-
1
-
-
84955326448
-
The emerging hallmarks of cancer metabolism
-
Pavlova, N.N., Thompson, C.B., The emerging hallmarks of cancer metabolism. Cell Metab. 23 (2016), 27–47.
-
(2016)
Cell Metab.
, vol.23
, pp. 27-47
-
-
Pavlova, N.N.1
Thompson, C.B.2
-
2
-
-
78651010566
-
Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid
-
Farber, S., Diamond, L.K., Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid. N. Engl. J. Med. 238 (1948), 787–793.
-
(1948)
N. Engl. J. Med.
, vol.238
, pp. 787-793
-
-
Farber, S.1
Diamond, L.K.2
-
3
-
-
77955616558
-
Compartmentalization of mammalian folate-mediated one-carbon metabolism
-
Tibbetts, A.S., Appling, D.R., Compartmentalization of mammalian folate-mediated one-carbon metabolism. Annu. Rev. Nutr. 30 (2010), 57–81.
-
(2010)
Annu. Rev. Nutr.
, vol.30
, pp. 57-81
-
-
Tibbetts, A.S.1
Appling, D.R.2
-
4
-
-
72249114913
-
One-carbon metabolism-genome interactions in folate-associated pathologies
-
Stover, P.J., One-carbon metabolism-genome interactions in folate-associated pathologies. J. Nutr. 139 (2009), 2402–2405.
-
(2009)
J. Nutr.
, vol.139
, pp. 2402-2405
-
-
Stover, P.J.1
-
5
-
-
84959280789
-
Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells
-
Hosios, A.M., et al. Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells. Dev. Cell 36 (2016), 540–549.
-
(2016)
Dev. Cell
, vol.36
, pp. 540-549
-
-
Hosios, A.M.1
-
6
-
-
0942265677
-
Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor
-
Davis, S.R., et al. Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor. Am. J. Physiol. Endocrinol. Metab. 286 (2004), E272–E279.
-
(2004)
Am. J. Physiol. Endocrinol. Metab.
, vol.286
, pp. E272-E279
-
-
Davis, S.R.1
-
7
-
-
84975455372
-
Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway
-
Ducker, G.S., et al. Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway. Cell Metab. 23 (2016), 1140–1153.
-
(2016)
Cell Metab.
, vol.23
, pp. 1140-1153
-
-
Ducker, G.S.1
-
8
-
-
84901263663
-
Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells
-
Labuschagne, C.F., et al. Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells. Cell Rep. 7 (2014), 1248–1258.
-
(2014)
Cell Rep.
, vol.7
, pp. 1248-1258
-
-
Labuschagne, C.F.1
-
9
-
-
84957427247
-
Serine metabolism supports the methionine cycle and DNA/RNA methylation through de novo ATP synthesis in cancer cells
-
Maddocks, O.D., et al. Serine metabolism supports the methionine cycle and DNA/RNA methylation through de novo ATP synthesis in cancer cells. Mol. Cell 61 (2016), 210–221.
-
(2016)
Mol. Cell
, vol.61
, pp. 210-221
-
-
Maddocks, O.D.1
-
10
-
-
84912139448
-
Characterization of the usage of the serine metabolic network in human cancer
-
Mehrmohamadi, M., et al. Characterization of the usage of the serine metabolic network in human cancer. Cell Rep. 9 (2014), 1507–1519.
-
(2014)
Cell Rep.
, vol.9
, pp. 1507-1519
-
-
Mehrmohamadi, M.1
-
11
-
-
84980041497
-
The importance of serine metabolism in cancer
-
Mattaini, K.R., et al. The importance of serine metabolism in cancer. J. Cell Biol. 214 (2016), 249–257.
-
(2016)
J. Cell Biol.
, vol.214
, pp. 249-257
-
-
Mattaini, K.R.1
-
12
-
-
84982710922
-
PHGDH expression is required for mitochondrial redox homeostasis, breast cancer stem cell maintenance, and lung metastasis
-
Samanta, D., et al. PHGDH expression is required for mitochondrial redox homeostasis, breast cancer stem cell maintenance, and lung metastasis. Cancer Res. 76 (2016), 4430–4442.
-
(2016)
Cancer Res.
, vol.76
, pp. 4430-4442
-
-
Samanta, D.1
-
13
-
-
84975247161
-
Mitochondrial dysfunction remodels one-carbon metabolism in human cells
-
Bao, X.R., et al. Mitochondrial dysfunction remodels one-carbon metabolism in human cells. Elife, 5, 2016, e10575.
-
(2016)
Elife
, vol.5
, pp. e10575
-
-
Bao, X.R.1
-
14
-
-
84881177291
-
Serine, glycine and one-carbon units: cancer metabolism in full circle
-
Locasale, J.W., Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat. Rev. Cancer 13 (2013), 572–583.
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 572-583
-
-
Locasale, J.W.1
-
15
-
-
84897392385
-
Serine and glycine metabolism in cancer
-
Amelio, I., et al. Serine and glycine metabolism in cancer. Trends Biochem. Sci. 39 (2014), 191–198.
-
(2014)
Trends Biochem. Sci.
, vol.39
, pp. 191-198
-
-
Amelio, I.1
-
16
-
-
84994772445
-
One-carbon metabolism in health and disease
-
Ducker, G.S., Rabinowitz, J.D., One-carbon metabolism in health and disease. Cell Metab. 25 (2016), 27–42.
-
(2016)
Cell Metab.
, vol.25
, pp. 27-42
-
-
Ducker, G.S.1
Rabinowitz, J.D.2
-
17
-
-
84988431514
-
Serine and one-carbon metabolism in cancer
-
Yang, M., Vousden, K.H., Serine and one-carbon metabolism in cancer. Nat. Rev. Cancer 16 (2016), 650–662.
-
(2016)
Nat. Rev. Cancer
, vol.16
, pp. 650-662
-
-
Yang, M.1
Vousden, K.H.2
-
18
-
-
84955456527
-
Division of labour: how does folate metabolism partition between one-carbon metabolism and amino acid oxidation?
-
Brosnan, M.E., et al. Division of labour: how does folate metabolism partition between one-carbon metabolism and amino acid oxidation?. Biochem. J. 472 (2015), 135–146.
-
(2015)
Biochem. J.
, vol.472
, pp. 135-146
-
-
Brosnan, M.E.1
-
19
-
-
84872905650
-
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
-
Maddocks, O.D., et al. Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature 493 (2013), 542–546.
-
(2013)
Nature
, vol.493
, pp. 542-546
-
-
Maddocks, O.D.1
-
20
-
-
85018159283
-
Modulating the therapeutic response of tumours to dietary serine and glycine starvation
-
Maddocks, O.D.K., et al. Modulating the therapeutic response of tumours to dietary serine and glycine starvation. Nature 544 (2017), 372–376.
-
(2017)
Nature
, vol.544
, pp. 372-376
-
-
Maddocks, O.D.K.1
-
21
-
-
78650996423
-
Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis
-
Pollari, S., et al. Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis. Breast Cancer Res. Treat. 125 (2011), 421–430.
-
(2011)
Breast Cancer Res. Treat.
, vol.125
, pp. 421-430
-
-
Pollari, S.1
-
22
-
-
84974727436
-
Chromatin-bound MDM2 regulates serine metabolism and redox homeostasis independently of p53
-
Riscal, R., et al. Chromatin-bound MDM2 regulates serine metabolism and redox homeostasis independently of p53. Mol. Cell 62 (2016), 890–902.
-
(2016)
Mol. Cell
, vol.62
, pp. 890-902
-
-
Riscal, R.1
-
23
-
-
84861420588
-
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation
-
Jain, M., et al. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science 336 (2012), 1040–1044.
-
(2012)
Science
, vol.336
, pp. 1040-1044
-
-
Jain, M.1
-
24
-
-
84878396462
-
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
-
Commisso, C., et al. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature 497 (2013), 633–637.
-
(2013)
Nature
, vol.497
, pp. 633-637
-
-
Commisso, C.1
-
25
-
-
84961288972
-
Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein
-
Kamphorst, J.J., et al. Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Res. 75 (2015), 544–553.
-
(2015)
Cancer Res.
, vol.75
, pp. 544-553
-
-
Kamphorst, J.J.1
-
26
-
-
84926252071
-
Autophagy in maligant transformation and cancer progression
-
Galluzzi, L., et al. Autophagy in maligant transformation and cancer progression. EMBO J. 34 (2015), 856–880.
-
(2015)
EMBO J.
, vol.34
, pp. 856-880
-
-
Galluzzi, L.1
-
27
-
-
84984704073
-
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion
-
Sousa, C.M., et al. Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature 536 (2016), 479–483.
-
(2016)
Nature
, vol.536
, pp. 479-483
-
-
Sousa, C.M.1
-
28
-
-
84869082905
-
Serine is a natural ligand and allosteric activator of pyruvate kinase M2
-
Chaneton, B., et al. Serine is a natural ligand and allosteric activator of pyruvate kinase M2. Nature 491 (2012), 458–462.
-
(2012)
Nature
, vol.491
, pp. 458-462
-
-
Chaneton, B.1
-
29
-
-
84860793042
-
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
-
Ye, J., et al. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proc. Natl. Acad. Sci. U. S. A. 109 (2012), 6904–6909.
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. 6904-6909
-
-
Ye, J.1
-
30
-
-
0014409133
-
The mechanism of end product inhibition of serine biosynthesis. I. Purification and kinetics of phosphoglycerate dehydrogenase
-
Sugimoto, E., Pizer, L.I., The mechanism of end product inhibition of serine biosynthesis. I. Purification and kinetics of phosphoglycerate dehydrogenase. J. Biol. Chem. 243 (1968), 2081–2089.
-
(1968)
J. Biol. Chem.
, vol.243
, pp. 2081-2089
-
-
Sugimoto, E.1
Pizer, L.I.2
-
31
-
-
0022360016
-
Enzymes of serine metabolism in normal and neoplastic rat tissues
-
Snell, K., Enzymes of serine metabolism in normal and neoplastic rat tissues. Biochim. Biophys. Acta 843 (1985), 276–281.
-
(1985)
Biochim. Biophys. Acta
, vol.843
, pp. 276-281
-
-
Snell, K.1
-
32
-
-
80051923932
-
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
-
Possemato, R., et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 476 (2011), 346–350.
-
(2011)
Nature
, vol.476
, pp. 346-350
-
-
Possemato, R.1
-
33
-
-
80052258995
-
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
-
Locasale, J.W., et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat. Genet. 43 (2011), 869–874.
-
(2011)
Nat. Genet.
, vol.43
, pp. 869-874
-
-
Locasale, J.W.1
-
34
-
-
84856087055
-
Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis
-
Zhang, W.C., et al. Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell 148 (2012), 259–272.
-
(2012)
Cell
, vol.148
, pp. 259-272
-
-
Zhang, W.C.1
-
35
-
-
84964216448
-
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate
-
Pacold, M.E., et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat. Chem. Biol. 12 (2016), 452–458.
-
(2016)
Nat. Chem. Biol.
, vol.12
, pp. 452-458
-
-
Pacold, M.E.1
-
36
-
-
84959449345
-
Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers
-
Mullarky, E., et al. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proc. Natl. Acad. Sci. U. S. A. 113 (2016), 1778–1783.
-
(2016)
Proc. Natl. Acad. Sci. U. S. A.
, vol.113
, pp. 1778-1783
-
-
Mullarky, E.1
-
37
-
-
85009391338
-
Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity
-
Wang, Q., et al. Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem. Biol. 24 (2016), 55–65.
-
(2016)
Cell Chem. Biol.
, vol.24
, pp. 55-65
-
-
Wang, Q.1
-
38
-
-
84891913582
-
Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth
-
Chen, J., et al. Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth. Oncotarget 4 (2013), 2502–2511.
-
(2013)
Oncotarget
, vol.4
, pp. 2502-2511
-
-
Chen, J.1
-
39
-
-
84949102276
-
NRF2 regulates serine biosynthesis in non-small cell lung cancer
-
DeNicola, G.M., et al. NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nat. Genet. 47 (2015), 1475–1481.
-
(2015)
Nat. Genet.
, vol.47
, pp. 1475-1481
-
-
DeNicola, G.M.1
-
40
-
-
84953327405
-
KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism
-
Zhao, E., et al. KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism. Cell Rep. 14 (2016), 506–519.
-
(2016)
Cell Rep.
, vol.14
, pp. 506-519
-
-
Zhao, E.1
-
41
-
-
84889684498
-
The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation
-
Ding, J., et al. The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation. Cell Metab. 18 (2013), 896–907.
-
(2013)
Cell Metab.
, vol.18
, pp. 896-907
-
-
Ding, J.1
-
42
-
-
79960060305
-
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
-
DeNicola, G.M., et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 475 (2011), 106–109.
-
(2011)
Nature
, vol.475
, pp. 106-109
-
-
DeNicola, G.M.1
-
43
-
-
84957899529
-
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
-
Ben-Sahra, I., et al. mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle. Science 351 (2016), 728–733.
-
(2016)
Science
, vol.351
, pp. 728-733
-
-
Ben-Sahra, I.1
-
44
-
-
84920540540
-
p53 Protein-mediated regulation of phosphoglycerate dehydrogenase (PHGDH) is crucial for the apoptotic response upon serine starvation
-
Ou, Y., et al. p53 Protein-mediated regulation of phosphoglycerate dehydrogenase (PHGDH) is crucial for the apoptotic response upon serine starvation. J. Biol. Chem. 290 (2015), 457–466.
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 457-466
-
-
Ou, Y.1
-
45
-
-
84996554610
-
LKB1 loss links serine metabolism to DNA methylation and tumorigenesis
-
Kottakis, F., et al. LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature 539 (2016), 390–395.
-
(2016)
Nature
, vol.539
, pp. 390-395
-
-
Kottakis, F.1
-
46
-
-
85007566411
-
Transforming growth factor (TGF)-β promotes de novo serine synthesis for collagen production
-
Nigdelioglu, R., et al. Transforming growth factor (TGF)-β promotes de novo serine synthesis for collagen production. J. Biol. Chem. 291 (2016), 27239–27251.
-
(2016)
J. Biol. Chem.
, vol.291
, pp. 27239-27251
-
-
Nigdelioglu, R.1
-
47
-
-
84897414311
-
Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer
-
Nilsson, R., et al. Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer. Nat. Commun., 5, 2014, 3128.
-
(2014)
Nat. Commun.
, vol.5
, pp. 3128
-
-
Nilsson, R.1
-
48
-
-
84904504373
-
Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells
-
Lewis, C.A., et al. Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells. Mol. Cell 55 (2014), 253–263.
-
(2014)
Mol. Cell
, vol.55
, pp. 253-263
-
-
Lewis, C.A.1
-
49
-
-
85041012891
-
Serine one-carbon catabolism with formate overflow
-
Meiser, J., et al. Serine one-carbon catabolism with formate overflow. Sci. Adv., 2, 2016, e1601273.
-
(2016)
Sci. Adv.
, vol.2
, pp. e1601273
-
-
Meiser, J.1
-
50
-
-
84915746768
-
Serine catabolism regulates mitochondrial redox control during hypoxia
-
Ye, J., et al. Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov. 4 (2014), 1406–1417.
-
(2014)
Cancer Discov.
, vol.4
, pp. 1406-1417
-
-
Ye, J.1
-
51
-
-
80355129300
-
Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation
-
Vazquez, A., et al. Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation. PLoS One, 6, 2011, e25881.
-
(2011)
PLoS One
, vol.6
, pp. e25881
-
-
Vazquez, A.1
-
52
-
-
84948412126
-
Histone methylation dynamics and gene regulation occur through the sensing of one-carbon metabolism
-
Mentch, S.J., et al. Histone methylation dynamics and gene regulation occur through the sensing of one-carbon metabolism. Cell Metab. 22 (2015), 861–873.
-
(2015)
Cell Metab.
, vol.22
, pp. 861-873
-
-
Mentch, S.J.1
-
53
-
-
77957366305
-
DNA methylation and cancer
-
Kulis, M., Esteller, M., DNA methylation and cancer. Adv. Genet. 70 (2010), 27–56.
-
(2010)
Adv. Genet.
, vol.70
, pp. 27-56
-
-
Kulis, M.1
Esteller, M.2
-
54
-
-
84898814417
-
Gene expression regulation mediated through reversible mA RNA methylation
-
Fu, Y., et al. Gene expression regulation mediated through reversible mA RNA methylation. Nat. Rev. Genet. 15 (2014), 293–306.
-
(2014)
Nat. Rev. Genet.
, vol.15
, pp. 293-306
-
-
Fu, Y.1
-
55
-
-
48649091869
-
Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia
-
Kikuchi, G., et al. Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia. Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 84 (2008), 246–263.
-
(2008)
Proc. Jpn. Acad. Ser. B Phys. Biol. Sci.
, vol.84
, pp. 246-263
-
-
Kikuchi, G.1
-
56
-
-
84928395993
-
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
-
Kim, D., et al. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature 520 (2015), 363–367.
-
(2015)
Nature
, vol.520
, pp. 363-367
-
-
Kim, D.1
-
57
-
-
0032723334
-
Dietary glycine prevents the development of liver tumors caused by the peroxisome proliferator WY-14,643
-
Rose, M.L., et al. Dietary glycine prevents the development of liver tumors caused by the peroxisome proliferator WY-14,643. Carcinogenesis 20 (1999), 2075–2081.
-
(1999)
Carcinogenesis
, vol.20
, pp. 2075-2081
-
-
Rose, M.L.1
-
58
-
-
0032902830
-
Dietary glycine inhibits the growth of B16 melanoma tumors in mice
-
Rose, M.L., et al. Dietary glycine inhibits the growth of B16 melanoma tumors in mice. Carcinogenesis 20 (1999), 793–798.
-
(1999)
Carcinogenesis
, vol.20
, pp. 793-798
-
-
Rose, M.L.1
-
59
-
-
84861824545
-
The nutrigenetics and nutrigenomics of the dietary requirement for choline
-
Corbin, K.D., Zeisel, S.H., The nutrigenetics and nutrigenomics of the dietary requirement for choline. Prog. Mol. Biol. Transl. Sci. 108 (2012), 159–177.
-
(2012)
Prog. Mol. Biol. Transl. Sci.
, vol.108
, pp. 159-177
-
-
Corbin, K.D.1
Zeisel, S.H.2
|