메뉴 건너뛰기




Volumn 27, Issue 9, 2017, Pages 645-657

Serine and Functional Metabolites in Cancer

Author keywords

cancer; functional metabolites; one carbon metabolism; serine metabolism

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARBON; NUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; S ADENOSYLMETHIONINE; SERINE;

EID: 85020450794     PISSN: 09628924     EISSN: 18793088     Source Type: Journal    
DOI: 10.1016/j.tcb.2017.05.001     Document Type: Review
Times cited : (125)

References (59)
  • 1
    • 84955326448 scopus 로고    scopus 로고
    • The emerging hallmarks of cancer metabolism
    • Pavlova, N.N., Thompson, C.B., The emerging hallmarks of cancer metabolism. Cell Metab. 23 (2016), 27–47.
    • (2016) Cell Metab. , vol.23 , pp. 27-47
    • Pavlova, N.N.1    Thompson, C.B.2
  • 2
    • 78651010566 scopus 로고
    • Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid
    • Farber, S., Diamond, L.K., Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid. N. Engl. J. Med. 238 (1948), 787–793.
    • (1948) N. Engl. J. Med. , vol.238 , pp. 787-793
    • Farber, S.1    Diamond, L.K.2
  • 3
    • 77955616558 scopus 로고    scopus 로고
    • Compartmentalization of mammalian folate-mediated one-carbon metabolism
    • Tibbetts, A.S., Appling, D.R., Compartmentalization of mammalian folate-mediated one-carbon metabolism. Annu. Rev. Nutr. 30 (2010), 57–81.
    • (2010) Annu. Rev. Nutr. , vol.30 , pp. 57-81
    • Tibbetts, A.S.1    Appling, D.R.2
  • 4
    • 72249114913 scopus 로고    scopus 로고
    • One-carbon metabolism-genome interactions in folate-associated pathologies
    • Stover, P.J., One-carbon metabolism-genome interactions in folate-associated pathologies. J. Nutr. 139 (2009), 2402–2405.
    • (2009) J. Nutr. , vol.139 , pp. 2402-2405
    • Stover, P.J.1
  • 5
    • 84959280789 scopus 로고    scopus 로고
    • Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells
    • Hosios, A.M., et al. Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells. Dev. Cell 36 (2016), 540–549.
    • (2016) Dev. Cell , vol.36 , pp. 540-549
    • Hosios, A.M.1
  • 6
    • 0942265677 scopus 로고    scopus 로고
    • Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor
    • Davis, S.R., et al. Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor. Am. J. Physiol. Endocrinol. Metab. 286 (2004), E272–E279.
    • (2004) Am. J. Physiol. Endocrinol. Metab. , vol.286 , pp. E272-E279
    • Davis, S.R.1
  • 7
    • 84975455372 scopus 로고    scopus 로고
    • Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway
    • Ducker, G.S., et al. Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway. Cell Metab. 23 (2016), 1140–1153.
    • (2016) Cell Metab. , vol.23 , pp. 1140-1153
    • Ducker, G.S.1
  • 8
    • 84901263663 scopus 로고    scopus 로고
    • Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells
    • Labuschagne, C.F., et al. Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells. Cell Rep. 7 (2014), 1248–1258.
    • (2014) Cell Rep. , vol.7 , pp. 1248-1258
    • Labuschagne, C.F.1
  • 9
    • 84957427247 scopus 로고    scopus 로고
    • Serine metabolism supports the methionine cycle and DNA/RNA methylation through de novo ATP synthesis in cancer cells
    • Maddocks, O.D., et al. Serine metabolism supports the methionine cycle and DNA/RNA methylation through de novo ATP synthesis in cancer cells. Mol. Cell 61 (2016), 210–221.
    • (2016) Mol. Cell , vol.61 , pp. 210-221
    • Maddocks, O.D.1
  • 10
    • 84912139448 scopus 로고    scopus 로고
    • Characterization of the usage of the serine metabolic network in human cancer
    • Mehrmohamadi, M., et al. Characterization of the usage of the serine metabolic network in human cancer. Cell Rep. 9 (2014), 1507–1519.
    • (2014) Cell Rep. , vol.9 , pp. 1507-1519
    • Mehrmohamadi, M.1
  • 11
    • 84980041497 scopus 로고    scopus 로고
    • The importance of serine metabolism in cancer
    • Mattaini, K.R., et al. The importance of serine metabolism in cancer. J. Cell Biol. 214 (2016), 249–257.
    • (2016) J. Cell Biol. , vol.214 , pp. 249-257
    • Mattaini, K.R.1
  • 12
    • 84982710922 scopus 로고    scopus 로고
    • PHGDH expression is required for mitochondrial redox homeostasis, breast cancer stem cell maintenance, and lung metastasis
    • Samanta, D., et al. PHGDH expression is required for mitochondrial redox homeostasis, breast cancer stem cell maintenance, and lung metastasis. Cancer Res. 76 (2016), 4430–4442.
    • (2016) Cancer Res. , vol.76 , pp. 4430-4442
    • Samanta, D.1
  • 13
    • 84975247161 scopus 로고    scopus 로고
    • Mitochondrial dysfunction remodels one-carbon metabolism in human cells
    • Bao, X.R., et al. Mitochondrial dysfunction remodels one-carbon metabolism in human cells. Elife, 5, 2016, e10575.
    • (2016) Elife , vol.5 , pp. e10575
    • Bao, X.R.1
  • 14
    • 84881177291 scopus 로고    scopus 로고
    • Serine, glycine and one-carbon units: cancer metabolism in full circle
    • Locasale, J.W., Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat. Rev. Cancer 13 (2013), 572–583.
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 572-583
    • Locasale, J.W.1
  • 15
    • 84897392385 scopus 로고    scopus 로고
    • Serine and glycine metabolism in cancer
    • Amelio, I., et al. Serine and glycine metabolism in cancer. Trends Biochem. Sci. 39 (2014), 191–198.
    • (2014) Trends Biochem. Sci. , vol.39 , pp. 191-198
    • Amelio, I.1
  • 16
    • 84994772445 scopus 로고    scopus 로고
    • One-carbon metabolism in health and disease
    • Ducker, G.S., Rabinowitz, J.D., One-carbon metabolism in health and disease. Cell Metab. 25 (2016), 27–42.
    • (2016) Cell Metab. , vol.25 , pp. 27-42
    • Ducker, G.S.1    Rabinowitz, J.D.2
  • 17
    • 84988431514 scopus 로고    scopus 로고
    • Serine and one-carbon metabolism in cancer
    • Yang, M., Vousden, K.H., Serine and one-carbon metabolism in cancer. Nat. Rev. Cancer 16 (2016), 650–662.
    • (2016) Nat. Rev. Cancer , vol.16 , pp. 650-662
    • Yang, M.1    Vousden, K.H.2
  • 18
    • 84955456527 scopus 로고    scopus 로고
    • Division of labour: how does folate metabolism partition between one-carbon metabolism and amino acid oxidation?
    • Brosnan, M.E., et al. Division of labour: how does folate metabolism partition between one-carbon metabolism and amino acid oxidation?. Biochem. J. 472 (2015), 135–146.
    • (2015) Biochem. J. , vol.472 , pp. 135-146
    • Brosnan, M.E.1
  • 19
    • 84872905650 scopus 로고    scopus 로고
    • Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
    • Maddocks, O.D., et al. Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature 493 (2013), 542–546.
    • (2013) Nature , vol.493 , pp. 542-546
    • Maddocks, O.D.1
  • 20
    • 85018159283 scopus 로고    scopus 로고
    • Modulating the therapeutic response of tumours to dietary serine and glycine starvation
    • Maddocks, O.D.K., et al. Modulating the therapeutic response of tumours to dietary serine and glycine starvation. Nature 544 (2017), 372–376.
    • (2017) Nature , vol.544 , pp. 372-376
    • Maddocks, O.D.K.1
  • 21
    • 78650996423 scopus 로고    scopus 로고
    • Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis
    • Pollari, S., et al. Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis. Breast Cancer Res. Treat. 125 (2011), 421–430.
    • (2011) Breast Cancer Res. Treat. , vol.125 , pp. 421-430
    • Pollari, S.1
  • 22
    • 84974727436 scopus 로고    scopus 로고
    • Chromatin-bound MDM2 regulates serine metabolism and redox homeostasis independently of p53
    • Riscal, R., et al. Chromatin-bound MDM2 regulates serine metabolism and redox homeostasis independently of p53. Mol. Cell 62 (2016), 890–902.
    • (2016) Mol. Cell , vol.62 , pp. 890-902
    • Riscal, R.1
  • 23
    • 84861420588 scopus 로고    scopus 로고
    • Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation
    • Jain, M., et al. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science 336 (2012), 1040–1044.
    • (2012) Science , vol.336 , pp. 1040-1044
    • Jain, M.1
  • 24
    • 84878396462 scopus 로고    scopus 로고
    • Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
    • Commisso, C., et al. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature 497 (2013), 633–637.
    • (2013) Nature , vol.497 , pp. 633-637
    • Commisso, C.1
  • 25
    • 84961288972 scopus 로고    scopus 로고
    • Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein
    • Kamphorst, J.J., et al. Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Res. 75 (2015), 544–553.
    • (2015) Cancer Res. , vol.75 , pp. 544-553
    • Kamphorst, J.J.1
  • 26
    • 84926252071 scopus 로고    scopus 로고
    • Autophagy in maligant transformation and cancer progression
    • Galluzzi, L., et al. Autophagy in maligant transformation and cancer progression. EMBO J. 34 (2015), 856–880.
    • (2015) EMBO J. , vol.34 , pp. 856-880
    • Galluzzi, L.1
  • 27
    • 84984704073 scopus 로고    scopus 로고
    • Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion
    • Sousa, C.M., et al. Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature 536 (2016), 479–483.
    • (2016) Nature , vol.536 , pp. 479-483
    • Sousa, C.M.1
  • 28
    • 84869082905 scopus 로고    scopus 로고
    • Serine is a natural ligand and allosteric activator of pyruvate kinase M2
    • Chaneton, B., et al. Serine is a natural ligand and allosteric activator of pyruvate kinase M2. Nature 491 (2012), 458–462.
    • (2012) Nature , vol.491 , pp. 458-462
    • Chaneton, B.1
  • 29
    • 84860793042 scopus 로고    scopus 로고
    • Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
    • Ye, J., et al. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proc. Natl. Acad. Sci. U. S. A. 109 (2012), 6904–6909.
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. 6904-6909
    • Ye, J.1
  • 30
    • 0014409133 scopus 로고
    • The mechanism of end product inhibition of serine biosynthesis. I. Purification and kinetics of phosphoglycerate dehydrogenase
    • Sugimoto, E., Pizer, L.I., The mechanism of end product inhibition of serine biosynthesis. I. Purification and kinetics of phosphoglycerate dehydrogenase. J. Biol. Chem. 243 (1968), 2081–2089.
    • (1968) J. Biol. Chem. , vol.243 , pp. 2081-2089
    • Sugimoto, E.1    Pizer, L.I.2
  • 31
    • 0022360016 scopus 로고
    • Enzymes of serine metabolism in normal and neoplastic rat tissues
    • Snell, K., Enzymes of serine metabolism in normal and neoplastic rat tissues. Biochim. Biophys. Acta 843 (1985), 276–281.
    • (1985) Biochim. Biophys. Acta , vol.843 , pp. 276-281
    • Snell, K.1
  • 32
    • 80051923932 scopus 로고    scopus 로고
    • Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
    • Possemato, R., et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 476 (2011), 346–350.
    • (2011) Nature , vol.476 , pp. 346-350
    • Possemato, R.1
  • 33
    • 80052258995 scopus 로고    scopus 로고
    • Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
    • Locasale, J.W., et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat. Genet. 43 (2011), 869–874.
    • (2011) Nat. Genet. , vol.43 , pp. 869-874
    • Locasale, J.W.1
  • 34
    • 84856087055 scopus 로고    scopus 로고
    • Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis
    • Zhang, W.C., et al. Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell 148 (2012), 259–272.
    • (2012) Cell , vol.148 , pp. 259-272
    • Zhang, W.C.1
  • 35
    • 84964216448 scopus 로고    scopus 로고
    • A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate
    • Pacold, M.E., et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat. Chem. Biol. 12 (2016), 452–458.
    • (2016) Nat. Chem. Biol. , vol.12 , pp. 452-458
    • Pacold, M.E.1
  • 36
    • 84959449345 scopus 로고    scopus 로고
    • Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers
    • Mullarky, E., et al. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proc. Natl. Acad. Sci. U. S. A. 113 (2016), 1778–1783.
    • (2016) Proc. Natl. Acad. Sci. U. S. A. , vol.113 , pp. 1778-1783
    • Mullarky, E.1
  • 37
    • 85009391338 scopus 로고    scopus 로고
    • Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity
    • Wang, Q., et al. Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem. Biol. 24 (2016), 55–65.
    • (2016) Cell Chem. Biol. , vol.24 , pp. 55-65
    • Wang, Q.1
  • 38
    • 84891913582 scopus 로고    scopus 로고
    • Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth
    • Chen, J., et al. Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth. Oncotarget 4 (2013), 2502–2511.
    • (2013) Oncotarget , vol.4 , pp. 2502-2511
    • Chen, J.1
  • 39
    • 84949102276 scopus 로고    scopus 로고
    • NRF2 regulates serine biosynthesis in non-small cell lung cancer
    • DeNicola, G.M., et al. NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nat. Genet. 47 (2015), 1475–1481.
    • (2015) Nat. Genet. , vol.47 , pp. 1475-1481
    • DeNicola, G.M.1
  • 40
    • 84953327405 scopus 로고    scopus 로고
    • KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism
    • Zhao, E., et al. KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism. Cell Rep. 14 (2016), 506–519.
    • (2016) Cell Rep. , vol.14 , pp. 506-519
    • Zhao, E.1
  • 41
    • 84889684498 scopus 로고    scopus 로고
    • The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation
    • Ding, J., et al. The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation. Cell Metab. 18 (2013), 896–907.
    • (2013) Cell Metab. , vol.18 , pp. 896-907
    • Ding, J.1
  • 42
    • 79960060305 scopus 로고    scopus 로고
    • Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
    • DeNicola, G.M., et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 475 (2011), 106–109.
    • (2011) Nature , vol.475 , pp. 106-109
    • DeNicola, G.M.1
  • 43
    • 84957899529 scopus 로고    scopus 로고
    • mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
    • Ben-Sahra, I., et al. mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle. Science 351 (2016), 728–733.
    • (2016) Science , vol.351 , pp. 728-733
    • Ben-Sahra, I.1
  • 44
    • 84920540540 scopus 로고    scopus 로고
    • p53 Protein-mediated regulation of phosphoglycerate dehydrogenase (PHGDH) is crucial for the apoptotic response upon serine starvation
    • Ou, Y., et al. p53 Protein-mediated regulation of phosphoglycerate dehydrogenase (PHGDH) is crucial for the apoptotic response upon serine starvation. J. Biol. Chem. 290 (2015), 457–466.
    • (2015) J. Biol. Chem. , vol.290 , pp. 457-466
    • Ou, Y.1
  • 45
    • 84996554610 scopus 로고    scopus 로고
    • LKB1 loss links serine metabolism to DNA methylation and tumorigenesis
    • Kottakis, F., et al. LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature 539 (2016), 390–395.
    • (2016) Nature , vol.539 , pp. 390-395
    • Kottakis, F.1
  • 46
    • 85007566411 scopus 로고    scopus 로고
    • Transforming growth factor (TGF)-β promotes de novo serine synthesis for collagen production
    • Nigdelioglu, R., et al. Transforming growth factor (TGF)-β promotes de novo serine synthesis for collagen production. J. Biol. Chem. 291 (2016), 27239–27251.
    • (2016) J. Biol. Chem. , vol.291 , pp. 27239-27251
    • Nigdelioglu, R.1
  • 47
    • 84897414311 scopus 로고    scopus 로고
    • Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer
    • Nilsson, R., et al. Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer. Nat. Commun., 5, 2014, 3128.
    • (2014) Nat. Commun. , vol.5 , pp. 3128
    • Nilsson, R.1
  • 48
    • 84904504373 scopus 로고    scopus 로고
    • Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells
    • Lewis, C.A., et al. Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells. Mol. Cell 55 (2014), 253–263.
    • (2014) Mol. Cell , vol.55 , pp. 253-263
    • Lewis, C.A.1
  • 49
    • 85041012891 scopus 로고    scopus 로고
    • Serine one-carbon catabolism with formate overflow
    • Meiser, J., et al. Serine one-carbon catabolism with formate overflow. Sci. Adv., 2, 2016, e1601273.
    • (2016) Sci. Adv. , vol.2 , pp. e1601273
    • Meiser, J.1
  • 50
    • 84915746768 scopus 로고    scopus 로고
    • Serine catabolism regulates mitochondrial redox control during hypoxia
    • Ye, J., et al. Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov. 4 (2014), 1406–1417.
    • (2014) Cancer Discov. , vol.4 , pp. 1406-1417
    • Ye, J.1
  • 51
    • 80355129300 scopus 로고    scopus 로고
    • Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation
    • Vazquez, A., et al. Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation. PLoS One, 6, 2011, e25881.
    • (2011) PLoS One , vol.6 , pp. e25881
    • Vazquez, A.1
  • 52
    • 84948412126 scopus 로고    scopus 로고
    • Histone methylation dynamics and gene regulation occur through the sensing of one-carbon metabolism
    • Mentch, S.J., et al. Histone methylation dynamics and gene regulation occur through the sensing of one-carbon metabolism. Cell Metab. 22 (2015), 861–873.
    • (2015) Cell Metab. , vol.22 , pp. 861-873
    • Mentch, S.J.1
  • 53
    • 77957366305 scopus 로고    scopus 로고
    • DNA methylation and cancer
    • Kulis, M., Esteller, M., DNA methylation and cancer. Adv. Genet. 70 (2010), 27–56.
    • (2010) Adv. Genet. , vol.70 , pp. 27-56
    • Kulis, M.1    Esteller, M.2
  • 54
    • 84898814417 scopus 로고    scopus 로고
    • Gene expression regulation mediated through reversible mA RNA methylation
    • Fu, Y., et al. Gene expression regulation mediated through reversible mA RNA methylation. Nat. Rev. Genet. 15 (2014), 293–306.
    • (2014) Nat. Rev. Genet. , vol.15 , pp. 293-306
    • Fu, Y.1
  • 55
    • 48649091869 scopus 로고    scopus 로고
    • Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia
    • Kikuchi, G., et al. Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia. Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 84 (2008), 246–263.
    • (2008) Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. , vol.84 , pp. 246-263
    • Kikuchi, G.1
  • 56
    • 84928395993 scopus 로고    scopus 로고
    • SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
    • Kim, D., et al. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature 520 (2015), 363–367.
    • (2015) Nature , vol.520 , pp. 363-367
    • Kim, D.1
  • 57
    • 0032723334 scopus 로고    scopus 로고
    • Dietary glycine prevents the development of liver tumors caused by the peroxisome proliferator WY-14,643
    • Rose, M.L., et al. Dietary glycine prevents the development of liver tumors caused by the peroxisome proliferator WY-14,643. Carcinogenesis 20 (1999), 2075–2081.
    • (1999) Carcinogenesis , vol.20 , pp. 2075-2081
    • Rose, M.L.1
  • 58
    • 0032902830 scopus 로고    scopus 로고
    • Dietary glycine inhibits the growth of B16 melanoma tumors in mice
    • Rose, M.L., et al. Dietary glycine inhibits the growth of B16 melanoma tumors in mice. Carcinogenesis 20 (1999), 793–798.
    • (1999) Carcinogenesis , vol.20 , pp. 793-798
    • Rose, M.L.1
  • 59
    • 84861824545 scopus 로고    scopus 로고
    • The nutrigenetics and nutrigenomics of the dietary requirement for choline
    • Corbin, K.D., Zeisel, S.H., The nutrigenetics and nutrigenomics of the dietary requirement for choline. Prog. Mol. Biol. Transl. Sci. 108 (2012), 159–177.
    • (2012) Prog. Mol. Biol. Transl. Sci. , vol.108 , pp. 159-177
    • Corbin, K.D.1    Zeisel, S.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.