Activation of GPR40 attenuates chronic inflammation induced impact on pancreatic β-cells health and function

BMC Cell Biology

Volumn 15, Issue 1, 2014, Pages

  Verma, Mahesh K ^a   Sadasivuni, Manoj K ^a   Yateesh, Aggunda N ^a   Neelima, Korrapati ^a   Mrudula, Srikanth ^a   Reddy, Madhusudhan ^a   Smitha, Rachapalli ^a   Biswas, Sanghamitra ^a   Chandravanshi, Bhawna ^a   Pallavi, Puttrevana M ^a   Oommen, Anup M ^a   Jagannath, Madanahalli R ^a   Somesh, Baggavalli B ^a  

^a Connexios Life Sciences Pvt Ltd ^*  (India)

Author keywords

ATP; cAMP; GPR40; Inflammation; Insulin content; Insulin secretion; cell apoptosis; cell survival

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; ADENOSINE TRIPHOSPHATE; CALCINEURIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CNX 011 67; CYCLIC AMP; CYTOCHROME C; G PROTEIN COUPLED RECEPTOR 40; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; JANUS KINASE; MESSENGER RNA; NITRIC OXIDE SYNTHASE; PHOSPHOLIPASE C; PROTEIN BCL 2; PROTEIN DERIVATIVE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NFAT3; TRANSCRIPTION FACTOR PDX 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; G PROTEIN COUPLED RECEPTOR; G-PROTEIN-COUPLED RECEPTOR 40, RAT; GLUCOSE; INSULIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CHRONIC INFLAMMATION; CYTOKINE PRODUCTION; CYTOPLASM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; INSULIN RELEASE; INSULIN SYNTHESIS; INSULINOMA CELL LINE; MALE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; AGONISTS; ANIMAL; CELL CULTURE; CELL LINE; CHRONIC DISEASE; DRUG EFFECTS; IMMUNOLOGY; INFLAMMATION; PANCREAS ISLET; WISTAR RAT;

RATTUS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; CALCINEURIN; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELL LINE; CELLS, CULTURED; CHRONIC DISEASE; GLUCOSE; INFLAMMATION; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; RATS; RATS, WISTAR; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84903334877     PISSN: None     EISSN: 14712121     Source Type: Journal    
DOI: 10.1186/1471-2121-15-24     Document Type: Article

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