Acamprosate in a mouse model of fragile X syndrome: Modulation of spontaneous cortical activity, ERK1/2 activation, locomotor behavior, and anxiety

Journal of Neurodevelopmental Disorders

Volumn 9, Issue 1, 2017, Pages

  Schaefer, Tori L ^a   Davenport, Matthew H ^a   Grainger, Lindsay M ^a   Robinson, Chandler K ^a   Earnheart, Anthony T ^a   Stegman, Melinda S ^a,c   Lang, Anna L ^a,d   Ashworth, Amy A ^a,e   Molinaro, Gemma ^b   Huber, Kimberly M ^b   Erickson, Craig A ^a  

^a CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^d University of Louisville School of Medicine   (United States)

^e BlackbookHR   (United States)

Author keywords

Anxiety; Dendritic spine density; Electrophysiology; Extracellular signal related kinase; Fragile X syndrome; Hippocampus; Hyperactivity; Open field; Striatum

Indexed keywords

ACAMPROSATE; CALCIUM CHLORIDE; CALCIUM ION; FRAGILE X MENTAL RETARDATION PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3;

ADULT; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; AUDIOGENIC SEIZURE; BRAIN CORTEX; BRAIN ELECTROPHYSIOLOGY; BRAIN TISSUE; CELL DENSITY; CONTROLLED STUDY; DENDRITIC SPINE; DENTATE GYRUS; DRUG MECHANISM; ELEVATED ZERO MAZE TEST; ENZYME ACTIVATION; FEMALE; FRAGILE X SYNDROME; HABITUATION; LOCOMOTION; MALE; MOUSE; NEOCORTEX; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; PREPULSE INHIBITION; PRIORITY JOURNAL;

EID: 85020726449     PISSN: 18661947     EISSN: 18661955     Source Type: Journal    
DOI: 10.1186/s11689-017-9184-y     Document Type: Article

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