Potency of umbilical cord blood-and Wharton's jelly-derived mesenchymal stem cells for scarless wound healing

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Doi, Hanako ^a   Kitajima, Yuriko ^a   Luo, Lan ^a   Yan, Chan ^a   Tateishi, Seiko ^a   Ono, Yusuke ^a   Urata, Yoshishige ^a   Goto, Shinji ^a   Mori, Ryoichi ^a   Masuzaki, Hideaki ^a   Shimokawa, Isao ^a   Hirano, Akiyoshi ^a   Li, Tao Sheng ^a  

^a NAGASAKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AUTACOID; BIOLOGICAL MARKER; COLLAGEN; CYTOKINE;

ANGIOGENESIS; ANIMAL; BIOSYNTHESIS; CELL PROLIFERATION; CYTOLOGY; DISEASE MODEL; FEMALE; FETUS BLOOD; FIBROSIS; GENE EXPRESSION; GENETICS; IMMUNOPHENOTYPING; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; METABOLISM; MOUSE; NUDE MOUSE; PATHOLOGY; PHENOTYPE; PREGNANCY; SKIN; WHARTON JELLY; WOUND HEALING;

ANIMALS; BIOMARKERS; CELL PROLIFERATION; COLLAGEN; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; FETAL BLOOD; FIBROSIS; GENE EXPRESSION; IMMUNOPHENOTYPING; INFLAMMATION MEDIATORS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE; MICE, NUDE; NEOVASCULARIZATION, PHYSIOLOGIC; PHENOTYPE; PREGNANCY; SKIN; WHARTON JELLY; WOUND HEALING;

EID: 84953267277     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep18844     Document Type: Article

References (26)

1. Gurtner, G. C., Werner, S., Barrandon, Y., Longaker, M. T. Wound repair and regeneration. Nature 453, 314-321, doi: 10.1038/nature07039 (2008).
2. Martin, P. Wound healing-aiming for perfect skin regeneration. Science (New York, N.Y.) 276, 75-81 (1997).
3. Shin, D., Minn, K. W. The effect of myofibroblast on contracture of hypertrophic scar. Plastic and reconstructive surgery 113, 633-640, doi: 10.1097/01.prs.0000101530.33096.5b (2004).
4. Ferguson, M. W. et al. Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebocontrolled, phase I/II studies. Lancet 373, 1264-1274, doi: 10.1016/s0140-6736(09)60322-6 (2009).
5. Larson, B. J., Longaker, M. T., Lorenz, H. P. Scarless fetal wound healing: a basic science review. Plastic and reconstructive surgery 126, 1172-1180, doi: 10.1097/PRS.0b013e3181eae781 (2010).
6. Le Blanc, K., Mougiakakos, D. Multipotent mesenchymal stromal cells and the innate immune system. Nature reviews. Immunology 12, 383-396, doi: 10.1038/nri3209 (2012).
7. Bura, A. et al. Phase I trial: the use of autologous cultured adipose-derived stroma/stem cells to treat patients with non-revascularizable critical limb ischemia. Cytotherapy 16, 245-257, doi: 10.1016/j.jcyt.2013.11.011 (2014).
8. Yoshikawa, T. et al. Wound therapy by marrow mesenchymal cell transplantation. Plastic and reconstructive surgery 121, 860-877, doi: 10.1097/01.prs.0000299922.96006.24 (2008).
9. Liu, S. et al. Mesenchymal stem cells prevent hypertrophic scar formation via inflammatory regulation when undergoing apoptosis. The Journal of investigative dermatology 134, 2648-2657, doi: 10.1038/jid.2014.169 (2014).
10. Pelosi, E., Castelli, G., Testa, U. Human umbilical cord is a unique and safe source of various types of stem cells suitable for treatment of hematological diseases and for regenerative medicine. Blood cells, molecules & diseases 49, 20-28, doi: 10.1016/j.bcmd.2012.02.007 (2012).
11. Kern, S., Eichler, H., Stoeve, J., Kluter, H., Bieback, K. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem cells 24, 1294-1301, doi: 10.1634/stemcells.2005-0342 (2006).
12. Manca, M. F. et al. Characterization of mesenchymal stromal cells derived from full-term umbilical cord blood. Cytotherapy 10, 54-68, doi: 10.1080/14653240701732763 (2008).
13. Shin, M. K. et al. The effects of platelet-rich clot releasate on the expression of MMP-1 and type I collagen in human adult dermal fibroblasts: PRP is a stronger MMP-1 stimulator. Molecular biology reports 41, 3-8, doi: 10.1007/s11033-013-2718-9 (2014).
14. Lund, L. R. et al. Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice. The EMBO journal 25, 2686-2697, doi: 10.1038/sj.emboj.7601173 (2006).
15. Stramer, B. M., Mori, R., Martin, P. The inflammation-fibrosis link A Jekyll and Hyde role for blood cells during wound repair. The Journal of investigative dermatology 127, 1009-1017, doi: 10.1038/sj.jid.5700811 (2007).
16. Luo, G. et al. Promotion of cutaneous wound healing by local application of mesenchymal stem cells derived from human umbilical cord blood. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 18, 506-513, doi: 10.1111/j.1524-475X.2010.00616.x (2010).
17. Fong, C. Y. et al. Human Wharton's jelly stem cells and its conditioned medium enhance healing of excisional and diabetic wounds. Journal of cellular biochemistry 115, 290-302, doi: 10.1002/jcb.24661 (2014).
18. Cutler, A. J., Limbani, V., Girdlestone, J., Navarrete, C. V. Umbilical cord-derived mesenchymal stromal cells modulate monocyte function to suppress T cell proliferation. Journal of immunology 185, 6617-6623, doi: 10.4049/jimmunol.1002239 (2010).
19. Cardoso, T. C. et al. Isolation and characterization of Wharton's jelly-derived multipotent mesenchymal stromal cells obtained from bovine umbilical cord and maintained in a defined serum-free three-dimensional system. BMC biotechnology 12, 18, doi: 10.1186/1472-6750-12-18 (2012).
20. Lee, W. C. et al. Multivariate biophysical markers predictive of mesenchymal stromal cell multipotency. Proceedings of the National Academy of Sciences of the United States of America 111, E4409-4418, doi: 10.1073/pnas.1402306111 (2014).
21. Peranteau, W. H. et al. IL-10 overexpression decreases inflammatory mediators and promotes regenerative healing in an adult model of scar formation. The Journal of investigative dermatology 128, 1852-1860, doi: 10.1038/sj.jid.5701232 (2008).
22. Shephard, P. et al. Myofibroblast differentiation is induced in keratinocyte-fibroblast co-cultures and is antagonistically regulated by endogenous transforming growth factor-beta and interleukin-1. Am J Pathol 164, 2055-2066 (2004).
23. Gawronska-Kozak, B., Bogacki, M., Rim, J. S., Monroe, W. T., Manuel, J. A. Scarless skin repair in immunodeficient mice. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 14, 265-276, doi: 10.1111/j.1743-6109.2006.00121.x (2006).
24. Wu, Y. et al. Bone marrow-derived mesenchymal stem cell attenuates skin fibrosis development in mice. International wound journal 11, 701-710, doi: 10.1111/iwj.12034 (2014).
25. Sabapathy, V., Sundaram, B., V, M. S., Mankuzhy, P., Kumar, S. Human Wharton's Jelly Mesenchymal Stem Cells plasticity augments scar-free skin wound healing with hair growth. PloS one 9, e93726, doi: 10.1371/journal.pone.0093726 (2014).
26. Junqueira, L. C., Bignolas, G., Brentani, R. R. Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. The Histochemical journal 11, 447-455 (1979).