메뉴 건너뛰기




Volumn 5, Issue 12, 2014, Pages 1238-1245

Elucidating molecular mass and shape of a neurotoxic aβ oligomer

Author keywords

AFM; Alzheimer's disease; A oligomer; Neurotoxicity; NU4 antibody

Indexed keywords

AMYLOID BETA PROTEIN; MONOCLONAL ANTIBODY; OLIGOMER; ANTIBODY; IMMUNOTOXIN;

EID: 84918535270     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn500156r     Document Type: Article
Times cited : (21)

References (44)
  • 1
    • 84875354777 scopus 로고    scopus 로고
    • 2013 Alzheimer's disease facts and figures Alzheimer's Association
    • Thies, W., Bleiler, L., and Assoc, A. s. (2013) 2013 Alzheimer's disease facts and figures Alzheimer's Association. Alzheimer's Dementia 9, 208-245.
    • (2013) Alzheimer's Dementia , vol.9 , pp. 208-245
    • Thies, W.1    Bleiler, L.2
  • 2
    • 34248172449 scopus 로고    scopus 로고
    • Structure and functions of the human amyloid precursor protein: The whole is more than the sum of its parts
    • Gralle, M., and Ferreira, S. T. (2007) Structure and functions of the human amyloid precursor protein: The whole is more than the sum of its parts. Prog. Neurobiol. 82, 11-32.
    • (2007) Prog. Neurobiol. , vol.82 , pp. 11-32
    • Gralle, M.1    Ferreira, S.T.2
  • 3
    • 0035297712 scopus 로고    scopus 로고
    • Targeting small A beta oligomers: The solution to an Alzheimer's disease conundrum?
    • Klein, W. L., Krafft, G. A., and Finch, C. E. (2001) Targeting small A beta oligomers: The solution to an Alzheimer's disease conundrum? Trends Neurosci. 24, 219-224.
    • (2001) Trends Neurosci , vol.24 , pp. 219-224
    • Klein, W.L.1    Krafft, G.A.2    Finch, C.E.3
  • 4
    • 0037135111 scopus 로고    scopus 로고
    • Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy, J., and Selkoe, D. J. (2002) Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science 297, 353-356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 6
    • 77955919696 scopus 로고    scopus 로고
    • ADDLs and the signaling web that leads to Alzheimer's disease
    • Krafft, G. A., and Klein, W. L. (2010) ADDLs and the signaling web that leads to Alzheimer's disease. Neuropharmacology 59, 230-242.
    • (2010) Neuropharmacology , vol.59 , pp. 230-242
    • Krafft, G.A.1    Klein, W.L.2
  • 7
    • 84857642949 scopus 로고    scopus 로고
    • The toxic A beta oligomer and Alzheimer's disease: An emperor in need of clothes
    • Benilova, I., Karran, E., and De Strooper, B. (2012) The toxic A beta oligomer and Alzheimer's disease: An emperor in need of clothes. Nat. Neurosci. 15, 349-357.
    • (2012) Nat. Neurosci. , vol.15 , pp. 349-357
    • Benilova, I.1    Karran, E.2    De Strooper, B.3
  • 8
    • 79951761390 scopus 로고    scopus 로고
    • The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: Oligomer size or conformation?
    • Broersen, K., Rousseau, F., and Schymkowitz, J. (2010) The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: Oligomer size or conformation? Alzheimer's Res. Ther. 2, 12.
    • (2010) Alzheimer's Res. Ther. , vol.2 , pp. 12
    • Broersen, K.1    Rousseau, F.2    Schymkowitz, J.3
  • 9
    • 79960760550 scopus 로고    scopus 로고
    • An overlooked neurotoxic species in Alzheimer's disease
    • Benilova, I., and De Strooper, B. (2011) An overlooked neurotoxic species in Alzheimer's disease. Nat. Neurosci. 14, 949-950.
    • (2011) Nat. Neurosci. , vol.14 , pp. 949-950
    • Benilova, I.1    De Strooper, B.2
  • 12
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
    • Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J., and Selkoe, D. J. (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416, 535-539.
    • (2002) Nature , vol.416 , pp. 535-539
    • Walsh, D.M.1    Klyubin, I.2    Fadeeva, J.V.3    Cullen, W.K.4    Anwyl, R.5    Wolfe, M.S.6    Rowan, M.J.7    Selkoe, D.J.8
  • 16
    • 84861914969 scopus 로고    scopus 로고
    • Neurotoxicity and Memory Deficits Induced by Soluble Low-Molecular-Weight Amyloid-beta(1-42) Oligomers Are Revealed In Vivo by Using a Novel Animal Model
    • Brouillette, J., Caillierez, R., Zommer, N., Alves-Pires, C., Benilova, I., Blum, D., De Strooper, B., and Buee, L. (2012) Neurotoxicity and Memory Deficits Induced by Soluble Low-Molecular-Weight Amyloid-beta(1-42) Oligomers Are Revealed In Vivo by Using a Novel Animal Model. J. Neurosci. 32, 7852-7861.
    • (2012) J. Neurosci. , vol.32 , pp. 7852-7861
    • Brouillette, J.1    Caillierez, R.2    Zommer, N.3    Alves-Pires, C.4    Benilova, I.5    Blum, D.6    De Strooper, B.7    Buee, L.8
  • 17
    • 0042838303 scopus 로고    scopus 로고
    • Alzheimer's disease-affected brain: Presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss
    • Gong, Y. S., Chang, L., Viola, K. L., Lacor, P. N., Lambert, M. P., Finch, C. E., Krafft, G. A., and Klein, W. L. (2003) Alzheimer's disease-affected brain: Presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc. Natl. Acad. Sci. U.S.A. 100, 10417-10422.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 10417-10422
    • Gong, Y.S.1    Chang, L.2    Viola, K.L.3    Lacor, P.N.4    Lambert, M.P.5    Finch, C.E.6    Krafft, G.A.7    Klein, W.L.8
  • 20
    • 77954835300 scopus 로고    scopus 로고
    • High-molecular-weight beta-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients
    • Fukumoto, H., Tokuda, T., Kasai, T., Ishigami, N., Hidaka, H., Kondo, M., Allsop, D., and Nakagawa, M. (2010) High-molecular-weight beta-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients. FASEB J. 24, 2716-2726.
    • (2010) FASEB J. , vol.24 , pp. 2716-2726
    • Fukumoto, H.1    Tokuda, T.2    Kasai, T.3    Ishigami, N.4    Hidaka, H.5    Kondo, M.6    Allsop, D.7    Nakagawa, M.8
  • 25
    • 33645220400 scopus 로고    scopus 로고
    • Targeting amyloid-beta peptide (A beta) oligomers by passive immunization with a conformationselective monoclonal antibody improves learning and memory in A beta precursor protein (APP) transgenic mice
    • Lee, E. B., Leng, L. Z., Zhang, B., Kwong, L., Trojanowski, J. Q., Abel, T., and Lee, V. M. Y. (2006) Targeting amyloid-beta peptide (A beta) oligomers by passive immunization with a conformationselective monoclonal antibody improves learning and memory in A beta precursor protein (APP) transgenic mice. J. Biol. Chem. 281, 4292-4299.
    • (2006) J. Biol. Chem. , vol.281 , pp. 4292-4299
    • Lee, E.B.1    Leng, L.Z.2    Zhang, B.3    Kwong, L.4    Trojanowski, J.Q.5    Abel, T.6    Lee, V.M.Y.7
  • 27
    • 65649093323 scopus 로고    scopus 로고
    • Targeting Generation of Antibodies Specific to Conformational Epitopes of Amyloid beta-Derived Neurotoxins
    • Lambert, M. P., Velasco, P. T., Viola, K. L., and Klein, W. L. (2009) Targeting Generation of Antibodies Specific to Conformational Epitopes of Amyloid beta-Derived Neurotoxins. CNS Neurol. Disord.: Drug Targets 8, 65-81.
    • (2009) CNS Neurol. Disord.: Drug Targets , vol.8 , pp. 65-81
    • Lambert, M.P.1    Velasco, P.T.2    Viola, K.L.3    Klein, W.L.4
  • 28
  • 29
    • 0035993237 scopus 로고    scopus 로고
    • Abeta toxicity in Alzheimer's disease: Globular oligomers (ADDLs) as new vaccine and drug targets
    • Klein, W. L. (2002) Abeta toxicity in Alzheimer's disease: Globular oligomers (ADDLs) as new vaccine and drug targets. Neurochem. Int. 41, 345-352.
    • (2002) Neurochem. Int. , vol.41 , pp. 345-352
    • Klein, W.L.1
  • 36
    • 0034054531 scopus 로고    scopus 로고
    • High-resolution imaging of antibodies by tapping-mode atomic force microscopy: Attractive and repulsive tip-sample interaction regimes
    • San Paulo, A., and Garcia, R. (2000) High-resolution imaging of antibodies by tapping-mode atomic force microscopy: Attractive and repulsive tip-sample interaction regimes. Biophys. J. 78, 1599-1605.
    • (2000) Biophys. J. , vol.78 , pp. 1599-1605
    • San Paulo, A.1    Garcia, R.2
  • 38
    • 84913138929 scopus 로고
    • Some recently developed fractionation procedures and their application to peptide and protein hormones
    • Porath, J. (1963) Some recently developed fractionation procedures and their application to peptide and protein hormones. Pure Appl. Chem. 6, 233-244.
    • (1963) Pure Appl. Chem. , vol.6 , pp. 233-244
    • Porath, J.1
  • 39
    • 33644803646 scopus 로고    scopus 로고
    • Morphology and adhesion of biomolecules on silicon based surfaces
    • Bhushan, B., Tokachichu, D. R., Keener, M. T., and Lee, S. C. (2005) Morphology and adhesion of biomolecules on silicon based surfaces. Acta Biomater 1, 327-341.
    • (2005) Acta Biomater , vol.1 , pp. 327-341
    • Bhushan, B.1    Tokachichu, D.R.2    Keener, M.T.3    Lee, S.C.4
  • 42
    • 84859524810 scopus 로고    scopus 로고
    • Insights into the mechanism of Alzheimer's beta-amyloid aggregation as a function of concentration by using atomic force microscopy
    • Mustata, G. M., Shekhawat, G. S., Lambert, M. P., Viola, K. L., Velasco, P. T., Klein, W. L., and Dravid, V. P. (2012) Insights into the mechanism of Alzheimer's beta-amyloid aggregation as a function of concentration by using atomic force microscopy. Appl. Phys. Lett. 100, 133704.
    • (2012) Appl. Phys. Lett. , vol.100 , pp. 133704
    • Mustata, G.M.1    Shekhawat, G.S.2    Lambert, M.P.3    Viola, K.L.4    Velasco, P.T.5    Klein, W.L.6    Dravid, V.P.7
  • 44
    • 0027226219 scopus 로고
    • Optimized Survival of Hippocampal-Neurons in B27-Supplemented Neurobasal, a New Serum-Free Medium Combination
    • Brewer, G. J., Torricelli, J. R., Evege, E. K., and Price, P. J. (1993) Optimized Survival of Hippocampal-Neurons in B27-Supplemented Neurobasal, a New Serum-Free Medium Combination. J. Neurosci. Res. 35, 567-576.
    • (1993) J. Neurosci. Res. , vol.35 , pp. 567-576
    • Brewer, G.J.1    Torricelli, J.R.2    Evege, E.K.3    Price, P.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.