ADAM17 substrate release in proximal tubule drives kidney fibrosis

JCI Insight

Volumn 1, Issue 13, 2016, Pages

  Kefaloyianni, Eirini ^a   Muthu, Muthu Lakshmi ^a   Kaeppler, Jakob ^a   Sun, Xiaoming ^a   Sabbisetti, Venkata ^a   Chalaris, Athena ^b   Rose John, Stefan ^b   Wong, Eitan ^c   Sagi, Irit ^c   Waikar, Sushrut S ^a   Rennke, Helmut ^a   Humphreys, Benjamin D ^d   Bonventre, Joseph V ^a   Herrlich, Andreas ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF KIEL   (Germany)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAM PROTEIN; AMPHIREGULIN; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN A DISINTEGRIN AND METALLOPROTEASE 17; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ACUTE KIDNEY FAILURE; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CHRONIC KIDNEY FAILURE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME RELEASE; ENZYME SUBSTRATE; ENZYME SYNTHESIS; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; KIDNEY BIOPSY; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY PROXIMAL TUBULE; MACROPHAGE; MALE; MOLECULAR INTERACTION; MOLECULAR MECHANICS; MOUSE; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; PROXIMAL TUBULE CELL; REAL TIME POLYMERASE CHAIN REACTION; RENAL ISCHEMIA REPERFUSION INJURY; SIGNAL TRANSDUCTION; UPREGULATION; URETER OBSTRUCTION; URINE SAMPLING; WESTERN BLOTTING;

EID: 85055607205     PISSN: None     EISSN: 23793708     Source Type: Journal    
DOI: 10.1172/jci.insight.87023     Document Type: Article

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