Altered expression of lipid metabolism and immune response genes in the frontal cortex of suicide completers

Journal of Affective Disorders

Volumn 120, Issue 1-3, 2010, Pages 24-31

  Lalovic, Aleksandra ^a   Klempan, Tim ^a   Sequeira, Adolfo ^a   Luheshi, Giamal ^b   Turecki, Gustavo ^a  

^a MCGILL UNIVERSITY   (Canada)

^b DOUGLAS MENTAL HEALTH UNIVERSITY INSTITUTE   (Canada)

Author keywords

Cholesterol; Cytokines; Depression; Microarray; Post mortem; Suicide

Indexed keywords

ACYL COENZYME A DESATURASE; LEPTIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE;

ADULT; ARTICLE; BRAIN TISSUE; CADAVER; CLINICAL ARTICLE; COMPARATIVE STUDY; DISEASE ASSOCIATION; DOWN REGULATION; FRONTAL CORTEX; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; IMMUNE RESPONSE; LIPID METABOLISM; MAJOR DEPRESSION; MALE; MICROARRAY ANALYSIS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SUICIDE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADOLESCENT; ADULT; DEPRESSIVE DISORDER, MAJOR; DOWN-REGULATION; FATTY ACID DESATURASES; FRONTAL LOBE; HUMANS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROTEIN ARRAY ANALYSIS; RECEPTORS, LEPTIN; STEAROYL-COA DESATURASE; SUICIDE; YOUNG ADULT;

EID: 71649089978     PISSN: 01650327     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jad.2009.04.007     Document Type: Article

References (60)

1. Ahima R.S., and Osei S.Y. Leptin signaling. Physiol. Behav. 81 (2004) 223-241
2. Alvarez J.C., Cremniter D., Lesieur P., Gregoire A., Gilton A., Macquin-Mavier I., Jarreau C., and Spreux-Varoquaux O. Low blood cholesterol and low platelet serotonin levels in violent suicide attempters. Biol. Psychiatry 45 (1999) 1066-1069
3. Arango V., Underwood M.D., and Mann J.J. Postmortem findings in suicide victims. Implications for in vivo imaging studies. Ann. N.Y. Acad. Sci. 836 (1997) 269-287
4. Atmaca M., Kuloglu M., Tezcan E., Gecici O., and Ustundag B. Serum cholesterol and leptin levels in patients with borderline personality disorder. Neuropsychobiology 45 (2002) 167-171
5. Atmaca M., Kuloglu M., Tezcan E., Ustundag B., Gecici O., and Firidin B. Serum leptin and cholesterol values in suicide attempters. Neuropsychobiology 45 (2002) 124-127
6. Atmaca M., Kuloglu M., Tezcan E., and Ustundag B. Serum leptin and cholesterol levels in schizophrenic patients with and without suicide attempts. Acta Psychiatr. Scand. 108 (2003) 208-214
7. Atmaca M., Kuloglu M., Tezcan E., and Ustundag B. Serum leptin and cholesterol values in violent and non-violent suicide attempters. Psychiatry Res. 158 (2008) 87-91
8. Benjamini Y., and Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. Royal Stat. Soc., B 57 (1995) 289-300
9. Bland J.M., and Altman D.G. Multiple significance tests: the Bonferroni method. BMJ 310 (1995) 170
10. Burguera B., Couce M.E., Long J., Lamsam J., Laakso K., Jensen M.D., Parisi J.E., and Lloyd R.V. The long form of the leptin receptor (OB-Rb) is widely expressed in the human brain. Neuroendocrinology 71 (2000) 187-195
11. Cohen P., Miyazaki M., Socci N.D., Hagge-Greenberg A., Liedtke W., Soukas A.A., Sharma R., Hudgins L.C., Ntambi J.M., and Friedman J.M. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science 297 (2002) 240-243
12. Couce M.E., Burguera B., Parisi J.E., Jensen M.D., and Lloyd R.V. Localization of leptin receptor in the human brain. Neuroendocrinology 66 (1997) 145-150
13. Duman R.S., Malberg J., Nakagawa S., and D Sa C. Neuronal plasticity and survival in mood disorders. Biol. Psychiatry 48 (2000) 732-739
14. Edwards R., Peet M., Shay J., and Horrobin D. Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients. J. Affect. Disord. 48 (1998) 149-155
15. Ellison L.F., and Morrison H.I. Low serum cholesterol concentration and risk of suicide. Epidemiology 12 (2001) 168-172
16. Engelberg H. Low serum cholesterol and suicide. Lancet 339 (1992) 727-729
17. Falasca M., and Maffucci T. Role of class II phosphoinositide 3-kinase in cell signalling. Biochem. Soc. Trans. 35 (2007) 211-214
18. Ferno J., Raeder M.B., Vik-Mo A.O., Skrede S., Glambek M., Tronstad K.J., Breilid H., Lovlie R., Berge R.K., Stansberg C., and Steen V.M. Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action?. Pharmacogenomics J. 5 (2005) 298-304
19. Friedman J.M., and Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 395 (1998) 763-770
20. Garland M.R., Hallahan B., McNamara M., Carney P.A., Grimes H., Hibbeln J.R., Harkin A., and Conroy R.M. Lipids and essential fatty acids in patients presenting with self-harm. Br. J. Psychiatry 190 (2007) 112-117
21. Golomb B.A. Cholesterol and violence: is there a connection?. Ann. Intern. Med. 128 (1998) 478-487
22. Golomb B.A., Stattin H., and Mednick S. Low cholesterol and violent crime. J. Psychiatr. Res. 34 (2000) 301-309
23. Harvey J. Novel actions of leptin in the hippocampus. Ann. Med. 35 (2003) 197-206
24. Harvey J., and Ashford M.L. Leptin in the CNS: much more than a satiety signal. Neuropharmacology 44 (2003) 845-854
25. Huan M., Hamazaki K., Sun Y., Itomura M., Liu H., Kang W., Watanabe S., Terasawa K., and Hamazaki T. Suicide attempt and n - 3 fatty acid levels in red blood cells: a case control study in China. Biol. Psychiatry 56 (2004) 490-496
26. Jow G.M., Yang T.T., and Chen C.L. Leptin and cholesterol levels are low in major depressive disorder, but high in schizophrenia. J. Affect. Disord. 90 (2006) 21-27
27. Kalkman H.O. The role of the phosphatidylinositide 3-kinase-protein kinase B pathway in schizophrenia. Pharmacol. Ther. 110 (2006) 117-134
28. Kim C., Lesage A., Seguin M., Chawky N., Vanier C., Lipp O., and Turecki G. Patterns of co-morbidity in male suicide completers. Psychol. Med. 33 (2003) 1299-1309
29. Kraus T., Haack M., Schuld A., Hinze-Selch D., and Pollmacher T. Low leptin levels but normal body mass indices in patients with depression or schizophrenia. Neuroendocrinology 73 (2001) 243-247
30. Kunugi H., Takei N., Aoki H., and Nanko S. Low serum cholesterol in suicide attempters. Biol. Psychiatry 41 (1997) 196-200
31. Lalovic A., Levy E., Canetti L., Sequeira A., Montoudis A., and Turecki G. Fatty acid composition in postmortem brains of suicide completers. J. Psychiatry Neurosci. 32 (2007) 363-370
32. Lalovic A., Levy E., Luheshi G., Canetti L., Grenier E., Sequeira A., and Turecki G. Cholesterol content in brains of suicide completers. Int. J. Neuropsychopharmacol. 10 (2007) 159-166
33. Lesage A.D., Boyer R., Grunberg F., Vanier C., Morissette R., Menard-Buteau C., and Loyer M. Suicide and mental disorders: a case-control study of young men. Am. J. Psychiatry 151 (1994) 1063-1068
34. Logan A.C. Neurobehavioral aspects of omega-3 fatty acids: possible mechanisms and therapeutic value in major depression. Altern. Med. Rev. 8 (2003) 410-425
35. Lu X.Y., Kim C.S., Frazer A., and Zhang W. Leptin: a potential novel antidepressant. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 1593-1598
36. Maes M., Bosmans E., Meltzer H.Y., Scharpe S., and Suy E. Interleukin-1 beta: a putative mediator of HPA axis hyperactivity in major depression?. Am. J. Psychiatry 150 (1993) 1189-1193
37. Maes M., Meltzer H.Y., Bosmans E., Bergmans R., Vandoolaeghe E., Ranjan R., and Desnyder R. Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression. J. Affect. Disord. 34 (1995) 301-309
38. Maes M., Smith R., Christophe A., Cosyns P., Desnyder R., and Meltzer H. Fatty acid composition in major depression: decreased omega 3 fractions in cholesteryl esters and increased C20: 4 omega 6/C20:5 omega 3 ratio in cholesteryl esters and phospholipids. J. Affect. Disord. 38 (1996) 35-46
39. Maes M., Smith R., Christophe A., Vandoolaeghe E., Van Gastel A., Neels H., Demedts P., Wauters A., and Meltzer H.Y. Lower serum high-density lipoprotein cholesterol (HDL-C) in major depression and in depressed men with serious suicidal attempts: relationship with immune-inflammatory markers. Acta Psychiatr. Scand. 95 (1997) 212-221
40. Maes M., Christophe A., Delanghe J., Altamura C., Neels H., and Meltzer H.Y. Lowered omega3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients. Psychiatry Res. 85 (1999) 275-291
41. Mann J.J., Brent D.A., and Arango V. The neurobiology and genetics of suicide and attempted suicide: a focus on the serotonergic system. Neuropsychopharmacology 24 (2001) 467-477
42. Martin-Pena A., Acebes A., Rodriguez J.R., Sorribes A., de Polavieja G.G., Fernandez-Funez P., and Ferrus A. Age-independent synaptogenesis by phosphoinositide 3 kinase. J. Neurosci. 26 (2006) 10199-10208
43. Medina J.M., and Tabernero A. Astrocyte-synthesized oleic acid behaves as a neurotrophic factor for neurons. J. Physiol. (Paris) 96 (2002) 265-271
44. Middleton F.A., Pato C.N., Gentile K.L., McGann L., Brown A.M., Trauzzi M., Diab H., Morley C.P., Medeiros H., Macedo A., Azevedo M.H., and Pato M.T. Gene expression analysis of peripheral blood leukocytes from discordant sib-pairs with schizophrenia and bipolar disorder reveals points of convergence between genetic and functional genomic approaches. Am. J. Med. Genet., B Neuropsychiatr. Genet. 136 (2005) 12-25
45. Miyazaki M., Kim Y.C., Gray-Keller M.P., Attie A.D., and Ntambi J.M. The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1. J. Biol. Chem. 275 (2000) 30132-30138
46. Modai I., Valevski A., Dror S., and Weizman A. Serum cholesterol levels and suicidal tendencies in psychiatric inpatients. J. Clin. Psychiatry 55 (1994) 252-254
47. Ongur D., Drevets W.C., and Price J.L. Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 13290-13295
48. Peet M., Murphy B., Shay J., and Horrobin D. Depletion of omega-3 fatty acid levels in red blood cell membranes of depressive patients. Biol. Psychiatry 43 (1998) 315-319
49. Pfrieger F.W. Cholesterol homeostasis and function in neurons of the central nervous system. Cell. Mol. Life Sci. 60 (2003) 1158-1171
50. Raeder M.B., Ferno J., Glambek M., Stansberg C., and Steen V.M. Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells. Neurosci. Lett. 395 (2006) 185-190
51. Rajkowska G., Miguel-Hidalgo J.J., Wei J., Dilley G., Pittman S.D., Meltzer H.Y., Overholser J.C., Roth B.L., and Stockmeier C.A. Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression. Biol. Psychiatry 45 (1999) 1085-1098
52. Sequeira A., Klempan T., Canetti L., Ffrench-Mullen J., Benkelfat C., Rouleau G.A., and Turecki G. Patterns of gene expression in the limbic system of suicides with and without major depression. Mol. Psychiatry 12 (2007) 640-655
53. Slonim D.K. From patterns to pathways: gene expression data analysis comes of age. Nat. Genet. 32 (2002) 502-508 (Suppl)
54. Sublette M.E., Hibbeln J.R., Galfalvy H., Oquendo M.A., and Mann J.J. Omega-3 polyunsaturated essential fatty acid status as a predictor of future suicide risk. Am. J. Psychiatry 163 (2006) 1100-1102
55. Tanskanen A., Hibbeln J.R., Hintikka J., Haatainen K., Honkalampi K., and Viinamaki H. Fish consumption, depression, and suicidality in a general population. Arch. Gen. Psychiatry 58 (2001) 512-513
56. Turecki G., Briere R., Dewar K., Antonetti T., Lesage A.D., Seguin M., Chawky N., Vanier C., Alda M., Joober R., Benkelfat C., and Rouleau G.A. Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide. Am. J. Psychiatry 156 (1999) 1456-1458
57. Velasco A., Tabernero A., and Medina J.M. Role of oleic acid as a neurotrophic factor is supported in vivo by the expression of GAP-43 subsequent to the activation of SREBP-1 and the up-regulation of stearoyl-CoA desaturase during postnatal development of the brain. Brain Res. 977 (2003) 103-111
58. Westfall P.H., and Young S.S. Resampling-based Multiple Testing (1993), John Wiley & Sons, New York
59. Westling S., Ahren B., Traskman-Bendz L., and Westrin A. Low CSF leptin in female suicide attempters with major depression. J. Affect. Disord. 81 (2004) 41-48
60. Zureik M., Courbon D., and Ducimetiere P. Serum cholesterol concentration and death from suicide in men: Paris prospective study I. BMJ 313 (1996) 649-651