Biocatalytic process optimization based on mechanistic modeling of cholic acid oxidation with cofactor regeneration

Biotechnology and Bioengineering

Volumn 108, Issue 6, 2011, Pages 1307-1317

  Braun, Michael ^a   Link, Hannes ^a   Liu, Luo ^b   Schmid, Rolf D ^b   Weuster Botz, Dirk ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF STUTTGART   (Germany)

Author keywords

Biocatalysis; Cofactor regeneration; Hydroxysteroid dehydrogenase; In silico optimization; Mechanistic model; Process modelling

Indexed keywords

BIOCATALYSIS; COFACTOR REGENERATION; HYDROXYSTEROID DEHYDROGENASE; IN-SILICO; MECHANISTIC MODELS; PROCESS MODELLING;

ACETONE; BATCH DATA PROCESSING; ENZYMES; KINETIC THEORY; OPTIMIZATION; OXIDATION; PROCESS CONTROL; SYNTHESIS (CHEMICAL);

PROCESS DESIGN;

12 OXOCHENODEOXYCHOLIC ACID; 12ALPHA HYDROXYSTEROID DEHYDROGENASE; ACETONE; ALCOHOL DEHYDROGENASE; BACTERIAL ENZYME; CHENODEOXYCHOLIC ACID DERIVATIVE; CHOLIC ACID; HYDROXYSTEROID DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BATCH PROCESS; BIOCATALYSIS; CONCENTRATION (PARAMETERS); ENZYME ACTIVITY; ENZYME KINETICS; NONHUMAN; OXIDATION; OXIDATION KINETICS; PREDICTION; PROCESS MODEL; PROCESS OPTIMIZATION; REACTION ANALYSIS; REDUCTION; REGENERATION; THERMOANAEROBACTER; THERMOANAEROBACTER ETHANOLICUS;

ACETONE; ALCOHOL DEHYDROGENASE; BIOCATALYSIS; CHOLIC ACID; CLOSTRIDIUM; HUMANS; HYDROXYSTEROID DEHYDROGENASES; KINETICS; MODELS, BIOLOGICAL; OXIDATION-REDUCTION; THERMOANAEROBACTER;

CLOSTRIDIUM; THERMOANAEROBACTER ETHANOLICUS;

EID: 79954593169     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.23047     Document Type: Article

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