FoxO3a modulates hypoxia stress induced oxidative stress and apoptosis in cardiac microvascular endothelial cells

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Zhang, Shenwei ^a   Zhao, Yilin ^b   Xu, Ming ^c   Yu, Li ^a   Zhao, Yujie ^a   Chen, Jianghong ^b   Yuan, Yiqiang ^a   Zheng, Qiangsun ^b   Niu, Xiaolin ^b  

^a Office of Community Medicine and Preventive Health Care   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FKHRL1;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOACCUMULATION; CARDIAC MICROVASCULAR ENDOTHELIAL CELL; CELL HYPOXIA; CELL STRESS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FOXO3A GENE; GENE EXPRESSION REGULATION; GENE SILENCING; HIF 1ALPHA GENE; MALE; MICROVASCULAR ENDOTHELIAL CELL; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REGULATORY MECHANISM;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL HYPOXIA; CORONARY VESSELS; ENDOTHELIUM, VASCULAR; FORKHEAD TRANSCRIPTION FACTORS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; OXIDATIVE STRESS; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING;

EID: 84894279719     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0080342     Document Type: Article

References (38)

1. Braunwald E, Bristow MR (2000) Congestive heart failure: fifty years of progress. Circulation 102: IV14-23.
2. Li JM, Mullen AM, Shah AM (2001) Phenotypic properties and characteristics of superoxide production by mouse coronary microvascular endothelial cells. J Mol Cell Cardiol 33: 1119-1131. (Pubitemid 32579279)
3. Scarabelli T, Stephanou A, Rayment N, Pasini E, Comini L, et al. (2001) Apoptosis of endothelial cells precedes myocyte cell apoptosis in ischemia/reperfusion injury. Circulation 104: 253-256. (Pubitemid 32666943)
4. Millar TM, Phan V, Tibbles LA (2007) ROS generation in endothelial hypoxia and reoxygenation stimulates MAP kinase signaling and kinase-dependent neutrophil recruitment. Free Radic Biol Med 42: 1165-1177. (Pubitemid 46428512)
5. Guzy RD, Hoyos B, Robin E, Chen H, Liu L, et al. (2005) Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab 1: 401-408. (Pubitemid 43960623)
6. Prabhakar NR, Kumar GK, Nanduri J, Semenza GL (2007) ROS signaling in systemic and cellular responses to chronic intermittent hypoxia. Antioxid Redox Signal 9: 1397-1403. (Pubitemid 47255019)
7. Kim BM, Chung HW (2007) Hypoxia/reoxygenation induces apoptosis through a ROS-mediated caspase-8/Bid/Bax pathway in human lymphocytes. Biochem Biophys Res Commun 363: 745-750. (Pubitemid 47513693)
8. Accili D, Arden KC (2004) FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117: 421-426.
9. van der Horst A, Burgering BM (2007) Stressing the role of FoxO proteins in lifespan and disease. Nat Rev Mol Cell Biol 8: 440-450.
10. Skurk C, Maatz H, Kim HS, Yang J, Abid MR, et al. (2004) The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP. J Biol Chem 279: 1513-1525. (Pubitemid 38082681)
11. Arden KC (2007) FoxOs in tumor suppression and stem cell maintenance. Cell 128: 235-237.
12. Samarin J, Wessel J, Cicha I, Kroening S, Warnecke C, et al. (2010) FoxO proteins mediate hypoxic induction of connective tissue growth factor in endothelial cells. J Biol Chem 285: 4328-4336.
13. Zhang Z, Li W, Sun D, Zhao L, Zhang R, et al. (2011) Toll-like receptor 4 signaling in dysfunction of cardiac microvascular endothelial cells under hypoxia/reoxygenation. Inflamm Res 60: 37-45.
14. Zhang Z, Li S, Cui M, Gao X, Sun D, et al. (2013) Rosuvastatin enhances the therapeutic efficacy of adipose-derived mesenchymal stem cells for myocardial infarction via PI3K/Akt and MEK/ERK pathways. Basic Res Cardiol 108: 333.
15. Sun D, Huang J, Zhang Z, Gao H, Li J, et al. (2012) Luteolin limits infarct size and improves cardiac function after myocardium ischemia/reperfusion injury in diabetic rats. PLoS One 7: e33491.
16. Nguyen LK, Cavadas MA, Scholz CC, Fitzpatrick SF, Bruning U, et al. (2013) A dynamic model of the hypoxia-inducible factor 1alpha (HIF-1alpha) network. J Cell Sci 126: 1454-1463.
17. Wartenberg M, Ling FC, Muschen M, Klein F, Acker H, et al. (2003) Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species. FASEB J 17: 503-505.
18. Bonello S, Zahringer C, BelAiba RS, Djordjevic T, Hess J, et al. (2007) Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site. Arterioscler Thromb Vasc Biol 27: 755-761. (Pubitemid 46606703)
19. Ronnebaum SM, Patterson C (2010) The FoxO family in cardiac function and dysfunction. Annu Rev Physiol 72: 81-94.
20. Myatt SS, Brosens JJ, Lam EW (2011) Sense and sensitivity: FOXO and ROS in cancer development and treatment. Antioxid Redox Signal 14: 675-687.
21. Ali SS, Hsiao M, Zhao HW, Dugan LL, Haddad GG, et al. (2012) Hypoxia-adaptation involves mitochondrial metabolic depression and decreased ROS leakage. PLoS One 7: e36801.
22. Gonzalez C, Sanz-Alfayate G, Agapito MT, Gomez-Nino A, Rocher A, et al. (2002) Significance of ROS in oxygen sensing in cell systems with sensitivity to physiological hypoxia. Respir Physiol Neurobiol 132: 17-41. (Pubitemid 34765687)
23. Singal PK, Bello-Klein A, Farahmand F, Sandhawalia V (2001) Oxidative stress and functional deficit in diabetic cardiomyopathy. Adv Exp Med Biol 498: 213-220. (Pubitemid 34113543)
24. Dvoriantchikova G, Grant J, Santos AR, Hernandez E, Ivanov D (2012) Neuronal NAD(P)H oxidases contribute to ROS production and mediate RGC death after ischemia. Invest Ophthalmol Vis Sci 53: 2823-2830.
25. Morey M, Corominas M, Serras F (2003) DIAP1 suppresses ROS-induced apoptosis caused by impairment of the selD/sps1 homolog in Drosophila. J Cell Sci 116: 4597-4604. (Pubitemid 37461614)
26. Sanada M, Kuroda K, Ueda M (2011) ROS production and apoptosis induction by formation of Gts1p-mediated protein aggregates. Biosci Biotechnol Biochem 75: 1546-1553.
27. Kim JJ, Lee SB, Park JK, Yoo YD (2010) TNF-alpha-induced ROS production triggering apoptosis is directly linked to Romo1 and Bcl-X(L). Cell Death Differ 17: 1420-1434.
28. Du SC, Ge QM, Lin N, Dong Y, Su Q (2012) ROS-mediated lipopolysaccharide-induced apoptosis in INS-1 cells by modulation of Bcl-2 and Bax. Cell Mol Biol (Noisy-le-grand) 58 Suppl: OL1654-1659.
29. Jiang L, Pan X, Chen Y, Wang K, Du Y, et al. (2011) Preferential involvement of both ROS and ceramide in fenretinide-induced apoptosis of HL60 rather than NB4 and U937 cells. Biochem Biophys Res Commun 405: 314-318.
30. Oh J, Hur MW, Lee CE (2009) SOCS1 protects protein tyrosine phosphatases by thioredoxin upregulation and attenuates Jaks to suppress ROS-mediated apoptosis. Oncogene 28: 3145-3156.
31. Kou B, Zhang J, Singer DR (2009) Effects of cyclic strain on endothelial cell apoptosis and tubulogenesis are dependent on ROS production via NAD(P)H subunit p22phox. Microvasc Res 77: 125-133.
32. Nakamura T, Sakamoto K (2008) Forkhead transcription factor FOXO subfamily is essential for reactive oxygen species-induced apoptosis. Mol Cell Endocrinol 281: 47-55. (Pubitemid 350296601)
33. Ferber EC, Peck B, Delpuech O, Bell GP, East P, et al. (2012) FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression. Cell Death Differ 19: 968-979.
34. Kops GJ, Dansen TB, Polderman PE, Saarloos I, Wirtz KW, et al. (2002) Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419: 316-321.
35. Harford TJ, Shaltouki A, Weyman CM (2010) Increased expression of the pro-apoptotic Bcl2 family member PUMA and apoptosis by the muscle regulatory transcription factor MyoD in response to a variety of stimuli. Apoptosis 15: 71-82.
36. Hagenbuchner J, Kuznetsov A, Hermann M, Hausott B, Obexer P, et al. (2012) FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3. J Cell Sci 125: 1191-1203.
37. Lee BC, Park BH, Kim SY, Lee YJ (2011) Role of Bim in diallyl trisulfide-induced cytotoxicity in human cancer cells. J Cell Biochem 112: 118-127.
38. Luo H, Yang Y, Duan J, Wu P, Jiang Q, et al. (2013) PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-treated colorectal cancer cells. Cell Death Dis 4: e481.