-
1
-
-
27744522671
-
Information networks in the mammary gland
-
Hennighausen L, Robinson GW. 2005. Information networks in the mammary gland. Nat Rev Mol Cell Biol 6:715-725. http://dx.doi.org/10.1038/nrm1714.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 715-725
-
-
Hennighausen, L.1
Robinson, G.W.2
-
2
-
-
35548936522
-
Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice
-
Feng Y, Manka D, Wagner KU, Khan SA. 2007. Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice. Proc Natl Acad Sci U S A 104:14718-14723. http://dx.doi.org/10.1073/pnas.0706933104.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 14718-14723
-
-
Feng, Y.1
Manka, D.2
Wagner, K.U.3
Khan, S.A.4
-
3
-
-
33144474647
-
Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland
-
Mallepell S, Krust A, Chambon P, Brisken C. 2006. Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland. Proc Natl Acad Sci U S A 103:2196-2201. http://dx.doi.org/10.1073/pnas.0510974103.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 2196-2201
-
-
Mallepell, S.1
Krust, A.2
Chambon, P.3
Brisken, C.4
-
4
-
-
0030911681
-
Mammary gland development is mediated by both stromal and epithelial progesterone receptors
-
Humphreys RC, Lydon J, O'Malley BW, Rosen JM. 1997. Mammary gland development is mediated by both stromal and epithelial progesterone receptors. Mol Endocrinol 11:801-811. http://dx.doi.org/10.1210/mend.11.6.9891.
-
(1997)
Mol Endocrinol
, vol.11
, pp. 801-811
-
-
Humphreys, R.C.1
Lydon, J.2
O'Malley, B.W.3
Rosen, J.M.4
-
5
-
-
8544242334
-
Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse
-
Ormandy CJ, Camus A, Barra J, Damotte D, Lucas B, Buteau H, Edery M, Brousse N, Babinet C, Binart N, Kelly PA. 1997. Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes Dev 11:167-178. http://dx.doi.org/10.1101/gad.11.2.167.
-
(1997)
Genes Dev
, vol.11
, pp. 167-178
-
-
Ormandy, C.J.1
Camus, A.2
Barra, J.3
Damotte, D.4
Lucas, B.5
Buteau, H.6
Edery, M.7
Brousse, N.8
Babinet, C.9
Binart, N.10
Kelly, P.A.11
-
6
-
-
0030670222
-
Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene
-
Horseman ND, Zhao W, Montecino-Rodriguez E, Tanaka M, Nakashima K, Engle SJ, Smith F, Markoff E, Dorshkind K. 1997. Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene. EMBO J 16:6926-6935. http://dx.doi.org/10.1093/emboj/16.23.6926.
-
(1997)
EMBO J
, vol.16
, pp. 6926-6935
-
-
Horseman, N.D.1
Zhao, W.2
Montecino-Rodriguez, E.3
Tanaka, M.4
Nakashima, K.5
Engle, S.J.6
Smith, F.7
Markoff, E.8
Dorshkind, K.9
-
7
-
-
12244286724
-
Loss of interleukin 6 results in delayed mammary gland involution: a possible role for mitogenactivated protein kinase and not signal transducer and activator of transcription 3
-
Zhao L, Melenhorst JJ, Hennighausen L. 2002. Loss of interleukin 6 results in delayed mammary gland involution: a possible role for mitogenactivated protein kinase and not signal transducer and activator of transcription 3. Mol Endocrinol 16:2902-2912. http://dx.doi.org/10.1210/me.2001-0330.
-
(2002)
Mol Endocrinol
, vol.16
, pp. 2902-2912
-
-
Zhao, L.1
Melenhorst, J.J.2
Hennighausen, L.3
-
8
-
-
0042977593
-
A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland
-
Kritikou EA, Sharkey A, Abell K, Came PJ, Anderson E, Clarkson RW, Watson CJ. 2003. A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland. Development 130:3459-3468. http://dx.doi.org/10.1242/dev.00578.
-
(2003)
Development
, vol.130
, pp. 3459-3468
-
-
Kritikou, E.A.1
Sharkey, A.2
Abell, K.3
Came, P.J.4
Anderson, E.5
Clarkson, R.W.6
Watson, C.J.7
-
9
-
-
56749180714
-
A dual role for oncostatin M signaling in the differentiation and death of mammary epithelial cells in vivo
-
Tiffen PG, Omidvar N, Marquez-Almuina N, Croston D, Watson CJ, Clarkson RW. 2008. A dual role for oncostatin M signaling in the differentiation and death of mammary epithelial cells in vivo. Mol Endocrinol 22:2677-2688. http://dx.doi.org/10.1210/me.2008-0097.
-
(2008)
Mol Endocrinol
, vol.22
, pp. 2677-2688
-
-
Tiffen, P.G.1
Omidvar, N.2
Marquez-Almuina, N.3
Croston, D.4
Watson, C.J.5
Clarkson, R.W.6
-
10
-
-
52949086435
-
The Stat family of transcription factors have diverse roles in mammary gland development
-
Watson CJ, Neoh K. 2008. The Stat family of transcription factors have diverse roles in mammary gland development. Semin Cell Dev Biol 19: 401-406. http://dx.doi.org/10.1016/j.semcdb.2008.07.021.
-
(2008)
Semin Cell Dev Biol
, vol.19
, pp. 401-406
-
-
Watson, C.J.1
Neoh, K.2
-
11
-
-
84872716806
-
The two faces of Janus kinases and their respective STATs in mammary gland development and cancer
-
Wagner KU, Schmidt JW. 2011. The two faces of Janus kinases and their respective STATs in mammary gland development and cancer. J Carcinog 10:32. http://dx.doi.org/10.4103/1477-3163.90677.
-
(2011)
J Carcinog
, vol.10
, pp. 32
-
-
Wagner, K.U.1
Schmidt, J.W.2
-
12
-
-
78449258706
-
Loss of STAT1 from mouse mammary epithelium results in an increased Neu-induced tumor burden
-
Klover PJ, Muller WJ, Robinson GW, Pfeiffer RM, Yamaji D, Hennighausen L. 2010. Loss of STAT1 from mouse mammary epithelium results in an increased Neu-induced tumor burden. Neoplasia 12:899-905. http://dx.doi.org/10.1593/neo.10716.
-
(2010)
Neoplasia
, vol.12
, pp. 899-905
-
-
Klover, P.J.1
Muller, W.J.2
Robinson, G.W.3
Pfeiffer, R.M.4
Yamaji, D.5
Hennighausen, L.6
-
13
-
-
0029906982
-
Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation
-
Liu X, Robinson GW, Hennighausen L. 1996. Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation. Mol Endocrinol 10:1496-1506.
-
(1996)
Mol Endocrinol
, vol.10
, pp. 1496-1506
-
-
Liu, X.1
Robinson, G.W.2
Hennighausen, L.3
-
14
-
-
0028217452
-
Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response
-
Wakao H, Gouilleux F, Groner B. 1994. Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J 13:2182-2191.
-
(1994)
EMBO J
, vol.13
, pp. 2182-2191
-
-
Wakao, H.1
Gouilleux, F.2
Groner, B.3
-
15
-
-
0028173290
-
Regulation of the sheep beta-lactoglobulin gene by lactogenic hormones is mediated by a transcription factor that binds an interferon-gamma activation site-related element
-
Burdon TG, Maitland KA, Clark AJ, Wallace R, Watson CJ. 1994. Regulation of the sheep beta-lactoglobulin gene by lactogenic hormones is mediated by a transcription factor that binds an interferon-gamma activation site-related element. Mol Endocrinol 8:1528-1536. http://dx.doi.org/10.1210/mend.8.11.7877621.
-
(1994)
Mol Endocrinol
, vol.8
, pp. 1528-1536
-
-
Burdon, T.G.1
Maitland, K.A.2
Clark, A.J.3
Wallace, R.4
Watson, C.J.5
-
16
-
-
0034808097
-
Differential interactions of specific nuclear factor I isoforms with the glucocorticoid receptor and STAT5 in the cooperative regulation of WAP gene transcription
-
Mukhopadhyay SS, Wyszomierski SL, Gronostajski RM, Rosen JM. 2001. Differential interactions of specific nuclear factor I isoforms with the glucocorticoid receptor and STAT5 in the cooperative regulation of WAP gene transcription. Mol Cell Biol 21:6859-6869. http://dx.doi.org/10.1128/MCB.21.20.6859-6869.2001.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 6859-6869
-
-
Mukhopadhyay, S.S.1
Wyszomierski, S.L.2
Gronostajski, R.M.3
Rosen, J.M.4
-
17
-
-
0031671474
-
Functional release of Stat5a-null mammary tissue through the activation of compensating signals including Stat5b
-
Liu X, Gallego MI, Smith GH, Robinson GW, Hennighausen L. 1998. Functional release of Stat5a-null mammary tissue through the activation of compensating signals including Stat5b. Cell Growth Differ 9:795-803.
-
(1998)
Cell Growth Differ
, vol.9
, pp. 795-803
-
-
Liu, X.1
Gallego, M.I.2
Smith, G.H.3
Robinson, G.W.4
Hennighausen, L.5
-
18
-
-
4444268818
-
Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation
-
Cui Y, Riedlinger G, Miyoshi K, Tang W, Li C, Deng CX, Robinson GW, Hennighausen L. 2004. Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol 24:8037-8047. http://dx.doi.org/10.1128/MCB.24.18.8037-8047.2004.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 8037-8047
-
-
Cui, Y.1
Riedlinger, G.2
Miyoshi, K.3
Tang, W.4
Li, C.5
Deng, C.X.6
Robinson, G.W.7
Hennighausen, L.8
-
19
-
-
34548165283
-
The IL-4/IL-13/Stat6 signalling pathway promotes luminal mammary epithelial cell development
-
Khaled WT, Read EK, Nicholson SE, Baxter FO, Brennan AJ, Came PJ, Sprigg N, McKenzie AN, Watson CJ. 2007. The IL-4/IL-13/Stat6 signalling pathway promotes luminal mammary epithelial cell development. Development 134:2739-2750. http://dx.doi.org/10.1242/dev.003194.
-
(2007)
Development
, vol.134
, pp. 2739-2750
-
-
Khaled, W.T.1
Read, E.K.2
Nicholson, S.E.3
Baxter, F.O.4
Brennan, A.J.5
Came, P.J.6
Sprigg, N.7
McKenzie, A.N.8
Watson, C.J.9
-
20
-
-
0037138370
-
Signaling through the JAK/STAT pathway, recent advances and future challenges
-
Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW. 2002. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene 285:1-24. http://dx.doi.org/10.1016/S0378-1119(02)00398-0.
-
(2002)
Gene
, vol.285
, pp. 1-24
-
-
Kisseleva, T.1
Bhattacharya, S.2
Braunstein, J.3
Schindler, C.W.4
-
21
-
-
0032076183
-
Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses
-
Rodig SJ, Meraz MA, White JM, Lampe PA, Riley JK, Arthur CD, King KL, Sheehan KC, Yin L, Pennica D, Johnson EM, Jr, Schreiber RD. 1998. Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell 93:373-383. http://dx.doi.org/10.1016/S0092-8674(00)81166-6.
-
(1998)
Cell
, vol.93
, pp. 373-383
-
-
Rodig, S.J.1
Meraz, M.A.2
White, J.M.3
Lampe, P.A.4
Riley, J.K.5
Arthur, C.D.6
King, K.L.7
Sheehan, K.C.8
Yin, L.9
Pennica, D.10
Johnson, E.M.11
Schreiber, R.D.12
-
22
-
-
0032076542
-
Jak2 is essential for signaling through a variety of cytokine receptors
-
Parganas E, Wang D, Stravopodis D, Topham DJ, Marine JC, Teglund S, Vanin EF, Bodner S, Colamonici OR, van Deursen JM, Grosveld G, Ihle JN. 1998. Jak2 is essential for signaling through a variety of cytokine receptors. Cell 93:385-395. http://dx.doi.org/10.1016/S0092-8674(00)81167-8.
-
(1998)
Cell
, vol.93
, pp. 385-395
-
-
Parganas, E.1
Wang, D.2
Stravopodis, D.3
Topham, D.J.4
Marine, J.C.5
Teglund, S.6
Vanin, E.F.7
Bodner, S.8
Colamonici, O.R.9
van Deursen, J.M.10
Grosveld, G.11
Ihle, J.N.12
-
23
-
-
18244432009
-
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
-
Neubauer H, Cumano A, Muller M, Wu H, Huffstadt U, Pfeffer K. 1998. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 93:397-409. http://dx.doi.org/10.1016/S0092-8674(00)81168-X.
-
(1998)
Cell
, vol.93
, pp. 397-409
-
-
Neubauer, H.1
Cumano, A.2
Muller, M.3
Wu, H.4
Huffstadt, U.5
Pfeffer, K.6
-
24
-
-
0036185883
-
Jak2 is an essential tyrosine kinase involved in pregnancy-mediated development of mammary secretory epithelium
-
Shillingford JM, Miyoshi K, Robinson GW, Grimm SL, Rosen JM, Neubauer H, Pfeffer K, Hennighausen L. 2002. Jak2 is an essential tyrosine kinase involved in pregnancy-mediated development of mammary secretory epithelium. Mol Endocrinol 16:563-570. http://dx.doi.org/10.1210/mend.16.3.0805.
-
(2002)
Mol Endocrinol
, vol.16
, pp. 563-570
-
-
Shillingford, J.M.1
Miyoshi, K.2
Robinson, G.W.3
Grimm, S.L.4
Rosen, J.M.5
Neubauer, H.6
Pfeffer, K.7
Hennighausen, L.8
-
25
-
-
2942587457
-
Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice
-
Wagner KU, Krempler A, Triplett AA, Qi Y, George NM, Zhu J, Rui H. 2004. Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice. Mol Cell Biol 24:5510-5520. http://dx.doi.org/10.1128/MCB.24.12.5510-5520.2004.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 5510-5520
-
-
Wagner, K.U.1
Krempler, A.2
Triplett, A.A.3
Qi, Y.4
George, N.M.5
Zhu, J.6
Rui, H.7
-
26
-
-
84925884149
-
Generation of conditional knockout mice
-
Sakamoto K, Gurumurthy CB, Wagner KU. 2014. Generation of conditional knockout mice. Methods Mol Biol 1194:21-35. http://dx.doi.org/10.1007/978-1-4939-1215-5_2.
-
(2014)
Methods Mol Biol
, vol.1194
, pp. 21-35
-
-
Sakamoto, K.1
Gurumurthy, C.B.2
Wagner, K.U.3
-
27
-
-
0030658840
-
Cre-mediated gene deletion in the mammary gland
-
Wagner KU, Wall RJ, St-Onge L, Gruss P, Wynshaw-Boris A, Garrett L, Li M, Furth PA, Hennighausen L. 1997. Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res 25:4323-4330. http://dx.doi.org/10.1093/nar/25.21.4323.
-
(1997)
Nucleic Acids Res
, vol.25
, pp. 4323-4330
-
-
Wagner, K.U.1
Wall, R.J.2
St-Onge, L.3
Gruss, P.4
Wynshaw-Boris, A.5
Garrett, L.6
Li, M.7
Furth, P.A.8
Hennighausen, L.9
-
28
-
-
0035543866
-
Spatial and temporal expression of the Cre gene under the control of theMMTV-LTRin different lines of transgenic mice
-
Wagner KU, McAllister K, Ward T, Davis B, Wiseman R, Hennighausen L. 2001. Spatial and temporal expression of the Cre gene under the control of theMMTV-LTRin different lines of transgenic mice. Transgenic Res 10:545-553. http://dx.doi.org/10.1023/A:1013063514007.
-
(2001)
Transgenic Res
, vol.10
, pp. 545-553
-
-
Wagner, K.U.1
McAllister, K.2
Ward, T.3
Davis, B.4
Wiseman, R.5
Hennighausen, L.6
-
29
-
-
0034737405
-
A novel reporter mouse strain that expresses enhanced green fluorescent protein upon Cre-mediated recombination
-
Kawamoto S, Niwa H, Tashiro F, Sano S, Kondoh G, Takeda J, Tabayashi K, Miyazaki J. 2000. A novel reporter mouse strain that expresses enhanced green fluorescent protein upon Cre-mediated recombination. FEBS Lett 470:263-268. http://dx.doi.org/10.1016/S0014-5793(00)01338-7.
-
(2000)
FEBS Lett
, vol.470
, pp. 263-268
-
-
Kawamoto, S.1
Niwa, H.2
Tashiro, F.3
Sano, S.4
Kondoh, G.5
Takeda, J.6
Tabayashi, K.7
Miyazaki, J.8
-
30
-
-
41149127750
-
Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development
-
Labi V, Erlacher M, Kiessling S, Manzl C, Frenzel A, O'Reilly L, Strasser A, Villunger A. 2008. Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development. J Exp Med 205:641-655. http://dx.doi.org/10.1084/jem.20071658.
-
(2008)
J Exp Med
, vol.205
, pp. 641-655
-
-
Labi, V.1
Erlacher, M.2
Kiessling, S.3
Manzl, C.4
Frenzel, A.5
O'Reilly, L.6
Strasser, A.7
Villunger, A.8
-
31
-
-
0033607506
-
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
-
Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Kontgen F, Adams JM, Strasser A. 1999. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286:1735-1738. http://dx.doi.org/10.1126/science.286.5445.1735.
-
(1999)
Science
, vol.286
, pp. 1735-1738
-
-
Bouillet, P.1
Metcalf, D.2
Huang, D.C.3
Tarlinton, D.M.4
Kay, T.W.5
Kontgen, F.6
Adams, J.M.7
Strasser, A.8
-
32
-
-
84899647425
-
Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf
-
Labi V, Woess C, Tuzlak S, Erlacher M, Bouillet P, Strasser A, Tzankov A, Villunger A. 2014. Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf. Blood 123:2652-2662. http://dx.doi.org/10.1182/blood-2013-11-537217.
-
(2014)
Blood
, vol.123
, pp. 2652-2662
-
-
Labi, V.1
Woess, C.2
Tuzlak, S.3
Erlacher, M.4
Bouillet, P.5
Strasser, A.6
Tzankov, A.7
Villunger, A.8
-
33
-
-
84964981863
-
-
8th ed. National Academies Press, Washington, DC
-
National Research Council. 2011. Guide for the care and use of laboratory animals, 8th ed. National Academies Press, Washington, DC.
-
(2011)
Guide for the care and use of laboratory animals
-
-
-
34
-
-
10644224189
-
Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice
-
Krempler A, Qi Y, Triplett AA, Zhu J, Rui H, Wagner KU. 2004. Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice. Genesis 40:52-57. http://dx.doi.org/10.1002/gene.20063.
-
(2004)
Genesis
, vol.40
, pp. 52-57
-
-
Krempler, A.1
Qi, Y.2
Triplett, A.A.3
Zhu, J.4
Rui, H.5
Wagner, K.U.6
-
35
-
-
34547441513
-
The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells
-
Sakamoto K, Creamer BA, Triplett AA, Wagner KU. 2007. The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells. Mol Endocrinol 21:1877-1892. http://dx.doi.org/10.1210/me.2006-0316.
-
(2007)
Mol Endocrinol
, vol.21
, pp. 1877-1892
-
-
Sakamoto, K.1
Creamer, B.A.2
Triplett, A.A.3
Wagner, K.U.4
-
36
-
-
0031265265
-
Oxytocin and milk removal are required for postpartum mammary-gland development
-
Wagner KU, Young WS, Liu X, Ginns EI, Li M, Furth PA, Hennighausen L. 1997. Oxytocin and milk removal are required for postpartum mammary-gland development. Genes Funct 1:233-244. http://dx.doi.org/10.1046/j.1365-4624.1997.00024.x.
-
(1997)
Genes Funct
, vol.1
, pp. 233-244
-
-
Wagner, K.U.1
Young, W.S.2
Liu, X.3
Ginns, E.I.4
Li, M.5
Furth, P.A.6
Hennighausen, L.7
-
37
-
-
84871809302
-
STAR: ultrafast universal RNA-seq aligner
-
Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, Batut P, Chaisson M, Gingeras TR. 2013. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29:15-21. http://dx.doi.org/10.1093/bioinformatics/bts635.
-
(2013)
Bioinformatics
, vol.29
, pp. 15-21
-
-
Dobin, A.1
Davis, C.A.2
Schlesinger, F.3
Drenkow, J.4
Zaleski, C.5
Jha, S.6
Batut, P.7
Chaisson, M.8
Gingeras, T.R.9
-
38
-
-
84873637249
-
Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration
-
Yamaji D, Kang K, Robinson GW, Hennighausen L. 2013. Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration. Nucleic Acids Res 41: 1622-1636. http://dx.doi.org/10.1093/nar/gks1310.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. 1622-1636
-
-
Yamaji, D.1
Kang, K.2
Robinson, G.W.3
Hennighausen, L.4
-
39
-
-
84895779092
-
Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis
-
Schmidt JW, Wehde BL, Sakamoto K, Triplett AA, Anderson SM, Tsichlis PN, Leone G, Wagner KU. 2014. Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis. Mol Cell Biol 34:1363-1377. http://dx.doi.org/10.1128/MCB.01220-13.
-
(2014)
Mol Cell Biol
, vol.34
, pp. 1363-1377
-
-
Schmidt, J.W.1
Wehde, B.L.2
Sakamoto, K.3
Triplett, A.A.4
Anderson, S.M.5
Tsichlis, P.N.6
Leone, G.7
Wagner, K.U.8
-
40
-
-
0034658024
-
Serine phosphorylation of STATs
-
Decker T, Kovarik P. 2000. Serine phosphorylation of STATs. Oncogene 19:2628-2637. http://dx.doi.org/10.1038/sj.onc.1203481.
-
(2000)
Oncogene
, vol.19
, pp. 2628-2637
-
-
Decker, T.1
Kovarik, P.2
-
41
-
-
6344278615
-
Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK
-
Zhao L, Hart S, Cheng J, Melenhorst JJ, Bierie B, Ernst M, Stewart C, Schaper F, Heinrich PC, Ullrich A, Robinson GW, Hennighausen L. 2004. Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK. J Biol Chem 279:44093-44100. http://dx.doi.org/10.1074/jbc.M313131200.
-
(2004)
J Biol Chem
, vol.279
, pp. 44093-44100
-
-
Zhao, L.1
Hart, S.2
Cheng, J.3
Melenhorst, J.J.4
Bierie, B.5
Ernst, M.6
Stewart, C.7
Schaper, F.8
Heinrich, P.C.9
Ullrich, A.10
Robinson, G.W.11
Hennighausen, L.12
-
42
-
-
84859647855
-
Conditional deletion of Stat3 in mammary epithelium impairs the acute phase response and modulates immune cell numbers during post-lactational regression
-
Hughes K, Wickenden JA, Allen JE, Watson CJ. 2012. Conditional deletion of Stat3 in mammary epithelium impairs the acute phase response and modulates immune cell numbers during post-lactational regression. J Pathol 227:106-117. http://dx.doi.org/10.1002/path.3961.
-
(2012)
J Pathol
, vol.227
, pp. 106-117
-
-
Hughes, K.1
Wickenden, J.A.2
Allen, J.E.3
Watson, C.J.4
-
43
-
-
0033214903
-
Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3
-
Chapman RS, Lourenco PC, Tonner E, Flint DJ, Selbert S, Takeda K, Akira S, Clarke AR, Watson CJ. 1999. Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes Dev 13:2604-2616. http://dx.doi.org/10.1101/gad.13.19.2604.
-
(1999)
Genes Dev
, vol.13
, pp. 2604-2616
-
-
Chapman, R.S.1
Lourenco, P.C.2
Tonner, E.3
Flint, D.J.4
Selbert, S.5
Takeda, K.6
Akira, S.7
Clarke, A.R.8
Watson, C.J.9
-
44
-
-
84937054186
-
Abnormal mammary development in 129:STAT1-null mice is stroma-dependent
-
Chen JQ, Mori H, Cardiff RD, Trott JF, Hovey RC, Hubbard NE, Engelberg JA, Tepper CG, Willis BJ, Khan IH, Ravindran RK, Chan SR, Schreiber RD, Borowsky AD. 2015. Abnormal mammary development in 129:STAT1-null mice is stroma-dependent. PLoS One 10:e0129895. http://dx.doi.org/10.1371/journal.pone.0129895.
-
(2015)
PLoS One
, vol.10
-
-
Chen, J.Q.1
Mori, H.2
Cardiff, R.D.3
Trott, J.F.4
Hovey, R.C.5
Hubbard, N.E.6
Engelberg, J.A.7
Tepper, C.G.8
Willis, B.J.9
Khan, I.H.10
Ravindran, R.K.11
Chan, S.R.12
Schreiber, R.D.13
Borowsky, A.D.14
-
45
-
-
0028922433
-
A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6
-
Guschin D, Rogers N, Briscoe J, Witthuhn B, Watling D, Horn F, Pellegrini S, Yasukawa K, Heinrich P, Stark GR, Ihle GR, Kerr IM. 1995. A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6. EMBO J 14:1421-1429.
-
(1995)
EMBO J
, vol.14
, pp. 1421-1429
-
-
Guschin, D.1
Rogers, N.2
Briscoe, J.3
Witthuhn, B.4
Watling, D.5
Horn, F.6
Pellegrini, S.7
Yasukawa, K.8
Heinrich, P.9
Stark, G.R.10
Ihle, G.R.11
Kerr, I.M.12
-
46
-
-
0028296179
-
Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130
-
Lutticken C, Wegenka UM, Yuan J, Buschmann J, Schindler C, Ziemiecki A, Harpur AG, Wilks AF, Yasukawa K, Taga T, Kishimoto T. 1994. Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. Science 263:89-92. http://dx.doi.org/10.1126/science.8272872.
-
(1994)
Science
, vol.263
, pp. 89-92
-
-
Lutticken, C.1
Wegenka, U.M.2
Yuan, J.3
Buschmann, J.4
Schindler, C.5
Ziemiecki, A.6
Harpur, A.G.7
Wilks, A.F.8
Yasukawa, K.9
Taga, T.10
Kishimoto, T.11
-
47
-
-
79960383874
-
STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis
-
Corcoran RB, Contino G, Deshpande V, Tzatsos A, Conrad C, Benes CH, Levy DE, Settleman J, Engelman JA, Bardeesy N. 2011. STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis. Cancer Res 71: 5020-5029. http://dx.doi.org/10.1158/0008-5472.CAN-11-0908.
-
(2011)
Cancer Res
, vol.71
, pp. 5020-5029
-
-
Corcoran, R.B.1
Contino, G.2
Deshpande, V.3
Tzatsos, A.4
Conrad, C.5
Benes, C.H.6
Levy, D.E.7
Settleman, J.8
Engelman, J.A.9
Bardeesy, N.10
-
48
-
-
79959956046
-
The JAK2/STAT3 signaling pathway is required for growth of CD44(+)CD24(-) stem cell-like breast cancer cells in human tumors
-
Marotta LL, Almendro V, Marusyk A, Shipitsin M, Schemme J, Walker SR, Bloushtain-Qimron N, Kim JJ, Choudhury SA, Maruyama R, Wu Z, Gonen M, Mulvey LA, Bessarabova MO, Huh SJ, Silver SJ, Kim SY, Park SY, Lee HE, Anderson KS, Richardson AL, Nikolskaya T, Nikolsky Y, Liu XS, Root DE, Hahn WC, Frank DA, Polyak K. 2011. The JAK2/STAT3 signaling pathway is required for growth of CD44(+)CD24(-) stem cell-like breast cancer cells in human tumors. J Clin Invest 121:2723-2735. http://dx.doi.org/10.1172/JCI44745.
-
(2011)
J Clin Invest
, vol.121
, pp. 2723-2735
-
-
Marotta, L.L.1
Almendro, V.2
Marusyk, A.3
Shipitsin, M.4
Schemme, J.5
Walker, S.R.6
Bloushtain-Qimron, N.7
Kim, J.J.8
Choudhury, S.A.9
Maruyama, R.10
Wu, Z.11
Gonen, M.12
Mulvey, L.A.13
Bessarabova, M.O.14
Huh, S.J.15
Silver, S.J.16
Kim, S.Y.17
Park, S.Y.18
Lee, H.E.19
Anderson, K.S.20
Richardson, A.L.21
Nikolskaya, T.22
Nikolsky, Y.23
Liu, X.S.24
Root, D.E.25
Hahn, W.C.26
Frank, D.A.27
Polyak, K.28
more..
-
49
-
-
84900865954
-
Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden
-
Abubaker K, Luwor RB, Zhu H, McNally O, Quinn MA, Burns CJ, Thompson EW, Findlay JK, Ahmed N. 2014. Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden. BMC Cancer 14:317. http://dx.doi.org/10.1186/1471-2407-14-317.
-
(2014)
BMC Cancer
, vol.14
, pp. 317
-
-
Abubaker, K.1
Luwor, R.B.2
Zhu, H.3
McNally, O.4
Quinn, M.A.5
Burns, C.J.6
Thompson, E.W.7
Findlay, J.K.8
Ahmed, N.9
-
50
-
-
84887392984
-
+ chronic myeloid leukemia
-
+ chronic myeloid leukemia. Blood 122: 2167-2175. http://dx.doi.org/10.1182/blood-2013-02-485573.
-
(2013)
Blood
, vol.122
, pp. 2167-2175
-
-
Warsch, W.1
Walz, C.2
Sexl, V.3
-
51
-
-
77957586805
-
Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer
-
Sakamoto K, Triplett AA, Schuler LA, Wagner KU. 2010. Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer. Oncogene 29:5359-5369. http://dx.doi.org/10.1038/onc.2010.274.
-
(2010)
Oncogene
, vol.29
, pp. 5359-5369
-
-
Sakamoto, K.1
Triplett, A.A.2
Schuler, L.A.3
Wagner, K.U.4
-
52
-
-
69249118165
-
Targeting Janus kinase 2 in Her2/neu-expressing mammary cancer: implications for cancer prevention and therapy
-
Sakamoto K, Lin WC, Triplett AA, Wagner KU. 2009. Targeting Janus kinase 2 in Her2/neu-expressing mammary cancer: implications for cancer prevention and therapy. Cancer Res 69:6642-6650. http://dx.doi.org/10.1158/0008-5472.CAN-09-0746.
-
(2009)
Cancer Res
, vol.69
, pp. 6642-6650
-
-
Sakamoto, K.1
Lin, W.C.2
Triplett, A.A.3
Wagner, K.U.4
-
53
-
-
34548549283
-
Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer
-
Berishaj M, Gao SP, Ahmed S, Leslie K, Al Ahmadie H, Gerald WL, Bornmann W, Bromberg JF. 2007. Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer. Breast Cancer Res 9:R32. http://dx.doi.org/10.1186/bcr1680.
-
(2007)
Breast Cancer Res
, vol.9
, pp. R32
-
-
Berishaj, M.1
Gao, S.P.2
Ahmed, S.3
Leslie, K.4
Al Ahmadie, H.5
Gerald, W.L.6
Bornmann, W.7
Bromberg, J.F.8
-
54
-
-
36849012237
-
Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
-
Gao SP, Mark KG, Leslie K, Pao W, Motoi N, Gerald WL, Travis WD, Bornmann W, Veach D, Clarkson B, Bromberg JF. 2007. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. J Clin Invest 117:3846-3856. http://dx.doi.org/10.1172/JCI31871.
-
(2007)
J Clin Invest
, vol.117
, pp. 3846-3856
-
-
Gao, S.P.1
Mark, K.G.2
Leslie, K.3
Pao, W.4
Motoi, N.5
Gerald, W.L.6
Travis, W.D.7
Bornmann, W.8
Veach, D.9
Clarkson, B.10
Bromberg, J.F.11
-
55
-
-
0037844864
-
Independent and cooperative activation of chromosomal c-fos promoter by STAT3
-
Yang E, Lerner L, Besser D, Darnell JE, Jr. 2003. Independent and cooperative activation of chromosomal c-fos promoter by STAT3. J Biol Chem 278:15794-15799. http://dx.doi.org/10.1074/jbc.M213073200.
-
(2003)
J Biol Chem
, vol.278
, pp. 15794-15799
-
-
Yang, E.1
Lerner, L.2
Besser, D.3
Darnell, J.E.4
-
56
-
-
0034931503
-
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
-
Han Z, Boyle DL, Chang L, Bennett B, Karin M, Yang L, Manning AM, Firestein GS. 2001. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest 108:73-81. http://dx.doi.org/10.1172/JCI12466.
-
(2001)
J Clin Invest
, vol.108
, pp. 73-81
-
-
Han, Z.1
Boyle, D.L.2
Chang, L.3
Bennett, B.4
Karin, M.5
Yang, L.6
Manning, A.M.7
Firestein, G.S.8
-
57
-
-
0036240838
-
Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors
-
Vincenti MP, Brinckerhoff CE. 2002. Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors. Arthritis Res 4:157-164. http://dx.doi.org/10.1186/ar401.
-
(2002)
Arthritis Res
, vol.4
, pp. 157-164
-
-
Vincenti, M.P.1
Brinckerhoff, C.E.2
-
58
-
-
84949539191
-
The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland
-
Schuler F, Baumgartner F, Klepsch V, Chamson M, Muller-Holzner E, Watson CJ, Oh S, Hennighausen L, Tymoszuk P, Doppler W, Villunger A. 2016. The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland. Cell Death Differ 23:41-51. http://dx.doi.org/10.1038/cdd.2015.61.
-
(2016)
Cell Death Differ
, vol.23
, pp. 41-51
-
-
Schuler, F.1
Baumgartner, F.2
Klepsch, V.3
Chamson, M.4
Muller-Holzner, E.5
Watson, C.J.6
Oh, S.7
Hennighausen, L.8
Tymoszuk, P.9
Doppler, W.10
Villunger, A.11
-
59
-
-
79952257741
-
Stat3 controls lysosomal-mediated cell death in vivo
-
Kreuzaler PA, Staniszewska AD, Li W, Omidvar N, Kedjouar B, Turkson J, Poli V, Flavell RA, Clarkson RW, Watson CJ. 2011. Stat3 controls lysosomal-mediated cell death in vivo. Nat Cell Biol 13:303-309. http://dx.doi.org/10.1038/ncb2171.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 303-309
-
-
Kreuzaler, P.A.1
Staniszewska, A.D.2
Li, W.3
Omidvar, N.4
Kedjouar, B.5
Turkson, J.6
Poli, V.7
Flavell, R.A.8
Clarkson, R.W.9
Watson, C.J.10
|