-
1
-
-
77955616558
-
Compartmentalization of mammalian folate-mediated onecarbon metabolism
-
A. S. Tibbetts, D. R. Appling, Compartmentalization of mammalian folate-mediated onecarbon metabolism. Annu. Rev. Nutr. 30, 57-81 (2010).
-
(2010)
Annu. Rev. Nutr.
, vol.30
, pp. 57-81
-
-
Tibbetts, A.S.1
Appling, D.R.2
-
2
-
-
84881177291
-
Serine, glycine and one-carbon units: Cancer metabolism in full circle
-
J. W. Locasale, Serine, glycine and one-carbon units: Cancer metabolism in full circle. Nat. Rev. Cancer 13, 572-583 (2013).
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 572-583
-
-
Locasale, J.W.1
-
3
-
-
0018137465
-
Arrest of cell growth in G1 phase of cell cycle by serine deprivation
-
R. W. Allen, M. Moskowitz, Arrest of cell growth in G1 phase of cell cycle by serine deprivation. Exp. Cell Res. 116, 127-137 (1978).
-
(1978)
Exp. Cell Res.
, vol.116
, pp. 127-137
-
-
Allen, R.W.1
Moskowitz, M.2
-
4
-
-
0021966410
-
One-carbon metabolism in lectin-activated human-lymphocytes
-
P. B. Rowe, D. Sauer, D. Fahey, G. Craig, E. Mccairns, One-carbon metabolism in lectin-activated human-lymphocytes. Arch. Biochem. Biophys. 236, 277-288 (1985).
-
(1985)
Arch. Biochem. Biophys.
, vol.236
, pp. 277-288
-
-
Rowe, P.B.1
Sauer, D.2
Fahey, D.3
Craig, G.4
Mccairns, E.5
-
5
-
-
84872905650
-
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
-
O. D. K. Maddocks, C. R. Berkers, S. M. Mason, L. Zheng, K. Blyth, E. Gottlieb, K. H. Vousden, Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature 493, 542-546 (2013).
-
(2013)
Nature
, vol.493
, pp. 542-546
-
-
Maddocks, O.D.K.1
Berkers, C.R.2
Mason, S.M.3
Zheng, L.4
Blyth, K.5
Gottlieb, E.6
Vousden, K.H.7
-
6
-
-
84901263663
-
Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells
-
C. F. Labuschagne, N. J. F. van den Broek, G. M. Mackay, K. H. Vousden, O. D. K. Maddocks, Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells. Cell Rep. 7, 1248-1258 (2014).
-
(2014)
Cell Rep.
, vol.7
, pp. 1248-1258
-
-
Labuschagne, C.F.1
Van Den Broek, N.J.F.2
Mackay, G.M.3
Vousden, K.H.4
Maddocks, O.D.K.5
-
8
-
-
80355129300
-
Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation
-
A. Vazquez, E. K. Markert, Z. N. Oltvai, Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation. PLOS ONE 6, e25881 (2011).
-
(2011)
PLOS ONE
, vol.6
, pp. e25881
-
-
Vazquez, A.1
Markert, E.K.2
Oltvai, Z.N.3
-
9
-
-
0027160524
-
Characterization of the folate-dependent mitochondrial oxidation of carbon 3 of serine
-
L. F. Garcia-Martinez, D. R. Appling, Characterization of the folate-dependent mitochondrial oxidation of carbon 3 of serine. Biochemistry 32, 4671-4676 (1993).
-
(1993)
Biochemistry
, vol.32
, pp. 4671-4676
-
-
Garcia-Martinez, L.F.1
Appling, D.R.2
-
10
-
-
84861420588
-
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation
-
M. Jain, R. Nilsson, S. Sharma, N. Madhusudhan, T. Kitami, A. L. Souza, R. Kafri, M. W. Kirschner, C. B. Clish, V. K. Mootha, Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science 336, 1040-1044 (2012).
-
(2012)
Science
, vol.336
, pp. 1040-1044
-
-
Jain, M.1
Nilsson, R.2
Sharma, S.3
Madhusudhan, N.4
Kitami, T.5
Souza, A.L.6
Kafri, R.7
Kirschner, M.W.8
Clish, C.B.9
Mootha, V.K.10
-
11
-
-
84955456527
-
Division of labour: How does folate metabolism partition between one-carbon metabolism and amino acid oxidation?
-
M. E. Brosnan, L. MacMillan, J. R. Stevens, J. T. Brosnan, Division of labour: How does folate metabolism partition between one-carbon metabolism and amino acid oxidation? Biochem. J. 472, 135-146 (2015).
-
(2015)
Biochem. J.
, vol.472
, pp. 135-146
-
-
Brosnan, M.E.1
MacMillan, L.2
Stevens, J.R.3
Brosnan, J.T.4
-
12
-
-
84858782079
-
AMPK: A nutrient and energy sensor that maintains energy homeostasis
-
D. G. Hardie, F. A. Ross, S. A. Hawley, AMPK: A nutrient and energy sensor that maintains energy homeostasis. Nat. Rev. Mol. Cell Biol. 13, 251-262 (2012).
-
(2012)
Nat. Rev. Mol. Cell Biol.
, vol.13
, pp. 251-262
-
-
Hardie, D.G.1
Ross, F.A.2
Hawley, S.A.3
-
13
-
-
0026457218
-
Nonviability of cells with oxidative defects in galactose medium: A screening test for affected patient fibroblasts
-
B. H. Robinson, R. Petrova-Benedict, J. R. Buncic, D. C. Wallace, Nonviability of cells with oxidative defects in galactose medium: A screening test for affected patient fibroblasts. Biochem. Med. Metab. Biol. 48, 122-126 (1992).
-
(1992)
Biochem. Med. Metab. Biol.
, vol.48
, pp. 122-126
-
-
Robinson, B.H.1
Petrova-Benedict, R.2
Buncic, J.R.3
Wallace, D.C.4
-
14
-
-
84904504373
-
Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells
-
C. A. Lewis, S. J. Parker, B. P. Fiske, D. McCloskey, D. Y. Gui, C. R. Green, N. I. Vokes, A. M. Feist, M. G. Vander Heiden, C. M. Metallo, Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells. Mol. Cell 55, 253-263 (2014).
-
(2014)
Mol. Cell
, vol.55
, pp. 253-263
-
-
Lewis, C.A.1
Parker, S.J.2
Fiske, B.P.3
McCloskey, D.4
Gui, D.Y.5
Green, C.R.6
Vokes, N.I.7
Feist, A.M.8
Vander Heiden, M.G.9
Metallo, C.M.10
-
15
-
-
84964612429
-
Give it or take it: The flux of one-carbon in cancer cells
-
J. Meiser, A. Vazquez, Give it or take it: The flux of one-carbon in cancer cells. Febs J., 10.1111/febs.13731 (2016).
-
(2016)
Febs J.
-
-
Meiser, J.1
Vazquez, A.2
-
16
-
-
0025676019
-
Activity of an NAD-dependent 5, 10-methylenetetrahydrofolate dehydrogenase in normal tissue, neoplastic cells, and oncogene-transformed cells
-
G. K. Smith, S. D. Banks, T. J. Monaco, R. Rigual, D. S. Duch, R. J. Mullin, B. E. Huber, Activity of an NAD-dependent 5, 10-methylenetetrahydrofolate dehydrogenase in normal tissue, neoplastic cells, and oncogene-transformed cells. Arch. Biochem. Biophys. 283, 367-371 (1990).
-
(1990)
Arch. Biochem. Biophys.
, vol.283
, pp. 367-371
-
-
Smith, G.K.1
Banks, S.D.2
Monaco, T.J.3
Rigual, R.4
Duch, D.S.5
Mullin, R.J.6
Huber, B.E.7
-
17
-
-
84975247161
-
Mitochondrial dysfunction remodels one-carbon metabolism in human cells
-
e10575
-
X. R. Bao, S. E. Ong, O. Goldberger, J. Peng, R. Sharma, D. A. Thompson, S. B. Vafai, A. G. Cox, E. Marutani, F. Ichinose, W. Goessling, A. Regev, S. A. Carr, C. B. Clish, V. K. Mootha, Mitochondrial dysfunction remodels one-carbon metabolism in human cells. eLife 5, pii: e10575 (2016).
-
(2016)
ELife
, vol.5
-
-
Bao, X.R.1
Ong, S.E.2
Goldberger, O.3
Peng, J.4
Sharma, R.5
Thompson, D.A.6
Vafai, S.B.7
Cox, A.G.8
Marutani, E.9
Ichinose, F.10
Goessling, W.11
Regev, A.12
Carr, S.A.13
Clish, C.B.14
Mootha, V.K.15
-
18
-
-
84975455372
-
Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway
-
G. S. Ducker, L. Chen, R. J. Morscher, J. M. Ghergurovich, M. Esposito, X. Teng, Y. Kang, J. D. Rabinowitz, Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway. Cell Metab. 23, 1140-1153 (2016).
-
(2016)
Cell Metab.
, vol.23
, pp. 1140-1153
-
-
Ducker, G.S.1
Chen, L.2
Morscher, R.J.3
Ghergurovich, J.M.4
Esposito, M.5
Teng, X.6
Kang, Y.7
Rabinowitz, J.D.8
-
19
-
-
84981329866
-
Suppression of MTHFD2 in MCF-7 breast cancer cells increases glycolysis, dependency on exogenous glycine, and sensitivity to folate depletion
-
C. Koufaris, S. Gallage, T. Yang, C. H. Lau, G. N. Valbuena, H. C. Keun, Suppression of MTHFD2 in MCF-7 breast cancer cells increases glycolysis, dependency on exogenous glycine, and sensitivity to folate depletion. J. Proteome Res. 15, 2618-2625 (2016).
-
(2016)
J. Proteome Res.
, vol.15
, pp. 2618-2625
-
-
Koufaris, C.1
Gallage, S.2
Yang, T.3
Lau, C.H.4
Valbuena, G.N.5
Keun, H.C.6
-
20
-
-
84890209181
-
Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia
-
J. Fan, J. J. Kamphorst, R. Mathew, M. K. Chung, E. White, T. Shlomi, J. D. Rabinowitz, Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia. Mol. Syst. Biol. 9, 712 (2013).
-
(2013)
Mol. Syst. Biol.
, vol.9
, pp. 712
-
-
Fan, J.1
Kamphorst, J.J.2
Mathew, R.3
Chung, M.K.4
White, E.5
Shlomi, T.6
Rabinowitz, J.D.7
-
21
-
-
84954028080
-
Quantification of folate metabolism using transient metabolic flux analysis
-
P. M. Tedeschi, N. Johnson-Farley, H. Lin, L. M. Shelton, T. Ooga, G. Mackay, N. Van Den Broek, J. R. Bertino, A. Vazquez, Quantification of folate metabolism using transient metabolic flux analysis. Cancer Metab. 3, 6 (2015).
-
(2015)
Cancer Metab.
, vol.3
, pp. 6
-
-
Tedeschi, P.M.1
Johnson-Farley, N.2
Lin, H.3
Shelton, L.M.4
Ooga, T.5
Mackay, G.6
Van Den Broek, N.7
Bertino, J.R.8
Vazquez, A.9
-
22
-
-
84961291647
-
In vivo kinetics of formate metabolism in folate-deficient and folate-replete rats
-
G. P. Morrow, L. MacMillan, S. G. Lamarre, S. K. Young, A. J. MacFarlane, M. E. Brosnan, J. T. Brosnan, In vivo kinetics of formate metabolism in folate-deficient and folate-replete rats. J. Biol. Chem. 290, 2244-2250 (2015).
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 2244-2250
-
-
Morrow, G.P.1
MacMillan, L.2
Lamarre, S.G.3
Young, S.K.4
MacFarlane, A.J.5
Brosnan, M.E.6
Brosnan, J.T.7
-
23
-
-
84907370814
-
Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
-
H. R. Bridges, A. J. Y. Jones, M. N. Pollak, J. Hirst, Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria. Biochem. J. 462, 475-487 (2014).
-
(2014)
Biochem. J.
, vol.462
, pp. 475-487
-
-
Bridges, H.R.1
Jones, A.J.Y.2
Pollak, M.N.3
Hirst, J.4
-
24
-
-
84918586438
-
Serine deprivation enhances antineoplastic activity of biguanides
-
S.-P. Gravel, L. Hulea, N. Toban, E. Birman, M.-J. Blouin, M. Zakikhani, Y. Zhao, I. Topisirovic, J. St-Pierre, M. Pollak, Serine deprivation enhances antineoplastic activity of biguanides. Cancer Res. 74, 7521-7533 (2014).
-
(2014)
Cancer Res.
, vol.74
, pp. 7521-7533
-
-
Gravel, S.-P.1
Hulea, L.2
Toban, N.3
Birman, E.4
Blouin, M.-J.5
Zakikhani, M.6
Zhao, Y.7
Topisirovic, I.8
St-Pierre, J.9
Pollak, M.10
-
25
-
-
12444279265
-
On the origin of cancer cells
-
O. Warburg, On the origin of cancer cells. Science 123, 309-314 (1956).
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
26
-
-
77951803596
-
Catabolic efficiency of aerobic glycolysis: The Warburg effect revisited
-
A. Vazquez, J. Liu, Y. Zhou, Z. N. Oltvai, Catabolic efficiency of aerobic glycolysis: The Warburg effect revisited. BMC Syst. Biol. 4, 58 (2010).
-
(2010)
BMC Syst. Biol.
, vol.4
, pp. 58
-
-
Vazquez, A.1
Liu, J.2
Zhou, Y.3
Oltvai, Z.N.4
-
27
-
-
84924287407
-
Proteomics-based metabolic modeling reveals that fatty acid oxidation (FAO) controls endothelial cell (EC) permeability
-
F. Patella, Z. T. Schug, E. Persi, L. J. Neilson, Z. Erami, D. Avanzato, F. Maione, J. R. Hernandez-Fernaud, G. Mackay, L. Zheng, S. Reid, C. Frezza, E. Giraudo, A. Fiorio Pla, K. Anderson, E. Ruppin, E. Gottlieb, S. Zanivan, Proteomics-based metabolic modeling reveals that fatty acid oxidation (FAO) controls endothelial cell (EC) permeability. Mol. Cell. Proteomics 14, 621-634 (2015).
-
(2015)
Mol. Cell. Proteomics
, vol.14
, pp. 621-634
-
-
Patella, F.1
Schug, Z.T.2
Persi, E.3
Neilson, L.J.4
Erami, Z.5
Avanzato, D.6
Maione, F.7
Hernandez-Fernaud, J.R.8
Mackay, G.9
Zheng, L.10
Reid, S.11
Frezza, C.12
Giraudo, E.13
Fiorio Pla, A.14
Anderson, K.15
Ruppin, E.16
Gottlieb, E.17
Zanivan, S.18
-
28
-
-
0035496104
-
APC, signal transduction and genetic instability in colorectal cancer
-
R. Fodde, R. Smits, H. Clevers, APC, signal transduction and genetic instability in colorectal cancer. Nat. Rev. Cancer 1, 55-67 (2001).
-
(2001)
Nat. Rev. Cancer
, vol.1
, pp. 55-67
-
-
Fodde, R.1
Smits, R.2
Clevers, H.3
-
29
-
-
84897420143
-
The metabolic demands of cancer cells are coupled to their size and protein synthesis rates
-
S. C. Dolfi, L. L.-Y. Chan, J. Qiu, P. M. Tedeschi, J. R. Bertino, K. M. Hirshfield, Z. N. Oltvai, A. Vazquez, The metabolic demands of cancer cells are coupled to their size and protein synthesis rates. Cancer Metab. 1, 20 (2013).
-
(2013)
Cancer Metab.
, vol.1
, pp. 20
-
-
Dolfi, S.C.1
Chan, L.L.-Y.2
Qiu, J.3
Tedeschi, P.M.4
Bertino, J.R.5
Hirshfield, K.M.6
Oltvai, Z.N.7
Vazquez, A.8
-
30
-
-
84902332213
-
Quantitative flux analysis reveals folate-dependent NADPH production
-
J. Fan, J. B. Ye, J. J. Kamphorst, T. Shlomi, C. B. Thompson, J. D. Rabinowitz, Quantitative flux analysis reveals folate-dependent NADPH production. Nature 510, 298-302 (2014).
-
(2014)
Nature
, vol.510
, pp. 298-302
-
-
Fan, J.1
Ye, J.B.2
Kamphorst, J.J.3
Shlomi, T.4
Thompson, C.B.5
Rabinowitz, J.D.6
-
31
-
-
78650664020
-
Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain
-
J. H. Yang, A. Wada, K. Yoshida, Y. Miyoshi, T. Sayano, K. Esaki, M. O. Kinoshita, S. Tomonaga, N. Azuma, M. Watanabe, K. Hamase, K. Zaitsu, T. Machida, A. Messing, S. Itohara, Y. Hirabayashi, S. Furuya, Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain. J. Biol. Chem. 285, 41380-41390 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 41380-41390
-
-
Yang, J.H.1
Wada, A.2
Yoshida, K.3
Miyoshi, Y.4
Sayano, T.5
Esaki, K.6
Kinoshita, M.O.7
Tomonaga, S.8
Azuma, N.9
Watanabe, M.10
Hamase, K.11
Zaitsu, K.12
Machida, T.13
Messing, A.14
Itohara, S.15
Hirabayashi, Y.16
Furuya, S.17
|