Author Correction: LKB1 loss links serine metabolism to DNA methylation and tumorigenesis (Nature, (2016), 539, 7629, (390-395), 10.1038/nature20132);LKB1 loss links serine metabolism to DNA methylation and tumorigenesis

Nature

Volumn 539, Issue 7629, 2016, Pages 390-395

  Kottakis, Filippos ^a,b,c   Nicolay, Brandon N ^a,c   Roumane, Ahlima ^a,b,c   Karnik, Rahul ^d,e,f   Gu, Hongcang ^d,e,f   Nagle, Julia M ^a,b,c   Boukhali, Myriam ^a,c   Hayward, Michele C ^g   Li, Yvonne Y ^c,h   Chen, Ting ^c,h   Liesa, Marc ^i,j   Hammerman, Peter S ^c,h,k   Wong, Kwok Kin ^c,h   Hayes, D Neil ^g   Shirihai, Orian S ^i,j   Dyson, Nicholas J ^a,c   Haas, Wilhelm ^a,c   Meissner, Alexander ^d,e,f   Bardeesy, Nabeel ^a,b,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e HARVARD STEM CELL INSTITUTE   (United States)

^f Harvard University   (United States)

^g UNIVERSITY OF NORTH CAROLINA   (United States)

^h DANA FARBER CANCER INSTITUTE   (United States)

ⁱ BOSTON UNIVERSITY   (United States)

^j School of Medicine ^*  (United States)

^k MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; DNA METHYLTRANSFERASE; GLYCINE; K RAS PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE LKB1; S ADENOSYLMETHIONINE; SERINE; AMINOTRANSFERASE; CHROMATIN; DNA (CYTOSINE 5) METHYLTRANSFERASE; ENZYME INHIBITOR; KRAS PROTEIN, HUMAN; MTOR PROTEIN, HUMAN; PHOSPHOSERINE AMINOTRANSFERASE; PROTEIN P21; PROTEIN SERINE THREONINE KINASE; RETROPOSON; STK11 PROTEIN, HUMAN; STK11 PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE;

CANCER; CELLS AND CELL COMPONENTS; GROWTH RATE; INHIBITION; METABOLISM; METHYLATION; PROTEIN; RODENT; TUMOR; VULNERABILITY;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DNA METHYLATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME SYNTHESIS; EPIGENETICS; EPITHELIUM CELL; GENE MUTATION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PANCREAS CELL; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEOMICS; RETROPOSON; UPREGULATION; ANIMAL; BIOSYNTHESIS; CELL CULTURE TECHNIQUE; CELL TRANSFORMATION; CHROMATIN; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; GENETICS; GLYCOLYSIS; METABOLISM; PANCREATIC DUCT; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; CHROMATIN; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; ENZYME INHIBITORS; EPITHELIAL CELLS; GENE SILENCING; GENES, TUMOR SUPPRESSOR; GLYCINE; GLYCOLYSIS; HUMANS; MICE; PANCREATIC DUCTS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS P21(RAS); RETROELEMENTS; S-ADENOSYLMETHIONINE; SERINE; TOR SERINE-THREONINE KINASES; TRANSAMINASES;

EID: 84996554610     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/s41586-019-1696-z     Document Type: Erratum

References (39)

1. Gut, P., Verdin, E. The nexus of chromatin regulation and intermediary metabolism. Nature 502, 489-498 (2013).
2. Etchegaray, J.-P., Mostoslavsky, R. Interplay between metabolism and epigenetics: a nuclear adaptation to environmental changes. Mol. Cell 62, 695-711 (2016).
3. Carey, B. W., Finley, L. W. S., Cross, J. R., Allis, C. D., Thompson, C. B. Intracellular ?-ketoglutarate maintains the pluripotency of embryonic stem cells. Nature 518, 413-416 (2015).
4. Shyh-Chang, N. et al. Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science 339, 222-226 (2013).
5. Losman, J.-A., Kaelin, W. G. Jr. What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer. Genes Dev. 27, 836-852 (2013).
6. Waddell, N. et al. Whole genomes redefine the mutational landscape of pancreatic cancer. Nature 518, 495-501 (2015).
7. Witkiewicz, A. K. et al. Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets. Nat. Commun. 6, 6744 (2015).
8. Su, G. H. et al. Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. Am. J. Pathol. 154, 1835-1840 (1999).
9. Giardiello, F. M. et al. Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology 119, 1447-1453 (2000).
10. Korsse, S. E. et al. Pancreatic cancer risk in Peutz-Jeghers syndrome patients: a large cohort study and implications for surveillance. J. Med. Genet. 50, 59-64 (2013).
11. Ji, H. et al. LKB1 modulates lung cancer differentiation and metastasis. Nature 448, 807-810 (2007).
12. Chen, Z. et al. A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. Nature 483, 613-617 (2012).
13. Wingo, S. N. et al. Somatic LKB1 mutations promote cervical cancer progression. PLoS One 4, e5137 (2009).
14. Liu, W. et al. LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma. Cancer Cell 21, 751-764 (2012).
15. Shackelford, D. B., Shaw, R. J. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat. Rev. Cancer 9, 563-575 (2009).
16. Cancer Genome Atlas Research Network. Comprehensive molecular profiling of lung adenocarcinoma. Nature 511, 543-550 (2014).
17. Ting, L., Rad, R., Gygi, S. P., Haas, W. MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics. Nat. Methods 8, 937-940 (2011).
18. Mehrmohamadi, M., Liu, X., Shestov, A. A., Locasale, J. W. Characterization of the usage of the serine metabolic network in human cancer. Cell Reports 9, 1507-1519 (2014).
19. Bardeesy, N. et al. Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc. Natl Acad. Sci. USA 103, 5947-5952 (2006).
20. Locasale, J. W. Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat. Rev. Cancer 13, 572-583 (2013).
21. Mentch, S. J. et al. Histone methylation dynamics and gene regulation occur through the sensing of one-carbon metabolism. Cell Metab. 22, 861-873 (2015).
22. Maddocks, O. D. K., Labuschagne, C. F., Adams, P. D., Vousden, K. H. Serine metabolism supports the methionine cycle and DNA/RNA methylation through de novo ATP synthesis in cancer cells. Mol. Cell 61, 210-221 (2016).
23. Possemato, R. et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 476, 346-350 (2011).
24. Schübeler, D. Function and information content of DNA methylation. Nature 517, 321-326 (2015).
25. Elbarbary, R. A., Lucas, B. A., Maquat, L. E. Retrotransposons as regulators of gene expression. Science http://dx. doi. org/10. 1126/science. aac7247 (2016).
26. Kulis, M., Queirós, A. C., Beekman, R., Martín-Subero, J. I. Intragenic DNA methylation in transcriptional regulation, normal differentiation and cancer. Biochim. Biophys. Acta 1829, 1161-1174 (2013).
27. Son, J. et al. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature 496, 101-105 (2013).
28. Lee, J. V. et al. Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation. Cell Metab. 20, 306-319 (2014).
29. Shim, E.-H. et al. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov. 4, 1290-1298 (2014).
30. Intlekofer, A. M. et al. Hypoxia induces production of L-2-hydroxyglutarate. Cell Metab. 22, 304-311 (2015).
31. Roulois, D. et al. DNA-demethylating agents target colorectal cancer cells by inducing viral mimicry by endogenous transcripts. Cell 162, 961-973 (2015).
32. Chiappinelli, K. B. et al. Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses. Cell 162, 974-986 (2015).
33. Treppendahl, M. B., Kristensen, L. S., Grønbæk, K. Predicting response to epigenetic therapy. J. Clin. Invest. 124, 47-55 (2014).
34. Locasale, J. W. et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat. Genet. 43, 869-874 (2011).
35. DeNicola, G. M. et al. NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nat. Genet. 47, 1475-1481 (2015).
36. Sun, L. et al. cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions. Cell Res. 25, 429-444 (2015).
37. Ye, J. et al. Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov. 4, 1406-1417 (2014).
38. Zhang, W. C. et al. Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell 148, 259-272 (2012).
39. Ben-Sahra, I., Howell, J. J., Asara, J. M., Manning, B. D. Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1. Science 339, 1323-1328 (2013).