TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice

Neuropharmacology

Volumn 105, Issue , 2016, Pages 196-206

  Jiang, Teng ^a,b   Zhang, Ying Dong ^a   Chen, Qi ^c   Gao, Qing ^a   Zhu, Xi Chen ^c   Zhou, Jun Shan ^a   Shi, Jian Quan ^a   Lu, Huan ^c   Tan, Lan ^c,d   Yu, Jin Tai ^b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NANJING MEDICAL UNIVERSITY   (China)

^d QINGDAO UNIVERSITY   (China)

Author keywords

Alzheimer's disease; M2 phenotype; Microglia; Neuroinflammation; Tau kinase; Tau pathology; TREM2

Indexed keywords

CYCLIN DEPENDENT KINASE 5; GLYCOGEN SYNTHASE KINASE 3BETA; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; MEMBRANE PROTEIN; PROTEIN ARG1; PROTEIN RETNLA; TAU PROTEIN; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; AUTACOID; IMMUNOGLOBULIN RECEPTOR; MAPT PROTEIN, MOUSE; TREM2 PROTEIN, MOUSE;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE EXACERBATION; ENZYME ACTIVITY; MALE; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; TASK PERFORMANCE; TAUOPATHY; ALZHEIMER DISEASE; ANIMAL; C57BL MOUSE; DISEASE MODEL; ENCEPHALITIS; EXPLORATORY BEHAVIOR; GENE VECTOR; LENTIVIRINAE; MAZE TEST; METABOLISM; PATHOLOGY; PHENOTYPE; PHOSPHORYLATION; PHYSIOLOGY; PSYCHOLOGY; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; ANIMALS; BRAIN; CYCLIN-DEPENDENT KINASE 5; DISEASE MODELS, ANIMAL; ENCEPHALITIS; EXPLORATORY BEHAVIOR; GENETIC VECTORS; GLYCOGEN SYNTHASE KINASE 3 BETA; INFLAMMATION MEDIATORS; LENTIVIRUS; MALE; MAZE LEARNING; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROGLIA; NEUROPROTECTION; PHENOTYPE; PHOSPHORYLATION; RECEPTORS, IMMUNOLOGIC; TAU PROTEINS;

EID: 84955238343     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2016.01.028     Document Type: Article

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