-
1
-
-
0018198405
-
Specific inhibition by NH4CL of autophagy-associated proteloysis in cultured fibroblasts
-
J.S. Amenta, T.J. Hlivko, A.G. McBee, H. Shinozuka, and S. Brocher Specific inhibition by NH4CL of autophagy-associated proteloysis in cultured fibroblasts Exp. Cell Res. 115 1978 357 366
-
(1978)
Exp. Cell Res.
, vol.115
, pp. 357-366
-
-
Amenta, J.S.1
Hlivko, T.J.2
McBee, A.G.3
Shinozuka, H.4
Brocher, S.5
-
2
-
-
79957916551
-
P62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects
-
B.J. Bartlett, P. Isakson, J. Lewerenz, H. Sanchez, R.W. Kotzebue, R.C. Cumming, G.L. Harris, I.P. Nezis, D.R. Schubert, A. Simonsen, and K.D. Finley P62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects Autophagy 7 2011 572 583
-
(2011)
Autophagy
, vol.7
, pp. 572-583
-
-
Bartlett, B.J.1
Isakson, P.2
Lewerenz, J.3
Sanchez, H.4
Kotzebue, R.W.5
Cumming, R.C.6
Harris, G.L.7
Nezis, I.P.8
Schubert, D.R.9
Simonsen, A.10
Finley, K.D.11
-
3
-
-
27944504351
-
P62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
-
G. Bjorkoy, T. Lamark, A. Brech, H. Outzen, M. Perander, A. Overvatn, H. Stenmark, and T. Johansen P62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death J. Cell Biol. 171 2005 603 614
-
(2005)
J. Cell Biol.
, vol.171
, pp. 603-614
-
-
Bjorkoy, G.1
Lamark, T.2
Brech, A.3
Outzen, H.4
Perander, M.5
Overvatn, A.6
Stenmark, H.7
Johansen, T.8
-
5
-
-
59349089711
-
Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin
-
C. Creppe, L. Malinouskaya, M.L. Volvert, M. Gillard, P. Close, O. Malaise, S. Laguesse, I. Cornez, S. Rahmouni, S. Ormenese, S. Belachew, B. Malgrange, J.P. Chapelle, U. Siebenlist, G. Moonen, A. Chariot, and L. Nguyen Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin Cell 136 2009 551 564
-
(2009)
Cell
, vol.136
, pp. 551-564
-
-
Creppe, C.1
Malinouskaya, L.2
Volvert, M.L.3
Gillard, M.4
Close, P.5
Malaise, O.6
Laguesse, S.7
Cornez, I.8
Rahmouni, S.9
Ormenese, S.10
Belachew, S.11
Malgrange, B.12
Chapelle, J.P.13
Siebenlist, U.14
Moonen, G.15
Chariot, A.16
Nguyen, L.17
-
7
-
-
34047175919
-
Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation
-
J.P. Dompierre, J.D. Godin, B.C. Charrin, F.P. Cordelieres, S.J. King, S. Humbert, and F. Saudou Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation J. Neurosci. 27 2007 3571 3583
-
(2007)
J. Neurosci.
, vol.27
, pp. 3571-3583
-
-
Dompierre, J.P.1
Godin, J.D.2
Charrin, B.C.3
Cordelieres, F.P.4
King, S.J.5
Humbert, S.6
Saudou, F.7
-
8
-
-
0037405043
-
Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle
-
S.C. Dryden, F.A. Nahhas, J.E. Nowak, A.S. Goustin, and M.A. Tainsky Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle Mol. Cell. Biol. 23 2003 3173 3185
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 3173-3185
-
-
Dryden, S.C.1
Nahhas, F.A.2
Nowak, J.E.3
Goustin, A.S.4
Tainsky, M.A.5
-
9
-
-
0023123336
-
A putative protein-sequestration site involving intermediate filaments for protein degradation by autophagy. Studies with transplanted Sendai-viral envelope proteins in HTC cells
-
R.T. Earl, E.H. Mangiapane, E.E. Billett, and R.J. Mayer A putative protein-sequestration site involving intermediate filaments for protein degradation by autophagy. Studies with transplanted Sendai-viral envelope proteins in HTC cells Biochem. J. 241 1987 809 815
-
(1987)
Biochem. J.
, vol.241
, pp. 809-815
-
-
Earl, R.T.1
Mangiapane, E.H.2
Billett, E.E.3
Mayer, R.J.4
-
10
-
-
41549136422
-
Paths of convergence: Sirtuins in aging and neurodegeneration
-
L. Gan, and L. Mucke Paths of convergence: sirtuins in aging and neurodegeneration Neuron 58 2008 10 14
-
(2008)
Neuron
, vol.58
, pp. 10-14
-
-
Gan, L.1
Mucke, L.2
-
11
-
-
58149267462
-
Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau
-
K.N. Green, J.S. Steffan, H. Martinez-Coria, X. Sun, S.S. Schreiber, L.M. Thompson, and F.M. LaFerla Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau J. Neurosci. 28 2008 11500 11510
-
(2008)
J. Neurosci.
, vol.28
, pp. 11500-11510
-
-
Green, K.N.1
Steffan, J.S.2
Martinez-Coria, H.3
Sun, X.4
Schreiber, S.S.5
Thompson, L.M.6
Laferla, F.M.7
-
12
-
-
53049103308
-
Structural basis for sorting mechanism of p62 in selective autophagy
-
Y. Ichimura, T. Kumanomidou, Y.S. Sou, T. Mizushima, J. Ezaki, T. Ueno, E. Kominami, T. Yamane, K. Tanaka, and M. Komatsu Structural basis for sorting mechanism of p62 in selective autophagy J. Biol. Chem. 283 2008 22847 22857
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 22847-22857
-
-
Ichimura, Y.1
Kumanomidou, T.2
Sou, Y.S.3
Mizushima, T.4
Ezaki, J.5
Ueno, T.6
Kominami, E.7
Yamane, T.8
Tanaka, K.9
Komatsu, M.10
-
13
-
-
28844475400
-
HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin
-
A. Iwata, B.E. Riley, J.A. Johnston, and R.R. Kopito HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin J. Biol. Chem. 280 2005 40282 40292
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 40282-40292
-
-
Iwata, A.1
Riley, B.E.2
Johnston, J.A.3
Kopito, R.R.4
-
14
-
-
0032576605
-
Aggresomes: A cellular response to misfolded proteins
-
J.A. Johnston, C.L. Ward, and R.R. Kopito Aggresomes: a cellular response to misfolded proteins J. Cell Biol. 143 1998 1883 1898
-
(1998)
J. Cell Biol.
, vol.143
, pp. 1883-1898
-
-
Johnston, J.A.1
Ward, C.L.2
Kopito, R.R.3
-
15
-
-
0034329418
-
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
-
Y. Kabeya, N. Mizushima, T. Ueno, A. Yamamoto, T. Kirisako, T. Noda, E. Kominami, Y. Ohsumi, and T. Yoshimori LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing EMBO J. 19 2000 5720 5728
-
(2000)
EMBO J.
, vol.19
, pp. 5720-5728
-
-
Kabeya, Y.1
Mizushima, N.2
Ueno, T.3
Yamamoto, A.4
Kirisako, T.5
Noda, T.6
Kominami, E.7
Ohsumi, Y.8
Yoshimori, T.9
-
16
-
-
0346020435
-
The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress
-
Y. Kawaguchi, J.J. Kovacs, A. McLaurin, J.M. Vance, A. Ito, and T.P. Yao The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress Cell 115 2003 727 738
-
(2003)
Cell
, vol.115
, pp. 727-738
-
-
Kawaguchi, Y.1
Kovacs, J.J.2
McLaurin, A.3
Vance, J.M.4
Ito, A.5
Yao, T.P.6
-
17
-
-
33646800306
-
Loss of autophagy in the central nervous system causes neurodegeneration in mice
-
M. Komatsu, S. Waguri, T. Chiba, S. Murata, J. Iwata, I. Tanida, T. Ueno, M. Koike, Y. Uchiyama, E. Kominami, and K. Tanaka Loss of autophagy in the central nervous system causes neurodegeneration in mice Nature 441 2006 880 884
-
(2006)
Nature
, vol.441
, pp. 880-884
-
-
Komatsu, M.1
Waguri, S.2
Chiba, T.3
Murata, S.4
Iwata, J.5
Tanida, I.6
Ueno, T.7
Koike, M.8
Uchiyama, Y.9
Kominami, E.10
Tanaka, K.11
-
18
-
-
0034578389
-
Aggresomes, inclusion bodies and protein aggregation
-
R.R. Kopito Aggresomes, inclusion bodies and protein aggregation Trends Cell Biol. 10 2000 524 530
-
(2000)
Trends Cell Biol.
, vol.10
, pp. 524-530
-
-
Kopito, R.R.1
-
19
-
-
77649337122
-
HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy
-
J.Y. Lee, H. Koga, Y. Kawaguchi, W. Tang, E. Wong, Y.S. Gao, U.B. Pandey, S. Kaushik, E. Tresse, J. Lu, J.P. Taylor, A.M. Cuervo, and T.P. Yao HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy EMBO J. 29 2010 969 980
-
(2010)
EMBO J.
, vol.29
, pp. 969-980
-
-
Lee, J.Y.1
Koga, H.2
Kawaguchi, Y.3
Tang, W.4
Wong, E.5
Gao, Y.S.6
Pandey, U.B.7
Kaushik, S.8
Tresse, E.9
Lu, J.10
Taylor, J.P.11
Cuervo, A.M.12
Yao, T.P.13
-
21
-
-
0032454039
-
Effects of amyloid precursor protein derivatives and oxidative stress on basal forebrain cholinergic systems in Alzheimer's disease
-
M.P. Mattson, and W.A. Pedersen Effects of amyloid precursor protein derivatives and oxidative stress on basal forebrain cholinergic systems in Alzheimer's disease Int. J. Dev. Neurosci. 16 1998 737 753
-
(1998)
Int. J. Dev. Neurosci.
, vol.16
, pp. 737-753
-
-
Mattson, M.P.1
Pedersen, W.A.2
-
22
-
-
80053137033
-
The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS
-
M.M. Maxwell, E.M. Tomkinson, J. Nobles, J.W. Wizeman, A.M. Amore, L. Quinti, V. Chopra, S.M. Hersch, and A.G. Kazantsev The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS Hum. Mol. Genet. 20 2011 3986 3996
-
(2011)
Hum. Mol. Genet.
, vol.20
, pp. 3986-3996
-
-
Maxwell, M.M.1
Tomkinson, E.M.2
Nobles, J.3
Wizeman, J.W.4
Amore, A.M.5
Quinti, L.6
Chopra, V.7
Hersch, S.M.8
Kazantsev, A.G.9
-
23
-
-
39849109338
-
Autophagy fights disease through cellular self-digestion
-
N. Mizushima, B. Levine, A.M. Cuervo, and D.J. Klionsky Autophagy fights disease through cellular self-digestion Nature 451 2008 1069 1075
-
(2008)
Nature
, vol.451
, pp. 1069-1075
-
-
Mizushima, N.1
Levine, B.2
Cuervo, A.M.3
Klionsky, D.J.4
-
24
-
-
0021061819
-
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
-
T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J. Immunol. Methods 65 1983 55 63
-
(1983)
J. Immunol. Methods
, vol.65
, pp. 55-63
-
-
Mosmann, T.1
-
25
-
-
0037291214
-
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase
-
B.J. North, B.L. Marshall, M.T. Borra, J.M. Denu, and E. Verdin The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase Mol. Cell 11 2003 437 444
-
(2003)
Mol. Cell
, vol.11
, pp. 437-444
-
-
North, B.J.1
Marshall, B.L.2
Borra, M.T.3
Denu, J.M.4
Verdin, E.5
-
26
-
-
34547599329
-
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease
-
T.F. Outeiro, E. Kontopoulos, S.M. Altmann, I. Kufareva, K.E. Strathearn, A.M. Amore, C.B. Volk, M.M. Maxwell, J.C. Rochet, P.J. McLean, A.B. Young, R. Abagyan, M.B. Feany, B.T. Hyman, and A.G. Kazantsev Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease Science 317 2007 516 519
-
(2007)
Science
, vol.317
, pp. 516-519
-
-
Outeiro, T.F.1
Kontopoulos, E.2
Altmann, S.M.3
Kufareva, I.4
Strathearn, K.E.5
Amore, A.M.6
Volk, C.B.7
Maxwell, M.M.8
Rochet, J.C.9
McLean, P.J.10
Young, A.B.11
Abagyan, R.12
Feany, M.B.13
Hyman, B.T.14
Kazantsev, A.G.15
-
27
-
-
34548259958
-
P62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
-
S. Pankiv, T.H. Clausen, T. Lamark, A. Brech, J.A. Bruun, H. Outzen, A. Overvatn, G. Bjorkoy, and T. Johansen P62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy J. Biol. Chem. 282 2007 24131 24145
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 24131-24145
-
-
Pankiv, S.1
Clausen, T.H.2
Lamark, T.3
Brech, A.4
Bruun, J.A.5
Outzen, H.6
Overvatn, A.7
Bjorkoy, G.8
Johansen, T.9
-
28
-
-
33750618516
-
Microtubule acetylation promotes kinesin-1 binding and transport
-
N.A. Reed, D. Cai, T.L. Blasius, G.T. Jih, E. Meyhofer, J. Gaertig, and K.J. Verhey Microtubule acetylation promotes kinesin-1 binding and transport Curr. Biol. 16 2006 2166 2172
-
(2006)
Curr. Biol.
, vol.16
, pp. 2166-2172
-
-
Reed, N.A.1
Cai, D.2
Blasius, T.L.3
Jih, G.T.4
Meyhofer, E.5
Gaertig, J.6
Verhey, K.J.7
-
29
-
-
34547875773
-
Sirtuins: Critical regulators at the crossroads between cancer and aging
-
L.R. Saunders, and E. Verdin Sirtuins: critical regulators at the crossroads between cancer and aging Oncogene 26 2007 5489 5504
-
(2007)
Oncogene
, vol.26
, pp. 5489-5504
-
-
Saunders, L.R.1
Verdin, E.2
-
30
-
-
80255141868
-
Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress
-
L. Schneider, S. Giordano, B.R. Zelickson, M. Jhonson, G. Benavides, X. Ouyang, N. Fineberg, V.M. Darley-Usmar, and J. Zhang Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress Free Radic. Biol. Med. 51 2011 2007 2017
-
(2011)
Free Radic. Biol. Med.
, vol.51
, pp. 2007-2017
-
-
Schneider, L.1
Giordano, S.2
Zelickson, B.R.3
Jhonson, M.4
Benavides, G.5
Ouyang, X.6
Fineberg, N.7
Darley-Usmar, V.M.8
Zhang, J.9
-
31
-
-
33846240526
-
Sequestosome 1/p62-more than just a scaffold
-
M.L. Seibenhener, T. Geetha, and M.W. Wooten Sequestosome 1/p62-more than just a scaffold FEBS Lett. 581 2007 175 179
-
(2007)
FEBS Lett.
, vol.581
, pp. 175-179
-
-
Seibenhener, M.L.1
Geetha, T.2
Wooten, M.W.3
-
32
-
-
0038413759
-
Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function
-
H. Snyder, K. Mensah, C. Theisler, J. Lee, A. Matouschek, and B. Wolozin Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function J. Biol. Chem. 278 2003 11753 11759
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 11753-11759
-
-
Snyder, H.1
Mensah, K.2
Theisler, C.3
Lee, J.4
Matouschek, A.5
Wolozin, B.6
-
33
-
-
0033134869
-
Aggregates in neurodegenerative disease: Crowds and power?
-
P.B. Tran, and R.J. Miller Aggregates in neurodegenerative disease: crowds and power? Trends Neurosci. 22 1999 194 197
-
(1999)
Trends Neurosci.
, vol.22
, pp. 194-197
-
-
Tran, P.B.1
Miller, R.J.2
-
34
-
-
0038309329
-
The molecular mechanism of autophagy
-
C.W. Wang, and D.J. Klionsky The molecular mechanism of autophagy Mol. Med. 9 2003 65 76
-
(2003)
Mol. Med.
, vol.9
, pp. 65-76
-
-
Wang, C.W.1
Klionsky, D.J.2
-
35
-
-
0345169048
-
Post-translational modifications regulate microtubule function
-
S. Westermann, and K. Weber Post-translational modifications regulate microtubule function Nat. Rev. Mol. Cell Biol. 4 2003 938 947
-
(2003)
Nat. Rev. Mol. Cell Biol.
, vol.4
, pp. 938-947
-
-
Westermann, S.1
Weber, K.2
-
36
-
-
33751034682
-
Aggregate-prone proteins are cleared from the cytosol by autophagy: Therapeutic implications
-
A. Williams, L. Jahreiss, S. Sarkar, S. Saiki, F.M. Menzies, B. Ravikumar, and D.C. Rubinsztein Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications Curr. Top. Dev. Biol. 76 2006 89 101
-
(2006)
Curr. Top. Dev. Biol.
, vol.76
, pp. 89-101
-
-
Williams, A.1
Jahreiss, L.2
Sarkar, S.3
Saiki, S.4
Menzies, F.M.5
Ravikumar, B.6
Rubinsztein, D.C.7
-
37
-
-
77954116814
-
Autophagy gone awry in neurodegenerative diseases
-
E. Wong, and A.M. Cuervo Autophagy gone awry in neurodegenerative diseases Nat. Neurosci. 13 2010 805 811
-
(2010)
Nat. Neurosci.
, vol.13
, pp. 805-811
-
-
Wong, E.1
Cuervo, A.M.2
-
38
-
-
78549296763
-
Acetylated microtubules are required for fusion of autophagosomes with lysosomes
-
R. Xie, S. Nguyen, W.L. McKeehan, and L. Liu Acetylated microtubules are required for fusion of autophagosomes with lysosomes BMC Cell Biol. 11 2010 89
-
(2010)
BMC Cell Biol.
, vol.11
, pp. 89
-
-
Xie, R.1
Nguyen, S.2
McKeehan, W.L.3
Liu, L.4
|