Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function

Journal of Neuroscience

Volumn 28, Issue 27, 2008, Pages 6983-6995

  Samuels, Ivy S ^a   Karlo, J Colleen ^a   Faruzzi, Alicia N ^b   Pickering, Kathryn ^c   Herrup, Karl ^d   Sweatt, J David ^b   Saitta, Sulagna C ^c   Landreth, Gary E ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b University of Alabama at Birmingham   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d RUTGERS UNIVERSITY   (United States)

Author keywords

Associative learning; Cortical development; Intermediate progenitor cell; MAP kinase; Neural progenitor cell; Neurogenesis

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BRAIN CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CHROMOSOME 22Q; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; GENE DELETION; GLIA CELL; GROWTH RETARDATION; MALE; MICROCEPHALY; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; STATE DEPENDENT LEARNING; STEM CELL; ANIMAL; BRAIN CORTEX; CELL COMMUNICATION; CELL CULTURE; CELL LINEAGE; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; LEARNING DISORDER; METABOLISM; MOUSE MUTANT; NERVE CELL; NEWBORN; PATHOPHYSIOLOGY; PHYSIOLOGY; PRENATAL DEVELOPMENT; SIGNAL TRANSDUCTION;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CELLS, CULTURED; CEREBRAL CORTEX; COGNITION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LEARNING DISORDERS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 1; NEURONS; STEM CELLS;

EID: 49049085537     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0679-08.2008     Document Type: Article

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