Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation

Journal of Allergy and Clinical Immunology

Volumn 136, Issue 4, 2015, Pages 1065-1073

  Ullah, Md Ashik ^a,b,c   Revez, Joana A ^c   Loh, Zhixuan ^b   Simpson, Jennifer ^b   Zhang, Vivian ^b   Bain, Lisa ^c   Varelias, Antiopi ^c   Rose John, Stefan ^d   Blumenthal, Antje ^b   Smyth, Mark J ^b,c   Hill, Geoffrey R ^c,e   Sukkar, Maria B ^a,f   Ferreira, Manuel A R ^c   Phipps, Simon ^b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^d UNIVERSITY OF KIEL   (Germany)

^e ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^f UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

Author keywords

allergy; endotype; eosinophils; IL 17; MR16 1; neutrophils; sgp130 Fc; Tocilizumab; T cell

Indexed keywords

HOUSE DUST ALLERGEN; INTERLEUKIN 17; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; ALLERGEN; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COCKROACH; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DERMATOPHAGOIDES; EXPERIMENTAL ASTHMA; GAMMA DELTA T LYMPHOCYTE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TH17 CELL; TH2 CELL; ANIMAL; ASTHMA; CHEMICALLY INDUCED; DRUG EFFECTS; IMMUNOLOGY; PATHOLOGY; PYROGLYPHIDAE;

ALLERGENS; ANIMALS; ASTHMA; COCKROACHES; INTERLEUKIN-6; MICE; PYROGLYPHIDAE; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RECEPTORS, INTERLEUKIN-6; SIGNAL TRANSDUCTION; TH17 CELLS; TH2 CELLS;

EID: 84941301482     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.02.032     Document Type: Article

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