Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia

Nature Communications

Volumn 7, Issue , 2016, Pages

  Sun, Kaiqi ^a,b   Zhang, Yujin ^a   D'Alessandro, Angelo ^c   Nemkov, Travis ^c   Song, Anren ^a   Wu, Hongyu ^a   Liu, Hong ^a,b   Adebiyi, Morayo ^a,b   Huang, Aji ^a   Wen, Yuan E ^a   Bogdanov, Mikhail V ^a   Vila, Alejandro ^a   O'Brien, John ^a   Kellems, Rodney E ^a,b   Dowhan, William ^a   Subudhi, Andrew W ^c   Jameson Van Houten, Sonja ^c   Julian, Colleen G ^c   Lovering, Andrew T ^d   Safo, Martin ^e   Hansen, Kirk C ^c   Roach, Robert C ^c   Xia, Yang ^a,b,f   more..

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF OREGON   (United States)

^e VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^f CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIPHOSPHOGLYCERIC ACID; GLUCOSE; GLYCOLYTIC ENZYME; HEMOGLOBIN; OXYGEN; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE 1; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LYSOPHOSPHOLIPID; PHOSPHOTRANSFERASE; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE; SPHINGOSINE KINASE;

ADAPTATION; ALTITUDE; CELLS AND CELL COMPONENTS; ENZYME ACTIVITY; HYPOXIA; LIPID; METABOLISM; OXYGEN; PHOSPHATE; RODENT;

ADAPTATION; ALTITUDE; ALTITUDE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ERYTHROCYTE; ERYTHROCYTE CULTURE; ERYTHROCYTE METABOLISM; FEMALE; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOLYSIS; HEART; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; KIDNEY CORTEX; LUNG FUNCTION; MALE; METABOLIC FLUX ANALYSIS; MOUSE; NONHUMAN; NORMAL HUMAN; OXYGEN SATURATION; PROTEIN LIPID INTERACTION; SEA LEVEL; ADULT; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; C57BL MOUSE; GENETICS; METABOLISM; MUTANT MOUSE STRAIN;

2,3-DIPHOSPHOGLYCERATE; ADAPTATION, PHYSIOLOGICAL; ADULT; ALTITUDE SICKNESS; ANIMALS; ERYTHROCYTES; FEMALE; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (PHOSPHORYLATING); GLYCOLYSIS; HUMANS; HYPOXIA; LYSOPHOSPHOLIPIDS; MALE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; OXYGEN; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); SPHINGOSINE;

EID: 84978734538     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms12086     Document Type: Article

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