Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathology

Acta Neuropathologica

Volumn 134, Issue 5, 2017, Pages 769-788

  Haure Mirande, Jean Vianney ^a   Audrain, Mickael ^a   Fanutza, Tomas ^a   Kim, Soong Ho ^a   Klein, William L ^b   Glabe, Charles ^c   Readhead, Ben ^a   Dudley, Joel T ^a   Blitzer, Robert D ^a   Wang, Minghui ^a   Zhang, Bin ^a   Schadt, Eric E ^a   Gandy, Sam ^a   Ehrlich, Michelle E ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer s disease; APP PSEN1; CR3 adapter; Microglia; TREM2 adapter; TYROBP DAP12

Indexed keywords

AMYLOID BETA PROTEIN; CD33 ANTIGEN; CHEMOKINE RECEPTOR CCR3; KILLER CELL ACTIVATING RECEPTOR ASSOCIATED PROTEIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; SYNAPTOPHYSIN; TAU PROTEIN; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TYROBP PROTEIN, MOUSE;

ALZHEIMER DISEASE; AMYLOIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BARNES MAZE TEST; BEHAVIORAL OBSERVATION; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FEMALE; GENE EXPRESSION; HIPPOCAMPUS; MALE; MICROGLIA; MISSENSE MUTATION; MORPHOLOGY; MOUSE; NEUROPROTECTION; NONHUMAN; PATHOGENESIS; PHAGOCYTOSIS; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TRANSGENE; ANIMAL; BRAIN; DISEASE MODEL; GENETICS; KNOCKOUT MOUSE; MAZE TEST; METABOLISM; MUTATION; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALZHEIMER DISEASE; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; MAZE LEARNING; MICE; MICE, KNOCKOUT; MICROGLIA; MUTATION; PHOSPHORYLATION; TAU PROTEINS;

EID: 85020753467     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-017-1737-3     Document Type: Article

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