NNZ-2566, a Novel Analog of (1–3) IGF-1, as a Potential Therapeutic Agent for Fragile X Syndrome

NeuroMolecular Medicine

Volumn 17, Issue 1, 2015, Pages 71-82

  Deacon, Robert M J ^a   Glass, Larry ^b   Snape, Mike ^c   Hurley, Michael J ^d   Altimiras, Francisco J ^e   Biekofsky, Rodolfo R ^a   Cogram, Patricia ^a,f  

^a NEURO DVI LLP   (United Kingdom)

^b Neuren Pharmaceuticals   (Australia)

^c Autism Therapeutics   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF CHILE   (Chile)

^f Fraunhofer Chile Research Foundation   (Chile)

Author keywords

Behavior; Biomarkers; Fragile X syndrome; Insulin growth factor 1; NNZ 2566

Indexed keywords

FRAGILE X MENTAL RETARDATION PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NNZ 2566; PROTEIN KINASE B; SOMATOMEDIN C DERIVATIVE; UNCLASSIFIED DRUG; AKT1 PROTEIN, MOUSE; FMR1 PROTEIN, MOUSE; NERVE PROTEIN; NEUROPROTECTIVE AGENT; OLIGOPEPTIDE; SOMATOMEDIN C; TROFINETIDE;

AMNESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DENDRITIC SPINE; FMR1 GENE; FRAGILE X SYNDROME; HUMAN; HYPERACTIVITY; IN VITRO STUDY; IN VIVO STUDY; LEARNING DISORDER; MACROORCHIDISM; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SOCIAL INTERACTION; ANIMAL; ANXIETY; BRAIN; C57BL MOUSE; CONDITIONED REFLEX; CONGENITAL MALFORMATION; DENDRITE; DRUG EFFECTS; DRUG SCREENING; EXPLORATORY BEHAVIOR; FEAR; GENETICS; HUMAN RELATION; KNOCKOUT MOUSE; MALE; MAZE TEST; METABOLISM; NESTING; PATHOPHYSIOLOGY; PHYSIOLOGY; TESTIS; ULTRASTRUCTURE;

ANIMALS; ANXIETY; BRAIN; CONDITIONING, CLASSICAL; DENDRITES; DRUG EVALUATION, PRECLINICAL; EXPLORATORY BEHAVIOR; FEAR; FRAGILE X MENTAL RETARDATION PROTEIN; FRAGILE X SYNDROME; INSULIN-LIKE GROWTH FACTOR I; INTERPERSONAL RELATIONS; MALE; MAP KINASE SIGNALING SYSTEM; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; NESTING BEHAVIOR; NEUROPROTECTIVE AGENTS; OLIGOPEPTIDES; PROTO-ONCOGENE PROTEINS C-AKT; TESTIS;

EID: 84925514207     PISSN: 15351084     EISSN: 15591174     Source Type: Journal    
DOI: 10.1007/s12017-015-8341-2     Document Type: Article

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