Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling

Autophagy

Volumn 12, Issue 9, 2016, Pages 1631-1646

  Choi, Hyowon ^a   Merceron, Christophe ^b,c,d   Mangiavini, Laura ^b,e   Seifert, Erin L ^a   Schipani, Ernestina ^b,f   Shapiro, Irving M ^a   Risbud, Makarand V ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c INSERM   (France)

^d UNIVERSITÉ DE NANTES   (France)

^e UNIVERSITY OF MILANO BICOCCA   (Italy)

^f UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

autophagy; HIF1; hypoxia; intervertebral disc; MTOR independent autophagy; nucleus pulposus

Indexed keywords

ADENYLATE KINASE; AUTOPHAGY PROTEIN 5; AUTOPHAGY RELATED PROTEIN 12; BECLIN 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN; PROTEIN BNIP3; RAPAMYCIN; ULK1 PROTEIN; UNCLASSIFIED DRUG; HIF1A PROTEIN, HUMAN; HIF1A PROTEIN, MOUSE; HIF1A PROTEIN, RAT; MTOR PROTEIN, HUMAN; MTOR PROTEIN, MOUSE; MTOR PROTEIN, RAT; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; CELL VIABILITY; CONTROLLED STUDY; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; MACROAUTOPHAGY; MALE; MOUSE; NONHUMAN; NUCLEUS PULPOSUS; OXIDATIVE STRESS; PROTEIN DEGRADATION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; CELL HYPOXIA; CELL SURVIVAL; CYTOLOGY; GENOTYPE; GLYCOLYSIS; INTERVERTEBRAL DISK DEGENERATION; LYSOSOME; METABOLISM; PHAGOSOME; PHOSPHORYLATION;

ANIMALS; AUTOPHAGY; CELL HYPOXIA; CELL SURVIVAL; GENOTYPE; GLYCOLYSIS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTERVERTEBRAL DISC DEGENERATION; LYSOSOMES; MICE; NUCLEUS PULPOSUS; OXIDATIVE STRESS; PHAGOSOMES; PHOSPHORYLATION; RATS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84981169866     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.1080/15548627.2016.1192753     Document Type: Article

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