Bile acid sensitivity and in vivo virulence of clinical Clostridium difficile isolates

Anaerobe

Volumn 41, Issue , 2016, Pages 32-36

  Lewis, Brittany B ^a   Carter, Rebecca A ^a   Pamer, Eric G ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Clostridium difficile; Secondary bile acid

Indexed keywords

BILE ACID; CLINDAMYCIN; DEOXYCHOLIC ACID; LITHOCHOLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; BILE ACID SYNTHESIS; C57BL 6 MOUSE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; GROWTH INHIBITION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PEPTOCLOSTRIDIUM DIFFICILE; PRIORITY JOURNAL; ANIMAL; BACTERIAL SPORE; C57BL MOUSE; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; HUMAN; MICROBIAL VIABILITY; MICROBIOLOGY; PATHOGENICITY; PSEUDOMEMBRANOUS COLITIS; VIRULENCE;

ANIMALS; CLOSTRIDIUM DIFFICILE; ENTEROCOLITIS, PSEUDOMEMBRANOUS; HUMANS; LITHOCHOLIC ACID; MICE, INBRED C57BL; MICROBIAL VIABILITY; SPORES, BACTERIAL; VIRULENCE;

EID: 85027957031     PISSN: 10759964     EISSN: 10958274     Source Type: Journal    
DOI: 10.1016/j.anaerobe.2016.05.010     Document Type: Article

References (40)

1. McDonald, L Clifford, Killgore, George E., Thompson, Angela, Owens, Robert C., Kazakova, Sophia V., Sambol, Susan P., Johnson, Stuart, Gerding, Dale N., An epidemic, toxin gene-variant strain of clostridium difficile. N. Engl. J. Med. 353:23 (2005), 2433–2441.
2. Riggs, Michelle M., Sethi, Ajay K., Zabarsky, Trina F., Eckstein, Elizabeth C., Jump, Robin L.P., Donskey, Curtis J., Asymptomatic carriers are a potential source for transmission of epidemic and nonepidemic clostridium difficile strains among long-term care facility residents. Clin. Infect. Dis. 45:8 (2007), 992–998.
3. He, Miao, Miyajima, Fabio, Roberts, Paul, Ellison, Louise, Pickard, Derek J., Martin, Melissa J., Connor, Thomas R., et al. Emergence and global spread of epidemic healthcare-associated clostridium difficile. Nat. Genet. 45:1 (2013), 109–113.
4. Bartlett, John G., Historical perspectives on studies of clostridium difficile and C. Difficile infection. Clin. Infect. Dis. 46:1 (2008), S4–S11.
5. Pépin, Jacques, Valiquette, Louis, Alary, Marie-Eve, Villemure, Philippe, Pelletier, Annick, Forget, Karine, Pépin, Karine, Chouinard, Daniel, Clostridium difficile-associated diarrhea in a region of quebec from 1991 to 2003: a changing pattern of disease severity. Can. Med. Assoc. J. 171:5 (2004), 466–472.
6. Feuerstadt, Paul, Das, Rohit, Brandt, Lawrence J., The evolution of urban C. Difficile infection (CDI): CDI in 2009–2011 is less severe and has better outcomes than CDI in 2006–2008. Am. J. Gastroenterol. 109:8 (2014), 1265–1276.
7. Lim, Sze K., Stuart, Rhonda L., Mackin, Kate E., Carter, Glen P., Kotsanas, Despina, Francis, Michelle J., Easton, Marion, et al. Emergence of a ribotype 244 strain of clostridium difficile associated with severe disease and related to the epidemic ribotype 027 strain. Clin. Infect. Dis. 58:12 (2014), 1723–1730.
8. Stabler, Richard A., Dawson, Lisa F., Valiente, Esmeralda, Cairns, Michelle D., Martin, Melissa J., Donahue, Elizabeth H., Riley, Thomas V., et al. Macro and micro diversity of clostridium difficile isolates from diverse sources and geographical locations. PLoS One, 7(3), 2012, e31559.
9. Quesada-Gómez, Carlos, López-Ureña, Diana, Acuña-Amador, Luis, Villalobos-Zúñiga, Manuel, Du, Tim, Freire, Rosemayre, Guzmán-Verri, Caterina, et al. Emergence of an outbreak-associated clostridium difficile variant with increased virulence. J. Clin. Microbiol. 53:4 (2015), 1216–1226.
10. Loo, Vivian G., Poirier, Louise, Miller, Mark A., Oughton, Matthew, Libman, Michael D., Michaud, Sophie, Bourgault, Anne-Marie, et al. A predominantly clonal multi-institutional outbreak of clostridium difficile-associated diarrhea with high morbidity and mortality. N. Engl. J. Med. 353:23 (2005), 2442–2449.
11. Goldenberg, Simon D., French, Gary L., Lack of association of tcdc type and binary toxin status with disease severity and outcome in toxigenic clostridium difficile. J. Infect. 62:5 (2011), 355–362.
12. Vohra, Prerna, Poxton, Ian R., Comparison of toxin and spore production in clinically relevant strains of clostridium difficile. Microbiology 157:Pt 5 (2011), 1343–1353.
13. Michelle, Merrigan, Venugopal, Anilrudh, Mallozzi, Michael, Roxas, Bryan, Viswanathan, V.K., Johnson, Stuart, Gerding, Dale N., Vedantam, Gayatri, Human hypervirulent clostridium difficile strains exhibit increased sporulation as well as robust toxin production. J. Bacteriol. 192:19 (2010), 4904–4911.
14. Emma, Stevenson, Minton, Nigel P., Kuehne, Sarah A., The role of flagella in clostridium difficile pathogenicity. Trends Microbiol. 23:5 (2015), 275–282.
15. Moore, P., Kyne, L., Martin, A., Solomon, K., Germination efficiency of clinical clostridium difficile spores and correlation with ribotype, disease severity and therapy failure. J. Med. Microbiol. 62:Pt 9 (2013), 1405–1413.
16. Carlson, Paul E., Kaiser, Alyssa M., McColm, Sarah A., Bauer, Jessica M., Young, Vincent B., Aronoff, David M., Hanna, Philip C., Variation in germination of clostridium difficile clinical isolates correlates to disease severity. Anaerobe 33 (2015), 64–70.
17. Wilson, K.H., Efficiency of various bile salt preparations for stimulation of clostridium difficile spore germination. J. Clin. Microbiol. 18:4 (1983), 1017–1019.
18. Sorg, Joseph A., Sonenshein, Abraham L., Bile salts and glycine as cogerminants for clostridium difficile spores. J. Bacteriol. 190:7 (2008), 2505–2512.
19. Sorg, Joseph A., Sonenshein, Abraham L., Chenodeoxycholate is an inhibitor of clostridium difficile spore germination. J. Bacteriol. 191:3 (2009), 1115–1117.
20. Sorg, Joseph A., Sonenshein, Abraham L., Inhibiting the initiation of clostridium difficile spore germination using analogs of chenodeoxycholic acid, a bile acid. J. Bacteriol. 192:19 (2010), 4983–4990.
21. Heeg, Daniela, Burns, David A., Cartman, Stephen T., Minton, Nigel P., Spores of clostridium difficile clinical isolates display a diverse germination response to bile salts. PLoS One, 7(2), 2012, e32381.
22. Weingarden, Alexa R., Chen, Chi, Bobr, Aleh, Yao, Dan, Lu, Yuwei, Nelson, Valerie M., Sadowsky, Michael J., Khoruts, Alexander, Microbiota transplantation restores normal fecal bile acid composition in recurrent clostridium difficile infection. Am. J. Physiol. Gastrointest. Liver Physiol. 306:4 (2014), G310–G319.
23. Ridlon, Jason M., Kang, Dae-Joong, Hylemon, Phillip B., Bile salt biotransformations by human intestinal bacteria. J. Lipid Res. 47:2 (2006), 241–259.
24. Russell, David W., The enzymes, regulation, and genetics of bile acid synthesis. Annu. Rev. Biochem. 72:1 (2003), 137–174.
25. Wilson, K.H., Kennedy, M.J., Fekety, F.R., Use of sodium taurocholate to enhance spore recovery on a medium selective for clostridium difficile. J. Clin. Microbiol. 15:3 (1982), 443–446.
26. Francis, Michael B., Allen, Charlotte A., Sorg, Joseph A., Muricholic acids inhibit clostridium difficile spore germination and growth. PLoS One, 8(9), 2013, e73653.
27. Theriot, Casey M., Koenigsknecht, Mark J., Carlson, Paul E., Hatton, Gabrielle E., Nelson, Adam M., Li, Bo, Huffnagle, Gary B., Li, Jun Z., Young, Vincent B., Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to clostridium difficile infection. Nat. Commun., 5, 2014, 3114.
28. Buffie, Charlie G., Bucci, Vanni, Stein, Richard R., McKenney, Peter T., Ling, Lilan, Gobourne, Asia, No, Daniel, et al. Precision microbiome reconstitution restores bile acid mediated resistance to clostridium difficile. Nature 517:7533 (2015), 205–208.
29. Theriot, Casey M., Bowman, Alison A., Young, Vincent B., Antibiotic-Induced alterations of the gut microbiota alter secondary bile acid production and allow for clostridium difficile spore germination and outgrowth in the large intestine. MSphere, 1(1), 2016 e00045–15.
30. Koenigsknecht, Mark J., Theriot, Casey M., Bergin, Ingrid L., Schumacher, Cassie A., Schloss, Patrick D., Young, Vincent B., Dynamics and establishment of clostridium difficile infection in the murine gastrointestinal tract. Infect. Immun. 83:3 (2015), 934–941.
31. Kinnebrew, Melissa A., Joo Lee, Yeon, Jenq, Robert R., Lipuma, Lauren, Littmann, Eric R., Gobourne, Asia, No, Daniel, van den Brink, Marcel, Pamer, Eric G., Taur, Ying, Early clostridium difficile infection during allogeneic hematopoietic stem cell transplantation. PLoS One, 9(3), 2014, e90158.
32. David, Griffiths, Fawley, Warren, Kachrimanidou, Melina, Bowden, Rory, Crook, Derrick W., Fung, Rowena, Golubchik, Tanya, Harding, Rosalind M., Jeffery, Katie JM., Jolley, Keith A., Multilocus sequence typing of clostridium difficile. J. Clin. Microbiol. 48:3 (2010), 770–778.
33. Janezic, Sandra, Rupnik, Maja, Genomic diversity of clostridium difficile strains. Res. Microbiol. 166:4 (2015), 353–360.
34. Sorg, Joseph A., Dineen, Sean S., Laboratory maintenance of clostridium difficile. Curr. Protoc. Microbiol., 2009 9A-1, 4–6.
35. Abt, Michael C., Lewis, Brittany B., Caballero, Silvia, Xiong, Huizhong, Carter, Rebecca A., Sušac, Bože, Ling, Lilan, Leiner, Ingrid, Pamer, Eric G., Innate immune defenses mediated by two ILC subsets are critical for protection against acute clostridium difficile infection. Cell Host Microbe 18:1 (2015), 27–37.
36. Buffie, Charlie G., Jarchum, Irene, Equinda, Michele, Lipuma, Lauren, Gobourne, Asia, Viale, Agnes, Ubeda, Carles, Xavier, Joao, Pamer, Eric G., Profound alterations of intestinal microbiota following a single dose of clindamycin results in sustained susceptibility to clostridium difficile-induced colitis. Infect. Immun. 80:1 (2012), 62–73.
37. Theriot, Casey M., Koumpouras, Charles C., Carlson, Paul E., Bergin, Ingrid I., Aronoff, David M., Young, Vincent B., Cefoperazone-treated mice as an experimental platform to assess differential virulence of clostridium difficile strains. Gut. Microbes 2:6 (2011), 326–334.
38. Giel, Jennifer L., Sorg, Joseph A., Sonenshein, Abraham L., Zhu, Jun, Metabolism of bile salts in mice influences spore germination in clostridium difficile. PLoS One, 5(1), 2010, e8740.
39. Chateau, N., Deschamps, A.M., Hadj Sassi, A., Heterogeneity of bile salts resistance in the Lactobacillus isolates of a probiotic consortium. Letts. Appl. Microbiol. 18 (1994), 42–44.
40. Olier, M., Rousseaux, S., Piveteau, P., Lemâıtre, J.P., Rousset, A., Guzzo, J., Screening of glutamate decarboxylase activity and bile salt resistance of human asymptomatic carriage, clinical, food, and environmental isolates of Listeria monocytogenes. Int. J. Food Microbiol. 93 (2004), 87–99.