Some current applications, limitations and future perspectives of lactic acid bacteria as probiotics

Food and Nutrition Research

Volumn 61, Issue 1, 2017, Pages

  Evivie, Smith Etareri ^a,b   Huo, Gui Cheng ^a   Igene, John Oamen ^b   Bian, Xin ^a  

^a NORTHEAST AGRICULTURAL UNIVERSITY   (China)

^b UNIVERSITY OF BENIN   (Nigeria)

Author keywords

Food; Health; Lactic acid bacteria; Obesity; Probiotics; Type 2 diabetes

Indexed keywords

FRUCTOSE OLIGOSACCHARIDE; GLUCOSE; HEMOGLOBIN A1C; PROBIOTIC AGENT; YOGHURT;

ABDOMINAL OBESITY; ADIPOCYTE; ANTIBACTERIAL ACTIVITY; ANTIDIABETIC ACTIVITY; BACTERIAL STRAIN; BACTERIAL SURVIVAL; BACTERIAL VIABILITY; DISEASE COURSE; DRUG MECHANISM; ENERGY EXPENDITURE; GASTROINTESTINAL TRANSIT; GLOBAL DISEASE BURDEN; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; HUMAN; ICE CREAM; INTESTINE FLORA; LACTIC ACID BACTERIUM; LACTOBACILLUS ACIDOPHILUS; LACTOBACILLUS CASEI; LACTOBACILLUS DELBRUECKII SUBSP. BULGARICUS; LACTOBACILLUS GASSERI; LACTOBACILLUS PARACASEI; LACTOBACILLUS RHAMNOSUS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; REVIEW; SOYBEAN MILK; STREPTOCOCCUS THERMOPHILUS;

EID: 85023753173     PISSN: 16546628     EISSN: None     Source Type: Journal    
DOI: 10.1080/16546628.2017.1318034     Document Type: Review

References (135)

1. Papadimitrou K, Pot B, Tsakalidou E. How microbes adapt to a diversity of food niches. Curr Opin Food Sci. 2015;2:29-35.
2. Gezginc Y, Topcal F, Comertpay S, et al. Quantitative analysis of the lactic acid and acetyldehyde produced by Streptococcus thermophilus and Lactobacillus bulgaricus strains isolated from traditional Turkish yoghurt using HPLC. J Diary Sci. 2015;98:1426-1434.
3. Klaenhammer TR, de Vos WM. An incredible scientific journey. The evolutionary tale of the lactic acid bacteria. In: Ledeboer A, Hugenholtz J, Kok J, Konings W, Wouters J, editors. The 10th LAB symposium. Thirty years of research on lactic acid bacteria. Rotterdam: 24 Media Labs; 2011. pp. 1-11.
4. Yoshida Y, Seki T, Matsunaka H, et al. Clinical effects of probiotic Bifidobacterium breve supplementation in adult patients with atopic dermatitis. Yonago Acta Medica. 2010;53:37-45.
5. Reid G, FAO joint. Regulatory and clinical aspects of dairy probiotics. In: Expert consultations on health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. FAO/ WHO Background Report; 2001. p. 15.
6. Szajewska H, Setty M, Mrukowica J. Probiotics in gastrointestinal diseases in children: hard and not-sohard evidence of efficacy. J Pediatrics Gastrointest Nutr. 2006;42:454-475.
7. Kurugol Z, Koturogolu G. Effects of Saccharomyces boulardii in children with acute diarrhea. Acta Pediatrica. 2005;94:44-47.
8. Song D, Ibrahim S, Hayek S. Recent application of probiotics in food and agricultural science. 2015 [cited 2015 Dec 10]. DOI:10.5772/50121.
9. Anal AK, Singh H. Recent advances in microencapsulation of probiotics for industrial applications and targeted delivery-a review. Trends Food Sci Technol. 2007;18:240-251.
10. Prakash S, Tomato-Duchesneau C, Saha S, et al. The gut microbiota and human health with emphasis on the use of microencapsulated bacterial cells: a review. J Biomed Biotechnol. 2011:12. Article ID 981214. DOI:10.1155/2011/981214.
11. Della Porta G, Castaldo F, Scognamiglio M, et al. Bacteria microencapsulation in PLGA micro devices by superficial emulsion extraction. Journal of Superficial Fluids. 2012;63:1-7.
12. Morrisa GA, Torreb JG, Ortegab A, et al. Molecular flexibility of citrus pectins by combined sedimentation and viscosity analysis. Food Hydrocoll. 2008;22:1435-1442.
13. EASO. Obesity facts and figures; 2016 [cited 2016 Apr 14]. Available from: http://easo.org/education-portal/obesity-facts-figures/
14. Finkelstein E, Ruhm A, Christopher J, et al. Economic causes and consequences of obesity. Annu Rev Public Health. 2005;26:239-257.
15. Wang J, Tang H, Zhang C, et al. Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice. Int Soc Microb Ecol. 2015;9:1-15.
16. Lakdawalla D, Philipson T. The growth of obesity and technological change: a theoretical and empirical examination. No. w8946. Cambridge (MA); National bureau of economic research, 2002.
17. Fry J, Finley W. The prevalence and costs of obesity in the EU. Proc Nutr Soc. 2005;64:359-362.
18. CDC. Trends in the intake of energy and macronutrients-United States, 1971-2000. Morb Mortal Wkly Rep. 2004;53(4):80-82.
19. Ley RE, Turnbaugh PJ, Klein S, et al. Microbial ecology: human gut microbes associated with obesity. Nature. 2006;444:1022-1023.
20. Takemura N, Okubo T, Sonoyama K. Lactobacillus plantarum strain No. 14 reduces adipocyte size in mice fed high-fat diet. Exp Biol Med (Maywood). 2010;235:849-856.
21. Lee BH, Lo YH, Pan TM. Anti-obesity activity of Lactobacillus fermented soy milk products. J Funct Foods. 2013;5(2):905-913.
22. Kadooka Y, Sato M, Imaizumi K, et al. Regulation of abdominal adiposity in probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial. Eur J Clin Nutr. 2010;64:636-643.
23. Ouwehand AC, Isolauri E, Kirjavainen PV, et al. The mucus binding of Bifidobacterium lactis Bb12 is enhanced in the presence of Lactobacillus GG and Lact. delbrueckii subsp. bulgaricus. Lett Appl Microbiol. 2000;30:10-13.
24. Yin YN, Yu QF, Fu N, et al. Effects of four bifidobacteria on obesity in high-fat diet induced rats. World J Gastroenterol. 2010;16:3394-3401.
25. Tsai YT, Cheng PC, Pan TM. Anti-obesity effects of gut microbiota are associated with lactic acid bacteria. Appl Microbiol Biotechnol. 2013;5346-5353. DOI:10.1007/s00253-013
26. Yoo SR, Kim YJ, Park DY, et al. Probiotics L. plantarum and L. curvatus in combination alter hepatic lipid metabolism and sup-press diet-induced obesity. Obesity (Silver Spring). 2013;21:2571-2578.
27. Mekkes MC, Weenen TC, Brummer RJ, et al. The development of probiotic treatment in obesity: A review. Benef Microbes. 2014;5(1):19-28. DOI:10.3920/BM2012.0069
28. Hong SM, Chung EC, Kim CH. Anti-obesity effect of fermented whey beverage using lactic acid bacteria in diet-induced obese rats. Korean J Food Sci Ann. 2015;35(5):653-659.
29. Karimi G, Sabran M, Jamaluddin R, et al. The antiobesity effects of Lactobacillus casei strain Shirota versus Orlistat on high fat diet-induced obese rats. Food Nutr Res. 2015;59. DOI:10.3402/fnr.v%v.29273.
30. Minami J, Kondo S, Yanagisawa N, et al. Oral administration of Bifidobacterium breve B-3 modifies metabolic functions in adults with obese tendencies in a randomized controlled trial. J Nutr Sci. 2015;4e17:1-7.
31. Ogawa A, Kobayashi T, Sakai F, et al. Lactobacillus gasseri SBT2055 suppresses fatty acid release through enlargement of fat emulsion size in vitro and promotes fecal fat excretion in healthy Japanese subjects. Lipids Health Dis. 2015;14:20.
32. Yoda K, Sun X, Kawase M, et al. A combination of probiotics and whey proteins enhances anti-obesity effects of calcium and dairy products during nutritional energy restriction in aP2-agouti transgenic mice. Br J Nutr. 2015;113:1689-1696. DOI:10.1017/S0007114515000914
33. Cheng MC, Tsai TY, Pan TM. Anti-obesity activity of the water extract of Lactobacillus paracasei subsp. paracasei NTU 101 fermented soy milk products. Food Funct. 2015;6(11):3522-3530.
34. Lee KH, Song JL, Park ES, et al. Anti-obesity effects of starter fermented kimchi on 3T3-L1 adipocytes. Prev Nutr Food Sci. 2015;20(4):298-302.
35. Toshimitsu T, Mochizuki J, Ikegami S, et al. Identification of a Lactobacillus plantarum strain that ameliorates chronic inflammation and metabolic disorders in obese and type 2 diabetic mice. J Dairy Sci. 2015;99(2):933-946.
36. Park SY, Cho SA, Kim SH, et al. Physiological characteristics and anti-obesity effect of lactobacillus plantarum Q180 isolated from feces. Korean J Food Sci Ann. 2014;34(5):647-655.
37. Lee SJ, Bose S, Chung SWS, et al. The effects of coadministration of probiotics with herbal medicine on obesity, metabolic endotoxemia and dysbiosis: A randomized double-blind controlled clinical trial. Clin Nutr. 2014;33(6):973-981.
38. Miyoshi M, Ogawa A, Higurashi S, et al. Anti-obesity effect of Lactobacillus gasseri SBT2055 accompanied by inhibition of pro-inflammatory gene expression in the visceral adipose tissue in diet-induced obese mice. Eur J Nutr. 2014;53(2):596-606.
39. Ji YS, Kim HN, Park HJ, et al. Modulation of the murine microbiome with a concomitant anti-obesity effect by Lactobacillus rhamnosus GG and Lactobacillus sakei NR28. Benef Microbes. 2012;3(1):13-22.
40. An HM, Park SY, Lee DK, et al. Antiobesity and lipidlowering effects of Bifidobacterium spp. in high fat diet-induced obese rats. Lipids Health Dis. 2011;10:116.
41. Kondo S, Xiao JZ, Satoh T, et al. Antiobesity effects of Bifidobacterium breve strain B-3 supplementation in a mouse model with high-fat diet-induced obesity. Biosci Biotechnol Biochem. 2010;74:1656-1661.
42. Lee HY, Park JH, Seok SH, et al. Human-originated bacteria, Lactobacillus rhamnosus PL60 produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice. Biochim Biophys Acta. 2006;1761:736-744.
43. Schuster DP, Duvuuri V. Diabetes mellitus. Clin Pediatr Med Surg. 2002;19:79-107.
44. Xu J, Lian F, Zhao L, et al. Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula. Int Soc Microb Ecol. 2015;9:552-562.
45. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15:539-553.
46. Whiting DR, Guariguata L, Weil C, et al. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 to 2030. Diabetes Res Clin Pract. 2011;94:311-321.
47. Tabuchi M, Ozaki M, Tamura A, et al. Antidiabetic effect of Lactobacillus GG in streptozotocin-induced diabetic rats. Biosci Biotechnol Biochem. 2003;67:1421-1424.
48. Yadav H, Jain S, Sinha PR. Antidiabetic effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats. Nutrition. 2007;23:62-68.
49. Yun SI, Park HO, Kang JH. Effects of Lactobacillus gasseri BNR17 on blood glucose levels and body weight in a mouse model of type 2 diabetes. J Appl Microbiol. 2009;107:1681-1686.
50. Honda K, Moto M, Uchida N, et al. Antidiabetic effects of lactic acid bacteria in normal and type-2 diabetic mice. J Clin Biochem Nutr. 2012;51(2):96-101.
51. Tsuneki H, Ishizuka M, Terasawa M, et al. Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db ⁄ db) mice and on glucose metabolism in healthy humans. BMC Pharmacol. 2004;4:18-27.
52. Owen CG, Martin RM, Whincup PH, et al. (2006) Does breastfeeding influence risk of type 2 diabetes in later life? A quantitative analysis of published evidence. American Journal of Clinical Nutrition, 84:1043-1054.
53. Martin R, Langa S, Reviriego C, et al. Human milk is a source of lactic acid bacteria for the infant gut. J Pediatrics. 2003;143:754-758.
54. Panwar H, Calderwood D, Grant IR, et al. Lactobacilli possess inhibitory activity against dipeptidylpeptidase-4 (DPP-4). Ann Microbiol. 2015. DOI:10.1007/s13213-015-1129-7
55. Zhang X, Zhao Y, Zhang M, et al. Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats. Plos One. 2012b;7:e42529.
56. Zeng Z, Luo J, Zuo F, et al. Screening for potential novel probiotic Lactobacillus strains based on high dipeptidyl peptidase IV and α-glucosidase inhibitory activity. J Funct Foods. 2016;20:486-495. DOI:10.1016/j.jff.2015.11.030
57. Li C, Nie SP, Zhu KX, et al. Lactobacillus plantarum NCU116 fermented carrot juice evokes changes of metabolites in serum from type 2 diabetic rats. Food Res Int. 2016;80:36-40. DOI:10.1016/j.foodres.2015.12.025
58. Lim S, Jeong JJ, Woo KH, et al. Lactobacillus sakei OK67 ameliorates high-fat diet-induced blood glucose intolerance and obesity in mice by inhibiting gut microbiota LPS production and inducing colon tight junction protein expression. Nutr Res. 2015. DOI:10.1016/j.nutres.2015.12.001
59. Videhult FK, Andersson Y, Öhlund I, et al. Impact of probiotics during weaning on the metabolic and inflammatory profile: follow-up at school age. Int J Food Sci Nutr. 2015;1-6. DOI:10.3109/09637486.2015.1025717
60. Tonucci LB, Dos Santos KMO, De Oliveira LL, et al. Clinical application of probiotics in type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled study. Clin Nutr. 2015. DOI:10.1016/j.clnu.2015.11.011
61. Chen P, Zhang Q, Dang H, et al. Screening for potential new probiotic based on probiotic properties and a-glucosidase inhibitory activity. Food Control. 2014;35:65-72.
62. Panwar H, Calderwood D, Grant IR, et al. Lactobacillus strains isolated from infant faeces possess potent inhibitory activity against intestinal alpha-and beta-glucosidases suggesting anti-diabetic potential. Eur J Nutr. 2014;52(7):1465-1474.
63. Chen P, Zhang Q, Dang H, et al. Oral administration of Lactobacillus rhamnosus CCFM0528 improves glucose tolerance and cytokine secretion in high-fat-fed, streptozotocin-induced type 2 diabetic mice. J Funct Foods. 2014;10(9):318-326.
64. Zhang Y, Wang L, Zhang J, et al. Probiotic Lactobacillus casei Zhang ameliorates high-fructoseinduced impaired glucose tolerance in hyperinsulinemia rats. Eur J Nutr. 2014;53(1):221-232.
65. Hsieh FC, Lee CL, Chai CY, et al. Oral administration of Lactobacillus reuteri GMNL-263 improves insulin resistance and ameliorates hepatic steatosis in high fructose-fed rats. Nutr Metab. 2013;10(35). Available from: http://www.nutritionandmetabolism.com/content/10/1/35
66. Asemi Z, Zare Z, Shakeri H, et al. Effect of multispecies probiotic supplements on metabolic profiles, hs-CRP, and oxidative stress in patients with type 2 diabetes. Ann Nutr Metab. 2013;63:1-9. DOI:10.1159/000349922
67. Ejtahed HS, Mohtadi-Nia J, Homayouni-Rad A, et al. Probiotic yogurt improves antioxidant status in type 2 diabetic patients. Nutrition. 2012;28:539-543.
68. Kim ST, Kim HB, Lee KH, et al. Steam-dried ginseng berry fermented with Lactobacillus plantarum controls the increase of blood glucose and body weight in type 2 obese diabetic db/db mice. J Agric Food Chem. 2012;60(21):5438-5445.
69. Ejtahed HS, Mohtadi-Nia J, Homayouni-Rad A, et al. Effect of probiotic yogurt containing Lactobacillus acidophilus and Bifidobacterium lactis on lipid profile in individuals with type 2 diabetes mellitus. J Dairy Sci. 2011;94:3288-3294.
70. Amar J, Chabo C, Waget A, et al. Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment. EMBO Mol Med. 2011;3:559-572. DOI:10.1002/emmm.201100159
71. Aslim B, Beyatli Y, Yuksekdag ZN. Production and monomer composition of exopolysaccharides by Lactobacillus delbrueckii subsp. bulgaricus and Streptpcpccus thermophilus strains isolated from traditional home-made yoghurts and raw milk. Int J Food Sci Technol. 2006;41:973-979.
72. Aslim B, Onbasili D, Yuksekdag ZN. Determination of lactic acid production and antagonistic against Helicobacter pylori by L. delbrueckii subsp. bulgaricus and S. thermophilus strains. Kafkas Univ Vet Fak Derg. 2011;17(4):609-614. DOI:10.9775/kvfd.2001.4326
73. Midola PD, Korman MG, Turdinge JD, et al. Helicobacter pylori resistance to tetracycline. Lancet. 1996;347:1194-1195.
74. Duboc P, Mollet B. Applications of exopolysaccharides in the dairy industry. Neth Milk Dairy J. 2001;11:759-768.
75. Ruijssenaars HJ, Stingele F, Hartmans S. Biodegradability of food-associated extracellular polysaccharides. Curr Microbiol. 2000;40:194-199.
76. Broadbent JR, McMahon DJ, Welker DL, et al. Biochemistry, genetics and applications of exopolysaccharide production in Streptococcus thermophilus. A review. J Dairy Sci. 2003;86:407-423.
77. Cerning J. Production of exocellular polysaccharides by lactic acid bacteria and dairy propionibacteria. Lait. 1995;75:463-472.
78. DeVuyst L, Degeest B. Heteropolysaccharides from lactic acid bacteria. FEMS Microbiol Rev. 1999;23 (2):153-177.
79. Guarner F, Perdigon G, Corthier G, et al. Should yoghurt cultures be considered probiotic? Br J Nutr. 2005;93:783-786.
80. Mater DDG, Bretigny L, Firmesse O, et al. Streptococcus thermophilus and Lactobacillus delbueckii subsp bulgaricus survive gastrointestinal transit of healthy volunteers consuming yoghurt. FEMS Microbiol Lett. 2005;250:185-187.
81. Iyer R, Tomar SK, Maheswari TU, et al. Streptococcus thermophilus Strains: multifunctional lactic acid bacteria. Int Dairy J. 2010;20:133-141.
82. Chen L, Zhao H, Zhang C, et al. γ-Aminobutyric acidrich yogurt fermented by Streptococcus salivarius subsp. thermophiles fmb5 apprars to have anti-diabetic effect on streptozotocin-induced diabetic mice. J Funct Foods. 2016;20:267-275.
83. Sah BNP, Vasiljevic T, McKechnie S, et al. Physicochemical, textural and rheological properties of probiotic yogurt fortified with fibre-rich pineapple peel powder during refrigerated storage. LWT-Food Sci Technol. 2016;65:978-986.
84. Ivey KL, Hodgson JM, Kerr DA, et al. The effect of yoghurt and its probiotics on blood pressure and serum lipid profile; a randomised controlled trial. Nut Metab Cardiovasc Dis. 2015;25:46-51. DOI:10.1016/j.numecd.2014.07.012
85. Nabavi S, Rafraf M, Somi M, et al. Probiotic yogurt improves body mass index and fasting insulin levels without affecting serum leptin and adiponectin levels in non-alcoholic fatty liver disease (NAFLD). J Funct Foods. 2015;18:684-691.
86. Bezerra M, Araujo A, Santos K, et al. Caprine frozen yoghurt produced with fresh and spray dried jambolan fruit pulp (Eugenia jambolana Lam) and Bifidobacterium animalis subsp. lactis BI-07. LWT Food Sci Technol. 2015;62:1099-1104.
87. Mohammadi AA, Jazayeri S, Khosravi-Darani K, et al. Effects of probiotics on biomarkers of oxidative stress and inflammatory factors in petrochemical workers: a randomized, double-blind, placebo-controlled trial. Int J Prev Med. 2015;6:82. DOI:10.4103/2008-7802.164146
88. Michael M, Phebus RK, Schmidt KA. Plant extract enhances the viability of Lactobacillus delbrueckii subsp. bulgaricus and Lactobacillus acidophilus in probiotic nonfat yogurt. Food Sci Nutr. 2015;3(1):48-55.
89. Foxx MJ, Ahuja KDK, Robertson IK, et al. Can probiotic yoghurt prevent diarrhea in children on antibiotics? A double-blind, randomized, placebo-controlled study. BMJ Open. 2015;5:e006474. DOI:10.1136/bmjopen-2014-006474
90. Hussein HA. Effect of probiotic yoghurt on management of antibiotic associated diarrhea among toddlers. World J Nurs Sci. 2015;1(3):24-34.
91. Bertelsen RJ, Brantsæter AL, Magnus MC, et al. Probiotic milk consumption in pregnancy and infancy and subsequent childhood allergic diseases. J Allergy Clin Immunol. 2014;133(1):165-171.
92. Omar JM, Chan YM, Jones ML, et al. Lactobacillus fermentum and Lactobacillus amylovorus as probiotics alter body adiposity and gut microflora in healthy persons. J Funct Foods. 2013;5:116-123.
93. Shadnoush M, Hosseini RS, Mehrabib Y, et al. Probiotic yogurt affects pro-and anti-inflammatory factors in patients with inflammatory bowel disease. Iranian J Pharm Res. 2013;12(4):929-936.
94. Asemi Z, Samimi M, Tabassi Z, et al. Effect of daily consumption of probiotic yoghurt on insulin resistance in pregnant women: a randomized controlled trial. Eur J Clin Nutr. 2013;67:71-74. DOI:10.1038/ejcn.2012.189
95. Jones ML, Martoni CJ, Parent M, et al. Cholesterollowering efficacy of a microencapsulated bile salt hydrolase-active Lactobacillus reuteri NCIMB 30242 yoghurt formulation in hypercholesterolaemic adults. Br J Nutr. 2012;107:1505-1513.
96. Hantoushzadeh S, Golshahi F, Javadian P, et al. Comparative efficacy of probiotic yoghurt and clindamycin in treatment of bacterial vaginosis in pregnant women: A randomized clinical trial. J Maternal-Fetal Med. 2012;25(7):1021-1024.
97. Ejtahed HS, Mohtadi-Nia J, Homayouni-Rad A, et al. The effects of probiotic yoghurt consumption on blood pressure and serum lipids in type 2 diabetic patients: randomized clinical trial. Iranian J Nutr Sci Food Technol. 2012;6(4):1-12.
98. Asemi Z, Jazayeri S, Najafi M, et al. Effects of daily consumption of probiotic yoghurt on inflammatory factors in pregnant women: a randomized controlled trial. Pakistan J Biol Sci. 2011;14(8):476-482.
99. Kabeerdoss J, Shobana Devi R, Regina Mary R, et al. Effect of yoghurt containing Bifidobacterium lactis Bb12® on faecal excretion of secretory immunoglobulin A and human beta-defensin 2 in healthy adult volunteers. Nutr J. 2011;10:138.
100. Shori AB, Baba AS. Antioxidant activity and inhibition of key enzymes linked to type-2 diabetes and hypertension by Azadirachta indica-yogurt. J Saudi Chem Soc. 2011;17:295-301.
101. Arbuckle WS. Ice cream. 4th ed. New York: Springer Science+Business Media; 1986. p. 453.
102. Soukoulis C, Fisk ID, Bohn T. Ice cream as a vehicle for incorporating health-promoting ingredients: conceptualization and overview of quality and storage stability. Compr Rev Food Sci Food Saf. 2014;13:627-655.
103. Granato D, Branco GF, Cruz AG, et al. Probiotic dairy products as functional foods. Compr Rev Food Sci Food Saf. 2010;9:455-470.
104. Akin MB, Akin MS, Kırmacı Z. Effects of inulin and sugar levels on the viability of yogurt and probiotic bacteria and the physical and sensory characteristics in probiotic ice-cream. Food Chem. 2007;104:93-99.
105. Santivarangkna C, Kulozik U, Foerst P. Inactivation mechanisms of lactic acid starter cultures preserved by drying processes. J Appl Microbiol. 2008;105:1-13.
106. Leandro EDS, De Araú Jo EA, Da Conceiç Ãoll, et al. Survival of Lactobacillus delbrueckii UFV H2b20 in ice cream produced with different fat levels and after submission to stress acid and bile salts. J Funct Foods. 2013;5(1):503-507.
107. Aboulfazli F, Salihin Baba A, Misran M. Effects of fermentation by Bifidobacterium bifidum on the rheology and physical properties of ice cream mixes made with cow and vegetable milks. Int J Food Sci Technol. 2015;50:942-949.
108. Fatemeh A, Bakr SA, Salihin BA. Effects of the replacement of cow milk with vegetable milk on the count of probiotics and changes in sugar and amino acid contents in fermented ice creams. LWT Food Sci Technol. 2016. DOI:10.1016/j.lwt.2016.02.056
109. Ferraz JL, Cruz AG, Cadena RS, et al. Sensory acceptance and survival of probiotic bacteria in ice cream produced with different overrun levels. J Food Sci. 2012;71(1):524-528.
110. Ranadheeraa CS, Evansa CA, Adamsa MC, et al. In vitro analysis of gastrointestinal tolerance and intestinal cell adhesion of probiotics in goat’s milk ice cream and yogurt. Food Res Int. 2012;49(2):619-625.
111. Ranadheeraa CS, Evansa CA, Adamsa MC, et al. Production of probiotic ice cream from goat’s milk and effect of packaging materials on product quality. Small Ruminant Res. 2013;112:174-180.
112. Mahantesha T, Parveen Reddy KM, Praveen Kumar NH, et al. Comparative study of probiotic ice cream and probiotic drink on salivary Streptococcus mutans levels in 6-12 years age group children. J Int Oral Health. 2015;7(9):47-50.
113. Dertlia E, Toker OS, Durak MZ, et al. Development of a fermented ice-cream as influenced by in situexopolysaccharide production: rheological, molecular, microstructural and sensory characterization. Carbohydr Polym. 2016;136:427-440.
114. McNamara EM Synbiotic ice cream as a probiotic carrier tested in a human blind crossover trial [A Masters’ thesis]. Graduate College of the University of Nebraska; 2016. p. 78.
115. Ahmadi A, Milani E, Madadlou A, et al. Synbiotic yogurt-ice cream produced via incorporation of microencapsulated Lactobacillus acidophilus (la-5) and fructooligosaccharide. J Food Sci Technol. 2014;51 (8):1568-1574.
116. Sagdic O, Oztuck I, Cankurt H. Interaction between some phenolic compounds and probiotic bacterium in functional ice cream production. Food Bioprocess Technol. 2012;5:2964-2971.
117. Evivie S. E. Preliminary studies on pharmaceutical microencapsulation for symbiotic application. J Appl Nat Sci. 2013;5(2):488-496.
118. Shah NP. Functional cultures and health benefits. Int Dairy J. 2007;17:1262-1277.
119. Kailasapathy K, Chin JC. Survival and therapeutic potential of probiotic organisms with reference to Lactobacillus acidophilus and Bifidobacterium spp. Immunol Biol. 2000;78:80-88.
120. Hekmat S, Reid G. Sensory properties of probiotic yogurt is comparable to standard yogurt. Nutr Res. 2006;26:163-166.
121. Aragon-Alegro LC, Alarcon Alegro JH, Roberta Cardarelli H, et al. Potentially probiotic and synbiotic chocolate mousse. LWT Food Sci Technol. 2007;40:669-675.
122. Rodrigues D, Rocha-Santos TAP, Pereira CI, et al. The potential effect of FOS and inulin upon probiotic bacterium performance in curdled milk matrices. LWT Food Sci Technol. 2011;44:100-108.
123. Oliveira LB, Jurkiewicz CH. Influence of inulin and acacia gum on the viability of probiotic bacteria in synbiotic fermented milk. Braz J Food Technol. 2009;12:138-144.
124. Champagne CP. 19 Some technological challenges in the addition of probiotic bacteria to foods. In: Charalampopoulos D, Rastall RA, editors. Prebiotics and Probiotics Science and Technology. New York: Springer; 2009. p. 761-804.
125. Antoine JM. Current challenges for probiotics in food. In: Lahtinne S, Salminen S, Von Wright A, et al., editor. Lactic acid bacteria: microbiological and functional aspects. London: CRC Press; 2011. p. 213-226.
126. Dos Santos FB, De Vos WM, Teusink B. Towards metageome-scale models for industrial applications-the case of lactic acid bacteria. Curr Opinions Biotechnol. 2013;24:200-206.
127. Landete JM. A review of food-grade vectors in lactic acid bacteria: from the laboratory to their application. Crit Rev Biotechnol. 2017. Available from: http://www.tandfonline.com/doi/full/10.3109/07388551.2016.1144044?scroll=top&needAccess=true
128. Chang CK, Wang SC, Chiu CK, et al. Effect of lactic acid bacteria isolated from fermented mustard on immunopotentiating activity. Asian J Trop Biomed. 2015;5(4):281-286.
129. Wu Q, Tun HM, Leung FCC, et al. Genomic insights into high exopolysaccharide-producing dairy starter bacterium Streptococcus thermophilus ASCC 1275. Sci Rep. 2014;4:4974. DOI:10.1038/srep04974
130. Li P, Gu Q, Zhou Q. Complete genome sequence of Lactobacillus plantarum LZ206, a potential probiotic strain with antimicrobial activity against foodborne pathogens. J Biotechnol. 2016;238:52-55.
131. Li B, Liu F, Tang Y, et al. Complete Genome Sequence of Lactobacillus helveticus KLDS 18701, a probiotic strain producing bacteriocin. J Biotechnol. 2015;212:90-91.
132. WHO. WHO’s first ever global estimates of foodborne diseases find children under 5 account for almost one third of deaths; 2015 [cited 2016 Apr 14]. Available from: http://www.who.int/mediacentre/news/releases/2015/foodborne-disease-estimates/en/
133. Bian X, Huo G, Evivie S. E., et al. In vitro assessment of antimicrobial potentials of lactobacillus helveticus strains isolated from traditional cheese in sinkiang China against food-borne pathogens. Food Funct. 2015. DOI:10.1039/C5FO01041A
134. Bian X, Muhammad Z, Evivie SE, et al. Screening of antifungal potentials of Lactobacillus helveticus 1.8701 against spoilage microorganism and their effects on physicochemical properties and shelf life of fermented soybean milk during preservation. Food Control. 2016;66(8):183-189.
135. Chakraborti CK. The status of synbiotics in colorectal cancer. Life Sci Med Res. LSMR-20. 2011. Available from: http://www.astonjournals.com/lsmr