-
1
-
-
52649107626
-
Cancer cell metabolism: Warburg and beyond
-
Hsu PP and Sabatini DM. Cancer cell metabolism: Warburg and beyond. Cell. 2008; 134(5):703-707.
-
(2008)
Cell.
, vol.134
, Issue.5
, pp. 703-707
-
-
Hsu, P.P.1
Sabatini, D.M.2
-
2
-
-
61849135453
-
Tumor suppressors and cell metabolism: a recipe for cancer growth
-
Jones RG and Thompson CB. Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes&development. 2009; 23(5):537-548.
-
(2009)
Genes&development.
, vol.23
, Issue.5
, pp. 537-548
-
-
Jones, R.G.1
Thompson, C.B.2
-
3
-
-
0021191196
-
Enzymes of serine metabolism in normal, developing and neoplastic rat tissues
-
Snell K. Enzymes of serine metabolism in normal, developing and neoplastic rat tissues. Advances in enzyme regulation. 1984; 22:325-400.
-
(1984)
Advances in enzyme regulation.
, vol.22
, pp. 325-400
-
-
Snell, K.1
-
4
-
-
0030890811
-
Cloning, sequencing and expression of rat liver 3-phosphoglycerate dehydrogenase
-
Achouri Y, Rider MH, Schaftingen EV and Robbi M. Cloning, sequencing and expression of rat liver 3-phosphoglycerate dehydrogenase. The Biochemical journal. 1997; 323 ( Pt 2):365-370.
-
(1997)
The Biochemical journal
, vol.323
, Issue.PART 2
, pp. 365-370
-
-
Achouri, Y.1
Rider, M.H.2
Schaftingen, E.V.3
Robbi, M.4
-
5
-
-
0013784861
-
Purification and properties of chicken liver D-3-phosphoglycerate dehydrogenase
-
Walsh DA and Sallach HJ. Purification and properties of chicken liver D-3-phosphoglycerate dehydrogenase. Biochemistry. 1965; 4(6):1076-1085.
-
(1965)
Biochemistry.
, vol.4
, Issue.6
, pp. 1076-1085
-
-
Walsh, D.A.1
Sallach, H.J.2
-
6
-
-
0014541341
-
Phosphoserine phosphatase distribution in normal and neoplastic rat tissues
-
Knox WE, Herzfeld A and Hudson J. Phosphoserine phosphatase distribution in normal and neoplastic rat tissues. Archives of biochemistry and biophysics. 1969; 132(2):397-403.
-
(1969)
Archives of biochemistry and biophysics.
, vol.132
, Issue.2
, pp. 397-403
-
-
Knox, W.E.1
Herzfeld, A.2
Hudson, J.3
-
7
-
-
0021991106
-
The reactions of the phosphorylated pathway of L-serine biosynthesis: thermodynamic relationships in rabbit liver in vivo
-
Lund K, Merrill DK and Guynn RW. The reactions of the phosphorylated pathway of L-serine biosynthesis: thermodynamic relationships in rabbit liver in vivo. Archives of biochemistry and biophysics. 1985; 237(1):186-196.
-
(1985)
Archives of biochemistry and biophysics.
, vol.237
, Issue.1
, pp. 186-196
-
-
Lund, K.1
Merrill, D.K.2
Guynn, R.W.3
-
8
-
-
80051923932
-
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
-
Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, Barretina J, et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature. 2011; 476(7360):346-350.
-
(2011)
Nature.
, vol.476
, Issue.7360
, pp. 346-350
-
-
Possemato, R.1
Marks, K.M.2
Shaul, Y.D.3
Pacold, M.E.4
Kim, D.5
Birsoy, K.6
Sethumadhavan, S.7
Woo, H.K.8
Jang, H.G.9
Jha, A.K.10
Chen, W.W.11
Barrett, F.G.12
Stransky, N.13
Tsun, Z.Y.14
Cowley, G.S.15
Barretina, J.16
-
9
-
-
80052258995
-
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
-
Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, Beroukhim R, et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nature genetics. 2011; 43(9):869-874.
-
(2011)
Nature genetics.
, vol.43
, Issue.9
, pp. 869-874
-
-
Locasale, J.W.1
Grassian, A.R.2
Melman, T.3
Lyssiotis, C.A.4
Mattaini, K.R.5
Bass, A.J.6
Heffron, G.7
Metallo, C.M.8
Muranen, T.9
Sharfi, H.10
Sasaki, A.T.11
Anastasiou, D.12
Mullarky, E.13
Vokes, N.I.14
Sasaki, M.15
Beroukhim, R.16
-
10
-
-
84875797484
-
Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention
-
Fan M, Pfeffer SR, Lynch HT, Cassidy P, Leachman S, Pfeffer LM and Kopelovich L. Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention. Oncotarget. 2013; 4(1):128-141.
-
(2013)
Oncotarget.
, vol.4
, Issue.1
, pp. 128-141
-
-
Fan, M.1
Pfeffer, S.R.2
Lynch, H.T.3
Cassidy, P.4
Leachman, S.5
Pfeffer, L.M.6
Kopelovich, L.7
-
11
-
-
84873318679
-
Control of nutrient stress-induced metabolic reprogramming by PKCzeta in tumorigenesis
-
Ma L, Tao Y, Duran A, Llado V, Galvez A, Barger JF, Castilla EA, Chen J, Yajima T, Porollo A, Medvedovic M, Brill LM, Plas DR, Riedl SJ, Leitges M, Diaz-Meco MT, et al. Control of nutrient stress-induced metabolic reprogramming by PKCzeta in tumorigenesis. Cell. 2013; 152(3):599-611.
-
(2013)
Cell.
, vol.152
, Issue.3
, pp. 599-611
-
-
Ma, L.1
Tao, Y.2
Duran, A.3
Llado, V.4
Galvez, A.5
Barger, J.F.6
Castilla, E.A.7
Chen, J.8
Yajima, T.9
Porollo, A.10
Medvedovic, M.11
Brill, L.M.12
Plas, D.R.13
Riedl, S.J.14
Leitges, M.15
Diaz-Meco, M.T.16
-
12
-
-
79958103961
-
Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells
-
Mazurek S. Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells. The international journal of biochemistry&cell biology. 2011; 43(7):969-980.
-
(2011)
The international journal of biochemistry&cell biology.
, vol.43
, Issue.7
, pp. 969-980
-
-
Mazurek, S.1
-
13
-
-
40749163248
-
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
-
Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL and Cantley LC. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature. 2008; 452(7184):230-233.
-
(2008)
Nature.
, vol.452
, Issue.7184
, pp. 230-233
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Harris, M.H.3
Ramanathan, A.4
Gerszten, R.E.5
Wei, R.6
Fleming, M.D.7
Schreiber, S.L.8
Cantley, L.C.9
-
15
-
-
79959342440
-
PKM2 and the tricky balance of growth and energy in cancer
-
Macintyre AN and Rathmell JC. PKM2 and the tricky balance of growth and energy in cancer. Molecular cell. 2011; 42(6):713-714.
-
(2011)
Molecular cell.
, vol.42
, Issue.6
, pp. 713-714
-
-
Macintyre, A.N.1
Rathmell, J.C.2
-
16
-
-
79959371914
-
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth
-
Lv L, Li D, Zhao D, Lin R, Chu Y, Zhang H, Zha Z, Liu Y, Li Z, Xu Y, Wang G, Huang Y, Xiong Y, Guan KL and Lei QY. Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Molecular cell. 2011; 42(6):719-730.
-
(2011)
Molecular cell.
, vol.42
, Issue.6
, pp. 719-730
-
-
Lv, L.1
Li, D.2
Zhao, D.3
Lin, R.4
Chu, Y.5
Zhang, H.6
Zha, Z.7
Liu, Y.8
Li, Z.9
Xu, Y.10
Wang, G.11
Huang, Y.12
Xiong, Y.13
Guan, K.L.14
Lei, Q.Y.15
-
17
-
-
84872174405
-
M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth
-
Cortes-Cros M, Hemmerlin C, Ferretti S, Zhang J, Gounarides JS, Yin H, Muller A, Haberkorn A, Chene P, Sellers WR and Hofmann F. M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth. Proceedings of the National Academy of Sciences of the United States of America. 2013; 110(2):489-494.
-
(2013)
Proceedings of the National Academy of Sciences of the United States of America.
, vol.110
, Issue.2
, pp. 489-494
-
-
Cortes-Cros, M.1
Hemmerlin, C.2
Ferretti, S.3
Zhang, J.4
Gounarides, J.S.5
Yin, H.6
Muller, A.7
Haberkorn, A.8
Chene, P.9
Sellers, W.R.10
Hofmann, F.11
-
18
-
-
84960340828
-
ML265: A potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model
-
Probe Reports from the NIH Molecular Libraries Program. (Bethesda (MD)
-
Walsh MJ, Brimacombe KR, Anastasiou D, Yu Y, Israelsen WJ, Hong BS, Tempel W, Dimov S, Veith H, Yang H, Kung C, Yen KE, Dang L, Salituro F, Auld DS, Park HW, et al. (2010). ML265: A potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model. Probe Reports from the NIH Molecular Libraries Program. (Bethesda (MD).
-
(2010)
-
-
Walsh, M.J.1
Brimacombe, K.R.2
Anastasiou, D.3
Yu, Y.4
Israelsen, W.J.5
Hong, B.S.6
Tempel, W.7
Dimov, S.8
Veith, H.9
Yang, H.10
Kung, C.11
Yen, K.E.12
Dang, L.13
Salituro, F.14
Auld, D.S.15
Park, H.W.16
-
19
-
-
84879890360
-
Comprehensive molecular characterization of clear cell renal cell carcinoma
-
Network CGAR. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature. 2013; 499(7456):43-49.
-
(2013)
Nature.
, vol.499
, Issue.7456
, pp. 43-49
-
-
Network, C.G.A.R.1
-
20
-
-
84869082905
-
Serine is a natural ligand and allosteric activator of pyruvate kinase M2
-
Chaneton B, Hillmann P, Zheng L, Martin AC, Maddocks OD, Chokkathukalam A, Coyle JE, Jankevics A, Holding FP, Vousden KH, Frezza C, O'Reilly M and Gottlieb E. Serine is a natural ligand and allosteric activator of pyruvate kinase M2. Nature. 2012; 491(7424):458-462.
-
(2012)
Nature.
, vol.491
, Issue.7424
, pp. 458-462
-
-
Chaneton, B.1
Hillmann, P.2
Zheng, L.3
Martin, A.C.4
Maddocks, O.D.5
Chokkathukalam, A.6
Coyle, J.E.7
Jankevics, A.8
Holding, F.P.9
Vousden, K.H.10
Frezza, C.11
O'Reilly, M.12
Gottlieb, E.13
-
21
-
-
84866697915
-
Small molecule activation of PKM2 in cancer cells induces serine auxotrophy
-
Kung C, Hixon J, Choe S, Marks K, Gross S, Murphy E, DeLaBarre B, Cianchetta G, Sethumadhavan S, Wang X, Yan S, Gao Y, Fang C, Wei W, Jiang F, Wang S, et al. Small molecule activation of PKM2 in cancer cells induces serine auxotrophy. Chemistry&biology. 2012; 19(9):1187-1198.
-
(2012)
Chemistry&biology.
, vol.19
, Issue.9
, pp. 1187-1198
-
-
Kung, C.1
Hixon, J.2
Choe, S.3
Marks, K.4
Gross, S.5
Murphy, E.6
DeLaBarre, B.7
Cianchetta, G.8
Sethumadhavan, S.9
Wang, X.10
Yan, S.11
Gao, Y.12
Fang, C.13
Wei, W.14
Jiang, F.15
Wang, S.16
-
22
-
-
84880425659
-
Phosphoglycerate dehydrogenase induces glioma cells proliferation and invasion by stabilizing forkhead box M1
-
Liu J, Guo S, Li Q, Yang L, Xia Z, Zhang L, Huang Z and Zhang N. Phosphoglycerate dehydrogenase induces glioma cells proliferation and invasion by stabilizing forkhead box M1. Journal of neuro-oncology. 2013; 111(3):245-255.
-
(2013)
Journal of neuro-oncology.
, vol.111
, Issue.3
, pp. 245-255
-
-
Liu, J.1
Guo, S.2
Li, Q.3
Yang, L.4
Xia, Z.5
Zhang, L.6
Huang, Z.7
Zhang, N.8
-
23
-
-
82555170271
-
Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation
-
Yang W, Xia Y, Ji H, Zheng Y, Liang J, Huang W, Gao X, Aldape K and Lu Z. Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation. Nature. 2011; 480(7375):118-122.
-
(2011)
Nature.
, vol.480
, Issue.7375
, pp. 118-122
-
-
Yang, W.1
Xia, Y.2
Ji, H.3
Zheng, Y.4
Liang, J.5
Huang, W.6
Gao, X.7
Aldape, K.8
Lu, Z.9
-
24
-
-
84881557242
-
Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer
-
Patra KC, Wang Q, Bhaskar PT, Miller L, Wang Z, Wheaton W, Chandel N, Laakso M, Muller WJ, Allen EL, Jha AK, Smolen GA, Clasquin MF, Robey RB and Hay N. Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer. Cancer cell. 2013.
-
(2013)
Cancer cell
-
-
Patra, K.C.1
Wang, Q.2
Bhaskar, P.T.3
Miller, L.4
Wang, Z.5
Wheaton, W.6
Chandel, N.7
Laakso, M.8
Muller, W.J.9
Allen, E.L.10
Jha, A.K.11
Smolen, G.A.12
Clasquin, M.F.13
Robey, R.B.14
Hay, N.15
-
25
-
-
0037603113
-
Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
-
Debnath J, Muthuswamy SK and Brugge JS. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods. 2003; 30(3):256-268.
-
(2003)
Methods.
, vol.30
, Issue.3
, pp. 256-268
-
-
Debnath, J.1
Muthuswamy, S.K.2
Brugge, J.S.3
-
26
-
-
84880811049
-
Targeting HSF1 sensitizes cancer cells to HSP90 inhibition
-
Chen Y, Chen J, Loo A, Jaeger S, Bagdasarian L, Yu J, Chung F, Korn J, Ruddy D, Guo R, McLaughlin ME, Feng F, Zhu P, Stegmeier F, Pagliarini R, Porter D, et al. Targeting HSF1 sensitizes cancer cells to HSP90 inhibition. Oncotarget. 2013.
-
(2013)
Oncotarget
-
-
Chen, Y.1
Chen, J.2
Loo, A.3
Jaeger, S.4
Bagdasarian, L.5
Yu, J.6
Chung, F.7
Korn, J.8
Ruddy, D.9
Guo, R.10
McLaughlin, M.E.11
Feng, F.12
Zhu, P.13
Stegmeier, F.14
Pagliarini, R.15
Porter, D.16
-
27
-
-
0242268881
-
Detection of point mutations of the Axin1 gene in colorectal cancers
-
Jin LH, Shao QJ, Luo W, Ye ZY, Li Q and Lin SC. Detection of point mutations of the Axin1 gene in colorectal cancers. International journal of cancer Journal international du cancer. 2003; 107(5):696-699.
-
(2003)
International journal of cancer Journal international du cancer.
, vol.107
, Issue.5
, pp. 696-699
-
-
Jin, L.H.1
Shao, Q.J.2
Luo, W.3
Ye, Z.Y.4
Li, Q.5
Lin, S.C.6
|