    Belzung, C.5
  • 23
    • 0030937293 scopus 로고    scopus 로고
    • More hippocampal neurons in adult mice living in an enriched environment
    • Kempermann, G., Kuhn, H. G. & Gage, F. H. More hippocampal neurons in adult mice living in an enriched environment. Nature 386, 493-495 (1997).
    • (1997) Nature , vol.386 , pp. 493-495
    • Kempermann, G.1    Kuhn, H.G.2    Gage, F.H.3
  • 24
  • 25
    • 84902543503 scopus 로고    scopus 로고
    • Functional dissociation of adultborn neurons along the dorsoventral axis of the dentate gyrus
    • Wu, M. V. & Hen, R. Functional dissociation of adultborn neurons along the dorsoventral axis of the dentate gyrus. Hippocampus 24, 751-761 (2014).
    • (2014) Hippocampus , vol.24 , pp. 751-761
    • Wu, M.V.1    Hen, R.2
  • 26
    • 70349118076 scopus 로고    scopus 로고
    • Antidepressants increase neural progenitor cells in the human hippocampus
    • Boldrini, M., et al. Antidepressants increase neural progenitor cells in the human hippocampus. Neuropsychopharmacology 34, 2376-2389 (2009).
    • (2009) Neuropsychopharmacology , vol.34 , pp. 2376-2389
    • Boldrini, M.1
  • 27
    • 80054031617 scopus 로고    scopus 로고
    • Transcriptome differentiation along the dorso-ventral axis in laser-captured microdissected rat hippocampal granular cell layer
    • Christensen, T., Bisgaard, C. F., Nielsen, H. B. & Wiborg, O. Transcriptome differentiation along the dorso-ventral axis in laser-captured microdissected rat hippocampal granular cell layer. Neuroscience 170, 731-741 (2010).
    • (2010) Neuroscience , vol.170 , pp. 731-741
    • Christensen, T.1    Bisgaard, C.F.2    Nielsen, H.B.3    Wiborg, O.4
  • 28
    • 74549154098 scopus 로고    scopus 로고
    • Synchronized activity between the ventral hippocampus and the medial prefrontal cortex during anxiety
    • Adhikari, A., Topiwala, M. A. & Gordon, J. A. Synchronized activity between the ventral hippocampus and the medial prefrontal cortex during anxiety. Neuron 65, 257-269 (2010).
    • (2010) Neuron , vol.65 , pp. 257-269
    • Adhikari, A.1    Topiwala, M.A.2    Gordon, J.A.3
  • 29
    • 84958119480 scopus 로고    scopus 로고
    • Direct ventral hippocampal-prefrontal input is required for anxiety-related neural activity and behavior
    • Padilla-Coreano, N., et al. Direct ventral hippocampal-prefrontal input is required for anxiety-related neural activity and behavior. Neuron 89, 857-866 (2016).
    • (2016) Neuron , vol.89 , pp. 857-866
    • Padilla-Coreano, N.1
  • 30
    • 1442299895 scopus 로고    scopus 로고
    • Encoding of emotional memories depends on amygdala and hippocampus and their interactions
    • Richardson, M. P., Strange, B. A. & Dolan, R. J. Encoding of emotional memories depends on amygdala and hippocampus and their interactions. Nat. Neurosci. 7, 278-285 (2004).
    • (2004) Nat. Neurosci. , vol.7 , pp. 278-285
    • Richardson, M.P.1    Strange, B.A.2    Dolan, R.J.3
  • 31
    • 84869767566 scopus 로고    scopus 로고
    • Synaptic and behavioral profile of multiple glutamatergic inputs to the nucleus accumbens
    • Britt, J. P., et al. Synaptic and behavioral profile of multiple glutamatergic inputs to the nucleus accumbens. Neuron 76, 790-803 (2012).
    • (2012) Neuron , vol.76 , pp. 790-803
    • Britt, J.P.1
  • 32
    • 84929191859 scopus 로고    scopus 로고
    • Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression
    • Bagot, R. C., et al. Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression. Nat. Commun. 6, 7062 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 7062
    • Bagot, R.C.1
  • 33
    • 84897005192 scopus 로고    scopus 로고
    • Adult hippocampal neurogenesis in depression: Behavioral implications and regulation by the stress system
    • Anacker, C. Adult hippocampal neurogenesis in depression: behavioral implications and regulation by the stress system. Curr. Top. Behav. Neurosci. 18, 25-43 (2014).
    • (2014) Curr. Top. Behav. Neurosci. , vol.18 , pp. 25-43
    • Anacker, C.1
  • 34
    • 79951956849 scopus 로고    scopus 로고
    • The glucocorticoid receptor: Pivot of depression and of antidepressant treatment?
    • Anacker, C., Zunszain, P. A., Carvalho, L. A. & Pariante, C. M. The glucocorticoid receptor: pivot of depression and of antidepressant treatment? Psychoneuroendocrinology 36, 415-425 (2011).
    • (2011) Psychoneuroendocrinology , vol.36 , pp. 415-425
    • Anacker, C.1    Zunszain, P.A.2    Carvalho, L.A.3    Pariante, C.M.4
  • 35
    • 84945353518 scopus 로고    scopus 로고
    • Neuroanatomic differences associated with stress susceptibility and resilience
    • Anacker, C., et al. Neuroanatomic differences associated with stress susceptibility and resilience. Biol. Psychiatry 79, 840-849 (2016).
    • (2016) Biol. Psychiatry , vol.79 , pp. 840-849
    • Anacker, C.1
  • 36
    • 84973526862 scopus 로고    scopus 로고
    • GluN2B-containing NMDA receptors on adult-born granule cells contribute to the antidepressant action of fluoxetine
    • Tannenholz, L., Hen, R. & Kheirbek, M. A. GluN2B-containing NMDA receptors on adult-born granule cells contribute to the antidepressant action of fluoxetine. Front. Neurosci. 10, 242 (2016).
    • (2016) Front. Neurosci. , vol.10 , pp. 242
    • Tannenholz, L.1    Hen, R.2    Kheirbek, M.A.3
  • 37
    • 84962018702 scopus 로고    scopus 로고
    • Distinct contribution of adultborn hippocampal granule cells to context encoding
    • Danielson, N. B., et al. Distinct contribution of adultborn hippocampal granule cells to context encoding. Neuron 90, 101-112 (2016).
    • (2016) Neuron , vol.90 , pp. 101-112
    • Danielson, N.B.1
  • 38
    • 0035833068 scopus 로고    scopus 로고
    • Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus
    • Cameron, H. A. & McKay, R. D. Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J. Comp. Neurol. 435, 406-417 (2001).
    • (2001) J. Comp. Neurol. , vol.435 , pp. 406-417
    • Cameron, H.A.1    McKay, R.D.2
  • 39
    • 34248577303 scopus 로고    scopus 로고
    • A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain
    • Ge, S., Yang, C. H., Hsu, K. S., Ming, G. L. & Song, H. A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. Neuron 54, 559-566 (2007).
    • (2007) Neuron , vol.54 , pp. 559-566
    • Ge, S.1    Yang, C.H.2    Hsu, K.S.3    Ming, G.L.4    Song, H.5
  • 40
    • 84953295438 scopus 로고    scopus 로고
    • Maturation and functional integration of new granule cells into the adult hippocampus
    • Toni, N. & Schinder, A. F. Maturation and functional integration of new granule cells into the adult hippocampus. Cold Spring Harb. Perspect. Biol. 8, a018903 (2016).
    • (2016) Cold Spring Harb. Perspect. Biol. , vol.8 , pp. a018903
    • Toni, N.1    Schinder, A.F.2
  • 41
    • 84857517938 scopus 로고    scopus 로고
    • 4-to 6-week-old adult-born hippocampal neurons influence novelty-evoked exploration and contextual fear conditioning
    • Denny, C. A., Burghardt, N. S., Schachter, D. M., Hen, R. & Drew, M. R. 4-to 6-week-old adult-born hippocampal neurons influence novelty-evoked exploration and contextual fear conditioning. Hippocampus 22, 1188-1201 (2012).
    • (2012) Hippocampus , vol.22 , pp. 1188-1201
    • Denny, C.A.1    Burghardt, N.S.2    Schachter, D.M.3    Hen, R.4    Drew, M.R.5
  • 42
    • 0033363319 scopus 로고    scopus 로고
    • Learning enhances adult neurogenesis in the hippocampal formation
    • Gould, E., Beylin, A., Tanapat, P., Reeves, A. & Shors, T. J. Learning enhances adult neurogenesis in the hippocampal formation. Nat. Neurosci. 2, 260-265 (1999).
    • (1999) Nat. Neurosci. , vol.2 , pp. 260-265
    • Gould, E.1    Beylin, A.2    Tanapat, P.3    Reeves, A.4    Shors, T.J.5
  • 43
    • 0035868717 scopus 로고    scopus 로고
    • Neurogenesis in the adult is involved in the formation of trace memories
    • Shors, T. J., et al. Neurogenesis in the adult is involved in the formation of trace memories. Nature 410, 372-376 (2001).
    • (2001) Nature , vol.410 , pp. 372-376
    • Shors, T.J.1
  • 44
    • 0036436191 scopus 로고    scopus 로고
    • Neurogenesis may relate to some but not all types of hippocampal-dependent learning
    • Shors, T. J., Townsend, D. A., Zhao, M., Kozorovitskiy, Y. & Gould, E. Neurogenesis may relate to some but not all types of hippocampal-dependent learning. Hippocampus 12, 578-584 (2002).
    • (2002) Hippocampus , vol.12 , pp. 578-584
    • Shors, T.J.1    Townsend, D.A.2    Zhao, M.3    Kozorovitskiy, Y.4    Gould, E.5
  • 45
    • 4444381084 scopus 로고    scopus 로고
    • Learning enhances the survival of new neurons beyond the time when the hippocampus is required for memory
    • Leuner, B., et al. Learning enhances the survival of new neurons beyond the time when the hippocampus is required for memory. J. Neurosci. 24, 7477-7481 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 7477-7481
    • Leuner, B.1
  • 46
    • 0344198502 scopus 로고    scopus 로고
    • Spatial memory performances of aged rats in the water maze predict levels of hippocampal neurogenesis
    • Drapeau, E., et al. Spatial memory performances of aged rats in the water maze predict levels of hippocampal neurogenesis. Proc. Natl Acad. Sci. USA 100, 14385-14390 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 14385-14390
    • Drapeau, E.1
  • 47
    • 1842504416 scopus 로고    scopus 로고
    • Learning may reduce neurogenesis in adult rat dentate gyrus
    • Ambrogini, P., et al. Learning may reduce neurogenesis in adult rat dentate gyrus. Neurosci. Lett. 359, 13-16 (2004).
    • (2004) Neurosci. Lett. , vol.359 , pp. 13-16
    • Ambrogini, P.1
  • 48
    • 0346874151 scopus 로고    scopus 로고
    • Differential effects of learning on neurogenesis: Learning increases or decreases the number of newly born cells depending on their birth date
    • Döbrössy, M. D., et al. Differential effects of learning on neurogenesis: learning increases or decreases the number of newly born cells depending on their birth date. Mol. Psychiatry 8, 974-982 (2003).
    • (2003) Mol. Psychiatry , vol.8 , pp. 974-982
    • Döbrössy, M.D.1
  • 49
    • 33645096734 scopus 로고    scopus 로고
    • Inhibition of neurogenesis interferes with hippocampus-dependent memory function
    • Winocur, G., Wojtowicz, J. M., Sekeres, M., Snyder, J. S. & Wang, S. Inhibition of neurogenesis interferes with hippocampus-dependent memory function. Hippocampus 16, 296-304 (2006).
    • (2006) Hippocampus , vol.16 , pp. 296-304
    • Winocur, G.1    Wojtowicz, J.M.2    Sekeres, M.3    Snyder, J.S.4    Wang, S.5
  • 50
    • 34548249099 scopus 로고    scopus 로고
    • Spatial learning depends on both the addition and removal of new hippocampal neurons
    • Dupret, D., et al. Spatial learning depends on both the addition and removal of new hippocampal neurons. PLoS Biol. 5, e214 (2007).
    • (2007) PLoS Biol. , vol.5 , pp. e214
    • Dupret, D.1
  • 51
    • 84910114779 scopus 로고    scopus 로고
    • The role of postnatal neurogenesis in supporting remote memory and spatial metric processing
    • Kesner, R. P., et al. The role of postnatal neurogenesis in supporting remote memory and spatial metric processing. Hippocampus 24, 1663-1671 (2014).
    • (2014) Hippocampus , vol.24 , pp. 1663-1671
    • Kesner, R.P.1
  • 52
    • 0032080116 scopus 로고    scopus 로고
    • Experience-induced neurogenesis in the senescent dentate gyrus
    • Kempermann, G., Kuhn, H. G. & Gage, F. H. Experience-induced neurogenesis in the senescent dentate gyrus. J. Neurosci. 18, 3206-3212 (1998).
    • (1998) J. Neurosci. , vol.18 , pp. 3206-3212
    • Kempermann, G.1    Kuhn, H.G.2    Gage, F.H.3
  • 53
    • 0033360314 scopus 로고    scopus 로고
    • Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
    • van Praag, H., Kempermann, G. & Gage, F. H. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat. Neurosci. 2, 266-270 (1999).
    • (1999) Nat. Neurosci. , vol.2 , pp. 266-270
    • Van Praag, H.1    Kempermann, G.2    Gage, F.H.3
  • 54
    • 33747827189 scopus 로고    scopus 로고
    • NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus
    • Tashiro, A., Sandler, V. M., Toni, N., Zhao, C. & Gage, F. H. NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus. Nature 442, 929-933 (2006).
    • (2006) Nature , vol.442 , pp. 929-933
    • Tashiro, A.1    Sandler, V.M.2    Toni, N.3    Zhao, C.4    Gage, F.H.5
  • 55
    • 84860127552 scopus 로고    scopus 로고
    • Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons
    • Kirby, E. D., et al. Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons. Mol. Psychiatry 17, 527-536 (2012).
    • (2012) Mol. Psychiatry , vol.17 , pp. 527-536
    • Kirby, E.D.1
  • 56
    • 84877126337 scopus 로고    scopus 로고
    • Physical exercise prevents stress-induced activation of granule neurons and enhances local inhibitory mechanisms in the dentate gyrus
    • Schoenfeld, T. J., Rada, P., Pieruzzini, P. R., Hsueh, B. & Gould, E. Physical exercise prevents stress-induced activation of granule neurons and enhances local inhibitory mechanisms in the dentate gyrus. J. Neurosci. 33, 7770-7777 (2013).
    • (2013) J. Neurosci. , vol.33 , pp. 7770-7777
    • Schoenfeld, T.J.1    Rada, P.2    Pieruzzini, P.R.3    Hsueh, B.4    Gould, E.5
  • 57
    • 80052991513 scopus 로고    scopus 로고
    • Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory
    • Stone, S. S., et al. Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory. J. Neurosci. 31, 13469-13484 (2011).
    • (2011) J. Neurosci. , vol.31 , pp. 13469-13484
    • Stone, S.S.1
  • 58
    • 33847163934 scopus 로고    scopus 로고
    • Preferential incorporation of adultgenerated granule cells into spatial memory networks in the dentate gyrus
    • Kee, N., Teixeira, C. M., Wang, A. H. & Frankland, P. W. Preferential incorporation of adultgenerated granule cells into spatial memory networks in the dentate gyrus. Nat. Neurosci. 10, 355-362 (2007).
    • (2007) Nat. Neurosci. , vol.10 , pp. 355-362
    • Kee, N.1    Teixeira, C.M.2    Wang, A.H.3    Frankland, P.W.4
  • 59
    • 33745698913 scopus 로고    scopus 로고
    • Potential role for adult neurogenesis in the encoding of time in new memories
    • Aimone, J. B., Wiles, J. & Gage, F. H. Potential role for adult neurogenesis in the encoding of time in new memories. Nat. Neurosci. 9, 723-727 (2006).
    • (2006) Nat. Neurosci. , vol.9 , pp. 723-727
    • Aimone, J.B.1    Wiles, J.2    Gage, F.H.3
  • 60
    • 84908137388 scopus 로고    scopus 로고
    • Temporally selective contextual encoding in the dentate gyrus of the hippocampus
    • Rangel, L. M., et al. Temporally selective contextual encoding in the dentate gyrus of the hippocampus. Nat. Commun. 5, 3181 (2014).
    • (2014) Nat. Commun. , vol.5 , pp. 3181
    • Rangel, L.M.1
  • 61
    • 33947498496 scopus 로고    scopus 로고
    • Experiencespecific functional modification of the dentate gyrus through adult neurogenesis: A critical period during an immature stage
    • Tashiro, A., Makino, H. & Gage, F. H. Experiencespecific functional modification of the dentate gyrus through adult neurogenesis: A critical period during an immature stage. J. Neurosci. 27, 3252-3259 (2007).
    • (2007) J. Neurosci. , vol.27 , pp. 3252-3259
    • Tashiro, A.1    Makino, H.2    Gage, F.H.3
  • 62
    • 82055202901 scopus 로고    scopus 로고
    • Functional convergence of developmentally and adult-generated granule cells in dentate gyrus circuits supporting hippocampusdependent memory
    • Stone, S. S., et al. Functional convergence of developmentally and adult-generated granule cells in dentate gyrus circuits supporting hippocampusdependent memory. Hippocampus 21, 1348-1362 (2011).
    • (2011) Hippocampus , vol.21 , pp. 1348-1362
    • Stone, S.S.1
  • 63
    • 58549096746 scopus 로고    scopus 로고
    • Computational influence of adult neurogenesis on memory encoding
    • Aimone, J. B., Wiles, J. & Gage, F. H. Computational influence of adult neurogenesis on memory encoding. Neuron 61, 187-202 (2009).
    • (2009) Neuron , vol.61 , pp. 187-202
    • Aimone, J.B.1    Wiles, J.2    Gage, F.H.3
  • 64
    • 70349873811 scopus 로고    scopus 로고
    • Additive neurogenesis as a strategy for avoiding interference in a sparselycoding dentate gyrus
    • Appleby, P. A. & Wiskott, L. Additive neurogenesis as a strategy for avoiding interference in a sparselycoding dentate gyrus. Network 20, 137-161 (2009).
    • (2009) Network , vol.20 , pp. 137-161
    • Appleby, P.A.1    Wiskott, L.2
  • 65
    • 79551523012 scopus 로고    scopus 로고
    • The role of additive neurogenesis and synaptic plasticity in a hippocampal memory model with grid-cell like input
    • Appleby, P. A., Kempermann, G. & Wiskott, L. The role of additive neurogenesis and synaptic plasticity in a hippocampal memory model with grid-cell like input. PLoS Comput. Biol. 7, e1001063 (2011).
    • (2011) PLoS Comput. Biol. , vol.7 , pp. e1001063
    • Appleby, P.A.1    Kempermann, G.2    Wiskott, L.3
  • 66
    • 84055191605 scopus 로고    scopus 로고
    • Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus
    • Lacefield, C. O., Itskov, V., Reardon, T., Hen, R. & Gordon, J. A. Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus. Hippocampus 22, 106-116 (2012).
    • (2012) Hippocampus , vol.22 , pp. 106-116
    • Lacefield, C.O.1    Itskov, V.2    Reardon, T.3    Hen, R.4    Gordon, J.A.5
  • 67
    • 84865598830 scopus 로고    scopus 로고
    • Adult-born hippocampal neurons promote cognitive flexibility in mice
    • Burghardt, N. S., Park, E. H., Hen, R. & Fenton, A. A. Adult-born hippocampal neurons promote cognitive flexibility in mice. Hippocampus 22, 1795-1808 (2012).
    • (2012) Hippocampus , vol.22 , pp. 1795-1808
    • Burghardt, N.S.1    Park, E.H.2    Hen, R.3    Fenton, A.A.4
  • 68
    • 84891520301 scopus 로고    scopus 로고
    • Adult neurogenesis modifies excitability of the dentate gyrus
    • Ikrar, T., et al. Adult neurogenesis modifies excitability of the dentate gyrus. Front. Neural Circuits 7, 204 (2013).
    • (2013) Front. Neural Circuits , vol.7 , pp. 204
    • Ikrar, T.1
  • 69
    • 84958567816 scopus 로고    scopus 로고
    • Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons
    • Drew, L. J., et al. Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons. Hippocampus 26, 763-778 (2016).
    • (2016) Hippocampus , vol.26 , pp. 763-778
    • Drew, L.J.1
  • 70
    • 84920725687 scopus 로고    scopus 로고
    • Delayed coupling to feedback inhibition during a critical period for the integration of adult-born granule cells
    • Temprana, S. G., et al. Delayed coupling to feedback inhibition during a critical period for the integration of adult-born granule cells. Neuron 85, 116-130 (2015).
    • (2015) Neuron , vol.85 , pp. 116-130
    • Temprana, S.G.1
  • 71
    • 0037252835 scopus 로고    scopus 로고
    • Effect of chronic stress on synaptic currents in rat hippocampal dentate gyrus neurons
    • Karst, H. & Joëls, M. Effect of chronic stress on synaptic currents in rat hippocampal dentate gyrus neurons. J. Neurophysiol. 89, 625-633 (2003).
    • (2003) J. Neurophysiol. , vol.89 , pp. 625-633
    • Karst, H.1    Joëls, M.2
  • 72
    • 0027729324 scopus 로고
    • Neuromodulatory systems and memory storage: Role of the amygdala
    • McGaugh, J. L., et al. Neuromodulatory systems and memory storage: role of the amygdala. Behav. Brain Res. 58, 81-90 (1993).
    • (1993) Behav. Brain Res. , vol.58 , pp. 81-90
    • McGaugh, J.L.1
  • 73
    • 0015083717 scopus 로고
    • Simple memory: A theory for archicortex
    • Marr, D. Simple memory: A theory for archicortex. Phil. Trans. R. Soc. Lond. B 262, 23-81 (1971).
    • (1971) Phil. Trans. R. Soc. Lond. B , vol.262 , pp. 23-81
    • Marr, D.1
  • 74
    • 24944583241 scopus 로고    scopus 로고
    • A computational principle for hippocampal learning and neurogenesis
    • Becker, S. A computational principle for hippocampal learning and neurogenesis. Hippocampus 15, 722-738 (2005).
    • (2005) Hippocampus , vol.15 , pp. 722-738
    • Becker, S.1
  • 75
    • 33847149696 scopus 로고    scopus 로고
    • Pattern separation in the dentate gyrus and CA3 of the hippocampus
    • Leutgeb, J. K., Leutgeb, S., Moser, M. B. & Moser, E. I. Pattern separation in the dentate gyrus and CA3 of the hippocampus. Science 315, 961-966 (2007).
    • (2007) Science , vol.315 , pp. 961-966
    • Leutgeb, J.K.1    Leutgeb, S.2    Moser, M.B.3    Moser, E.I.4
  • 76
    • 34447331941 scopus 로고    scopus 로고
    • Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network
    • McHugh, T. J., et al. Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network. Science 317, 94-99 (2007).
    • (2007) Science , vol.317 , pp. 94-99
    • McHugh, T.J.1
  • 77
    • 67650450542 scopus 로고    scopus 로고
    • A functional role for adult hippocampal neurogenesis in spatial pattern separation
    • Clelland, C. D., et al. A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science 325, 210-213 (2009).
    • (2009) Science , vol.325 , pp. 210-213
    • Clelland, C.D.1
  • 78
    • 33645097490 scopus 로고    scopus 로고
    • A functional hypothesis for adult hippocampal neurogenesis: Avoidance of catastrophic interference in the dentate gyrus
    • Wiskott, L., Rasch, M. J. & Kempermann, G. A functional hypothesis for adult hippocampal neurogenesis: avoidance of catastrophic interference in the dentate gyrus. Hippocampus 16, 329-343 (2006).
    • (2006) Hippocampus , vol.16 , pp. 329-343
    • Wiskott, L.1    Rasch, M.J.2    Kempermann, G.3
  • 79
    • 84870558067 scopus 로고    scopus 로고
    • Neurogenesis and generalization: A new approach to stratify and treat anxiety disorders
    • Kheirbek, M. A., Klemenhagen, K. C., Sahay, A. & Hen, R. Neurogenesis and generalization: A new approach to stratify and treat anxiety disorders. Nat. Neurosci. 15, 1613-1620 (2012).
    • (2012) Nat. Neurosci. , vol.15 , pp. 1613-1620
    • Kheirbek, M.A.1    Klemenhagen, K.C.2    Sahay, A.3    Hen, R.4
  • 80
    • 84878314484 scopus 로고    scopus 로고
    • Conflicts between local and global spatial frameworks dissociate neural representations of the lateral and medial entorhinal cortex
    • Neunuebel, J. P., Yoganarasimha, D., Rao, G. & Knierim, J. J. Conflicts between local and global spatial frameworks dissociate neural representations of the lateral and medial entorhinal cortex. J. Neurosci. 33, 9246-9258 (2013).
    • (2013) J. Neurosci. , vol.33 , pp. 9246-9258
    • Neunuebel, J.P.1    Yoganarasimha, D.2    Rao, G.3    Knierim, J.J.4
  • 81
    • 84856090354 scopus 로고    scopus 로고
    • Adult-born neurons are necessary for extended contextual discrimination
    • Tronel, S., et al. Adult-born neurons are necessary for extended contextual discrimination. Hippocampus 22, 292-298 (2012).
    • (2012) Hippocampus , vol.22 , pp. 292-298
    • Tronel, S.1
  • 83
    • 84866979208 scopus 로고    scopus 로고
    • TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function
    • Coba, M. P., et al. TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function. J. Neurosci. 32, 13987-13999 (2012).
    • (2012) J. Neurosci. , vol.32 , pp. 13987-13999
    • Coba, M.P.1
  • 84
    • 79955526702 scopus 로고    scopus 로고
    • Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
    • Sahay, A., et al. Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature 472, 466-470 (2011).
    • (2011) Nature , vol.472 , pp. 466-470
    • Sahay, A.1
  • 85
    • 84920626940 scopus 로고    scopus 로고
    • The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation
    • Kent, B. A., et al. The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation. Psychoneuroendocrinology 51, 431-439 (2015).
    • (2015) Psychoneuroendocrinology , vol.51 , pp. 431-439
    • Kent, B.A.1
  • 86
    • 84904246559 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories
    • Bekinschtein, P., et al. Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories. Hippocampus 24, 905-911 (2014).
    • (2014) Hippocampus , vol.24 , pp. 905-911
    • Bekinschtein, P.1
  • 87
    • 84887616048 scopus 로고    scopus 로고
    • BDNF in the dentate gyrus is required for consolidation of "pattern-separated" memories
    • Bekinschtein, P., et al. BDNF in the dentate gyrus is required for consolidation of "pattern-separated" memories. Cell Rep. 5, 759-768 (2013).
    • (2013) Cell Rep. , vol.5 , pp. 759-768
    • Bekinschtein, P.1
  • 88
    • 84991277135 scopus 로고    scopus 로고
    • Modulating neuronal competition dynamics in the dentate gyrus to rejuvenate aging memory circuits
    • McAvoy, K. M., et al. Modulating neuronal competition dynamics in the dentate gyrus to rejuvenate aging memory circuits. Neuron 91, 1356-1373 (2016).
    • (2016) Neuron , vol.91 , pp. 1356-1373
    • McAvoy, K.M.1
  • 89
    • 84859203130 scopus 로고    scopus 로고
    • Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion
    • Nakashiba, T., et al. Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion. Cell 149, 188-201 (2012).
    • (2012) Cell , vol.149 , pp. 188-201
    • Nakashiba, T.1
  • 90
    • 0028585928 scopus 로고
    • Hippocampal conjunctive encoding, storage, and recall: Avoiding a trade-off
    • O'Reilly, R. C. & McClelland, J. L. Hippocampal conjunctive encoding, storage, and recall: avoiding a trade-off. Hippocampus 4, 661-682 (1994).
    • (1994) Hippocampus , vol.4 , pp. 661-682
    • O'Reilly, R.C.1    McClelland, J.L.2
  • 91
    • 0027156030 scopus 로고
    • Spatial selectivity of unit activity in the hippocampal granular layer
    • Jung, M. W. & McNaughton, B. L. Spatial selectivity of unit activity in the hippocampal granular layer. Hippocampus 3, 165-182 (1993).
    • (1993) Hippocampus , vol.3 , pp. 165-182
    • Jung, M.W.1    McNaughton, B.L.2
  • 92
    • 84941051877 scopus 로고    scopus 로고
    • Adult hippocampal neurogenesis and pattern separation in DG: A role for feedback inhibition in modulating sparseness to govern population-based coding
    • McAvoy, K., Besnard, A. & Sahay, A. Adult hippocampal neurogenesis and pattern separation in DG: A role for feedback inhibition in modulating sparseness to govern population-based coding. Front. Syst. Neurosci. 9, 120 (2015).
    • (2015) Front. Syst. Neurosci. , vol.9 , pp. 120
    • McAvoy, K.1    Besnard, A.2    Sahay, A.3
  • 93
    • 77951498581 scopus 로고    scopus 로고
    • New neurons and new memories: How does adult hippocampal neurogenesis affect learning and memory?
    • Deng, W., Aimone, J. B. & Gage, F. H. New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat. Rev. Neurosci. 11, 339-350 (2010).
    • (2010) Nat. Rev. Neurosci. , vol.11 , pp. 339-350
    • Deng, W.1    Aimone, J.B.2    Gage, F.H.3
  • 94
    • 84903584973 scopus 로고    scopus 로고
    • Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis
    • Denny, C. A., et al. Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis. Neuron 83, 189-201 (2014).
    • (2014) Neuron , vol.83 , pp. 189-201
    • Denny, C.A.1
  • 95
    • 84872679920 scopus 로고    scopus 로고
    • Reactivation of neural ensembles during the retrieval of recent and remote memory
    • Tayler, K. K., Tanaka, K. Z., Reijmers, L. G. & Wiltgen, B. J. Reactivation of neural ensembles during the retrieval of recent and remote memory. Curr. Biol. 23, 99-106 (2013).
    • (2013) Curr. Biol. , vol.23 , pp. 99-106
    • Tayler, K.K.1    Tanaka, K.Z.2    Reijmers, L.G.3    Wiltgen, B.J.4
  • 96
    • 84880707543 scopus 로고    scopus 로고
    • Creating a false memory in the hippocampus
    • Ramirez, S., et al. Creating a false memory in the hippocampus. Science 341, 387-391 (2013).
    • (2013) Science , vol.341 , pp. 387-391
    • Ramirez, S.1
  • 97
    • 84907790422 scopus 로고    scopus 로고
    • Bidirectional switch of the valence associated with a hippocampal contextual memory engram
    • Redondo, R. L., et al. Bidirectional switch of the valence associated with a hippocampal contextual memory engram. Nature 513, 426-430 (2014).
    • (2014) Nature , vol.513 , pp. 426-430
    • Redondo, R.L.1
  • 98
    • 84923337943 scopus 로고    scopus 로고
    • Active avoidance requires a serial basal amygdala to nucleus accumbens shell circuit
    • Ramirez, F., Moscarello, J. M., LeDoux, J. E. & Sears, R. M. Active avoidance requires a serial basal amygdala to nucleus accumbens shell circuit. J. Neurosci. 35, 3470-3477 (2015).
    • (2015) J. Neurosci. , vol.35 , pp. 3470-3477
    • Ramirez, F.1    Moscarello, J.M.2    LeDoux, J.E.3    Sears, R.M.4
  • 99
    • 70350771278 scopus 로고    scopus 로고
    • Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory
    • Kitamura, T., et al. Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory. Cell 139, 814-827 (2009).
    • (2009) Cell , vol.139 , pp. 814-827
    • Kitamura, T.1
  • 100
    • 84900311811 scopus 로고    scopus 로고
    • Hippocampal neurogenesis regulates forgetting during adulthood and infancy
    • Akers, K. G., et al. Hippocampal neurogenesis regulates forgetting during adulthood and infancy. Science 344, 598-602 (2014).
    • (2014) Science , vol.344 , pp. 598-602
    • Akers, K.G.1
  • 102
    • 0035990493 scopus 로고    scopus 로고
    • Human hippocampal activation in the delayed matching-and nonmatching-to-sample memory tasks: An event-related functional MRI approach
    • Monk, C. S., et al. Human hippocampal activation in the delayed matching-and nonmatching-to-sample memory tasks: an event-related functional MRI approach. Behav. Neurosci. 116, 716-721 (2002).
    • (2002) Behav. Neurosci. , vol.116 , pp. 716-721
    • Monk, C.S.1
  • 103
    • 58149326818 scopus 로고    scopus 로고
    • Differential contributions of prefrontal and hippocampal dopamine D1 and D2 receptors in human cognitive functions
    • Takahashi, H., et al. Differential contributions of prefrontal and hippocampal dopamine D1 and D2 receptors in human cognitive functions. J. Neurosci. 28, 12032-12038 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 12032-12038
    • Takahashi, H.1
  • 104
    • 84939838875 scopus 로고    scopus 로고
    • Experience-dependent regulation of dentate gyrus excitability by adult-born granule cells
    • Park, E. H., Burghardt, N. S., Dvorak, D., Hen, R. & Fenton, A. A. Experience-dependent regulation of dentate gyrus excitability by adult-born granule cells. J. Neurosci. 35, 11656-11666 (2015).
    • (2015) J. Neurosci. , vol.35 , pp. 11656-11666
    • Park, E.H.1    Burghardt, N.S.2    Dvorak, D.3    Hen, R.4    Fenton, A.A.5
  • 105
    • 45849151100 scopus 로고    scopus 로고
    • Spatial relational memory requires hippocampal adult neurogenesis
    • Dupret, D., et al. Spatial relational memory requires hippocampal adult neurogenesis. PLoS ONE 3, e1959 (2008).
    • (2008) PLoS ONE , vol.3 , pp. e1959
    • Dupret, D.1
  • 106
    • 65549133778 scopus 로고    scopus 로고
    • Adultgenerated hippocampal neurons allow the flexible use of spatially precise learning strategies
    • Garthe, A., Behr, J. & Kempermann, G. Adultgenerated hippocampal neurons allow the flexible use of spatially precise learning strategies. PLoS ONE 4, e5464 (2009).
    • (2009) PLoS ONE , vol.4 , pp. e5464
    • Garthe, A.1    Behr, J.2    Kempermann, G.3
  • 107
    • 84910126967 scopus 로고    scopus 로고
    • Characterization of the role of adult neurogenesis in touch-screen discrimination learning
    • Swan, A. A., et al. Characterization of the role of adult neurogenesis in touch-screen discrimination learning. Hippocampus 24, 1581-1591 (2014).
    • (2014) Hippocampus , vol.24 , pp. 1581-1591
    • Swan, A.A.1
  • 108
    • 84933672229 scopus 로고    scopus 로고
    • The role of the hippocampus in flexible cognition and social behavior
    • Rubin, R. D., Watson, P. D., Duff, M. C. & Cohen, N. J. The role of the hippocampus in flexible cognition and social behavior. Front. Hum. Neurosci. 8, 742 (2014).
    • (2014) Front. Hum. Neurosci. , vol.8 , pp. 742
    • Rubin, R.D.1    Watson, P.D.2    Duff, M.C.3    Cohen, N.J.4
  • 109
    • 0029340352 scopus 로고
    • Why there are complementary learning systems in the hippocampus and neocortex: Insights from the successes and failures of connectionist models of learning and memory
    • McClelland, J. L., McNaughton, B. L., O'Reilly, R. C. Why there are complementary learning systems in the hippocampus and neocortex: insights from the successes and failures of connectionist models of learning and memory. Psychol. Rev. 102, 419-457 (1995).
    • (1995) Psychol. Rev. , vol.102 , pp. 419-457
    • McClelland, J.L.1    McNaughton, B.L.2    O'Reilly, R.C.3
  • 110
    • 84976324451 scopus 로고    scopus 로고
    • Adult neurogenesis and pattern separation in rodents: A critical evaluation of data, tasks and interpretation
    • Hvoslef-Eide, M. & Oomen, C. A. Adult neurogenesis and pattern separation in rodents: A critical evaluation of data, tasks and interpretation. Front. Biol. 11, 168-181 (2016).
    • (2016) Front. Biol. , vol.11 , pp. 168-181
    • Hvoslef-Eide, M.1    Oomen, C.A.2
  • 111
    • 84956808068 scopus 로고    scopus 로고
    • Mice in an enriched environment learn more flexibly because of adult hippocampal neurogenesis
    • Garthe, A., Roeder, I. & Kempermann, G. Mice in an enriched environment learn more flexibly because of adult hippocampal neurogenesis. Hippocampus 26, 261-271 (2016).
    • (2016) Hippocampus , vol.26 , pp. 261-271
    • Garthe, A.1    Roeder, I.2    Kempermann, G.3
  • 112
    • 84881368459 scopus 로고    scopus 로고
    • Loss of hippocampal neurogenesis, increased noveltyinduced activity, decreased home cage activity, and impaired reversal learning one year after irradiation of the young mouse brain
    • Kalm, M., Karlsson, N., Nilsson, M. K. & Blomgren, K. Loss of hippocampal neurogenesis, increased noveltyinduced activity, decreased home cage activity, and impaired reversal learning one year after irradiation of the young mouse brain. Exp. Neurol. 247, 402-409 (2013).
    • (2013) Exp. Neurol. , vol.247 , pp. 402-409
    • Kalm, M.1    Karlsson, N.2    Nilsson, M.K.3    Blomgren, K.4
  • 113
    • 84897963880 scopus 로고    scopus 로고
    • Not all water mazes are created equal: Cyclin D2 knockout mice with constitutively suppressed adult hippocampal neurogenesis do show specific spatial learning deficits
    • Garthe, A., Huang, Z., Kaczmarek, L., Filipkowski, R. K. & Kempermann, G. Not all water mazes are created equal: cyclin D2 knockout mice with constitutively suppressed adult hippocampal neurogenesis do show specific spatial learning deficits. Genes Brain Behav. 13, 357-364 (2014).
    • (2014) Genes Brain Behav. , vol.13 , pp. 357-364
    • Garthe, A.1    Huang, Z.2    Kaczmarek, L.3    Filipkowski, R.K.4    Kempermann, G.5
  • 114
    • 84940759126 scopus 로고    scopus 로고
    • Regulation of adult neurogenesis and plasticity by (early) stress, glucocorticoids, and inflammation
    • Lucassen, P. J., et al. Regulation of adult neurogenesis and plasticity by (early) stress, glucocorticoids, and inflammation. Cold Spring Harb. Perspect. Biol. 7, a021303 (2015).
    • (2015) Cold Spring Harb. Perspect. Biol. , vol.7 , pp. a021303
    • Lucassen, P.J.1
  • 115
    • 0042528720 scopus 로고    scopus 로고
    • Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
    • Santarelli, L., et al. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301, 805-809 (2003).
    • (2003) Science , vol.301 , pp. 805-809
    • Santarelli, L.1
  • 116
    • 81755172044 scopus 로고    scopus 로고
    • Antidepressants recruit new neurons to improve stress response regulation
    • Surget, A., et al. Antidepressants recruit new neurons to improve stress response regulation. Mol. Psychiatry 16, 1177-1188 (2011).
    • (2011) Mol. Psychiatry , vol.16 , pp. 1177-1188
    • Surget, A.1
  • 117
    • 48049094446 scopus 로고    scopus 로고
    • Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal
    • Surget, A., et al. Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal. Biol. Psychiatry 64, 293-301 (2008).
    • (2008) Biol. Psychiatry , vol.64 , pp. 293-301
    • Surget, A.1
  • 118
    • 84934934433 scopus 로고    scopus 로고
    • Activating positive memory engrams suppresses depression-like behaviour
    • Ramirez, S., et al. Activating positive memory engrams suppresses depression-like behaviour. Nature 522, 335-339 (2015).
    • (2015) Nature , vol.522 , pp. 335-339
    • Ramirez, S.1
  • 119
    • 0242391948 scopus 로고    scopus 로고
    • Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile rhesus monkeys
    • Coe, C. L., et al. Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile rhesus monkeys. Biol. Psychiatry 54, 1025-1034 (2003).
    • (2003) Biol. Psychiatry , vol.54 , pp. 1025-1034
    • Coe, C.L.1
  • 120
    • 0034718603 scopus 로고    scopus 로고
    • Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus
    • Lemaire, V., Koehl, M., Le Moal, M. & Abrous, D. N. Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus. Proc. Natl Acad. Sci. USA 97, 11032-11037 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 11032-11037
    • Lemaire, V.1    Koehl, M.2    Le Moal, M.3    Abrous, D.N.4
  • 121
    • 3343008569 scopus 로고    scopus 로고
    • Early life experience alters response of adult neurogenesis to stress
    • Mirescu, C., Peters, J. D. & Gould, E. Early life experience alters response of adult neurogenesis to stress. Nat. Neurosci. 7, 841-846 (2004).
    • (2004) Nat. Neurosci. , vol.7 , pp. 841-846
    • Mirescu, C.1    Peters, J.D.2    Gould, E.3
  • 122
    • 79954494320 scopus 로고    scopus 로고
    • Necessity of hippocampal neurogenesis for the therapeutic action of antidepressants in adult nonhuman primates
    • Perera, T. D., et al. Necessity of hippocampal neurogenesis for the therapeutic action of antidepressants in adult nonhuman primates. PLoS ONE 6, e17600 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e17600
    • Perera, T.D.1
  • 123
    • 34247856025 scopus 로고    scopus 로고
    • Antidepressant-induced neurogenesis in the hippocampus of adult nonhuman primates
    • Perera, T. D., et al. Antidepressant-induced neurogenesis in the hippocampus of adult nonhuman primates. J. Neurosci. 27, 4894-4901 (2007).
    • (2007) J. Neurosci. , vol.27 , pp. 4894-4901
    • Perera, T.D.1
  • 124
    • 84902549394 scopus 로고    scopus 로고
    • Impact of social status and antidepressant treatment on neurogenesis in the baboon hippocampus
    • Wu, M. V., et al. Impact of social status and antidepressant treatment on neurogenesis in the baboon hippocampus. Neuropsychopharmacology 39, 1861-1871 (2014).
    • (2014) Neuropsychopharmacology , vol.39 , pp. 1861-1871
    • Wu, M.V.1
  • 125
    • 77649340109 scopus 로고    scopus 로고
    • Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients
    • Lucassen, P. J., Stumpel, M. W., Wang, Q. & Aronica, E. Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients. Neuropharmacology 58, 940-949 (2010).
    • (2010) Neuropharmacology , vol.58 , pp. 940-949
    • Lucassen, P.J.1    Stumpel, M.W.2    Wang, Q.3    Aronica, E.4
  • 126
    • 67349216843 scopus 로고    scopus 로고
    • The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling
    • Bessa, J. M., et al. The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling. Mol. Psychiatry 14, 764-773 (2009).
    • (2009) Mol. Psychiatry , vol.14 , pp. 764-773
    • Bessa, J.M.1
  • 127
    • 65649125633 scopus 로고    scopus 로고
    • Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression
    • David, D. J., et al. Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. Neuron 62, 479-493 (2009).
    • (2009) Neuron , vol.62 , pp. 479-493
    • David, D.J.1
  • 128
    • 84939262538 scopus 로고    scopus 로고
    • Increasing adult hippocampal neurogenesis is sufficient to reduce anxiety and depression-like behaviors
    • Hill, A. S., Sahay, A. & Hen, R. Increasing adult hippocampal neurogenesis is sufficient to reduce anxiety and depression-like behaviors. Neuropsychopharmacology 40, 2368-2378 (2015).
    • (2015) Neuropsychopharmacology , vol.40 , pp. 2368-2378
    • Hill, A.S.1    Sahay, A.2    Hen, R.3
  • 129
    • 70349687254 scopus 로고    scopus 로고
    • Adult hippocampal neurogenesis is involved in anxiety-related behaviors
    • Revest, J. M., et al. Adult hippocampal neurogenesis is involved in anxiety-related behaviors. Mol. Psychiatry 14, 959-967 (2009).
    • (2009) Mol. Psychiatry , vol.14 , pp. 959-967
    • Revest, J.M.1
  • 130
    • 39649105423 scopus 로고    scopus 로고
    • Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice
    • Murray, F., Smith, D. W. & Hutson, P. H. Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice. Eur. J. Pharmacol. 583, 115-127 (2008).
    • (2008) Eur. J. Pharmacol. , vol.583 , pp. 115-127
    • Murray, F.1    Smith, D.W.2    Hutson, P.H.3
  • 131
    • 36949036445 scopus 로고    scopus 로고
    • Brief treatment with the glucocorticoid receptor antagonist mifepristone normalizes the reduction in neurogenesis after chronic stress
    • Oomen, C. A., Mayer, J. L., de Kloet, E. R., Joels, M. & Lucassen, P. J. Brief treatment with the glucocorticoid receptor antagonist mifepristone normalizes the reduction in neurogenesis after chronic stress. Eur. J. Neurosci. 26, 3395-3401 (2007).
    • (2007) Eur. J. Neurosci. , vol.26 , pp. 3395-3401
    • Oomen, C.A.1    Mayer, J.L.2    De Kloet, E.R.3    Joels, M.4    Lucassen, P.J.5
  • 132
    • 33745728406 scopus 로고    scopus 로고
    • Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone-induced reduction of adult hippocampal neurogenesis
    • Mayer, J. L., et al. Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone-induced reduction of adult hippocampal neurogenesis. J. Neuroendocrinol. 18, 629-631 (2006).
    • (2006) J. Neuroendocrinol. , vol.18 , pp. 629-631
    • Mayer, J.L.1
  • 133
    • 84878136730 scopus 로고    scopus 로고
    • Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis
    • Anacker, C., et al. Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis. Proc. Natl Acad. Sci. USA 110, 8708-8713 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 8708-8713
    • Anacker, C.1
  • 134
    • 84875218670 scopus 로고    scopus 로고
    • Glucocorticoid-related molecular signaling pathways regulating hippocampal neurogenesis
    • Anacker, C. A., et al. Glucocorticoid-related molecular signaling pathways regulating hippocampal neurogenesis. Neuropsychopharmacology 38, 872-883 (2013).
    • (2013) Neuropsychopharmacology , vol.38 , pp. 872-883
    • Anacker, C.A.1
  • 135
    • 67049096389 scopus 로고    scopus 로고
    • Suppression of adult neurogenesis leads to an increased hypothalamo-pituitary-adrenal axis response
    • Schloesser, R. J., Manji, H. K. & Martinowich, K. Suppression of adult neurogenesis leads to an increased hypothalamo-pituitary-adrenal axis response. Neuroreport 20, 553-557 (2009).
    • (2009) Neuroreport , vol.20 , pp. 553-557
    • Schloesser, R.J.1    Manji, H.K.2    Martinowich, K.3
  • 136
    • 80052050190 scopus 로고    scopus 로고
    • Adult hippocampal neurogenesis buffers stress responses and depressive behaviour
    • Snyder, J. S., Soumier, A., Brewer, M., Pickel, J. & Cameron, H. A. Adult hippocampal neurogenesis buffers stress responses and depressive behaviour. Nature 476, 458-461 (2011).
    • (2011) Nature , vol.476 , pp. 458-461
    • Snyder, J.S.1    Soumier, A.2    Brewer, M.3    Pickel, J.4    Cameron, H.A.5
  • 137
    • 84879414589 scopus 로고    scopus 로고
    • Sustained remission from depressive-like behavior depends on hippocampal neurogenesis
    • Mateus-Pinheiro, A., et al. Sustained remission from depressive-like behavior depends on hippocampal neurogenesis. Transl Psychiatry 3, e210 (2013).
    • (2013) Transl Psychiatry , vol.3 , pp. e210
    • Mateus-Pinheiro, A.1
  • 138
    • 70350537113 scopus 로고    scopus 로고
    • Adultborn hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain
    • Deng, W., Saxe, M. D., Gallina, I. S. & Gage, F. H. Adultborn hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain. J. Neurosci. 29, 13532-13542 (2009).
    • (2009) J. Neurosci. , vol.29 , pp. 13532-13542
    • Deng, W.1    Saxe, M.D.2    Gallina, I.S.3    Gage, F.H.4
  • 139
    • 84927653879 scopus 로고    scopus 로고
    • Correlates of cognitive flexibility in veterans seeking treatment for posttraumatic stress disorder
    • Keith, J., Velezmoro, R., O'Brien, C. Correlates of cognitive flexibility in veterans seeking treatment for posttraumatic stress disorder. J. Nerv. Ment. Dis. 203, 287-293 (2015).
    • (2015) J. Nerv. Ment. Dis. , vol.203 , pp. 287-293
    • Keith, J.1    Velezmoro, R.2    O'Brien, C.3
  • 140
    • 33847327941 scopus 로고    scopus 로고
    • Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder
    • Chamberlain, S. R., et al. Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder. Am. J. Psychiatry 164, 335-338 (2007).
    • (2007) Am. J. Psychiatry , vol.164 , pp. 335-338
    • Chamberlain, S.R.1
  • 141
    • 33748302934 scopus 로고    scopus 로고
    • A preliminary investigation of cognitive flexibility for emotional information in major depressive disorder and nonpsychiatric controls
    • Deveney, C. M. & Deldin, P. J. A preliminary investigation of cognitive flexibility for emotional information in major depressive disorder and nonpsychiatric controls. Emotion 6, 429-437 (2006).
    • (2006) Emotion , vol.6 , pp. 429-437
    • Deveney, C.M.1    Deldin, P.J.2
  • 142
    • 0034671366 scopus 로고    scopus 로고
    • Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
    • Malberg, J. E., Eisch, A. J., Nestler, E. J. & Duman, R. S. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J. Neurosci. 20, 9104-9110 (2000).
    • (2000) J. Neurosci. , vol.20 , pp. 9104-9110
    • Malberg, J.E.1    Eisch, A.J.2    Nestler, E.J.3    Duman, R.S.4
  • 143
    • 33744919791 scopus 로고    scopus 로고
    • Agomelatine, a new antidepressant, induces regional changes in hippocampal neurogenesis
    • Banasr, M., Soumier, A., Hery, M., Mocaer, E. & Daszuta, A. Agomelatine, a new antidepressant, induces regional changes in hippocampal neurogenesis. Biol. Psychiatry 59, 1087-1096 (2006).
    • (2006) Biol. Psychiatry , vol.59 , pp. 1087-1096
    • Banasr, M.1    Soumier, A.2    Hery, M.3    Mocaer, E.4    Daszuta, A.5
  • 144
    • 77954380113 scopus 로고    scopus 로고
    • The novel antidepressant agomelatine normalizes hippocampal neuronal activity and promotes neurogenesis in chronically stressed rats
    • Dagyte, G., et al. The novel antidepressant agomelatine normalizes hippocampal neuronal activity and promotes neurogenesis in chronically stressed rats. CNS Neurosci. Ther. 16, 195-207 (2010).
    • (2010) CNS Neurosci. Ther. , vol.16 , pp. 195-207
    • Dagyte, G.1
  • 145
    • 84866030690 scopus 로고    scopus 로고
    • Hippocampal angiogenesis and progenitor cell proliferation are increased with antidepressant use in major depression
    • Boldrini, M., et al. Hippocampal angiogenesis and progenitor cell proliferation are increased with antidepressant use in major depression. Biol. Psychiatry 72, 562-571 (2012).
    • (2012) Biol. Psychiatry , vol.72 , pp. 562-571
    • Boldrini, M.1
  • 146
    • 79959586058 scopus 로고    scopus 로고
    • Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor
    • Anacker, C., et al. Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor. Mol. Psychiatry 16, 738-750 (2011).
    • (2011) Mol. Psychiatry , vol.16 , pp. 738-750
    • Anacker, C.1
  • 147
    • 0036734833 scopus 로고    scopus 로고
    • Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice
    • Lee, J., Duan, W. & Mattson, M. P. Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. J. Neurochem. 82, 1367-1375 (2002).
    • (2002) J. Neurochem. , vol.82 , pp. 1367-1375
    • Lee, J.1    Duan, W.2    Mattson, M.P.3
  • 148
    • 71949111696 scopus 로고    scopus 로고
    • Impact of diet on adult hippocampal neurogenesis
    • Stangl, D. & Thuret, S. Impact of diet on adult hippocampal neurogenesis. Genes Nutr. 4, 271-282 (2009).
    • (2009) Genes Nutr. , vol.4 , pp. 271-282
    • Stangl, D.1    Thuret, S.2
  • 149
    • 84926158983 scopus 로고    scopus 로고
    • The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis
    • Walker, A. K., et al. The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis. Mol. Psychiatry 20, 500-508 (2015).
    • (2015) Mol. Psychiatry , vol.20 , pp. 500-508
    • Walker, A.K.1
  • 150
    • 84908346566 scopus 로고    scopus 로고
    • Mental and physical (MAP) training: A neurogenesis-inspired intervention that enhances health in humans
    • Shors, T. J., Olson, R. L., Bates, M. E., Selby, E. A. & Alderman, B. L. Mental and physical (MAP) training: A neurogenesis-inspired intervention that enhances health in humans. Neurobiol. Learn. Mem. 115, 3-9 (2014).
    • (2014) Neurobiol. Learn. Mem. , vol.115 , pp. 3-9
    • Shors, T.J.1    Olson, R.L.2    Bates, M.E.3    Selby, E.A.4    Alderman, B.L.5
  • 152
    • 33745684603 scopus 로고    scopus 로고
    • Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment
    • Meshi, D., et al. Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment. Nat. Neurosci. 9, 729-731 (2006).
    • (2006) Nat. Neurosci. , vol.9 , pp. 729-731
    • Meshi, D.1
  • 153
    • 3242784041 scopus 로고    scopus 로고
    • Functional implications of seizureinduced neurogenesis
    • Scharfman, H. E. Functional implications of seizureinduced neurogenesis. Adv. Exp. Med. Biol. 548, 192-212 (2004).
    • (2004) Adv. Exp. Med. Biol. , vol.548 , pp. 192-212
    • Scharfman, H.E.1
  • 154
    • 33846586998 scopus 로고    scopus 로고
    • Neuroscience. Is more neurogenesis always better?
    • Scharfman, H. E. & Hen, R. Neuroscience. Is more neurogenesis always better? Science 315, 336-338 (2007).
    • (2007) Science , vol.315 , pp. 336-338
    • Scharfman, H.E.1    Hen, R.2
  • 155
    • 0037015059 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo
    • Jin, K., et al. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc. Natl Acad. Sci. USA 99, 11946-11950 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 11946-11950
    • Jin, K.1
  • 156
    • 48749115329 scopus 로고    scopus 로고
    • TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment
    • Li, Y., et al. TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment. Neuron 59, 399-412 (2008).
    • (2008) Neuron , vol.59 , pp. 399-412
    • Li, Y.1
  • 157
    • 79955464637 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor is critically involved in basal and fluoxetinestimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors
    • Conboy, L., et al. Macrophage migration inhibitory factor is critically involved in basal and fluoxetinestimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors. Mol. Psychiatry 16, 533-547 (2011).
    • (2011) Mol. Psychiatry , vol.16 , pp. 533-547
    • Conboy, L.1
  • 158
    • 84945433786 scopus 로고    scopus 로고
    • 5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response
    • Samuels, B. A., et al. 5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response. Nat. Neurosci. 18, 1606-1616 (2015).
    • (2015) Nat. Neurosci. , vol.18 , pp. 1606-1616
    • Samuels, B.A.1
  • 159
    • 84961778106 scopus 로고    scopus 로고
    • Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells
    • Madroñal, N., et al. Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells. Nat. Commun. 7, 10923 (2016).
    • (2016) Nat. Commun. , vol.7 , pp. 10923
    • Madroñal, N.1
  • 162
    • 84877626914 scopus 로고    scopus 로고
    • Toward the future of psychiatric diagnosis: The seven pillars of RDoC
    • Cuthbert, B. N. & Insel, T. R. Toward the future of psychiatric diagnosis: The seven pillars of RDoC. BMC Med. 11, 126 (2013).
    • (2013) BMC Med. , vol.11 , pp. 126
    • Cuthbert, B.N.1    Insel, T.R.2
  • 163
    • 84920645919 scopus 로고    scopus 로고
    • From psychiatric disorders to animal models: A bidirectional and dimensional approach
    • Donaldson, Z. R. & Hen, R. From psychiatric disorders to animal models: A bidirectional and dimensional approach. Biol. Psychiatry 77, 15-21 (2014).
    • (2014) Biol. Psychiatry , vol.77 , pp. 15-21
    • Donaldson, Z.R.1    Hen, R.2
  • 164
    • 36048970985 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain
    • Manganas, L. N., et al. Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain. Science 318, 980-985 (2007).
    • (2007) Science , vol.318 , pp. 980-985
    • Manganas, L.N.1
  • 165
    • 77951792317 scopus 로고    scopus 로고
    • Noninvasive imaging of endogenous neural stem cell mobilization in vivo using positron emission tomography
    • Rueger, M. A., et al. Noninvasive imaging of endogenous neural stem cell mobilization in vivo using positron emission tomography. J. Neurosci. 30, 6454-6460 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 6454-6460
    • Rueger, M.A.1
  • 166
    • 84982892894 scopus 로고    scopus 로고
    • Noninvasive evaluation of cellular proliferative activity in brain neurogenic regions in rats under depression and treatment by enhanced [18F]FLT-PET imaging
    • Tamura, Y., et al. Noninvasive evaluation of cellular proliferative activity in brain neurogenic regions in rats under depression and treatment by enhanced [18F]FLT-PET imaging. J. Neurosci. 36, 8123-8131 (2016).
    • (2016) J. Neurosci. , vol.36 , pp. 8123-8131
    • Tamura, Y.1
  • 167
    • 34248375311 scopus 로고    scopus 로고
    • An in vivo correlate of exerciseinduced neurogenesis in the adult dentate gyrus
    • Pereira, A. C., et al. An in vivo correlate of exerciseinduced neurogenesis in the adult dentate gyrus. Proc. Natl Acad. Sci. USA 104, 5638-5643 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 5638-5643
    • Pereira, A.C.1
  • 168
    • 84896083027 scopus 로고    scopus 로고
    • Modeling hippocampal neurogenesis using human pluripotent stem cells
    • Yu, D. X., et al. Modeling hippocampal neurogenesis using human pluripotent stem cells. Stem Cell Rep. 2, 295-310 (2014).
    • (2014) Stem Cell Rep. , vol.2 , pp. 295-310
    • Yu, D.X.1
  • 169
    • 84959357347 scopus 로고    scopus 로고
    • Organoids as an in vitro model of human development and disease
    • Fatehullah, A., Tan, S. H. & Barker, N. Organoids as an in vitro model of human development and disease. Nat. Cell Biol. 18, 246-254 (2016).
    • (2016) Nat. Cell Biol. , vol.18 , pp. 246-254
    • Fatehullah, A.1    Tan, S.H.2    Barker, N.3
  • 170
    • 78650994901 scopus 로고    scopus 로고
    • Distinct pattern separation related transfer functions in human CA3/dentate and CA1 revealed using high-resolution fMRI and variable mnemonic similarity
    • Lacy, J. W., Yassa, M. A., Stark, S. M., Muftuler, L. T. & Stark, C. E. Distinct pattern separation related transfer functions in human CA3/dentate and CA1 revealed using high-resolution fMRI and variable mnemonic similarity. Learn. Mem. 18, 15-18 (2011).
    • (2011) Learn. Mem. , vol.18 , pp. 15-18
    • Lacy, J.W.1    Yassa, M.A.2    Stark, S.M.3    Muftuler, L.T.4    Stark, C.E.5
  • 171
    • 41149088380 scopus 로고    scopus 로고
    • Pattern separation in the human hippocampal CA3 and dentate gyrus
    • Bakker, A., Kirwan, C. B., Miller, M. & Stark, C. E. Pattern separation in the human hippocampal CA3 and dentate gyrus. Science 319, 1640-1642 (2008).
    • (2008) Science , vol.319 , pp. 1640-1642
    • Bakker, A.1    Kirwan, C.B.2    Miller, M.3    Stark, C.E.4
  • 172
    • 84906790522 scopus 로고    scopus 로고
    • Pattern separation of emotional information in hippocampal dentate and CA3
    • Leal, S. L., Tighe, S. K., Jones, C. K. & Yassa, M. A. Pattern separation of emotional information in hippocampal dentate and CA3. Hippocampus 24, 1146-1155 (2014).
    • (2014) Hippocampus , vol.24 , pp. 1146-1155
    • Leal, S.L.1    Tighe, S.K.2    Jones, C.K.3    Yassa, M.A.4
  • 173
    • 70449709576 scopus 로고    scopus 로고
    • Computational modeling and empirical studies of hippocampal neurogenesis-dependent memory: Effects of interference, stress and depression
    • Becker, S., Macqueen, G. & Wojtowicz, J. M. Computational modeling and empirical studies of hippocampal neurogenesis-dependent memory: effects of interference, stress and depression. Brain Res. 1299, 45-54 (2009).
    • (2009) Brain Res. , vol.1299 , pp. 45-54
    • Becker, S.1    Macqueen, G.2    Wojtowicz, J.M.3
  • 174
    • 84888794161 scopus 로고    scopus 로고
    • Neural activity in human hippocampal formation reveals the spatial context of retrieved memories
    • Miller, J. F., et al. Neural activity in human hippocampal formation reveals the spatial context of retrieved memories. Science 342, 1111-1114 (2013).
    • (2013) Science , vol.342 , pp. 1111-1114
    • Miller, J.F.1
  • 175
    • 84938204783 scopus 로고    scopus 로고
    • A role for adult hippocampal neurogenesis at multiple time scales: A study of recent and remote memory in humans
    • Déry, N., Goldstein, A. & Becker, S. A role for adult hippocampal neurogenesis at multiple time scales: A study of recent and remote memory in humans. Behav. Neurosci. 129, 435-449 (2015).
    • (2015) Behav. Neurosci. , vol.129 , pp. 435-449
    • Déry, N.1    Goldstein, A.2    Becker, S.3
  • 176
    • 84878822765 scopus 로고    scopus 로고
    • Adult hippocampal neurogenesis reduces memory interference in humans: Opposing effects of aerobic exercise and depression
    • Déry, N., et al. Adult hippocampal neurogenesis reduces memory interference in humans: opposing effects of aerobic exercise and depression. Front. Neurosci. 7, 66 (2013).
    • (2013) Front. Neurosci. , vol.7 , pp. 66
    • Déry, N.1
  • 177
    • 34047182583 scopus 로고    scopus 로고
    • Performance on a virtual reality spatial memory navigation task in depressed patients
    • Gould, N. F., et al. Performance on a virtual reality spatial memory navigation task in depressed patients. Am. J. Psychiatry 164, 516-519 (2007).
    • (2007) Am. J. Psychiatry , vol.164 , pp. 516-519
    • Gould, N.F.1
  • 178
    • 0030575417 scopus 로고    scopus 로고
    • Executive dysfunction in depression: The Wisconsin Card Sorting Test
    • Channon, S. Executive dysfunction in depression: The Wisconsin Card Sorting Test. J. Affect. Disord. 39, 107-114 (1996).
    • (1996) J. Affect. Disord. , vol.39 , pp. 107-114
    • Channon, S.1
  • 180
    • 0027318998 scopus 로고
    • A role for the hippocampus in card sorting?
    • Corcoran, R. & Upton, D. A role for the hippocampus in card sorting? Cortex 29, 293-304 (1993).
    • (1993) Cortex , vol.29 , pp. 293-304
    • Corcoran, R.1    Upton, D.2
  • 181
    • 0344393796 scopus 로고    scopus 로고
    • Orbital prefrontal cortex mediates reversal learning and not attentional set shifting in the rat
    • McAlonan, K. & Brown, V. J. Orbital prefrontal cortex mediates reversal learning and not attentional set shifting in the rat. Behav. Brain Res. 146, 97-103 (2003).
    • (2003) Behav. Brain Res. , vol.146 , pp. 97-103
    • McAlonan, K.1    Brown, V.J.2
  • 182
    • 84988564556 scopus 로고    scopus 로고
    • Attentional set-shifting across species
    • Brown, V. J. & Tait, D. S. Attentional set-shifting across species. Curr. Top. Behav. Neurosci. 28, 363-395 (2016).
    • (2016) Curr. Top. Behav. Neurosci. , vol.28 , pp. 363-395
    • Brown, V.J.1    Tait, D.S.2
  • 183
    • 84961290634 scopus 로고    scopus 로고
    • Reward-based spatial learning in unmedicated adults with obsessive-compulsive disorder
    • Marsh, R., et al. Reward-based spatial learning in unmedicated adults with obsessive-compulsive disorder. Am. J. Psychiatry 172, 383-392 (2015).
    • (2015) Am. J. Psychiatry , vol.172 , pp. 383-392
    • Marsh, R.1
  • 184
    • 84858606751 scopus 로고    scopus 로고
    • Interactivity and reward-related neural activation during a serious videogame
    • Cole, S. W., Yoo, D. J. & Knutson, B. Interactivity and reward-related neural activation during a serious videogame. PLoS ONE 7, e33909 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e33909
    • Cole, S.W.1    Yoo, D.J.2    Knutson, B.3
  • 185
    • 84963721858 scopus 로고    scopus 로고
    • Video games for neuro-cognitive optimization
    • Mishra, J., Anguera, J. A. & Gazzaley, A. Video games for neuro-cognitive optimization. Neuron 90, 214-218 (2016).
    • (2016) Neuron , vol.90 , pp. 214-218
    • Mishra, J.1    Anguera, J.A.2    Gazzaley, A.3
  • 186
    • 0033545171 scopus 로고    scopus 로고
    • Projections from the lateral, basal, and accessory basal nuclei of the amygdala to the hippocampal formation in rat
    • Pikkarainen, M., Rönkkö, S., Savander, V., Insausti, R. & Pitkänen, A. Projections from the lateral, basal, and accessory basal nuclei of the amygdala to the hippocampal formation in rat. J. Comp. Neurol. 403, 229-260 (1999).
    • (1999) J. Comp. Neurol. , vol.403 , pp. 229-260
    • Pikkarainen, M.1    Rönkkö, S.2    Savander, V.3    Insausti, R.4    Pitkänen, A.5
  • 187
    • 84882638498 scopus 로고    scopus 로고
    • BLA to vHPC inputs modulate anxiety-related behaviors
    • Felix-Ortiz, A. C., et al. BLA to vHPC inputs modulate anxiety-related behaviors. Neuron 79, 658-664 (2013).
    • (2013) Neuron , vol.79 , pp. 658-664
    • Felix-Ortiz, A.C.1
  • 188
    • 84942163652 scopus 로고    scopus 로고
    • Hippocampal theta input to the amygdala shapes feedforward inhibition to gate heterosynaptic plasticity
    • Bazelot, M., et al. Hippocampal theta input to the amygdala shapes feedforward inhibition to gate heterosynaptic plasticity. Neuron 87, 1290-1303 (2015).
    • (2015) Neuron , vol.87 , pp. 1290-1303
    • Bazelot, M.1
  • 189
    • 0026781307 scopus 로고
    • Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons
    • Watanabe, Y., Gould, E. & McEwen, B. S. Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons. Brain Res. 588, 341-345 (1992).
    • (1992) Brain Res. , vol.588 , pp. 341-345
    • Watanabe, Y.1    Gould, E.2    McEwen, B.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.