-
1
-
-
84865526718
-
Lifelong management of amyloid-beta metabolism to prevent Alzheimer's disease
-
Gandy S. Lifelong management of amyloid-beta metabolism to prevent Alzheimer's disease. N Engl J Med 2012; 367:864-866.
-
(2012)
N Engl J Med
, vol.367
, pp. 864-866
-
-
Gandy, S.1
-
3
-
-
84905183159
-
Immunomodulation and AD: Down but not out
-
Knight EM, Gandy S. Immunomodulation and AD: down but not out. J Clin Immunol 2014;34(suppl 1):S70-S73.
-
(2014)
J Clin Immunol
, vol.34
, pp. S70-S73
-
-
Knight, E.M.1
Gandy, S.2
-
4
-
-
0036327185
-
Human antibodies against amyloid beta peptide: A potential treatment for Alzheimer's disease
-
Dodel R, Hampel H, Depboylu C, et al. Human antibodies against amyloid beta peptide: a potential treatment for Alzheimer's disease. Ann Neurol 2002;52:253-256.
-
(2002)
Ann Neurol
, vol.52
, pp. 253-256
-
-
Dodel, R.1
Hampel, H.2
Depboylu, C.3
-
5
-
-
51749103554
-
Natural human antibodies to amyloid beta peptide
-
Szabo P, Relkin N, Weksler ME. Natural human antibodies to amyloid beta peptide. Autoimmun Rev 2008; 7:415-420.
-
(2008)
Autoimmun Rev
, vol.7
, pp. 415-420
-
-
Szabo, P.1
Relkin, N.2
Weksler, M.E.3
-
6
-
-
0036085702
-
Patients with Alzheimer disease have lower levels of serum anti-amyloid peptide antibodies than healthy elderly individuals
-
Weksler ME, Relkin N, Turkenich R, LaRusse S, Zhou L, Szabo P. Patients with Alzheimer disease have lower levels of serum anti-amyloid peptide antibodies than healthy elderly individuals. Exp Gerontol 2002; 37:943-948.
-
(2002)
Exp Gerontol
, vol.37
, pp. 943-948
-
-
Weksler, M.E.1
Relkin, N.2
Turkenich, R.3
LaRusse, S.4
Zhou, L.5
Szabo, P.6
-
7
-
-
84921474241
-
Intravenous immunoglobulin for Alzheimer's disease
-
Relkin N. Intravenous immunoglobulin for Alzheimer's disease. Clin Exp Immunol 2014;178(suppl 1):27-29.
-
(2014)
Clin Exp Immunol
, vol.178
, pp. 27-29
-
-
Relkin, N.1
-
8
-
-
78649745352
-
Human intravenous immunoglobulin provides protection against Ab toxicity by multiple mechanisms in a mouse model of Alzheimer's disease
-
Magga J, Puli L, Pihlaja R, et al. Human intravenous immunoglobulin provides protection against Ab toxicity by multiple mechanisms in a mouse model of Alzheimer's disease. J Neuroinflammation 2010;7:90.
-
(2010)
J Neuroinflammation
, vol.7
, pp. 90
-
-
Magga, J.1
Puli, L.2
Pihlaja, R.3
-
9
-
-
84861462771
-
Effects of human intravenous immunoglobulin on amyloid pathology and neuroinflammation in a mouse model of Alzheimer's disease
-
Puli L, Pomeshchik Y, Olas K, Malm T, Koistinaho J, Tanila H. Effects of human intravenous immunoglobulin on amyloid pathology and neuroinflammation in a mouse model of Alzheimer's disease. J Neuroinflammation 2012; 9:105.
-
(2012)
J Neuroinflammation
, vol.9
, pp. 105
-
-
Puli, L.1
Pomeshchik, Y.2
Olas, K.3
Malm, T.4
Koistinaho, J.5
Tanila, H.6
-
10
-
-
70049083865
-
18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease
-
Relkin NR, Szabo P, Adamiak B, et al. 18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease. Neurobiol Aging 2009;30:1728-1736.
-
(2009)
Neurobiol Aging
, vol.30
, pp. 1728-1736
-
-
Relkin, N.R.1
Szabo, P.2
Adamiak, B.3
-
11
-
-
67649268898
-
P4-351: Effects of uninterrrupted intravenous immunoglobulin treatment of Alzheimer's disease for nine months
-
Tsakanikas D, Shah K, Flores C, Assuras S, Relkin NR. P4-351: effects of uninterrrupted intravenous immunoglobulin treatment of Alzheimer's disease for nine months. Alzheimers Dement 2008;4:T776.
-
(2008)
Alzheimers Dement
, vol.4
, pp. T776
-
-
Tsakanikas, D.1
Shah, K.2
Flores, C.3
Assuras, S.4
Relkin, N.R.5
-
12
-
-
77955290621
-
Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers
-
Gandy S, Simon AJ, Steele JW, et al. Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers. Ann Neurol 2010;68:220-230.
-
(2010)
Ann Neurol
, vol.68
, pp. 220-230
-
-
Gandy, S.1
Simon, A.J.2
Steele, J.W.3
-
13
-
-
27644493692
-
Globular amyloid beta-peptide oligomer: A homogenous and stable neuropathological protein in Alzheimer's disease
-
Barghorn S, Nimmrich V, Striebinger A, et al. Globular amyloid beta-peptide oligomer: a homogenous and stable neuropathological protein in Alzheimer's disease. J Neurochem 2005;95:834-847.
-
(2005)
J Neurochem
, vol.95
, pp. 834-847
-
-
Barghorn, S.1
Nimmrich, V.2
Striebinger, A.3
-
14
-
-
0037022297
-
Conformational Abs recognizing a generic amyloid fibril epitope
-
O'Nuallain B, Wetzel R. Conformational Abs recognizing a generic amyloid fibril epitope. Proc Natl Acad Sci USA 2002;99:1485-1490.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 1485-1490
-
-
O'Nuallain, B.1
Wetzel, R.2
-
15
-
-
2342444028
-
Seeding specificity in amyloid growth induced by heterologous fibrils
-
O'Nuallain B, Williams AD, Westermark P, Wetzel R. Seeding specificity in amyloid growth induced by heterologous fibrils. J Biol Chem 2004;279:17490-17499.
-
(2004)
J Biol Chem
, vol.279
, pp. 17490-17499
-
-
O'Nuallain, B.1
Williams, A.D.2
Westermark, P.3
Wetzel, R.4
-
16
-
-
77956651669
-
Measurement of anti-beta amyloid antibodies in human blood
-
Szabo P, Mujalli DM, Rotondi ML, et al. Measurement of anti-beta amyloid antibodies in human blood. J Neuroimmunol 2010;227:167-174.
-
(2010)
J Neuroimmunol
, vol.227
, pp. 167-174
-
-
Szabo, P.1
Mujalli, D.M.2
Rotondi, M.L.3
-
17
-
-
84922243384
-
Evidence that small molecule enhancement of beta-hexosaminidase activity corrects the behavioral phenotype in Dutch APP (E693Q) mice through reduction of ganglioside-bound Abeta
-
Knight EM, Williams HN, Stevens AC, et al. Evidence that small molecule enhancement of beta-hexosaminidase activity corrects the behavioral phenotype in Dutch APP (E693Q) mice through reduction of ganglioside-bound Abeta. Mol Psychiatry 2015;20:109-117.
-
(2015)
Mol Psychiatry
, vol.20
, pp. 109-117
-
-
Knight, E.M.1
Williams, H.N.2
Stevens, A.C.3
-
18
-
-
84899898904
-
High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathology
-
Knight EM, Martins IV, Gumusgoz S, Allan SM, Lawrence CB. High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathology. Neurobiol Aging 2014;35:1821-1832.
-
(2014)
Neurobiol Aging
, vol.35
, pp. 1821-1832
-
-
Knight, E.M.1
Martins, I.V.2
Gumusgoz, S.3
Allan, S.M.4
Lawrence, C.B.5
-
19
-
-
84881178228
-
Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model
-
Steele JW, Lachenmayer ML, Ju S, et al. Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Mol Psychiatry 2013; 18:889-897.
-
(2013)
Mol Psychiatry
, vol.18
, pp. 889-897
-
-
Steele, J.W.1
Lachenmayer, M.L.2
Ju, S.3
-
20
-
-
33645520634
-
Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease
-
Jacobsen JS, Wu CC, Redwine JM, et al. Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 2006;103:5161-5166.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 5161-5166
-
-
Jacobsen, J.S.1
Wu, C.C.2
Redwine, J.M.3
-
21
-
-
67349172517
-
Spatial navigation testing discriminates two types of amnestic mild cognitive impairment
-
Laczo J, Vlcek K, Vyhnalek M, et al. Spatial navigation testing discriminates two types of amnestic mild cognitive impairment. Behav Brain Res 2009;202:252-259.
-
(2009)
Behav Brain Res
, vol.202
, pp. 252-259
-
-
Laczo, J.1
Vlcek, K.2
Vyhnalek, M.3
-
22
-
-
34447315525
-
Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo
-
Gandy S, Zhang YW, Ikin A, et al. Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo. J Neurochem 2007;102:619-626.
-
(2007)
J Neurochem
, vol.102
, pp. 619-626
-
-
Gandy, S.1
Zhang, Y.W.2
Ikin, A.3
-
23
-
-
84908498932
-
Proneurogenic group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Abeta oligomer mouse
-
Kim SH, Steele JW, Lee SW, et al. Proneurogenic group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Abeta oligomer mouse. Mol Psychiatry 2014; 19:1235-1242.
-
(2014)
Mol Psychiatry
, vol.19
, pp. 1235-1242
-
-
Kim, S.H.1
Steele, J.W.2
Lee, S.W.3
-
24
-
-
77949905345
-
Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formation
-
Wu JW, Breydo L, Isas JM, et al. Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formation. J Biol Chem 2010;285:6071-6079.
-
(2010)
J Biol Chem
, vol.285
, pp. 6071-6079
-
-
Wu, J.W.1
Breydo, L.2
Isas, J.M.3
-
25
-
-
68149162581
-
Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction
-
Tomic JL, Pensalfini A, Head E, Glabe CG. Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction. Neurobiol Dis 2009;35:352-358.
-
(2009)
Neurobiol Dis
, vol.35
, pp. 352-358
-
-
Tomic, J.L.1
Pensalfini, A.2
Head, E.3
Glabe, C.G.4
-
26
-
-
84937640921
-
Quaternary structure defines a large class of amyloid-beta oligomers neutralized by sequestration
-
Liu P, Reed MN, Kotilinek LA, et al. Quaternary structure defines a large class of amyloid-beta oligomers neutralized by sequestration. Cell Rep 2015;11:1760-1771.
-
(2015)
Cell Rep
, vol.11
, pp. 1760-1771
-
-
Liu, P.1
Reed, M.N.2
Kotilinek, L.A.3
-
27
-
-
84863859181
-
Low PiB PET retention in presence of pathologic CSF biomarkers in Arctic APP mutation carriers
-
Scholl M, Wall A, Thordardottir S, et al. Low PiB PET retention in presence of pathologic CSF biomarkers in Arctic APP mutation carriers. Neurology 2012;79:229-236.
-
(2012)
Neurology
, vol.79
, pp. 229-236
-
-
Scholl, M.1
Wall, A.2
Thordardottir, S.3
-
28
-
-
84946762413
-
Molecular systems evaluation of oligomerogenic APP and fibrillogenic APP/PSEN1 mouse models identifies shared features with human Alzheimer's brain molecular pathology
-
Epub 2016 Jan 19
-
Readhead B, Haure-Mirande JV, Zhang B, et al. Molecular systems evaluation of oligomerogenic APP and fibrillogenic APP/PSEN1 mouse models identifies shared features with human Alzheimer's brain molecular pathology. Mol Psychiatry Epub 2016 Jan 19.
-
Mol Psychiatry
-
-
Readhead, B.1
Haure-Mirande, J.V.2
Zhang, B.3
-
29
-
-
84925867468
-
Neuroinflammatory signals in Alzheimer disease and APP/PS1 transgenic mice: Correlations with plaques, tangles, and oligomeric species
-
Lopez-Gonzalez I, Schluter A, Aso E, et al. Neuroinflammatory signals in Alzheimer disease and APP/PS1 transgenic mice: correlations with plaques, tangles, and oligomeric species. J Neuropathol Exp Neurol 2015;74:319-344.
-
(2015)
J Neuropathol Exp Neurol
, vol.74
, pp. 319-344
-
-
Lopez-Gonzalez, I.1
Schluter, A.2
Aso, E.3
-
30
-
-
79955758133
-
Naturally occurring autoantibodies against beta-amyloid: Investigating their role in transgenic animal and in vitro models of Alzheimer's disease
-
Dodel R, Balakrishnan K, Keyvani K, et al. Naturally occurring autoantibodies against beta-amyloid: investigating their role in transgenic animal and in vitro models of Alzheimer's disease. J Neurosci 2011;31:5847-5854.
-
(2011)
J Neurosci
, vol.31
, pp. 5847-5854
-
-
Dodel, R.1
Balakrishnan, K.2
Keyvani, K.3
-
31
-
-
84881108511
-
IVIG immunotherapy protects against synaptic dysfunction in Alzheimer's disease through complement anaphylatoxin C5a-mediated AMPA-CREB-C/EBP signaling pathway
-
Gong B, Pan Y, Zhao W, et al. IVIG immunotherapy protects against synaptic dysfunction in Alzheimer's disease through complement anaphylatoxin C5a-mediated AMPA-CREB-C/EBP signaling pathway. Mol Immunol 2013;56:619-629.
-
(2013)
Mol Immunol
, vol.56
, pp. 619-629
-
-
Gong, B.1
Pan, Y.2
Zhao, W.3
-
32
-
-
73149090992
-
Antibody concentrations to Abeta1-42 monomer and soluble oligomers in untreated and antibody-antigendissociated intravenous immunoglobulin preparations
-
Klaver AC, Finke JM, Digambaranath J, Balasubramaniam M, Loeffler DA. Antibody concentrations to Abeta1-42 monomer and soluble oligomers in untreated and antibody-antigendissociated intravenous immunoglobulin preparations. Int Immunopharmacol 2010;10:115-119.
-
(2010)
Int Immunopharmacol
, vol.10
, pp. 115-119
-
-
Klaver, A.C.1
Finke, J.M.2
Digambaranath, J.3
Balasubramaniam, M.4
Loeffler, D.A.5
-
33
-
-
33746419618
-
Intravenous immunoglobulin enhances the clearance of fibrillar amyloid-beta peptide
-
Istrin G, Bosis E, Solomon B. Intravenous immunoglobulin enhances the clearance of fibrillar amyloid-beta peptide. J Neurosci Res 2006;84:434-443.
-
(2006)
J Neurosci Res
, vol.84
, pp. 434-443
-
-
Istrin, G.1
Bosis, E.2
Solomon, B.3
-
34
-
-
84897386461
-
IVIg protects the 3xTg-AD mouse model of Alzheimer's disease from memory deficit and Abeta pathology
-
St-Amour I, Pare I, Tremblay C, Coulombe K, Bazin R, Calon F. IVIg protects the 3xTg-AD mouse model of Alzheimer's disease from memory deficit and Abeta pathology. J Neuroinflammation 2014;11:54.
-
(2014)
J Neuroinflammation
, vol.11
, pp. 54
-
-
St-Amour, I.1
Pare, I.2
Tremblay, C.3
Coulombe, K.4
Bazin, R.5
Calon, F.6
-
35
-
-
84940173429
-
An N-terminal antibody promotes the transformation of amyloid fibrils into oligomers and enhances the neurotoxicity of amyloidbeta: The dust-raising effect
-
Liu YH, Bu XL, Liang CR, et al. An N-terminal antibody promotes the transformation of amyloid fibrils into oligomers and enhances the neurotoxicity of amyloidbeta: the dust-raising effect. J Neuroinflammation 2015; 12:153.
-
(2015)
J Neuroinflammation
, vol.12
, pp. 153
-
-
Liu, Y.H.1
Bu, X.L.2
Liang, C.R.3
-
37
-
-
84905184129
-
Clinical trials of intravenous immunoglobulin for Alzheimer's disease
-
Relkin N. Clinical trials of intravenous immunoglobulin for Alzheimer's disease. J Clin Immunol 2014;34(suppl 1): S74-S79.
-
(2014)
J Clin Immunol
, vol.34
, pp. S74-S79
-
-
Relkin, N.1
-
38
-
-
84911453499
-
Monoclonal antibodies against Abeta42 fibrils distinguish multiple aggregation state polymorphisms in vitro and in Alzheimer disease brain
-
Hatami A, Albay R III, Monjazeb S, Milton S, Glabe C. Monoclonal antibodies against Abeta42 fibrils distinguish multiple aggregation state polymorphisms in vitro and in Alzheimer disease brain. J Biol Chem 2014;289: 32131-32143.
-
(2014)
J Biol Chem
, vol.289
, pp. 32131-32143
-
-
Hatami, A.1
Albay, R.2
Monjazeb, S.3
Milton, S.4
Glabe, C.5
-
39
-
-
33846135452
-
Monoclonal antibodies that target pathological assemblies of Abeta
-
Lambert MP, Velasco PT, Chang L, et al. Monoclonal antibodies that target pathological assemblies of Abeta. J Neurochem 2007;100:23-35.
-
(2007)
J Neurochem
, vol.100
, pp. 23-35
-
-
Lambert, M.P.1
Velasco, P.T.2
Chang, L.3
-
40
-
-
0242668337
-
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
-
Kayed R, Head E, Thompson JL, et al. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 2003;300:486-489.
-
(2003)
Science
, vol.300
, pp. 486-489
-
-
Kayed, R.1
Head, E.2
Thompson, J.L.3
|