Fetal origins of mental health: The developmental origins of health and disease hypothesis

American Journal of Psychiatry

Volumn 174, Issue 4, 2017, Pages 319-328

  O'Donnell, Kieran J ^b   Meaney, Michael J ^a  

^a MCGILL UNIVERSITY   (Canada)

^b AGENCY FOR SCIENCE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; GLUCOCORTICOID;

ANXIETY; ARTICLE; ATTENTION DEFICIT DISORDER; BIRTH WEIGHT; CHILD ABUSE; DEPRESSION; FETUS DEVELOPMENT; FETUS GROWTH; HEREDITY; HUMAN; MATERNAL STRESS; MENTAL DISEASE; MENTAL HEALTH; MOOD; NERVE CELL DIFFERENTIATION; NONHUMAN; PREGNANCY OUTCOME; PRENATAL PERIOD; PSYCHOTHERAPY; PUERPERAL DEPRESSION; RISK FACTOR; THERAPY RESISTANCE; AFFECT; BLOOD; BRAIN; CHILD; CHRONIC DISEASE; COMPLICATION; EMBRYOLOGY; FEMALE; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; INFANT; INTRAUTERINE GROWTH RETARDATION; MALE; MATERNAL WELFARE; MENTAL STRESS; NEWBORN; PATHOPHYSIOLOGY; PHYSIOLOGY; PREGNANCY; PRENATAL EXPOSURE; PRESCHOOL CHILD; TEMPERAMENT;

AFFECT; BIRTH WEIGHT; BRAIN; CHILD; CHILD, PRESCHOOL; CHRONIC DISEASE; FEMALE; FETAL DEVELOPMENT; FETAL GROWTH RETARDATION; GENE-ENVIRONMENT INTERACTION; GLUCOCORTICOIDS; HUMANS; INFANT; INFANT, NEWBORN; MALE; MATERNAL HEALTH; MENTAL DISORDERS; NEURODEVELOPMENTAL DISORDERS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PSYCHOPATHOLOGY; RISK FACTORS; STRESS, PSYCHOLOGICAL; TEMPERAMENT;

EID: 85016926246     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2016.16020138     Document Type: Article

References (89)

1. Bateson P, Gluckman P, Hanson M: The biology of developmental plasticity and the predictive adaptive response hypothesis. J Physiol 2014; 592:2357-2368
2. Hales CN, Barker DJ: Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 1992; 35:595-601
3. Insel TR, Wang PS: Rethinking mental illness. JAMA 2010; 303: 1970-1971
4. Schlotz W, Phillips DI: Fetal origins of mental health: evidence and mechanisms. Brain Behav Immun 2009; 23:905-916
5. Räikkönen K, Pesonen AK, Roseboom TJ, et al: Early determinants of mental health. Best Pract Res Clin Endocrinol Metab 2012; 26:599-611
6. Breslau N, Chilcoat HD: Psychiatric sequelae of low birth weight at 11 years of age. Biol Psychiatry 2000; 47:1005-1011
7. Banerjee TD, Middleton F, Faraone SV: Environmental risk factors for attention-deficit hyperactivity disorder. Acta Paediatr 2007; 96: 1269-1274
8. Wiles NJ, Peters TJ, Heron J, et al: Fetal growth and childhood behavioral problems: results from the ALSPAC cohort. Am J Epidemiol 2006; 163:829-837
9. Sucksdorff M, Lehtonen L, Chudal R, et al: Preterm birth and poor fetal growth as risk factors of attention-deficit/ hyperactivity disorder. Pediatrics 2015; 136:e599-e608
10. Aizer A, Currie J: The intergenerational transmission of inequality: maternal disadvantage and health at birth. Science 2014; 344: 856-861
11. Costello EJ, Worthman C, Erkanli A, et al: Prediction from low birth weight to female adolescent depression: a test of competing hypotheses. Arch Gen Psychiatry 2007; 64:338-344
12. Thomas K, Harrison G, Zammit S, et al: Association of measures of fetal and childhood growth with non-clinical psychotic symptoms in 12-year-olds: the ALSPAC cohort. Br J Psychiatry 2009; 194:521-526
13. Abel KM, Wicks S, Susser ES, et al: Birth weight, schizophrenia, and adult mental disorder: is risk confined to the smallest babies? Arch Gen Psychiatry 2010; 67:923-930
14. Glover V: Maternal depression, anxiety, and stress during pregnancy and child outcome: what needs to be done. Best Pract Res Clin Obstet Gynaecol 2014; 28:25-35
15. O'Donnell KJ, Glover V, Barker ED, et al: The persisting effect of maternal mood in pregnancy on childhood psychopathology. Dev Psychopathol 2014; 26:393-403
16. Pearson RM, Evans J, Kounali D, et al: Maternal depression during pregnancy and the postnatal period: risks and possible mechanisms for offspring depression at age 18 years. JAMA Psychiatry 2013; 70: 1312-1319
17. HuizinkAC, de MedinaPG, MulderEJ, et al: Psychological measures of prenatal stress as predictors of infant temperament. J Am Acad Child Adolesc Psychiatry 2002; 41:1078-1085
18. Werner EA, MyersMM,Fifer WP, et al: Prenatal predictors of infant temperament. Dev Psychobiol 2007; 49:474-484
19. Davis EP, Glynn LM, Schetter CD, et al: Prenatal exposure to maternal depression and cortisol influences infant temperament. J Am Acad Child Adolesc Psychiatry 2007; 46:737-746
20. Velders FP, Dieleman G, Cents RA, et al: Variation in the glucocorticoid receptor gene at rs41423247 moderates the effect of prenatal maternal psychological symptoms on child cortisol reactivity and behavior. Neuropsychopharmacology 2012; 37:2541-2549
21. Chen L, Pan H, Tuan TA, et al: Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes. Dev Psychopathol 2015; 27:137-150
22. Qiu A, Tuan TA, Ong ML, et al: COMT haplotypes modulate associations of antenatal maternal anxiety and neonatal cortical morphology. Am J Psychiatry 2015; 172:163-172
23. Goodman SH, Rouse MH, Connell AM, et al: Maternal depression and child psychopathology: a meta-analytic review. Clin Child Fam Psychol Rev 2011; 14:1-27
24. Weinstock M: The long-term behavioural consequences of prenatal stress. Neurosci Biobehav Rev 2008; 32:1073-1086
25. O'Donnell K, O'Connor TG, Glover V: Prenatal stress and neurodevelopment of the child: focus on the HPA axis and role of the placenta. Dev Neurosci 2009; 31:285-292
26. Raznahan A, GreensteinD, Lee NR, et al: Prenatal growth in humans and postnatal brain maturation into late adolescence. Proc Natl Acad Sci USA 2012; 109:11366-11371
27. Buss C, Lord C, Wadiwalla M, et al: Maternal care modulates the relationship between prenatal risk and hippocampal volume in women but not in men. J Neurosci 2007; 27:2592-2595
28. Qiu A, Anh TT, Li Y, et al: Prenatal maternal depression alters amygdala functional connectivity in 6-month-old infants. Transl Psychiatry 2015; 5:e508
29. Sandman CA, Buss C, Head K, et al: Fetal exposure to maternal depressive symptoms is associated with cortical thickness in late childhood. Biol Psychiatry 2015; 77:324-334
30. Buss C,DavisEP,MuftulerLT, et al:High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6-9-year-old children. Psychoneuroendocrinology 2010; 35: 141-153
31. DiPietro JA, Kivlighan KT, Costigan KA, et al: Prenatal antecedents of newborn neurological maturation. Child Dev 2010; 81:115-130
32. Monk C, Myers MM, Sloan RP, et al: Effects of women's stresselicited physiological activity and chronic anxiety on fetal heart rate. J Dev Behav Pediatr 2003; 24:32-38
33. Rifkin-Graboi A, Meaney MJ, Chen H, et al: Antenatal maternal anxiety predicts variations in neural structures implicated in anxiety disorders in newborns. JAmAcadChild Adolesc Psychiatry 2015; 54: 313.e2-321e2
34. Meaney MJ, Szyf M, Seckl JR: Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health. Trends Mol Med 2007; 13:269-277
35. Chapman K, Holmes M, Seckl J: 11b-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action. Physiol Rev 2013; 93:1139-1206
36. Gitau R, Cameron A, Fisk NM, et al: Fetal exposure to maternal cortisol. Lancet 1998; 352:707-708
37. Holmes MC, Abrahamsen CT, French KL, et al: The mother or the fetus? 11beta-hydroxysteroid dehydrogenase type 2 null mice provide evidence for direct fetal programming of behavior by endogenous glucocorticoids. J Neurosci 2006; 26:3840-3844
38. Buss C,Davis EP, Shahbaba B, et al: Maternal cortisol over the course of pregnancy and subsequent child amygdala and hippocampus volumes and affective problems. Proc Natl Acad Sci USA 2012; 109: E1312-E1319
39. Buss C, Entringer S, Wadhwa PD: Fetal programming of brain development: intrauterine stress and susceptibility to psychopathology. Sci Signal 2012; 5:pt7
40. O'Connor TG, Heron J, Golding J, et al: Maternal antenatal anxiety and behavioural/emotional problems in children: a test of a programming hypothesis. JChildPsycholPsychiatry 2003;44:1025-1036
41. Huizink AC, Mulder EJ, Robles de Medina PG, et al: Is pregnancy anxiety a distinctive syndrome? Early Hum Dev 2004; 79:81-91
42. Wadhwa PD, Sandman CA, Porto M, et al: The association between prenatal stress and infant birth weight and gestational age at birth: a prospective investigation. Am J Obstet Gynecol 1993; 169:858-865
43. Giesbrecht GF, Campbell T, Letourneau N, et al: Psychological distress and salivary cortisol covary within persons during pregnancy. Psychoneuroendocrinology 2012; 37:270-279
44. VoegtlineKM,Costigan KA, Kivlighan KT, et al: Concurrent levels of maternal salivary cortisol are unrelated to self-reported psychological measures in low-risk pregnant women. Arch Women Ment Health 2013; 16:101-108
45. Kramer MS, Lydon J, Séguin L, et al: Stress pathways to spontaneous preterm birth: the role of stressors, psychological distress, and stress hormones. Am J Epidemiol 2009; 169:1319-1326
46. Baibazarova E, van de Beek C, Cohen-Kettenis PT, et al: Influence of prenatal maternal stress, maternal plasma cortisol, and cortisol in the amnioticfluidonbirthoutcomes and childtemperamentat 3 months. Psychoneuroendocrinology 2013; 38:907-915
47. Sarkar P, Bergman K,O'Connor TG, et al: Maternal antenatal anxiety and amniotic fluid cortisol and testosterone: possible implications for foetal programming. J Neuroendocrinol 2008; 20:489-496
48. O'Connor TG, Tang W, Gilchrist MA, et al: Diurnal cortisol patterns and psychiatric symptoms in pregnancy: short-term longitudinal study. Biol Psychol 2014; 96:35-41
49. Evans LM, Myers MM, Monk C: Pregnant women's cortisol is elevated with anxiety and depression-but only when comorbid. Arch Women Ment Health 2008; 11:239-248
50. Zijlmans MA, Riksen-Walraven JM, de Weerth C: Associations between maternal prenatal cortisol concentrations and child outcomes: a systematic review. Neurosci Biobehav Rev 2015; 53:1-24
51. Xiong X, Harville EW, Mattison DR, et al: Exposure to Hurricane Katrina, post-traumatic stress disorder and birth outcomes. Am J Med Sci 2008; 336:111-115
52. Graignic-Philippe R, Dayan J, Chokron S, et al: Effects of prenatal stress on fetal and child development: a critical literature review. Neurosci Biobehav Rev 2014; 43:137-162
53. Grote NK, Bridge JA, Gavin AR, et al: A meta-analysis of depression during pregnancyand the risk of preterm birth, low birthweight, and intrauterine growth restriction. Arch Gen Psychiatry 2010; 67: 1012-1024
54. Cartier J, Zeng Y, Drake AJ: Glucocorticoids and the prenatal programming of neurodevelopmental disorders. Current Opinion in Behavioral Sciences 2016; 7:1-7
55. Davis EP, Waffarn F, Sandman CA: Prenatal treatment with glucocorticoids sensitizes the HPA axis response to stress among fullterm infants. Dev Psychobiol 2011; 53:175-183
56. Alexander N, Rosenlöcher F, Stalder T, et al: Impact of antenatal synthetic glucocorticoid exposure on endocrine stress reactivity in term-born children. J Clin Endocrinol Metab 2012; 97:3538-3544
57. Gutteling BM, de Weerth C, Buitelaar JK: Maternal prenatal stress and 4-6 year old children's salivary cortisol concentrations pre-and post-vaccination. Stress 2004; 7:257-260
58. O'Connor TG, Bergman K, Sarkar P, et al: Prenatal cortisol exposure predicts infant cortisol response to acute stress.DevPsychobiol 2013; 55:145-155
59. Dalziel SR, Lim VK, Lambert A, et al: Antenatal exposure to betamethasone: psychological functioning and health related quality of life 31 years after inclusion in randomised controlled trial.BMJ2005; 331:665
60. Asztalos EV, Murphy KE, Willan AR, et al: Multiple courses of antenatal corticosteroids for preterm birth study: outcomes in children at 5 years of age (MACS-5). JAMA Pediatr 2013; 167: 1102-1110
61. Peltoniemi OM, Kari MA, Hallman M: Repeated antenatal corticosteroid treatment: a systematic review and meta-analysis. Acta Obstet Gynecol Scand 2011; 90:719-727
62. McKinlay CJ, Crowther CA, Middleton P, et al: Repeat antenatal glucocorticoids for women at risk of preterm birth: a Cochrane Systematic Review. Am J Obstet Gynecol 2012; 206:187-194
63. Davis EP, Sandman CA: The timing of prenatal exposure to maternal cortisol and psychosocial stress is associated with human infant cognitive development. Child Dev 2010; 81:131-148
64. Van Lieshout RJ, Boylan K: Increased depressive symptoms in female but not male adolescents born at low birth weight in the offspring of a national cohort. Can J Psychiatry 2010; 55:422-430
65. Freathy RM,Mook-Kanamori DO, Sovio U, et al: Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet 2010; 42:430-435
66. Horikoshi M, Yaghootkar H, Mook-Kanamori DO, et al: New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet 2013; 45:76-82
67. Wüst S, Federenko I, Hellhammer DH, et al: Genetic factors, perceived chronic stress, and the free cortisol response to awakening. Psychoneuroendocrinology 2000; 25:707-720
68. Rice F, Harold GT, Boivin J, et al: The links between prenatal stress and offspring development and psychopathology: disentangling environmental and inherited influences. Psychol Med 2010; 40: 335-345
69. Ouellet-Morin I, Boivin M, Dionne G, et al: Variations in heritability of cortisol reactivity to stress as a function of early familial adversity among 19-month-old twins. Arch Gen Psychiatry 2008; 65:211-218
70. Pluess M, Velders FP, Belsky J, et al: Serotonin transporter polymorphism moderates effects of prenatal maternal anxiety on infant negative emotionality. Biol Psychiatry 2011; 69:520-525
71. Broekman BF, Chan YH, Goh L, et al: Influence of birth weight on internalizing traits modulated by serotonergic genes. Pediatrics 2011; 128:e1250-e1258
72. Wazana A, Moss E, Jolicoeur-Martineau A, et al: The interplay of birth weight, dopamine receptor D4 gene (DRD4), and early maternal care in the prediction of disorganized attachment at 36 months of age. Dev Psychopathol 2015; 27:1145-1161
73. Teh AL, Pan H, Chen L, et al: The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes. Genome Res 2014; 24:1064-1074
74. Nomura Y, Wickramaratne PJ, Pilowsky DJ, et al: Low birth weight and risk of affective disorders and selected medical illness in offspring at high and low risk for depression. Compr Psychiatry 2007; 48:470-478
75. Wray NR, Goddard ME, Visscher PM: Prediction of individual genetic risk to disease from genome-wide association studies. Genome Res 2007; 17:1520-1528
76. O'Donnell KJ, Bugge Jensen A, Freeman L, et al: Maternal prenatal anxiety and downregulation of placental 11b-HSD2. Psychoneuroendocrinology 2012; 37:818-826
77. Bergman K, Sarkar P, O'Connor TG, et al: Maternal stress during pregnancy predicts cognitive ability and fearfulness in infancy. JAm Acad Child Adolesc Psychiatry 2007; 46:1454-1463
78. Jefferis BJ, Power C, Hertzman C: Birth weight, childhood socioeconomic environment, and cognitive development in the 1958 British birth cohort study. BMJ 2002; 325:305
79. Kelly YJ, Nazroo JY, McMunn A, et al: Birthweight and behavioural problems in children: a modifiable effect? Int J Epidemiol 2001; 30: 88-94
80. Bohnert KM, Breslau N: Stability of psychiatric outcomes of low birthweight: a longitudinal investigation. ArchGenPsychiatry 2008; 65:1080-1086
81. Tully LA, Arseneault L, Caspi A, et al: Does maternal warmth moderate the effects of birth weight on twins' attention-deficit/ hyperactivity disorder (ADHD) symptoms and low IQ? J Consult Clin Psychol 2004; 72:218-226
82. Bergman K, Sarkar P, Glover V, et al: Maternal prenatal cortisol and infant cognitive development: moderation by infant-mother attachment. Biol Psychiatry 2010; 67:1026-1032
83. Pluess M, Belsky J: Prenatal programming of postnatal plasticity? Dev Psychopathol 2011; 23:29-38
84. Boyce WT, Ellis BJ: Biological sensitivity to context, I: an evolutionary-developmental theory of the origins and functions of stress reactivity. Dev Psychopathol 2005; 17:271-301
85. Anderson JW, Johnstone BM, Remley DT: Breast-feeding and cognitive development: a meta-analysis. Am J Clin Nutr 1999; 70: 525-535
86. Blair C: Early intervention for low birth weight, preterm infants: the role of negative emotionality in the specification of effects. Dev Psychopathol 2002; 14:311-332
87. Grant KA, Sandman CA, Wing DA, et al: Prenatal programming of postnatal susceptibility to memory impairments: a developmental double jeopardy. Psychol Sci 2015; 26:1054-1062
88. Glover V, Bergman K, Sarkar P, et al: Association between maternal and amniotic fluid cortisol is moderated by maternal anxiety. Psychoneuroendocrinology 2009; 34:430-435
89. Nanni V, Uher R, Danese A: Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: a meta-analysis. Am J Psychiatry 2012; 169:141-151