Selective disruption of metabotropic glutamate receptor 5-homer interactions mimics phenotypes of fragile X syndrome in mice

Journal of Neuroscience

Volumn 36, Issue 7, 2016, Pages 2131-2147

  Guo, Weirui ^a   Molinaro, Gemma ^a   Collins, Katie A ^a   Hays, Seth A ^a   Paylor, Richard ^c   Worley, Paul F ^d   Szumlinski, Karen K ^b   Huber, Kimberly M ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Fragile X syndrome; Homer; LTD; mGluR5; Protein synthesis; UP states

Indexed keywords

3,5 DIHYDROXYPHENYLGLYCINE; FRAGILE X MENTAL RETARDATION 1 PROTEIN; INITIATION FACTOR 4E; INITIATION FACTOR 4E BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 5; MITOGEN ACTIVATED PROTEIN KINASE; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN; PROTEIN HOMER 1A; S6 KINASE; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAIN 3 PROTEIN; SYNAPSIN I; UNCLASSIFIED DRUG; CARRIER PROTEIN; FMR1 PROTEIN, MOUSE; FRAGILE X MENTAL RETARDATION PROTEIN; GRM5 PROTEIN, MOUSE; HOMER SCAFFOLDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; AUDIOGENIC SEIZURE; BEHAVIOR DISORDER; BRAIN TISSUE; COIMMUNOPRECIPITATION; CONTROLLED STUDY; ELEVATED PLUS MAZE TEST; FEMALE; FORCED SWIM TEST; FRAGILE X SYNDROME; GENE DELETION; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; LONG TERM DEPRESSION; MALE; MOUSE; NERVE CELL PLASTICITY; NERVE EXCITABILITY; NONHUMAN; PHENOTYPE; POSTSYNAPTIC DENSITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SENSORY GATING; SIGNAL TRANSDUCTION; TRANSLATION INITIATION; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; GENE TARGETING; GENETICS; IN VITRO STUDY; KNOCKOUT MOUSE; METABOLISM; NEOCORTEX; PATHOPHYSIOLOGY; SEIZURE;

ANIMALS; CARRIER PROTEINS; FRAGILE X MENTAL RETARDATION PROTEIN; FRAGILE X SYNDROME; GENE KNOCK-IN TECHNIQUES; HOMER SCAFFOLDING PROTEINS; IN VITRO TECHNIQUES; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOCORTEX; PHENOTYPE; RECEPTOR, METABOTROPIC GLUTAMATE 5; SEIZURES; SENSORY GATING;

EID: 84959419746     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2921-15.2016     Document Type: Article

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