메뉴 건너뛰기




Volumn 3, Issue 1, 2013, Pages 14-24

Metabolism of cholesterol and bile acids by the gut microbiota

Author keywords

Coprostanol; Deconjugation; Epimerization; Secondary bile acids

Indexed keywords

ARTICLE; BILE ACID METABOLISM; CHOLESTEROL METABOLISM; CHOLESTEROL STONE; COLON CANCER; DIET; EPIMERIZATION; ESTERIFICATION; HEPATOBILIARY SYSTEM; HUMAN; INFLAMMATION; INTESTINE FLORA; LIVER CANCER; METABOLIC DISORDER; NONHUMAN; OXIDATION; RISK;

EID: 84903524994     PISSN: None     EISSN: 20760817     Source Type: Journal    
DOI: 10.3390/pathogens3010014     Document Type: Article
Times cited : (441)

References (50)
  • 3
    • 33745594044 scopus 로고    scopus 로고
    • The gut flora as a forgotten organ
    • O'Hara, A.M.; Shanahan, F. The gut flora as a forgotten organ. EMBO Rep. 2006, 7, 688-693.
    • (2006) EMBO Rep , vol.7 , pp. 688-693
    • O'Hara, A.M.1    Shanahan, F.2
  • 6
    • 79957998380 scopus 로고    scopus 로고
    • Le microbiote intestinal: Composition et fonctions
    • Gérard, P. Le microbiote intestinal: Composition et fonctions. Phytothérapie 2011, 9, 72-75.
    • (2011) Phytothérapie , vol.9 , pp. 72-75
    • Gérard, P.1
  • 8
    • 0001456511 scopus 로고
    • New contributions in sterol metabolism
    • Schoenheimer, R. New contributions in sterol metabolism. Science 1931, 74, 579-584.
    • (1931) Science , vol.74 , pp. 579-584
    • Schoenheimer, R.1
  • 9
    • 0016206191 scopus 로고
    • Steroid balance and tissue cholesterol accumulation in germfree and conventional rats fed diets containing saturated and polyunsaturated fats
    • Kellogg, T.F. Steroid balance and tissue cholesterol accumulation in germfree and conventional rats fed diets containing saturated and polyunsaturated fats. J. Lipid Res. 1974, 15, 574-579.
    • (1974) J. Lipid Res , vol.15 , pp. 574-579
    • Kellogg, T.F.1
  • 10
    • 0027317219 scopus 로고
    • Conversion of cholesterol to coprostanol by the intestinal microflora during the first two years of human life
    • Midtvedt, A.C.; Midtvedt, T. Conversion of cholesterol to coprostanol by the intestinal microflora during the first two years of human life. J. Pediatr. Gastroenterol. Nutr. 1993, 17, 161-168.
    • (1993) J. Pediatr. Gastroenterol. Nutr , vol.17 , pp. 161-168
    • Midtvedt, A.C.1    Midtvedt, T.2
  • 11
    • 11144333636 scopus 로고    scopus 로고
    • Correlation between faecal microbial community structure and cholesterol-to-coprostanol conversion in the human gut
    • Veiga, P.; Juste, C.; Lepercq, P.; Saunier, K.; Beguet, F.; Gérard, P. Correlation between faecal microbial community structure and cholesterol-to-coprostanol conversion in the human gut. FEMS Microbiol. Lett. 2005, 242, 81-86.
    • (2005) FEMS Microbiol. Lett , vol.242 , pp. 81-86
    • Veiga, P.1    Juste, C.2    Lepercq, P.3    Saunier, K.4    Beguet, F.5    Gérard, P.6
  • 12
    • 0016259230 scopus 로고
    • Two patterns of neutral steroid conversion in the feces of normal North Americans
    • Wilkins, T.D.; Hackman, A.S. Two patterns of neutral steroid conversion in the feces of normal North Americans. Cancer Res. 1974, 34, 2250-2254.
    • (1974) Cancer Res , vol.34 , pp. 2250-2254
    • Wilkins, T.D.1    Hackman, A.S.2
  • 15
    • 0028057549 scopus 로고
    • Characterization of Eubacterium coprostanoligenes sp. nov., a cholesterol-reducing anaerobe
    • Freier, T.A.; Beitz, D.C.; Li, L.; Hartman, P.A. Characterization of Eubacterium coprostanoligenes sp. nov., a cholesterol-reducing anaerobe. Int. J. Syst. Bacteriol. 1994, 44, 137-142.
    • (1994) Int. J. Syst. Bacteriol , vol.44 , pp. 137-142
    • Freier, T.A.1    Beitz, D.C.2    Li, L.3    Hartman, P.A.4
  • 16
    • 0343961975 scopus 로고    scopus 로고
    • Mechanism of cholesterol reduction to coprostanol by Eubacterium coprostanoligenes ATCC 51222
    • Ren, D.; Li, L.; Schwabacher, A.W.; Young, J.W.; Beitz, D.C. Mechanism of cholesterol reduction to coprostanol by Eubacterium coprostanoligenes ATCC 51222. Steroids 1996, 61, 33-40.
    • (1996) Steroids , vol.61 , pp. 33-40
    • Ren, D.1    Li, L.2    Schwabacher, A.W.3    Young, J.W.4    Beitz, D.C.5
  • 17
    • 34648825070 scopus 로고    scopus 로고
    • Bacteroides sp. strain D8, the first cholesterol-reducing bacterium isolated from human feces
    • Gérard, P.; Lepercq, P.; Leclerc, M.; Gavini, F.; Raibaud, P.; Juste, C. Bacteroides sp. strain D8, the first cholesterol-reducing bacterium isolated from human feces. Appl. Environ. Microbiol. 2007, 73, 5742-5749.
    • (2007) Appl. Environ. Microbiol , vol.73 , pp. 5742-5749
    • Gérard, P.1    Lepercq, P.2    Leclerc, M.3    Gavini, F.4    Raibaud, P.5    Juste, C.6
  • 18
    • 0025332495 scopus 로고
    • Intestinal cholesterol metabolism
    • Lichtenstein, A.H. Intestinal cholesterol metabolism. Ann. Med. 1990, 22, 49-52.
    • (1990) Ann. Med , vol.22 , pp. 49-52
    • Lichtenstein, A.H.1
  • 19
    • 78649741587 scopus 로고    scopus 로고
    • Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism
    • Rabot, S.; Membrez, M.; Bruneau, A.; Gérard, P.; Harach, T.; Moser, M.; Raymond, F.; Mansourian, R.; Chou, C.J. Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism. FASEB J. 2010, 24, 4948-4959.
    • (2010) FASEB J , vol.24 , pp. 4948-4959
    • Rabot, S.1    Membrez, M.2    Bruneau, A.3    Gérard, P.4    Harach, T.5    Moser, M.6    Raymond, F.7    Mansourian, R.8    Chou, C.J.9
  • 21
    • 0018546789 scopus 로고
    • Effects of neomycin alone and in combination with cholestyramine on serum cholesterol and fecal steroids in hypercholesterolemic subjects
    • Miettinen, T.A. Effects of neomycin alone and in combination with cholestyramine on serum cholesterol and fecal steroids in hypercholesterolemic subjects. J. Clin. Investig. 1979, 64, 1485-1493.
    • (1979) J. Clin. Investig , vol.64 , pp. 1485-1493
    • Miettinen, T.A.1
  • 23
    • 0028935793 scopus 로고
    • Hypocholesterolemic effect of Eubacterium coprostanoligenes ATCC 51222 in rabbits
    • Li, L.; Buhman, K.K.; Hartman, P.A.; Beitz, D.C. Hypocholesterolemic effect of Eubacterium coprostanoligenes ATCC 51222 in rabbits. Lett. Appl. Microbiol. 1995, 20, 137-140.
    • (1995) Lett. Appl. Microbiol , vol.20 , pp. 137-140
    • Li, L.1    Buhman, K.K.2    Hartman, P.A.3    Beitz, D.C.4
  • 24
    • 0030162905 scopus 로고    scopus 로고
    • Effect of orally administered Eubacterium coprostanoligenes ATCC 51222 on plasma cholesterol concentration in laying hens
    • Li, L.; Baumann, C.A.; Meling, D.D.; Sell, J.L.; Beitz, D.C. Effect of orally administered Eubacterium coprostanoligenes ATCC 51222 on plasma cholesterol concentration in laying hens. Poult. Sci. 1996, 75, 743-745.
    • (1996) Poult. Sci , vol.75 , pp. 743-745
    • Li, L.1    Baumann, C.A.2    Meling, D.D.3    Sell, J.L.4    Beitz, D.C.5
  • 25
    • 0031878744 scopus 로고    scopus 로고
    • Effect of feeding of a cholesterol-reducing bacterium, Eubacterium coprostanoligenes, to germ-free mice
    • Li, L.; Batt, S.M.; Wannemuehler, M.; Dispirito, A.; Beitz, D.C. Effect of feeding of a cholesterol-reducing bacterium, Eubacterium coprostanoligenes, to germ-free mice. Lab. Anim. Sci. 1998, 48, 253-255.
    • (1998) Lab. Anim. Sci , vol.48 , pp. 253-255
    • Li, L.1    Batt, S.M.2    Wannemuehler, M.3    Dispirito, A.4    Beitz, D.C.5
  • 26
    • 1542331436 scopus 로고    scopus 로고
    • Gnotobiotic rats harboring human intestinal microbiota as a model for studying cholesterol-to-coprostanol conversion
    • Gérard, P.; Beguet, F.; Lepercq, P.; Rigottier-Gois, L.; Rochet, V.; Andrieux, C.; Juste, C. Gnotobiotic rats harboring human intestinal microbiota as a model for studying cholesterol-to-coprostanol conversion. FEMS Microbiol. Ecol. 2004, 47, 337-343.
    • (2004) FEMS Microbiol. Ecol , vol.47 , pp. 337-343
    • Gérard, P.1    Beguet, F.2    Lepercq, P.3    Rigottier-Gois, L.4    Rochet, V.5    Andrieux, C.6    Juste, C.7
  • 27
    • 77749259991 scopus 로고    scopus 로고
    • Bile salts of vertebrates: Structural variation and possible evolutionary significance
    • Hofmann, A.F.; Hagey, L.R.; Krasowski, M.D. Bile salts of vertebrates: Structural variation and possible evolutionary significance. J. Lipid Res. 2010, 51, 226-246.
    • (2010) J. Lipid Res , vol.51 , pp. 226-246
    • Hofmann, A.F.1    Hagey, L.R.2    Krasowski, M.D.3
  • 28
    • 84877259543 scopus 로고    scopus 로고
    • Transport and biological activities of bile acids
    • Zwicker, B.L.; Agellon, L.B. Transport and biological activities of bile acids. Int. J. Biochem. Cell Biol. 2013, 45, 1389-1398.
    • (2013) Int. J. Biochem. Cell Biol , vol.45 , pp. 1389-1398
    • Zwicker, B.L.1    Agellon, L.B.2
  • 31
    • 0016357193 scopus 로고
    • Microbial bile acid transformation
    • Midtvedt, T. Microbial bile acid transformation. Am. J. Clin. Nutr. 1974, 27, 1341-1347.
    • (1974) Am. J. Clin. Nutr , vol.27 , pp. 1341-1347
    • Midtvedt, T.1
  • 32
    • 51649086648 scopus 로고    scopus 로고
    • Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome
    • Jones, B.V.; Begley, M.; Hill, C.; Gahan, C.G.; Marchesi, J.R. Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome. Proc. Natl. Acad. Sci. USA 2008, 105, 13580-13585.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 13580-13585
    • Jones, B.V.1    Begley, M.2    Hill, C.3    Gahan, C.G.4    Marchesi, J.R.5
  • 33
    • 17144405290 scopus 로고    scopus 로고
    • Conjugated bile acid hydrolase is a tetrameric N-terminal thiol hydrolase with specific recognition of its cholyl but not of its tauryl product
    • Rossocha, M.; Schultz-Heienbrok, R.; von Moeller, H.; Coleman, J.P.; Saenger, W. Conjugated bile acid hydrolase is a tetrameric N-terminal thiol hydrolase with specific recognition of its cholyl but not of its tauryl product. Biochemistry 2005, 44, 5739-5748.
    • (2005) Biochemistry , vol.44 , pp. 5739-5748
    • Rossocha, M.1    Schultz-Heienbrok, R.2    von Moeller, H.3    Coleman, J.P.4    Saenger, W.5
  • 34
    • 0036037505 scopus 로고    scopus 로고
    • Cossart, P. Listeria monocytogenes bile salt hydrolase is a PrfA-regulated virulence factor involved in the intestinal and hepatic phases of listeriosis
    • Dussurget, O.; Cabanes, D.; Dehoux, P.; Lecuit, M.; Buchrieser, C.; Glaser, P.; Cossart, P. Listeria monocytogenes bile salt hydrolase is a PrfA-regulated virulence factor involved in the intestinal and hepatic phases of listeriosis. Mol. Microbiol. 2002, 45, 1095-1106.
    • (2002) Mol. Microbiol , vol.45 , pp. 1095-1106
    • Dussurget, O.1    Cabanes, D.2    Dehoux, P.3    Lecuit, M.4    Buchrieser, C.5    Glaser, P.6
  • 36
    • 33244467651 scopus 로고    scopus 로고
    • Bile salt biotransformations by human intestinal bacteria
    • Ridlon, J.M.; Kang, D.J.; Hylemon, P.B. Bile salt biotransformations by human intestinal bacteria. J. Lipid Res. 2006, 47, 241-259.
    • (2006) J. Lipid Res , vol.47 , pp. 241-259
    • Ridlon, J.M.1    Kang, D.J.2    Hylemon, P.B.3
  • 38
    • 11244333658 scopus 로고    scopus 로고
    • Isolates from normal human intestinal flora but not lactic acid bacteria exhibit 7alpha- and 7beta-hydroxysteroid dehydrogenase activities
    • Lepercq, P.; Gérard, P.; Béguet, F.; Grill, J.-P.; Relano, P.; Cayuela, C.; Juste, C. Isolates from normal human intestinal flora but not lactic acid bacteria exhibit 7alpha- and 7beta-hydroxysteroid dehydrogenase activities. Microb. Ecol. Health Dis. 2004, 16, 195-201.
    • (2004) Microb. Ecol. Health Dis , vol.16 , pp. 195-201
    • Lepercq, P.1    Gérard, P.2    Béguet, F.3    Grill, J.-P.4    Relano, P.5    Cayuela, C.6    Juste, C.7
  • 39
    • 0030000879 scopus 로고    scopus 로고
    • Crystal structures of the binary and ternary complexes of 7 alpha-hydroxysteroid dehydrogenase from Escherichia coli
    • Tanaka, N.; Nonaka, T.; Tanabe, T.; Yoshimoto, T.; Tsuru, D.; Mitsui, Y. Crystal structures of the binary and ternary complexes of 7 alpha-hydroxysteroid dehydrogenase from Escherichia coli. Biochemistry 1996, 35, 7715-7730.
    • (1996) Biochemistry , vol.35 , pp. 7715-7730
    • Tanaka, N.1    Nonaka, T.2    Tanabe, T.3    Yoshimoto, T.4    Tsuru, D.5    Mitsui, Y.6
  • 41
    • 0025967219 scopus 로고
    • Mechanism of intestinal 7 alpha-dehydroxylation of cholic acid: Evidence that allo-deoxycholic acid is an inducible side-product
    • Hylemon, P.B.; Melone, P.D.; Franklund, C.V.; Lund, E.; Bjorkhem, I. Mechanism of intestinal 7 alpha-dehydroxylation of cholic acid: Evidence that allo-deoxycholic acid is an inducible side-product. J. Lipid Res. 1991, 32, 89-96.
    • (1991) J. Lipid Res , vol.32 , pp. 89-96
    • Hylemon, P.B.1    Melone, P.D.2    Franklund, C.V.3    Lund, E.4    Bjorkhem, I.5
  • 42
    • 77951768945 scopus 로고    scopus 로고
    • Isolation and characterization of a bile acid inducible 7alpha-dehydroxylating operon in Clostridium hylemonae TN271
    • Ridlon, J.M.; Kang, D.J.; Hylemon, P.B. Isolation and characterization of a bile acid inducible 7alpha-dehydroxylating operon in Clostridium hylemonae TN271. Anaerobe 2010, 16, 137-146.
    • (2010) Anaerobe , vol.16 , pp. 137-146
    • Ridlon, J.M.1    Kang, D.J.2    Hylemon, P.B.3
  • 43
    • 0032150419 scopus 로고    scopus 로고
    • Purification and properties of a novel sulfatase from Pseudomonas testosteroni that hydrolyzed 3 beta-hydroxy-5-cholenoic acid 3-sulfate
    • Tazuke, Y.; Matsuda, K.; Adachi, K.; Tsukada, Y. Purification and properties of a novel sulfatase from Pseudomonas testosteroni that hydrolyzed 3 beta-hydroxy-5-cholenoic acid 3-sulfate. Biosci., Biotechnol., Biochem. 1998, 62, 1739-1744.
    • (1998) Biosci., Biotechnol., Biochem , vol.62 , pp. 1739-1744
    • Tazuke, Y.1    Matsuda, K.2    Adachi, K.3    Tsukada, Y.4
  • 46
    • 12344253203 scopus 로고    scopus 로고
    • Diet, anaerobic bacterial metabolism, and colon cancer: A review of the literature
    • McGarr, S.E.; Ridlon, J.M.; Hylemon, P.B. Diet, anaerobic bacterial metabolism, and colon cancer: A review of the literature. J. Clin. Gastroenterol. 2005, 39, 98-109.
    • (2005) J. Clin. Gastroenterol , vol.39 , pp. 98-109
    • McGarr, S.E.1    Ridlon, J.M.2    Hylemon, P.B.3
  • 49
    • 84875258580 scopus 로고    scopus 로고
    • Bile acids as modulators of gut microbiota linking dietary habits and inflammatory bowel disease: A potentially dangerous liaison
    • Trauner, M.; Fickert, P.; Tilg, H. Bile acids as modulators of gut microbiota linking dietary habits and inflammatory bowel disease: A potentially dangerous liaison. Gastroenterology 2013, 144, 844-846.
    • (2013) Gastroenterology , vol.144 , pp. 844-846
    • Trauner, M.1    Fickert, P.2    Tilg, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.