BNIP3 induction by hypoxia stimulates FASN-dependent free fatty acid production enhancing therapeutic potential of umbilical cord blood-derived human mesenchymal stem cells

Redox Biology

Volumn 13, Issue , 2017, Pages 426-443

  Jik Lee, Hyun ^a   Hyun Jung, Young ^a   Euhn Choi, Gee ^a   Hee Ko, So ^a   Lee, Sei Jung ^b   Hun Lee, Sang ^c,d   Jae Han, Ho ^a  

^a Seoul National University   (South Korea)

^b Daegu Haany University   (South Korea)

^c Soonchunhyang University   (South Korea)

^d Soonchunhyang University College of Medicine   (South Korea)

Author keywords

Bcl2 adenovirus E1B 19 kDa protein interacting protein 3 (BNIP3); Fatty acid synthase (FASN); Hypoxia; Mesenchymal stem cell; Mitophagy

Indexed keywords

CASPASE; COFILIN 1; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; F ACTIN; FATTY ACID; FATTY ACID SYNTHASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LIPID; OXYGEN; PALMITIC ACID; PROTEIN BNIP3; REACTIVE OXYGEN METABOLITE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTOR FKHRL1; BNIP3 PROTEIN, HUMAN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FASN PROTEIN, HUMAN; FOXO3 PROTEIN, HUMAN; HIF1A PROTEIN, HUMAN; MEMBRANE PROTEIN; ONCOPROTEIN; SREBF1 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL HYPOXIA; CELL MIGRATION; CONTROLLED STUDY; ENZYME DEGRADATION; FATTY ACID SYNTHESIS; GENE SILENCING; HUMAN; HUMAN CELL; LIPID METABOLISM; MALE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MIGRATION INHIBITION; MITOPHAGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; TRANSCRIPTION INITIATION; UMBILICAL CORD BLOOD CELL; WOUND HEALING; ANIMAL; CELL LINE; GENETICS; MESENCHYMAL STROMA CELL; METABOLISM; MITOCHONDRION; PROCEDURES;

ANIMALS; APOPTOSIS; CELL HYPOXIA; CELL LINE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; FATTY ACID SYNTHASE, TYPE I; FATTY ACIDS; FORKHEAD BOX PROTEIN O3; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MEMBRANE PROTEINS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; OXYGEN; PROTO-ONCOGENE PROTEINS; REACTIVE OXYGEN SPECIES; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; WOUND HEALING;

EID: 85022085396     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2017.07.004     Document Type: Article

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