Interactions between gut bacteria and bile in health and disease

Molecular Aspects of Medicine

Volumn 56, Issue , 2017, Pages 54-65

  Long, Sarah L ^a,b   Gahan, Cormac G M ^a,b   Joyce, Susan A ^a,b  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Bile acid inducible (BAI); Bile salt hydrolase (BSH); Lactobacillus; Microbiome; Microbiota

Indexed keywords

BILE ACID; BILE ACID INDUCIBLE ENZYME; BILE SALT; CELL RECEPTOR; FARNESOID X RECEPTOR; HYDROLASE; MICROBIAL ENZYME; PROTEIN TGR5; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR; AMIDASE; BACTERIAL PROTEIN; BAIH PROTEIN, EUBACTERIUM; CALCITRIOL RECEPTOR; CHOLOYLGLYCINE HYDROLASE; FARNESOID X-ACTIVATED RECEPTOR; G PROTEIN COUPLED RECEPTOR; GPBAR1 PROTEIN, HUMAN; OXIDOREDUCTASE;

BILE ACID METABOLISM; CLOSTRIDIUM; CLOSTRIDIUM DIFFICILE INFECTION; CONJUGATION; ENZYME ACTIVITY; ENZYME LOCALIZATION; HOMEOSTASIS; HUMAN; HYDROXYLATION; INFLAMMATORY BOWEL DISEASE; INTESTINE FLORA; LIPID METABOLISM; LIVER METABOLISM; MICROBIAL COMMUNITY; NONHUMAN; REVIEW; WEIGHT GAIN; ANIMAL; BIOTRANSFORMATION; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; HOST PATHOGEN INTERACTION; INTESTINE; LIVER; METABOLISM; MICROBIOLOGY; PATHOGENICITY; PATHOLOGY; PEPTOCLOSTRIDIUM DIFFICILE; PHYSIOLOGY; PSEUDOMEMBRANOUS COLITIS;

AMIDOHYDROLASES; ANIMALS; BACTERIAL PROTEINS; BILE ACIDS AND SALTS; BIOTRANSFORMATION; CLOSTRIDIUM DIFFICILE; ENTEROCOLITIS, PSEUDOMEMBRANOUS; GASTROINTESTINAL MICROBIOME; GENE EXPRESSION REGULATION; HOMEOSTASIS; HOST-PATHOGEN INTERACTIONS; HUMANS; INTESTINES; LIVER; NADH, NADPH OXIDOREDUCTASES; RECEPTORS, CALCITRIOL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, G-PROTEIN-COUPLED;

EID: 85020901911     PISSN: 00982997     EISSN: 18729452     Source Type: Journal    
DOI: 10.1016/j.mam.2017.06.002     Document Type: Review

References (174)

1. Abt, M.C., McKenney, P.T., Pamer, E.G., Clostridium difficile colitis: pathogenesis and host defence. Nat. Rev. Microbiol. 14:10 (2016), 609–620.
2. Alnouti, Y., Bile Acid sulfation: a pathway of bile acid elimination and detoxification. Toxicol. Sci. 108:2 (2009), 225–246.
3. Arrieta, M.C., Stiemsma, L.T., Dimitriu, P.A., Thorson, L., Russell, S., Yurist-Doutsch, S., Kuzeljevic, B., Gold, M.J., Britton, H.M., Lefebvre, D.L., Subbarao, P., Mandhane, P., Becker, A., McNagny, K.M., Sears, M.R., Kollmann, T., Mohn, W.W., Turvey, S.E., Finlay, B.B., Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci. Transl. Med., 7(307), 2015 307ra152.
4. Artymiuk, P.J., A sting in the (N-terminal) tail. Nat. Struct. Biol. 2:12 (1995), 1035–1037.
5. Barbachano, A., Fernandez-Barral, A., Ferrer-Mayorga, G., Costales-Carrera, A., Larriba, M.J., Munoz, A., The endocrine vitamin D system in the gut. Mol. Cell. Endocrinol., 2016 (in press).
6. Bateup, J.M., McConnell, M.A., Jenkinson, H.F., Tannock, G.W., Comparison of Lactobacillus strains with respect to bile salt hydrolase activity, colonization of the gastrointestinal tract, and growth rate of the murine host. Appl. Environ. Microbiol. 61:3 (1995), 1147–1149.
7. Begley, M., Gahan, C.G., Hill, C., The interaction between bacteria and bile. FEMS Microbiol. Rev. 29:4 (2005), 625–651.
8. Begley, M., Hill, C., Gahan, C.G.M., Bile salt hydrolase activity in probiotics. Appl. Environ. Microbiol. 72:3 (2006), 1729–1738.
9. Begley, M., Sleator, R.D., Gahan, C.G., Hill, C., Contribution of three bile-associated loci, bsh, pva, and btlB, to gastrointestinal persistence and bile tolerance of Listeria monocytogenes. Infect. Immun. 73:2 (2005), 894–904.
10. Bennett, M.J., McKnight, S.L., Coleman, J.P., Cloning and characterization of the NAD-dependent 7alpha-Hydroxysteroid dehydrogenase from Bacteroides fragilis. Curr. Microbiol. 47:6 (2003), 475–484.
11. Bjorkhem, I., Diczfalusy, U., Lutjohann, D., Removal of cholesterol from extrahepatic sources by oxidative mechanisms. Curr. Opin. Lipidol. 10:2 (1999), 161–165.
12. Bock, H.H., Lammert, F., Nuclear xeno-sensors as receptors for cholestatic bile acids: the second line of defense. Hepatology 35:1 (2002), 232–234.
13. Bokkenheuser, V.D., Winter, J., Dehazya, P., Kelly, W.G., Isolation and characterization of human fecal bacteria capable of 21-dehydroxylating corticoids. Appl. Environ. Microbiol. 34:5 (1977), 571–575.
14. Brannigan, J.A., Dodson, G., Duggleby, H.J., Moody, P.C., Smith, J.L., Tomchick, D.R., Murzin, A.G., A protein catalytic framework with an N-terminal nucleophile is capable of self-activation. Nature 378:6555 (1995), 416–419.
15. Branton, W., Jones, M., Tomaro-Duchesneau, C., Martoni, C., Prakash, S., In vitro characterization and safety of the probiotic strain Lactobacillus reuteri cardioviva NCIMB 30242. Int. J. Probiotics Prebiotics, 6(1), 2011, 1.
16. Braun, M., Link, H., Liu, L., Schmid, R.D., Weuster-Botz, D., Biocatalytic process optimization based on mechanistic modeling of cholic acid oxidation with cofactor regeneration. Biotechnol. Bioeng. 108:6 (2011), 1307–1317.
17. Buffie, C.G., Bucci, V., Stein, R.R., McKenney, P.T., Ling, L., Gobourne, A., No, D., Liu, H., Kinnebrew, M., Viale, A., Littmann, E., van den Brink, M.R., Jenq, R.R., Taur, Y., Sander, C., Cross, J.R., Toussaint, N.C., Xavier, J.B., Pamer, E.G., Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile. Nature 517:7533 (2015), 205–208.
18. Bull, I.D., Lockheart, M.J., Elhmmali, M.M., Roberts, D.J., Evershed, R.P., The origin of faeces by means of biomarker detection. Environ. Int. 27:8 (2002), 647–654.
19. Cali, J.J., Hsieh, C.L., Francke, U., Russell, D.W., Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis. J. Biol. Chem. 266:12 (1991), 7779–7783.
20. Chae, J.P., Valeriano, V.D., Kim, G.B., Kang, D.K., Molecular cloning, characterization and comparison of bile salt hydrolases from Lactobacillus johnsonii PF01. J. Appl. Microbiol. 114:1 (2013), 121–133.
21. Chatterjee, B., Echchgadda, I., Song, C.S., Vitamin D receptor regulation of the steroid/bile acid sulfotransferase SULT2A1. Methods Enzym. 400 (2005), 165–191.
22. Chiang, J.Y., Bile acids: regulation of synthesis. J. lipid Res. 50:10 (2009), 1955–1966.
23. Chiang, J.Y., Bile acid metabolism and signaling. Compr. Physiol. 3:3 (2013), 1191–1212.
24. Claesson, M.J., Jeffery, I.B., Conde, S., Power, S.E., O'Connor, E.M., Cusack, S., Harris, H.M., Coakley, M., Lakshminarayanan, B., O'Sullivan, O., Fitzgerald, G.F., Deane, J., O'Connor, M., Harnedy, N., O'Connor, K., O'Mahony, D., van Sinderen, D., Wallace, M., Brennan, L., Stanton, C., Marchesi, J.R., Fitzgerald, A.P., Shanahan, F., Hill, C., Ross, R.P., O'Toole, P.W., Gut microbiota composition correlates with diet and health in the elderly. Nature 488:7410 (2012), 178–184.
25. Coleman, J.P., Hudson, L.L., Cloning and characterization of a conjugated bile acid hydrolase gene from Clostridium perfringens. Appl. Environ. Microbiol. 61:7 (1995), 2514–2520.
26. Coleman, J.P., White, W.B., Hylemon, P.B., Molecular cloning of bile acid 7-dehydroxylase from Eubacterium sp. strain VPI 12708. J. Bacteriol. 169:4 (1987), 1516–1521.
27. Corzo, G., Gilliland, S.E., Bile salt hydrolase activity of three strains of Lactobacillus acidophilus1. J. Dairy Sci. 82:3 (1999), 472–480.
28. Craddock, A.L., Love, M.W., Daniel, R.W., Kirby, L.C., Walters, H.C., Wong, M.H., Dawson, P.A., Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am. J. Physiol. - Gastrointest. Liver Physiol. 274:1 (1998), G157–G169.
29. Damodharan, K., Lee, Y.S., Palaniyandi, S.A., Yang, S.H., Suh, J.W., Preliminary probiotic and technological characterization of Pediococcus pentosaceus strain KID7 and in vivo assessment of its cholesterol-lowering activity. Front. Microbiol., 6, 2015, 768.
30. Dawson, J.A., Mallonee, D.H., Bjorkhem, I., Hylemon, P.B., Expression and characterization of a C24 bile acid 7 alpha-dehydratase from Eubacterium sp. strain VPI 12708 in Escherichia coli. J. Lipid Res. 37:6 (1996), 1258–1267.
31. de Aguiar Vallim, T.Q., Tarling, E.J., Ahn, H., Hagey, L.R., Romanoski, C.E., Lee, R.G., Graham, M.J., Motohashi, H., Yamamoto, M., Edwards, P.A., MAFG is a transcriptional repressor of bile acid synthesis and metabolism. Cell. Metab. 21:2 (2015), 298–310.
32. de Aguiar Vallim, T.Q., Tarling, E.J., Edwards, P.A., Pleiotropic roles of bile acids in metabolism. Cell. Metab. 17:5 (2013), 657–669.
33. De la Puerta, C., Arrieta, F.J., Balsa, J.A., Botella-Carretero, J.I., Zamarron, I., Vazquez, C., Taurine and glucose metabolism: a review. Nutr. Hosp. 25:6 (2010), 910–919.
34. De Smet, I., De Boever, P., Verstraete, W., Cholesterol lowering in pigs through enhanced bacterial bile salt hydrolase activity. Br. J. Nutr. 79:2 (1998), 185–194.
35. De Smet, I., Van Hoorde, L., Vande Woestyne, M., Christiaens, H., Verstraete, W., Significance of bile salt hydrolytic activities of lactobacilli. J. Appl. Bacteriol. 79:3 (1995), 292–301.
36. Dean, M., Cervellati, C., Casanova, E., Squerzanti, M., Lanzara, V., Medici, A., Polverino de Laureto, P., Bergamini, C.M., Characterization of cholylglycine hydrolase from a bile-adapted strain of Xanthomonas maltophilia and its application for quantitative hydrolysis of conjugated bile salts. Appl. Environ. Microbiol. 68:6 (2002), 3126–3128.
37. Degirolamo, C., Rainaldi, S., Bovenga, F., Murzilli, S., Moschetta, A., Microbiota modification with probiotics induces hepatic bile acid synthesis via downregulation of the Fxr-Fgf15 axis in mice. Cell Rep. 7:1 (2014), 12–18.
38. Delpino, M.V., Marchesini, M.I., Estein, S.M., Comerci, D.J., Cassataro, J., Fossati, C.A., Baldi, P.C., A bile salt hydrolase of Brucella abortus contributes to the establishment of a successful infection through the oral route in mice. Infect. Immun. 75:1 (2007), 299–305.
39. Devkota, S., Wang, Y., Musch, M.W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D.A., Jabri, B., Chang, E.B., Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice. Nature 487:7405 (2012), 104–108.
40. Dietschy, J.M., Turley, S.D., Control of cholesterol turnover in the mouse. J. Biol. Chem. 277:6 (2002), 3801–3804.
41. Dior, M., Delagreverie, H., Duboc, H., Jouet, P., Coffin, B., Brot, L., Humbert, L., Trugnan, G., Seksik, P., Sokol, H., Rainteau, D., Sabate, J.M., Interplay between bile acid metabolism and microbiota in irritable bowel syndrome. Neurogastroenterol. Motil. 28:9 (2016), 1330–1340.
42. Duboc, H., Rainteau, D., Rajca, S., Humbert, L., Farabos, D., Maubert, M., Grondin, V., Jouet, P., Bouhassira, D., Seksik, P., Sokol, H., Coffin, B., Sabate, J.M., Increase in fecal primary bile acids and dysbiosis in patients with diarrhea-predominant irritable bowel syndrome. Neurogastroenterol. Motil. 24:6 (2012), 513–520 e246-517.
43. Duboc, H., Rajca, S., Rainteau, D., Benarous, D., Maubert, M.A., Quervain, E., Thomas, G., Barbu, V., Humbert, L., Despras, G., Bridonneau, C., Dumetz, F., Grill, J.P., Masliah, J., Beaugerie, L., Cosnes, J., Chazouilleres, O., Poupon, R., Wolf, C., Mallet, J.M., Langella, P., Trugnan, G., Sokol, H., Seksik, P., Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases. Gut 62:4 (2013), 531–539.
44. Duggleby, H.J., Tolley, S.P., Hill, C.P., Dodson, E.J., Dodson, G., Moody, P.C., Penicillin acylase has a single-amino-acid catalytic centre. Nature 373:6511 (1995), 264–268.
45. Dussurget, O., Cabanes, D., Dehoux, P., Lecuit, M., Buchrieser, C., Glaser, P., Cossart, P., Listeria monocytogenes bile salt hydrolase is a PrfA-regulated virulence factor involved in the intestinal and hepatic phases of listeriosis. Mol. Microbiol. 45:4 (2002), 1095–1106.
46. Edenharder, R., Schneider, J., 12 beta-dehydrogenation of bile acids by Clostridium paraputrificum, C. tertium, and C. difficile and epimerization at carbon-12 of deoxycholic acid by cocultivation with 12 alpha-dehydrogenating Eubacterium lentum. Appl. Environ. Microbiol. 49:4 (1985), 964–968.
47. Elkins, C.A., Moser, S.A., Savage, D.C., Genes encoding bile salt hydrolases and conjugated bile salt transporters in Lactobacillus johnsonii 100-100 and other Lactobacillus species. Microbiology 147:12 (2001), 3403–3412.
48. Eriksson, H., Gustafsson, J.A., Steroids in germfree and conventional rats. Distribution and excretion of labelled pregnenolone and corticosterone in male and female rats. Eur. J. Biochem. 15:1 (1970), 132–139.
49. Eyssen, H., De Pauw, G., Stragier, J., Verhulst, A., Cooperative formation of omega-muricholic acid by intestinal microorganisms. Appl. Environ. Microbiol. 45:1 (1983), 141–147.
50. Eyssen, H., Van Eldere, J., Parmentier, G., Huijghebaert, S., Mertens, J., Influence of microbial bile salt desulfation upon the fecal excretion of bile salts in gnotobiotic rats. J. Steroid Biochem. 22:4 (1985), 547–554.
51. Eyssen, H.J., De Pauw, G., Van Eldere, J., Formation of hyodeoxycholic acid from muricholic acid and hyocholic acid by an unidentified gram-positive rod termed HDCA-1 isolated from rat intestinal microflora. Appl. Environ. Microbiol. 65:7 (1999), 3158–3163.
52. Fang, F., Flynn, S., Li, Y., Claesson, M.J., van Pijkeren, J.-P., Collins, J.K., van Sinderen, D., O'Toole, P.W., Characterization of endogenous plasmids from Lactobacillus salivarius UCC118. Appl. Environ. Microbiol. 74:10 (2008), 3216–3228.
53. Fang, F., Li, Y., Bumann, M., Raftis, E.J., Casey, P.G., Cooney, J.C., Walsh, M.A., O'Toole, P.W., Allelic variation of bile salt hydrolase genes in Lactobacillus salivarius does not determine bile resistance levels. J. Bacteriol. 191:18 (2009), 5743–5757.
54. Ferrandi, E.E., Bertolesi, G.M., Polentini, F., Negri, A., Riva, S., Monti, D., In search of sustainable chemical processes: cloning, recombinant expression, and functional characterization of the 7alpha- and 7beta-hydroxysteroid dehydrogenases from Clostridium absonum. Appl. Microbiol. Biotechnol. 95:5 (2012), 1221–1233.
55. Francis, M.B., Allen, C.A., Shrestha, R., Sorg, J.A., Bile acid recognition by the Clostridium difficile germinant receptor, CspC, is important for establishing infection. PLoS Pathog., 9(5), 2013, e1003356.
56. Franz, C.M.A.P., Specht, I., Haberer, P., Holzapfel, W.H., Bile salt hydrolase activity of enterococci isolated from food: screening and quantitative determination. J. Food Prot. 64:5 (2001), 725–729.
57. Gerard, P., Metabolism of cholesterol and bile acids by the gut microbiota. Pathogens 3:1 (2013), 14–24.
58. Giamarellos-Bourboulis, E., Tang, J., Pyleris, E., Pistiki, A., Barbatzas, C., Brown, J., Lee, C.C., Harkins, T.T., Kim, G., Weitsman, S., Barlow, G.M., Funari, V.A., Pimentel, M., Molecular assessment of differences in the duodenal microbiome in subjects with irritable bowel syndrome. Scand. J. Gastroenterol. 50:9 (2015), 1076–1087.
59. Gilliland, S.E., Nelson, C.R., Maxwell, C., Assimilation of cholesterol by Lactobacillus acidophilus. Appl. Environ. Microbiol. 49:2 (1985), 377–381.
60. Giovannini, P.P., Grandini, A., Perrone, D., Pedrini, P., Fantin, G., Fogagnolo, M., 7alpha- and 12alpha-Hydroxysteroid dehydrogenases from Acinetobacter calcoaceticus lwoffii: a new integrated chemo-enzymatic route to ursodeoxycholic acid. Steroids 73:14 (2008), 1385–1390.
61. Gonzalez, F.J., Jiang, C., Patterson, A.D., An intestinal microbiota–farnesoid X receptor Axis modulates metabolic disease. Gastroenterology 151:5 (2016), 845–859.
62. Gopal-Srivastava, R., Hylemon, P.B., Purification and characterization of bile salt hydrolase from Clostridium perfringens. J. Lipid Res. 29:8 (1988), 1079–1085.
63. Govindarajan, K., MacSharry, J., Casey, P.G., Shanahan, F., Joyce, S.A., Gahan, C.G., Unconjugated bile acids influence expression of circadian genes: a potential mechanism for microbe-host crosstalk. PLoS One, 11(12), 2016, e0167319.
64. Graef, V., Furuya, E., Nishikaze, O., Hydrolysis of steroid glucuronides with beta-glucuronidase preparations from bovine liver, Helix pomatia, and E. coli. Clin. Chem. 23:3 (1977), 532–535.
65. Grill, J., Schneider, F., Crociani, J., Ballongue, J., Purification and characterization of conjugated bile salt hydrolase from Bifidobacterium longum BB536. Appl. Environ. Microbiol. 61:7 (1995), 2577–2582.
66. Grill, J.P., Cayuela, C., Antoine, J.M., Schneider, F., Isolation and characterization of a Lactobacillus amylovorus mutant depleted in conjugated bile salt hydrolase activity: relation between activity and bile salt resistance. J. Appl. Microbiol. 89:4 (2000), 553–563.
67. Grill, J.P., Manginot-Durr, C., Schneider, F., Ballongue, J., Bifidobacteria and probiotic effects: action of Bifidobacterium species on conjugated bile salts. Curr. Microbiol. 31:1 (1995), 23–27.
68. Gu, X.-C., Luo, X.-G., Wang, C.-X., Ma, D.-Y., Wang, Y., He, Y.-Y., Li, W., Zhou, H., Zhang, T.-C., Cloning and analysis of bile salt hydrolase genes from Lactobacillus plantarum CGMCC No. 8198. Biotechnol. Lett. 36:5 (2013), 975–983.
69. Gu, X.C., Luo, X.G., Wang, C.X., Ma, D.Y., Wang, Y., He, Y.Y., Li, W., Zhou, H., Zhang, T.C., Cloning and analysis of bile salt hydrolase genes from Lactobacillus plantarum CGMCC No. 8198. Biotechnol. Lett. 36:5 (2014), 975–983.
70. Guban, J., Korver, D.R., Allison, G.E., Tannock, G.W., Relationship of dietary antimicrobial drug administration with broiler performance, decreased population levels of Lactobacillus salivarius, and reduced bile salt deconjugation in the ileum of broiler chickens. Poult. Sci. 85:12 (2006), 2186–2194.
71. Hofmann, A.F., The enterohepatic circulation of bile acids in mammals: form and functions. Front. Biosci. 14 (2009), 2584–2598.
72. Hofmann, A.F., Hagey, L.R., Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics. Cell. Mol. life Sci. CMLS 65:16 (2008), 2461–2483.
73. Huijghebaert, S.M., Mertens, J.A., Eyssen, H.J., Isolation of a bile salt sulfatase-producing Clostridium strain from rat intestinal microflora. Appl. Environ. Microbiol. 43:1 (1982), 185–192.
74. Ichikawa, R., Takayama, T., Yoneno, K., Kamada, N., Kitazume, M.T., Higuchi, H., Matsuoka, K., Watanabe, M., Itoh, H., Kanai, T., Hisamatsu, T., Hibi, T., Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway. Immunology 136:2 (2012), 153–162.
75. Islam, K.B., Fukiya, S., Hagio, M., Fujii, N., Ishizuka, S., Ooka, T., Ogura, Y., Hayashi, T., Yokota, A., Bile acid is a host factor that regulates the composition of the cecal microbiota in rats. Gastroenterology 141:5 (2011), 1773–1781.
76. Jayashree, S., Pooja, S., Pushpanathan, M., Rajendhran, J., Gunasekaran, P., Identification and characterization of bile salt hydrolase genes from the genome of Lactobacillus fermentum MTCC 8711. Appl. Biochem. Biotechnol. 174:2 (2014), 855–866.
77. Jones, B.V., Begley, M., Hill, C., Gahan, C.G.M., Marchesi, J.R., Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome. Proc. Natl. Acad. Sci. 105:36 (2008), 13580–13585.
78. Jones, M., Martoni, C., Prakash, S., Cholesterol lowering and inhibition of sterol absorption by Lactobacillus reuteri NCIMB 30242: a randomized controlled trial. Eur. J. Clin. Nutr. 66:11 (2012), 1234–1241.
79. Jones, M.L., Martoni, C.J., Parent, M., Prakash, S., Cholesterol-lowering efficacy of a microencapsulated bile salt hydrolase-active Lactobacillus reuteri NCIMB 30242 yoghurt formulation in hypercholesterolaemic adults. Br. J. Nutr. 107:10 (2012), 1505–1513.
80. Jones, M.L., Martoni, C.J., Di Pietro, E., Simon, R.R., Prakash, S., Evaluation of clinical safety and tolerance of a Lactobacillus reuteri NCIMB 30242 supplement capsule: a randomized control trial. Regul. Toxicol. Pharmacol. 63:2 (2012), 313–320.
81. Jones, M.L., Tomaro-Duchesneau, C., Martoni, C.J., Prakash, S., Cholesterol lowering with bile salt hydrolase-active probiotic bacteria, mechanism of action, clinical evidence, and future direction for heart health applications. Expert. Opin. Biol. Ther. 13:5 (2013), 631–642.
82. Joyce, S.A., Gahan, C.G., The gut microbiota and the metabolic health of the host. Curr. Opin. Gastroenterol. 30:2 (2014), 120–127.
83. Joyce, S.A., Gahan, C.G., Bile acid modifications at the microbe-host interface: potential for nutraceutical and pharmaceutical interventions in host health. Annu. Rev. Food. Sci. Technol. 7 (2016), 313–333.
84. Joyce, S.A., MacSharry, J., Casey, P.G., Kinsella, M., Murphy, E.F., Shanahan, F., Hill, C., Gahan, C.G., Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut. Proc. Natl. Acad. Sci. 111:20 (2014), 7421–7426.
85. Joyce, S.A., Shanahan, F., Hill, C., Gahan, C.G., Bacterial bile salt hydrolase in host metabolism: potential for influencing gastrointestinal microbe-host crosstalk. Gut Microbes 5:5 (2014), 669–674.
86. Kang, D.J., Ridlon, J.M., Moore, D.R. 2nd, Barnes, S., Hylemon, P.B., Clostridium scindens baiCD and baiH genes encode stereo-specific 7alpha/7beta-hydroxy-3-oxo-delta4-cholenoic acid oxidoreductases. Biochim. Biophys. Acta 1781:1–2 (2008), 16–25.
87. Karlsson, F.H., Tremaroli, V., Nookaew, I., Bergstrom, G., Behre, C.J., Fagerberg, B., Nielsen, J., Backhed, F., Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature 498:7452 (2013), 99–103.
88. Kawamoto, K., Horibe, I., Uchida, K., Purification and characterization of a new hydrolase for conjugated bile acids, chenodeoxycholyltaurine hydrolase, from Bacteroides vulgatus. J. Biochem. 106:6 (1989), 1049–1053.
89. Kelsey, M.I., Sexton, S.A., The biosynthesis of ethyl esters of lithocholic acid and isolithocholic acid by rat intestinal microflora. J. Steroid Biochem. 7:9 (1976), 641–647.
90. Kim, B., Park, K.Y., Ji, Y., Park, S., Holzapfel, W., Hyun, C.K., Protective effects of Lactobacillus rhamnosus GG against dyslipidemia in high-fat diet-induced obese mice. Biochem. Biophys. Res. Commun. 473:2 (2016), 530–536.
91. Kim, G.-B., Miyamoto, C.M., Meighen, E.A., Lee, B.H., Cloning and characterization of the bile salt hydrolase genes (bsh) from Bifidobacterium bifidum strains. Appl. Environ. Microbiol. 70:9 (2004), 5603–5612.
92. Kim, G.B., Brochet, M., Lee, B.H., Cloning and characterization of a bile salt hydrolase (bsh) from Bifidobacterium adolescentis. Biotechnol. Lett. 27:12 (2005), 817–822.
93. Kim, G.B., Yi, S.H., Lee, B.H., Purification and characterization of three different types of bile salt hydrolases from Bifidobacterium strains. J. Dairy Sci. 87:2 (2004), 258–266.
94. Kisiela, M., Skarka, A., Ebert, B., Maser, E., Hydroxysteroid dehydrogenases (HSDs) in bacteria: a bioinformatic perspective. J. Steroid Biochem. Mol. Biol. 129:1–2 (2012), 31–46.
95. Koeth, R.A., Wang, Z., Levison, B.S., Buffa, J.A., Org, E., Sheehy, B.T., Britt, E.B., Fu, X., Wu, Y., Li, L., Smith, J.D., DiDonato, J.A., Chen, J., Li, H., Wu, G.D., Lewis, J.D., Warrier, M., Brown, J.M., Krauss, R.M., Tang, W.H., Bushman, F.D., Lusis, A.J., Hazen, S.L., Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat. Med. 19:5 (2013), 576–585.
96. Korpela, K., Salonen, A., Virta, L.J., Kekkonen, R.A., Forslund, K., Bork, P., de Vos, W.M., Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children. Nat. Commun., 7, 2016, 10410.
97. Krissinel, E., Henrick, K., Inference of macromolecular assemblies from crystalline state. J. Mol. Biol. 372:3 (2007), 774–797.
98. Kumar, R.S., Brannigan, J.A., Prabhune, A.A., Pundle, A.V., Dodson, G.G., Dodson, E.J., Suresh, C.G., Structural and functional analysis of a conjugated bile salt hydrolase from Bifidobacterium longum reveals an evolutionary relationship with penicillin V acylase. J. Biol. Chem. 281:43 (2006), 32516–32525.
99. Lambert, J.M., Bongers, R.S., de Vos, W.M., Kleerebezem, M., Functional analysis of four bile salt hydrolase and penicillin acylase family members in Lactobacillus plantarum WCFS1. Appl. Environ. Microbiol. 74:15 (2008), 4719–4726.
100. Lambert, J.M., Siezen, R.J., de Vos, W.M., Kleerebezem, M., Improved annotation of conjugated bile acid hydrolase superfamily members in Gram-positive bacteria. Microbiology 154:8 (2008), 2492–2500.
101. Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.M., Kennedy, S., Leonard, P., Li, J., Burgdorf, K., Grarup, N., Jorgensen, T., Brandslund, I., Nielsen, H.B., Juncker, A.S., Bertalan, M., Levenez, F., Pons, N., Rasmussen, S., Sunagawa, S., Tap, J., Tims, S., Zoetendal, E.G., Brunak, S., Clement, K., Dore, J., Kleerebezem, M., Kristiansen, K., Renault, P., Sicheritz-Ponten, T., de Vos, W.M., Zucker, J.D., Raes, J., Hansen, T., Bork, P., Wang, J., Ehrlich, S.D., Pedersen, O., Richness of human gut microbiome correlates with metabolic markers. Nature 500:7464 (2013), 541–546.
102. Leone, V., Gibbons, S.M., Martinez, K., Hutchison, A.L., Huang, E.Y., Cham, C.M., Pierre, J.F., Heneghan, A.F., Nadimpalli, A., Hubert, N., Zale, E., Wang, Y., Huang, Y., Theriault, B., Dinner, A.R., Musch, M.W., Kudsk, K.A., Prendergast, B.J., Gilbert, J.A., Chang, E.B., Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism. Cell Host Microbe 17:5 (2015), 681–689.
103. Lepercq, P., Gerard, P., Beguet, F., Raibaud, P., Grill, J.P., Relano, P., Cayuela, C., Juste, C., Epimerization of chenodeoxycholic acid to ursodeoxycholic acid by Clostridium baratii isolated from human feces. FEMS Microbiol. Lett. 235:1 (2004), 65–72.
104. Lewis, B.B., Carter, R.A., Pamer, E.G., Bile acid sensitivity and in vivo virulence of clinical Clostridium difficile isolates. Anaerobe 41 (2016), 32–36.
105. Li, F., Jiang, C., Krausz, K.W., Li, Y., Albert, I., Hao, H., Fabre, K.M., Mitchell, J.B., Patterson, A.D., Gonzalez, F.J., Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity. Nat. Commun., 4, 2013, 2384.
106. Li, T., Chiang, J.Y., Nuclear receptors in bile acid metabolism. Drug Metab. Rev. 45:1 (2013), 145–155.
107. Li, T., Chiang, J.Y., Bile acid signaling in metabolic disease and drug therapy. Pharmacol. Rev. 66:4 (2014), 948–983.
108. Liong, M.T., Shah, N.P., Bile salt deconjugation ability, bile salt hydrolase activity and cholesterol co-precipitation ability of lactobacilli strains. Int. Dairy J. 15:4 (2005), 391–398.
109. Liou, A.P., Paziuk, M., Luevano, J.M. Jr., Machineni, S., Turnbaugh, P.J., Kaplan, L.M., Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity. Sci. Transl. Med., 5(178), 2013 178ra141.
110. Lundeen, S.G., Savage, D.C., Characterization and purification of bile salt hydrolase from Lactobacillus sp. strain 100-100. J. Bacteriol. 172:8 (1990), 4171–4177.
111. Macdonald, I.A., Bokkenheuser, V.D., Winter, J., McLernon, A.M., Mosbach, E.H., Degradation of steroids in the human gut. J. Lipid Res. 24:6 (1983), 675–700.
112. Macdonald, I.A., Hutchison, D.M., Forrest, T.P., Formation of urso- and ursodeoxy-cholic acids from primary bile acids by Clostridium absonum. J. Lipid Res. 22:3 (1981), 458–466.
113. Mallonee, D.H., Adams, J.L., Hylemon, P.B., The bile acid-inducible baiB gene from Eubacterium sp. strain VPI 12708 encodes a bile acid-coenzyme A ligase. J. Bacteriol. 174:7 (1992), 2065–2071.
114. Mallonee, D.H., Hylemon, P.B., Sequencing and expression of a gene encoding a bile acid transporter from Eubacterium sp. strain VPI 12708. J. Bacteriol. 178:24 (1996), 7053–7058.
115. Mallonee, D.H., White, W.B., Hylemon, P.B., Cloning and sequencing of a bile acid-inducible operon from Eubacterium sp. strain VPI 12708. J. Bacteriol. 172:12 (1990), 7011–7019.
116. Masuda, N., Oda, H., Hirano, S., Masuda, M., Tanaka, H., 7 alpha-Dehydroxylation of bile acids by resting cells of a Eubacterium lentum-like intestinal anaerobe, strain c-25. Appl. Environ. Microbiol. 47:4 (1984), 735–739.
117. Matsuoka, K., Kanai, T., The gut microbiota and inflammatory bowel disease. Semin. Immunopathol. 37:1 (2015), 47–55.
118. McAuliffe, O., Cano, R.J., Klaenhammer, T.R., Genetic analysis of two bile salt hydrolase activities in Lactobacillus acidophilus NCFM. Appl. Environ. Microbiol. 71:8 (2005), 4925–4929.
119. Nebert, D.W., Dalton, T.P., The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis. Nat. Rev. Cancer 6:12 (2006), 947–960.
120. O'Keefe, S.J., Li, J.V., Lahti, L., Ou, J., Carbonero, F., Mohammed, K., Posma, J.M., Kinross, J., Wahl, E., Ruder, E., Vipperla, K., Naidoo, V., Mtshali, L., Tims, S., Puylaert, P.G., DeLany, J., Krasinskas, A., Benefiel, A.C., Kaseb, H.O., Newton, K., Nicholson, J.K., de Vos, W.M., Gaskins, H.R., Zoetendal, E.G., Fat, fibre and cancer risk in African Americans and rural Africans. Nat. Commun., 6, 2015, 6342.
121. Ogundare, M., Theofilopoulos, S., Lockhart, A., Hall, L.J., Arenas, E., Sjovall, J., Brenton, A.G., Wang, Y., Griffiths, W.J., Cerebrospinal fluid steroidomics: are bioactive bile acids present in brain?. J. Biol. Chem. 285:7 (2010), 4666–4679.
122. Oinonen, C., Rouvinen, J., Structural comparison of Ntn-hydrolases. Protein Sci. 9:12 (2000), 2329–2337.
123. Ooi, L.G., Ahmad, R., Yuen, K.H., Liong, M.T., Lactobacillus gasseri [corrected] CHO-220 and inulin reduced plasma total cholesterol and low-density lipoprotein cholesterol via alteration of lipid transporters. J. Dairy Sci. 93:11 (2010), 5048–5058.
124. Panigrahi, P., Sule, M., Sharma, R., Ramasamy, S., Suresh, C.G., An improved method for specificity annotation shows a distinct evolutionary divergence among the microbial enzymes of the cholylglycine hydrolase family. Microbiology 160:6 (2014), 1162–1174.
125. Parks, D.J., Blanchard, S.G., Bledsoe, R.K., Chandra, G., Consler, T.G., Kliewer, S.A., Stimmel, J.B., Willson, T.M., Zavacki, A.M., Moore, D.D., Lehmann, J.M., Bile acids: natural ligands for an orphan nuclear receptor. Science 284:5418 (1999), 1365–1368.
126. Parséus, A., Sommer, N., Sommer, F., Caesar, R., Molinaro, A., Ståhlman, M., Greiner, T.U., Perkins, R., Bäckhed, F., Microbiota-induced obesity requires farnesoid X receptor. Gut 66:3 (2017), 429–437.
127. Pedrini, P., Andreotti, E., Guerrini, A., Dean, M., Fantin, G., Giovannini, P.P., Xanthomonas maltophilia CBS 897.97 as a source of new 7β- and 7α-hydroxysteroid dehydrogenases and cholylglycine hydrolase: improved biotransformations of bile acids. Steroids 71:3 (2006), 189–198.
128. Pereira-Fantini, P.M., Bines, J.E., Lapthorne, S., Fouhy, F., Scurr, M., Cotter, P.D., Gahan, C.G., Joyce, S.A., Short bowel syndrome (SBS)-associated alterations within the gut-liver axis evolve early and persist long-term in the piglet model of short bowel syndrome. J. Gastroenterol. Hepatol. 31:12 (2016), 1946–1955.
129. Pereira-Fantini, P.M., Lapthorne, S., Joyce, S.A., Dellios, N.L., Wilson, G., Fouhy, F., Thomas, S.L., Scurr, M., Hill, C., Gahan, C.G., Cotter, P.D., Fuller, P.J., Hardikar, W., Bines, J.E., Altered FXR signalling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease. J. Hepatol. 61:5 (2014), 1115–1125.
130. Pereira, D.I., Gibson, G.R., Cholesterol assimilation by lactic acid bacteria and bifidobacteria isolated from the human gut. Appl. Environ. Microbiol. 68:9 (2002), 4689–4693.
131. Ren, J., Sun, K., Wu, Z., Yao, J., Guo, B., All 4 bile salt hydrolase proteins are responsible for the hydrolysis activity in Lactobacillus plantarum ST-III. J. Food Sci. 76:9 (2011), M622–M628.
132. Ridlon, J.M., Hylemon, P.B., Identification and characterization of two bile acid coenzyme A transferases from Clostridium scindens, a bile acid 7alpha-dehydroxylating intestinal bacterium. J. Lipid Res. 53:1 (2012), 66–76.
133. Ridlon, J.M., Kang, D.J., Hylemon, P.B., Bile salt biotransformations by human intestinal bacteria. J. Lipid Res. 47:2 (2006), 241–259.
134. Ridlon, J.M., Kang, D.J., Hylemon, P.B., Isolation and characterization of a bile acid inducible 7alpha-dehydroxylating operon in Clostridium hylemonae TN271. Anaerobe 16:2 (2010), 137–146.
135. Rodriguez-Antona, C., Ingelman-Sundberg, M., Cytochrome P450 pharmacogenetics and cancer. Oncogene 25:11 (2006), 1679–1691.
136. Rossocha, M., Schultz-Heienbrok, R., von Moeller, H., Coleman, J.P., Saenger, W., Conjugated bile acid hydrolase is a tetrameric N-Terminal thiol hydrolase with specific recognition of its cholyl but not of its tauryl product. Biochemistry 44:15 (2005), 5739–5748.
137. Runge-Morris, M., Kocarek, T.A., Falany, C.N., Regulation of the cytosolic sulfotransferases by nuclear receptors. Drug Metab. Rev. 45:1 (2013), 15–33.
138. Ryan, K.K., Tremaroli, V., Clemmensen, C., Kovatcheva-Datchary, P., Myronovych, A., Karns, R., Wilson-Perez, H.E., Sandoval, D.A., Kohli, R., Backhed, F., Seeley, R.J., FXR is a molecular target for the effects of vertical sleeve gastrectomy. Nature 509:7499 (2014), 183–188.
139. Sacquet, E.C., Raibaud, P.M., Mejean, C., Riottot, M.J., Leprince, C., Leglise, P.C., Bacterial formation of omega-muricholic acid in rats. Appl. Environ. Microbiol. 37:6 (1979), 1127–1131.
140. Sayin, S.I., Wahlstrom, A., Felin, J., Jantti, S., Marschall, H.U., Bamberg, K., Angelin, B., Hyotylainen, T., Oresic, M., Backhed, F., Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell. Metab. 17:2 (2013), 225–235.
141. Sjovall, J., Dietary glycine and taurine on bile acid conjugation in man; bile acids and steroids 75. Proc. Soc. Exp. Biol. Med. 100:4 (1959), 676–678.
142. Smet, I.D., Hoorde, L.V., Saeyer, N.D., Woestyne, M.V., Verstraete, W., In vitro study of bile salt hydrolase (BSH) activity of BSH isogenic Lactobacillus plantarum 80 strains and estimation of cholesterol lowering through enhanced BSH activity. Microb. Ecol. Health Dis., 7(6), 2011.
143. Smith, K., Zeng, X., Lin, J., Discovery of bile salt hydrolase inhibitors using an efficient high-throughput screening system. PLoS One, 9(1), 2014, e85344.
144. Sorg, J.A., Sonenshein, A.L., Inhibiting the initiation of Clostridium difficile spore germination using analogs of chenodeoxycholic acid, a bile acid. J. Bacteriol. 192:19 (2010), 4983–4990.
145. Sridevi, N., Prabhune, A.A., Brevibacillus sp: a novel thermophilic source for the production of bile salt hydrolase. Appl. Biochem. Biotech. 157:2 (2009), 254–262.
146. Sridevi, N., Srivastava, S., Khan, B.M., Prabhune, A.A., Characterization of the smallest dimeric bile salt hydrolase from a thermophile Brevibacillus sp. Extremophiles 13:2 (2009), 363–370.
147. Stellwag, E.J., Hylemon, P.B., Purification and characterization of bile salt hydrolase from Bacteroides fragilis subsp. fragilis. Biochim. Biophys. Acta 452:1 (1976), 165–176.
148. Swann, J.R., Want, E.J., Geier, F.M., Spagou, K., Wilson, I.D., Sidaway, J.E., Nicholson, J.K., Holmes, E., Systemic gut microbial modulation of bile acid metabolism in host tissue compartments. Proc. Natl. Acad. Sci. U. S. A. 108:Suppl. 1 (2011), 4523–4530.
149. Sweeney, T.E., Morton, J.M., Metabolic surgery: action via hormonal milieu changes, changes in bile acids or gut microbiota? A summary of the literature. Best. Pract. Res. Clin. Gastroenterol. 28:4 (2014), 727–740.
150. Tabibian, J.H., O'Hara, S.P., Trussoni, C.E., Tietz, P.S., Splinter, P.L., Mounajjed, T., Hagey, L.R., LaRusso, N.F., Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis. Hepatology 63:1 (2016), 185–196.
151. Tanaka, H., Hashiba, H., Kok, J., Mierau, I., Bile salt hydrolase of Bifidobacterium longum—biochemical and genetic characterization. Appl. Environ. Microbiol. 66:6 (2000), 2502–2512.
152. Tannock, G.W., Dashkevicz, M.P., Feighner, S.D., Lactobacilli and bile salt hydrolase in the murine intestinal tract. Appl. Environ. Microbiol. 55:7 (1989), 1848–1851.
153. Tazuke, Y., Matsuda, K., Adachi, K., Tsukada, Y., Purification and properties of a novel sulfatase from Pseudomonas testosteroni that hydrolyzed 3 beta-hydroxy-5-cholenoic acid 3-sulfate. Biosci. Biotechnol. Biochem. 62:9 (1998), 1739–1744.
154. Thaiss, C.A., Levy, M., Korem, T., Dohnalova, L., Shapiro, H., Jaitin, D.A., David, E., Winter, D.R., Gury-BenAri, M., Tatirovsky, E., Tuganbaev, T., Federici, S., Zmora, N., Zeevi, D., Dori-Bachash, M., Pevsner-Fischer, M., Kartvelishvily, E., Brandis, A., Harmelin, A., Shibolet, O., Halpern, Z., Honda, K., Amit, I., Segal, E., Elinav, E., Microbiota diurnal rhythmicity programs host transcriptome oscillations. Cell 167:6 (2016), 1495–1510 e1412.
155. Thaiss, C.A., Zeevi, D., Levy, M., Zilberman-Schapira, G., Suez, J., Tengeler, A.C., Abramson, L., Katz, M.N., Korem, T., Zmora, N., Kuperman, Y., Biton, I., Gilad, S., Harmelin, A., Shapiro, H., Halpern, Z., Segal, E., Elinav, E., Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis. Cell 159:3 (2014), 514–529.
156. Tomaro-Duchesneau, C., Cholesterol assimilation by Lactobacillus probiotic bacteria: an in vitro investigation. Biomed. Res. Int., 2014, 2014, 380316.
157. Tomaro-Duchesneau, C., Saha, S., Malhotra, M., Coussa-Charley, M., Al-Salami, H., Jones, M.L., Labbé, A., Prakash, S., Lactobacillus fermentum NCIMB 5221 has a greater ferulic acid production compared to other ferulic acid esterase producing lactobacilli. Int. J. Probiotics Prebiotics 7:1 (2012), 23–32.
158. Tomaro-Duchesneau, C., Saha, S., Malhotra, M., Coussa-Charley, M., Kahouli, I., Jones, M.L., Labbé, A., Prakash, S., Probiotic ferulic acid esterase active Lactobacillus fermentum NCIMB 5221 APA microcapsules for oral delivery: preparation and in vitro characterization. Pharmaceuticals 5:2 (2012), 236–248.
159. Van Eldere, J., Mertens, J., Eyssen, H., Influence of intestinal bacterial desulfation on the enterohepatic circulation of dehydroepiandrosterone sulfate. J. Steroid Biochem. 36:5 (1990), 451–456.
160. Vitek, L., Haluzik, M., The role of bile acids in metabolic regulation. J. Endocrinol. 228:3 (2016), R85–R96.
161. Vizoso Pinto, M.G., Franz, C.M.A.P., Schillinger, U., Holzapfel, W.H., Lactobacillus spp. with in vitro probiotic properties from human faeces and traditional fermented products. Int. J. Food Microbiol. 109:3 (2006), 205–214.
162. Wang, W., Wu, Z., Dai, Z., Yang, Y., Wang, J., Wu, G., Glycine metabolism in animals and humans: implications for nutrition and health. Amino Acids 45:3 (2013), 463–477.
163. Wang, Z., Zeng, X., Mo, Y., Smith, K., Guo, Y., Lin, J., Identification and characterization of a bile salt hydrolase from Lactobacillus salivarius for development of novel alternatives to antibiotic growth promoters. Appl. Environ. Microbiol. 78:24 (2012), 8795–8802.
164. Watanabe, M., Houten, S.M., Mataki, C., Christoffolete, M.A., Kim, B.W., Sato, H., Messaddeq, N., Harney, J.W., Ezaki, O., Kodama, T., Schoonjans, K., Bianco, A.C., Auwerx, J., Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 439:7075 (2006), 484–489.
165. Weingarden, A.R., Chen, C., Bobr, A., Yao, D., Lu, Y., Nelson, V.M., Sadowsky, M.J., Khoruts, A., Microbiota transplantation restores normal fecal bile acid composition in recurrent Clostridium difficile infection. Am. J. Physiol. Gastrointest. Liver Physiol. 306:4 (2014), G310–G319.
166. Weingarden, A.R., Dosa, P.I., DeWinter, E., Steer, C.J., Shaughnessy, M.K., Johnson, J.R., Khoruts, A., Sadowsky, M.J., Changes in colonic bile acid composition following fecal microbiota transplantation are sufficient to control Clostridium difficile germination and growth. PLoS One, 11(1), 2016, e0147210.
167. Wells, J.E., Hylemon, P.B., Identification and characterization of a bile acid 7alpha-dehydroxylation operon in Clostridium sp. strain TO-931, a highly active 7alpha-dehydroxylating strain isolated from human feces. Appl. Environ. Microbiol. 66:3 (2000), 1107–1113.
168. Wijaya, A., Hermann, A., Abriouel, H., Specht, I., Yousif, N.M.K., Holzapfel, W.H., Franz, C.M.A.P., Cloning of the bile salt hydrolase (bsh) gene from Enterococcus faecium FAIR-E 345 and chromosomal location of bsh genes in food enterococci. J. Food Prot. 67:12 (2004), 2772–2778.
169. Xie, W., Radominska-Pandya, A., Shi, Y., Simon, C.M., Nelson, M.C., Ong, E.S., Waxman, D.J., Evans, R.M., An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc. Natl. Acad. Sci. U. S. A. 98:6 (2001), 3375–3380.
170. Xu, F., Guo, F., Hu, X.-J., Lin, J., Crystal structure of bile salt hydrolase from Lactobacillus salivarius. Acta Crystallogr. Sect. F. 72:5 (2016), 376–381.
171. Yokota, A., Fukiya, S., Islam, K.B., Ooka, T., Ogura, Y., Hayashi, T., Hagio, M., Ishizuka, S., Is bile acid a determinant of the gut microbiota on a high-fat diet?. Gut Microbes 3:5 (2012), 455–459.
172. Yoshimoto, S., Loo, T.M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., Honda, K., Ishikawa, Y., Hara, E., Ohtani, N., Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature 499:7456 (2013), 97–101.
173. Zheng, X., Chen, T., Zhao, A., Wang, X., Xie, G., Huang, F., Liu, J., Zhao, Q., Wang, S., Wang, C., Zhou, M., Panee, J., He, Z., Jia, W., The brain metabolome of male rats across the lifespan. Sci. Rep., 6, 2016, 24125.
174. Zhou, H., Hylemon, P.B., Bile acids are nutrient signaling hormones. Steroids 86 (2014), 62–68.