-
1
-
-
64049116643
-
Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections
-
Stacey AR, Norris PJ, Qin L, et al. Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections. J Virol 2009; 83:3719-33.
-
(2009)
J Virol
, vol.83
, pp. 3719-3733
-
-
Stacey, A.R.1
Norris, P.J.2
Qin, L.3
-
3
-
-
84893171544
-
Dynamics of immune reconstitution and activation markers in HIV+ treatment-naive patients treated with raltegravir, tenofovir disoproxil fumarate and emtricitabine
-
Funderburg NT, Andrade A, Chan ES, et al. Dynamics of immune reconstitution and activation markers in HIV+ treatment-naive patients treated with raltegravir, tenofovir disoproxil fumarate and emtricitabine. PLoS One 2013; 8:e83514.
-
(2013)
PLoS One
, vol.8
, pp. e83514
-
-
Funderburg, N.T.1
Andrade, A.2
Chan, E.S.3
-
4
-
-
84983246866
-
Comparison of the metabolic effects of ritonavir-boosted darunavir or atazanavir versus raltegravir, and the impact of ritonavir plasma exposure: ACTG 5257
-
Ofotokun I, Na LH, Landovitz RJ, et al. Comparison of the metabolic effects of ritonavir-boosted darunavir or atazanavir versus raltegravir, and the impact of ritonavir plasma exposure: ACTG 5257. Clin Infect Dis 2015; 60:1842-51.
-
(2015)
Clin Infect Dis
, vol.60
, pp. 1842-1851
-
-
Ofotokun, I.1
Na, L.H.2
Landovitz, R.J.3
-
5
-
-
84938598472
-
Changes in inflammation and immune activation with atazanavir-, raltegravir-, darunavir-based initial antiviral therapy: ACTG 5260s
-
Kelesidis T, Tran TT, Stein JH, et al. Changes in inflammation and immune activation with atazanavir-, raltegravir-, darunavir-based initial antiviral therapy: ACTG 5260s. Clin Infect Dis 2015; 61:651-60.
-
(2015)
Clin Infect Dis
, vol.61
, pp. 651-660
-
-
Kelesidis, T.1
Tran, T.T.2
Stein, J.H.3
-
6
-
-
84910010874
-
Soluble markers of inflammation and coagulation but not T-cell activation predict non-AIDS-defining morbid events during suppressive antiretroviral treatment
-
Tenorio AR, Zheng Y, Bosch RJ, et al. Soluble markers of inflammation and coagulation but not T-cell activation predict non-AIDS-defining morbid events during suppressive antiretroviral treatment. J Infect Dis 2014; 210:1248-59.
-
(2014)
J Infect Dis
, vol.210
, pp. 1248-1259
-
-
Tenorio, A.R.1
Zheng, Y.2
Bosch, R.J.3
-
7
-
-
57149107119
-
The effects of IL-6 on CD4 T cell responses
-
Dienz O, Rincon M. The effects of IL-6 on CD4 T cell responses. Clin Immunol 2009; 130:27-33.
-
(2009)
Clin Immunol
, vol.130
, pp. 27-33
-
-
Dienz, O.1
Rincon, M.2
-
8
-
-
0025248775
-
Interleukin-1 induces interleukin-6 production in peripheral blood monocytes
-
Tosato G, Jones KD. Interleukin-1 induces interleukin-6 production in peripheral blood monocytes. Blood 1990; 75:1305-10.
-
(1990)
Blood
, vol.75
, pp. 1305-1310
-
-
Tosato, G.1
Jones, K.D.2
-
9
-
-
84951924017
-
The cardiomyocyte as a source of cytokines in cardiac injury
-
Aoyagi T, Matsui T. The cardiomyocyte as a source of cytokines in cardiac injury. J Cell Sci Ther 2012; S5:3.
-
(2012)
J Cell Sci Ther
, vol.S5
, pp. 3
-
-
Aoyagi, T.1
Matsui, T.2
-
10
-
-
33748121115
-
Interleukin-6 and chronic inflammation
-
Gabay C. Interleukin-6 and chronic inflammation. Arthritis Res Ther 2006; 8 (suppl 2):S3.
-
(2006)
Arthritis Res Ther
, vol.8
, pp. S3
-
-
Gabay, C.1
-
12
-
-
0024360388
-
The biology of interleukin-6
-
Kishimoto T. The biology of interleukin-6. Blood 1989; 74:1-10.
-
(1989)
Blood
, vol.74
, pp. 1-10
-
-
Kishimoto, T.1
-
14
-
-
0035164602
-
The soluble interleukin 6 receptor: Mechanisms of production and implications in disease
-
Jones SA, Horiuchi S, Topley N, Yamamoto N, Fuller GM. The soluble interleukin 6 receptor: mechanisms of production and implications in disease. FASEB J 2001; 15:43-58.
-
(2001)
FASEB J
, vol.15
, pp. 43-58
-
-
Jones, S.A.1
Horiuchi, S.2
Topley, N.3
Yamamoto, N.4
Fuller, G.M.5
-
16
-
-
0038341934
-
Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice
-
Lin ZQ, Kondo T, Ishida Y, Takayasu T, Mukaida N. Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice. J Leukoc Biol 2003; 73:713-21.
-
(2003)
J Leukoc Biol
, vol.73
, pp. 713-721
-
-
Lin, Z.Q.1
Kondo, T.2
Ishida, Y.3
Takayasu, T.4
Mukaida, N.5
-
17
-
-
84892476632
-
Interleukin-6 signaling drives fibrosis in unresolved inflammation
-
Fielding CA, Jones GW, McLoughlin RM, et al. Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity 2014; 40:40-50.
-
(2014)
Immunity
, vol.40
, pp. 40-50
-
-
Fielding, C.A.1
Jones, G.W.2
McLoughlin, R.M.3
-
18
-
-
0242268405
-
Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age
-
Jacoby JJ, Kalinowski A, Liu MG, et al. Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age. Proc Natl Acad Sci USA 2003; 100: 12929-34.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 12929-12934
-
-
Jacoby, J.J.1
Kalinowski, A.2
Liu, M.G.3
-
19
-
-
16844377774
-
Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling
-
Zhang XL, Topley N, Ito T, Phillips A. Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling. J Biol Chem 2005; 280:12239-45.
-
(2005)
J Biol Chem
, vol.280
, pp. 12239-12245
-
-
Zhang, X.L.1
Topley, N.2
Ito, T.3
Phillips, A.4
-
20
-
-
73349121322
-
Interleukin (IL)-6 modulates transforming growth factor-beta expression in skin and dermal fibroblasts from IL-6-deficient mice
-
Luckett-Chastain LR, Gallucci RM. Interleukin (IL)-6 modulates transforming growth factor-beta expression in skin and dermal fibroblasts from IL-6-deficient mice. Br J Dermatol 2009; 161:237-48.
-
(2009)
Br J Dermatol
, vol.161
, pp. 237-248
-
-
Luckett-Chastain, L.R.1
Gallucci, R.M.2
-
21
-
-
79952216365
-
Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections
-
Zeng M, Smith AJ, Wietgrefe SW, et al. Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections. J Clin Invest 2011; 121:998-1008.
-
(2011)
J Clin Invest
, vol.121
, pp. 998-1008
-
-
Zeng, M.1
Smith, A.J.2
Wietgrefe, S.W.3
-
22
-
-
33846785628
-
Simian immunodeficiency virusinduced lymphatic tissue fibrosis is mediated by transforming growth factor beta 1-positive regulatory T cells and begins in early infection
-
Estes JD, Wietgrefe S, Schacker T, et al. Simian immunodeficiency virusinduced lymphatic tissue fibrosis is mediated by transforming growth factor beta 1-positive regulatory T cells and begins in early infection. J Infect Dis 2007; 195:551-61.
-
(2007)
J Infect Dis
, vol.195
, pp. 551-561
-
-
Estes, J.D.1
Wietgrefe, S.2
Schacker, T.3
-
23
-
-
33646689587
-
Lymphatic tissue fibrosis is associated with reduced numbers of naive CD4+ T cells in human immunodeficiency virus type 1 infection
-
Schacker TW, Brenchley JM, Beilman GJ, et al. Lymphatic tissue fibrosis is associated with reduced numbers of naive CD4+ T cells in human immunodeficiency virus type 1 infection. Clin Vaccine Immunol 2006; 13:556-60.
-
(2006)
Clin Vaccine Immunol
, vol.13
, pp. 556-560
-
-
Schacker, T.W.1
Brenchley, J.M.2
Beilman, G.J.3
-
25
-
-
17044377812
-
IL-6 increases primed cell expansion and survival
-
Rochman I, Paul WE, Ben-Sasson SZ. IL-6 increases primed cell expansion and survival. J Immunol 2005; 174:4761-7.
-
(2005)
J Immunol
, vol.174
, pp. 4761-4767
-
-
Rochman, I.1
Paul, W.E.2
Ben-Sasson, S.Z.3
-
26
-
-
18344410191
-
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo
-
Atreya R, Mudter J, Finotto S, et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo. Nat Med 2000; 6:583-8.
-
(2000)
Nat Med
, vol.6
, pp. 583-588
-
-
Atreya, R.1
Mudter, J.2
Finotto, S.3
-
27
-
-
6344247561
-
Inhibition of T cell apoptosis in the aqueous humor of patients with uveitis by IL-6/soluble IL-6 receptor trans-signaling
-
Curnow SJ, Scheel-Toellner D, JenkinsonW, et al. Inhibition of T cell apoptosis in the aqueous humor of patients with uveitis by IL-6/soluble IL-6 receptor trans-signaling. J Immunol 2004; 173:5290-7.
-
(2004)
J Immunol
, vol.173
, pp. 5290-5297
-
-
Curnow, S.J.1
Scheel-Toellner, D.2
Jenkinson, W.3
-
28
-
-
0033557944
-
Both Stat3-activation and Stat3-independent BCL2 downregulation are important for interleukin-6-induced apoptosis of 1A9-M cells
-
Oritani K, Tomiyama Y, Kincade PW, et al. Both Stat3-activation and Stat3-independent BCL2 downregulation are important for interleukin-6-induced apoptosis of 1A9-M cells. Blood 1999; 93:1346-54.
-
(1999)
Blood
, vol.93
, pp. 1346-1354
-
-
Oritani, K.1
Tomiyama, Y.2
Kincade, P.W.3
-
29
-
-
0023920214
-
B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes
-
Lotz M, Jirik F, Kabouridis P, et al. B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes. J Exp Med 1988; 167:1253-8.
-
(1988)
J Exp Med
, vol.167
, pp. 1253-1258
-
-
Lotz, M.1
Jirik, F.2
Kabouridis, P.3
-
30
-
-
84901675589
-
Inflammatory cytokines drive CD4+ Tcell cycling and impaired responsiveness to interleukin 7: Implications for immune failure in HIV disease
-
Shive CL, Mudd JC, Funderburg NT, et al. Inflammatory cytokines drive CD4+ Tcell cycling and impaired responsiveness to interleukin 7: implications for immune failure in HIV disease. J Infect Dis 2014; 210:619-29.
-
(2014)
J Infect Dis
, vol.210
, pp. 619-629
-
-
Shive, C.L.1
Mudd, J.C.2
Funderburg, N.T.3
-
31
-
-
55949084601
-
Inflammatory and coagulation biomarkers and mortality in patients with HIV infection
-
Kuller LH, Tracy R, Belloso W, et al. Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med 2008; 5:e203.
-
(2008)
PLoS Med
, vol.5
, pp. e203
-
-
Kuller, L.H.1
Tracy, R.2
Belloso, W.3
-
32
-
-
84902281875
-
Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection
-
Hunt PW, Sinclair E, Rodriguez B, et al. Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection. J Infect Dis 2014; 210:1228-38.
-
(2014)
J Infect Dis
, vol.210
, pp. 1228-1238
-
-
Hunt, P.W.1
Sinclair, E.2
Rodriguez, B.3
-
33
-
-
80052882129
-
Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells
-
Lederman MM, Calabrese L, Funderburg NT, et al. Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells. J Infect Dis 2011; 204:1217-26.
-
(2011)
J Infect Dis
, vol.204
, pp. 1217-1226
-
-
Lederman, M.M.1
Calabrese, L.2
Funderburg, N.T.3
-
34
-
-
84949009807
-
Inflammation perturbs the IL-7 axis, promoting senescence and exhaustion that broadly characterize immune failure in treated HIV infection
-
Shive CL, Clagett B, McCausland MR, et al. Inflammation perturbs the IL-7 axis, promoting senescence and exhaustion that broadly characterize immune failure in treated HIV infection. J Acquir Immune Defic Syndr 2016; 71:483-92.
-
(2016)
J Acquir Immune Defic Syndr
, vol.71
, pp. 483-492
-
-
Shive, C.L.1
Clagett, B.2
McCausland, M.R.3
-
35
-
-
0037165877
-
Involvement of Bcl-2 and IL-2R in HIVpositive patients whose CD4 cell counts fail to increase rapidly with highly active antiretroviral therapy
-
David D, Keller H, Nait-Ighil L, et al. Involvement of Bcl-2 and IL-2R in HIVpositive patients whose CD4 cell counts fail to increase rapidly with highly active antiretroviral therapy. AIDS 2002; 16:1093-101.
-
(2002)
AIDS
, vol.16
, pp. 1093-1101
-
-
David, D.1
Keller, H.2
Nait-Ighil, L.3
-
36
-
-
0025330501
-
Interleukin 6 induces human immunodeficiency virus expression in infected monocytic cells alone and in synergy with tumor necrosis factor alpha by transcriptional and post-transcriptional mechanisms
-
Poli G, Bressler P, Kinter A, et al. Interleukin 6 induces human immunodeficiency virus expression in infected monocytic cells alone and in synergy with tumor necrosis factor alpha by transcriptional and post-transcriptional mechanisms. J Exp Med 1990; 172:151-8.
-
(1990)
J Exp Med
, vol.172
, pp. 151-158
-
-
Poli, G.1
Bressler, P.2
Kinter, A.3
-
37
-
-
33745908245
-
Regulatory dysfunction of the interleukin-7 receptor in CD4 and CD8 lymphocytes from HIV-infected patients-effects of antiretroviral therapy
-
Colle JH, Moreau JL, Fontanet A, et al. Regulatory dysfunction of the interleukin-7 receptor in CD4 and CD8 lymphocytes from HIV-infected patients-effects of antiretroviral therapy. J Acquir Immune Defic Syndr 2006; 42:277-85.
-
(2006)
J Acquir Immune Defic Syndr
, vol.42
, pp. 277-285
-
-
Colle, J.H.1
Moreau, J.L.2
Fontanet, A.3
-
38
-
-
33845481806
-
The correlation between levels of IL-7Ralpha expression and responsiveness to IL-7 is lost in CD4 lymphocytes from HIV-infected patients
-
Colle JH, Moreau JL, Fontanet A, Lambotte O, Delfraissy JF, Theze J. The correlation between levels of IL-7Ralpha expression and responsiveness to IL-7 is lost in CD4 lymphocytes from HIV-infected patients. AIDS 2007; 21:101-3.
-
(2007)
AIDS
, vol.21
, pp. 101-103
-
-
Colle, J.H.1
Moreau, J.L.2
Fontanet, A.3
Lambotte, O.4
Delfraissy, J.F.5
Theze, J.6
-
40
-
-
34249660614
-
SOCS proteins, cytokine signalling and immune regulation
-
Yoshimura A, Naka T, Kubo M. SOCS proteins, cytokine signalling and immune regulation. Nat Rev Immunol 2007; 7:454-65.
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 454-465
-
-
Yoshimura, A.1
Naka, T.2
Kubo, M.3
-
41
-
-
62649139025
-
Immunological and inflammatory functions of the interleukin-1 family
-
Dinarello CA. Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 2009; 27:519-50.
-
(2009)
Annu Rev Immunol
, vol.27
, pp. 519-550
-
-
Dinarello, C.A.1
-
43
-
-
0023953471
-
Biology of interleukin 1
-
Dinarello CA. Biology of interleukin 1. FASEB J 1988; 2:108-15.
-
(1988)
FASEB J
, vol.2
, pp. 108-115
-
-
Dinarello, C.A.1
-
44
-
-
75549091673
-
The IL-1 family: Regulators of immunity
-
Sims JE, Smith DE. The IL-1 family: regulators of immunity. Nat Rev Immunol 2010; 10:89-102.
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 89-102
-
-
Sims, J.E.1
Smith, D.E.2
-
45
-
-
84874206379
-
IL-1 family cytokines trigger sterile inflammatory disease
-
Lukens JR, Gross JM, Kanneganti TD. IL-1 family cytokines trigger sterile inflammatory disease. Front Immunol 2012; 3:315.
-
(2012)
Front Immunol
, vol.3
, pp. 315
-
-
Lukens, J.R.1
Gross, J.M.2
Kanneganti, T.D.3
-
46
-
-
0024382479
-
Neopterin and alpha and beta interleukin-1 levels in sera of patients with human immunodeficiency virus infection
-
Reddy MM, Grieco MH. Neopterin and alpha and beta interleukin-1 levels in sera of patients with human immunodeficiency virus infection. J Clin Microbiol 1989; 27:1919-23.
-
(1989)
J Clin Microbiol
, vol.27
, pp. 1919-1923
-
-
Reddy, M.M.1
Grieco, M.H.2
-
47
-
-
0030795924
-
The IL-1 system in HIV infection: Peripheral concentrations of IL-1beta, IL-1 receptor antagonist and soluble IL-1 receptor type II
-
Kreuzer KA, Dayer JM, Rockstroh JK, Sauerbruch T, Spengler U. The IL-1 system in HIV infection: peripheral concentrations of IL-1beta, IL-1 receptor antagonist and soluble IL-1 receptor type II. Clin Exp Immunol 1997; 109:54-8.
-
(1997)
Clin Exp Immunol
, vol.109
, pp. 54-58
-
-
Kreuzer, K.A.1
Dayer, J.M.2
Rockstroh, J.K.3
Sauerbruch, T.4
Spengler, U.5
-
48
-
-
84922414182
-
Intestinal microbiota, microbial translocation, and systemic inflammation in chronic HIV infection
-
Dinh DM, Volpe GE, Duffalo C, et al. Intestinal microbiota, microbial translocation, and systemic inflammation in chronic HIV infection. J Infect Dis 2015; 211:19-27.
-
(2015)
J Infect Dis
, vol.211
, pp. 19-27
-
-
Dinh, D.M.1
Volpe, G.E.2
Duffalo, C.3
-
49
-
-
0018875241
-
Two distinct factors are required for induction of T-cell growth
-
Larsson EL, Iscove NN, Coutinho A. Two distinct factors are required for induction of T-cell growth. Nature 1980; 283:664-6.
-
(1980)
Nature
, vol.283
, pp. 664-666
-
-
Larsson, E.L.1
Iscove, N.N.2
Coutinho, A.3
-
50
-
-
0019022864
-
The functional relationship of the interleukins
-
51-178. These references are available in the Supplementary Appendix
-
Smith KA, Lachman LB, Oppenheim JJ, Favata MF. The functional relationship of the interleukins. J Exp Med 1980; 151:1551-6. 51-178. These references are available in the Supplementary Appendix.
-
(1980)
J Exp Med
, vol.151
, pp. 1551-1556
-
-
Smith, K.A.1
Lachman, L.B.2
Oppenheim, J.J.3
Favata, M.F.4
|