p53 Protein-mediated regulation of phosphoglycerate dehydrogenase (PHGDH) is crucial for the apoptotic response upon serine starvation

Journal of Biological Chemistry

Volumn 290, Issue 1, 2015, Pages 457-466

  Ou, Yang ^a   Wang, Shang Jui ^a   Jiang, Le ^a   Zheng, Bin ^b   Gu, Wei ^a  

^a New York Presbyterian Columbia University Medical Center   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; CELL DEATH; DERMATOLOGY; ONCOLOGY;

APOPTOTIC RESPONSE; BIOSYNTHESIS PATHWAYS; HUMAN CANCER; MELANOMA CELLS; METABOLIC ENZYMES; OVER-EXPRESSION; PHOSPHOGLYCERATE DEHYDROGENASE; RATE-LIMITING STEPS;

AMINO ACIDS;

ACTIVATING TRANSCRIPTION FACTOR 4; CASPASE 3; DOXORUBICIN; NUTLIN 3; PHOSPHOGLYCERATE DEHYDROGENASE; PROTEIN BAX; PROTEIN MDM2; PROTEIN NOXA; PROTEIN P21; PROTEIN P53; PUMA PROTEIN; SERINE; ANTINEOPLASTIC AGENT; ATF4 PROTEIN, HUMAN; IMIDAZOLE DERIVATIVE; PIPERAZINE DERIVATIVE; SMALL INTERFERING RNA;

AMINO ACID METABOLISM; APOPTOSIS; ARTICLE; CELL DEATH; CELL FATE; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; ENZYME REGULATION; ENZYME REPRESSION; HUMAN; HUMAN CELL; MELANOMA; NUCLEIC ACID SYNTHESIS; PHGDH GENE; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UPREGULATION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DEFICIENCY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; MELANOCYTE; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOLOGY; TUMOR CELL LINE;

ACTIVATING TRANSCRIPTION FACTOR 4; ANTINEOPLASTIC AGENTS; APOPTOSIS; BASE SEQUENCE; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HUMANS; IMIDAZOLES; MELANOCYTES; MOLECULAR SEQUENCE DATA; PHOSPHOGLYCERATE DEHYDROGENASE; PIPERAZINES; RNA, SMALL INTERFERING; SERINE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84920540540     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.616359     Document Type: Article

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