Activation of ERK/MAP kinase in the amygdala is required for memory consolidation of Pavlovian fear conditioning

Journal of Neuroscience

Volumn 20, Issue 21, 2000, Pages 8177-8187

  Schafe, G E ^a   Atkins, C M ^a   Swank, M W ^a   Bauer, E P ^a   Sweatt, J D ^a   Ledoux, J E ^a  

^a NEW YORK UNIVERSITY   (United States)

Author keywords

Amygdala; ERK; Fear conditioning; Learning; LTP; MAPK

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUDITORY STIMULATION; CONDITIONING; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEAR; LONG TERM MEMORY; MALE; MEMORY CONSOLIDATION; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SHOCK; SHORT TERM MEMORY; SIGNAL TRANSDUCTION;

EID: 0034331242     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-21-08177.2000     Document Type: Article

References (48)

1. Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory
2. The MAPK cascade is required for mammalian associative learning
3. Acquisition of fear conditioning in rats requires the synthesis of mRNA in the amygdala
4. Specific and differential activation of mitogen-activated protein kinase cascades by unfamiliar taste in the insular cortex of the behaving rat
5. A mitogen-activated protein kinase cascade in the CA1/CA2 subfield of the dorsal hippocampus is essential for long-term spatial memory
6. Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
7. Different training procedures recruit either one or two critical periods for contextual memory consolidation, each of which requires protein synthesis and PKA
8. A role for the Ras signaling pathway in synaptic transmission and long-term memory
9. Long-term synaptic potentiation in the amygdala
10. Synaptic plasticity in fear conditioning circuits: Induction of LTP in the lateral nucleus of the amygdala by stimulation of the medial geniculate body
11. p42/44 MAP kinase inhibitor PD098059 attenuates multiple forms of synaptic plasticity in rat dentate gyrus in vitro
12. Activation of p42 mitogen-activated protein kinase in hippocampal long-term potentiation
13. A requirement for the mitogen-activated protein kinase cascade in hippocampal long-term potentiation
14. Identification of a novel inhibitor of mitogen-activated protein kinase kinase
15. The neuroanatomical and neurochemical basis of conditioned fear
16. CREB: A mediator of long-term memory from mollusks to mammals
17. Antisense oligodeoxynucleotide-mediated disruption of hippocampal cAMP response element binding protein levels impairs consolidation of memory for water maze training
18. Postsynaptic induction and PKA-dependent expression of LTP in the lateral amygdala
19. Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning
20. 2+ stimulation of CREB-dependent transcription and ERK nuclear translocation
21. Making new connections: Role of ERK/MAP kinase signaling in neuronal plasticity
22. The extracellular signal-regulated kinase cascade is required for NMDA receptor-independent LTP in area CA1 but not area CA3 of the hippocampus
23. Spaced training induces normal long-term memory in CREB mutant mice
24. A kinase to remember: Dual roles for MAP kinase in long-term memory
25. cAMP response element-binding protein in the amygdala is required for long- but not short-term conditioned taste aversion memory
26. Emotion circuits in the brain
27. Topographic organization of neurons in acoustic thalamus that project to the amygdala
28. Specific induction of early growth response gene 1 in the lateral nucleus of the amygdala following contextual fear conditioning in rats
29. Long-term potentiation in the amygdala: A mechanism for emotional learning and memory
30. Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs
31. MAP kinase translocates into the nucleus of the presynaptic cell and is required for long-term facilitation in Aplysia
32. Fear conditioning induces a lasting potentiation of synaptic currents in vitro
33. Is the Ras-MAPK signalling pathway necessary for long-term memory formation?
34. The mitogen-activated protein kinase cascade couples PKA and PKC to cAMP response element binding protein phosphorylation in area CA1 of hippocampus
35. LTP is accompanied by commensurate enhancement of auditory-evoked responses in a fear conditioning circuit
36. Fear conditioning induces associative long-term potentiation in the amygdala
37. Immediate-early gene expression in the amygdala following footshock stress and contextual fear conditioning
38. Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of ras
39. Memory consolidation of auditory Pavlovian fear conditioning requires protein synthesis and PKA in the amygdala
40. Memory consolidation for contextual and auditory fear memory is dependent on protein synthesis, PKA, and MAP kinase
41. A necessity for MAP kinase activation in mammalian spatial learning
42. Action potential initiation and backpropagation in neurons of the mammalian CNS
43. Phosphorylation of MAP kinase and CREB in mouse cortex and amygdala during taste aversion learning
44. Pharmacological antagonism of tyrosine kinases and MAP kinase in brainstem blocks taste aversion learning in mice
45. L-type voltage-gated calcium channels mediate NMDA-independent associative long-term potentiation at thalamic input synapses to the amygdala
46. Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila
47. CREB as a memory modulator: Induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila