-
1
-
-
43749098985
-
DNA methylation landscapes: Provocative insights from epigenomics
-
Suzuki, M. M. & Bird, A. DNA methylation landscapes: provocative insights from epigenomics. Nature Rev. Genet. 9, 465-476 (2008).
-
(2008)
Nature Rev. Genet.
, vol.9
, pp. 465-476
-
-
Suzuki, M.M.1
Bird, A.2
-
2
-
-
84886860116
-
TET enzymes. TDG and the dynamics of DNA demethylation
-
Kohli, R. M. & Zhang, Y. TET enzymes, TDG and the dynamics of DNA demethylation. Nature 502, 472-479 (2013).
-
(2013)
Nature
, vol.502
, pp. 472-479
-
-
Kohli, R.M.1
Zhang, Y.2
-
3
-
-
84863986133
-
Functions of DNA methylation: Islands, start sites, gene bodies and beyond
-
Jones, P. A. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nature Rev. Genet. 13, 484-492 (2012).
-
(2012)
Nature Rev. Genet.
, vol.13
, pp. 484-492
-
-
Jones, P.A.1
-
4
-
-
83855163995
-
Uncovering the role of 5-hydroxymethylcytosine in the epigenome
-
Branco, M. R., Ficz, G. & Reik, W. Uncovering the role of 5-hydroxymethylcytosine in the epigenome. Nature Rev. Genet. 13, 7-13 (2012).
-
(2012)
Nature Rev. Genet.
, vol.13
, pp. 7-13
-
-
Branco, M.R.1
Ficz, G.2
Reik, W.3
-
5
-
-
80052933429
-
DNA demethylation dynamics
-
Bhutani, N., Burns, D. M. & Blau, H. M. DNA demethylation dynamics. Cell 146, 866-872 (2011).
-
(2011)
Cell
, vol.146
, pp. 866-872
-
-
Bhutani, N.1
Burns, D.M.2
Blau, H.M.3
-
6
-
-
0034610814
-
The language of covalent histone modifications
-
Strahl, B. D. & Allis, C. D. The language of covalent histone modifications. Nature 403, 41-45 (2000).
-
(2000)
Nature
, vol.403
, pp. 41-45
-
-
Strahl, B.D.1
Allis, C.D.2
-
7
-
-
35349006314
-
Histone lysine demethylases: Emerging roles in development, physiology and disease
-
Shi, Y. Histone lysine demethylases: emerging roles in development, physiology and disease. Nature Rev. Genet. 8, 829-833 (2007).
-
(2007)
Nature Rev. Genet.
, vol.8
, pp. 829-833
-
-
Shi, Y.1
-
8
-
-
33747455678
-
JmjC-domain-containing proteins and histone demethylation
-
Klose, R. J., Kallin, E. M. & Zhang, Y. JmjC-domain-containing proteins and histone demethylation. Nature Rev. Genet. 7, 715-727 (2006).
-
(2006)
Nature Rev. Genet.
, vol.7
, pp. 715-727
-
-
Klose, R.J.1
Kallin, E.M.2
Zhang, Y.3
-
10
-
-
78649267733
-
Grand challenge commentary: RNA epigenetics? Nature Chem
-
He, C. Grand challenge commentary: RNA epigenetics? Nature Chem. Biol. 6, 863-865 (2010).
-
(2010)
Biol.
, vol.6
, pp. 863-865
-
-
He, C.1
-
13
-
-
84875692043
-
MODOMICS: A database of RNA modification pathways-2013 update
-
Machnicka, M. A. et al. MODOMICS: a database of RNA modification pathways-2013 update. Nucleic Acids Res. 41, D262-D267 (2013).
-
(2013)
Nucleic Acids Res.
, vol.41
-
-
Machnicka, M.A.1
-
15
-
-
81355146483
-
6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
-
6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nature Chem. Biol. 7, 885-887 (2011).
-
(2011)
Nature Chem. Biol.
, vol.7
, pp. 885-887
-
-
Jia, G.1
-
16
-
-
84872274463
-
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility
-
Zheng, G. et al. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol. Cell 49, 18-29 (2013).
-
(2013)
Mol. Cell
, vol.49
, pp. 18-29
-
-
Zheng, G.1
-
18
-
-
84862649489
-
Comprehensive analysis of mRNA methylation reveals enrichment in 3? UTRs and near stop codons
-
Meyer, K. D. et al. Comprehensive analysis of mRNA methylation reveals enrichment in 3? UTRs and near stop codons. Cell 149, 1635-1646 (2012).
-
(2012)
Cell
, vol.149
, pp. 1635-1646
-
-
Meyer, K.D.1
-
19
-
-
0016770156
-
Methylated nucleotides block 5? Terminus of HeLa-cell messenger-RNA
-
Wei, C. M., Gershowitz, A. & Moss, B. Methylated nucleotides block 5? terminus of HeLa-cell messenger-RNA. Cell 4, 379-386 (1975).
-
(1975)
Cell
, vol.4
, pp. 379-386
-
-
Wei, C.M.1
Gershowitz, A.2
Moss, B.3
-
20
-
-
0017177599
-
6-methyladenosine and 5?-terminal 7-methylguanosine in cap structures
-
6-methyladenosine and 5?-terminal 7-methylguanosine in cap structures. J. Virol. 20, 45-53 (1976).
-
(1976)
J. Virol.
, vol.20
, pp. 45-53
-
-
Krug, R.M.1
Morgan, M.A.2
Shatkin, A.J.3
-
21
-
-
0017278383
-
Nucleotide methylation patterns in eukaryotic mRNA
-
Rottman, F. M., Desrosiers, R. C. & Friderici, K. Nucleotide methylation patterns in eukaryotic mRNA. Prog. Nucleic Acid. Res. Mol. Biol. 19, 21-38 (1976).
-
(1976)
Prog. Nucleic Acid. Res. Mol. Biol.
, vol.19
, pp. 21-38
-
-
Rottman, F.M.1
Desrosiers, R.C.2
Friderici, K.3
-
22
-
-
0017622044
-
6-methyladenosine in the Rous sarcoma virus genome
-
6-methyladenosine in the Rous sarcoma virus genome. J. Mol. Biol. 11 3, 165-179 (1977).
-
(1977)
J. Mol. Biol.
, vol.113
, pp. 165-179
-
-
Beemon, K.1
Keith, J.2
-
23
-
-
0017708804
-
Comparison of methylated sequences in messenger RNA and heterogeneous nuclear RNA from mouse L cells
-
Schibler, U., Kelley, D. E. & Perry, R. P. Comparison of methylated sequences in messenger RNA and heterogeneous nuclear RNA from mouse L cells. J. Mol. Biol. 11 5, 695-714 (1977).
-
(1977)
J. Mol. Biol.
, vol.115
, pp. 695-714
-
-
Schibler, U.1
Kelley, D.E.2
Perry, R.P.3
-
24
-
-
0017367836
-
6-methyladenosine sites of HeLa cell messenger ribonucleic acid
-
6-methyladenosine sites of HeLa cell messenger ribonucleic acid. Biochemistry 16, 1672-1676 (1977).
-
(1977)
Biochemistry
, vol.16
, pp. 1672-1676
-
-
Wei, C.M.1
Moss, B.2
-
25
-
-
0024259949
-
An in vitro system for accurate methylation of internal adenosine residues in messenger RNA
-
Narayan, P. & Rottman, F. M. An in vitro system for accurate methylation of internal adenosine residues in messenger RNA. Science 242, 1159-1162 (1988).
-
(1988)
Science
, vol.242
, pp. 1159-1162
-
-
Narayan, P.1
Rottman, F.M.2
-
28
-
-
0016314015
-
Sequences containing methylated nucleotides at 5? Termini of messenger-RNAs-possible implications for processing
-
Rottman, F., Shatkin, A. J. & Perry, R. P. Sequences containing methylated nucleotides at 5? termini of messenger-RNAs-possible implications for processing. Cell 3, 197-199 (1974).
-
(1974)
Cell
, vol.3
, pp. 197-199
-
-
Rottman, F.1
Shatkin, A.J.2
Perry, R.P.3
-
29
-
-
77956504033
-
Yeast targets for mRNA methylation
-
Bodi, Z., Button, J. D., Grierson, D. & Fray, R. G. Yeast targets for mRNA methylation. Nucleic Acids Res. 38, 5327-5335 (2010).
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. 5327-5335
-
-
Bodi, Z.1
Button, J.D.2
Grierson, D.3
Fray, R.G.4
-
30
-
-
0028936082
-
Mobilities of modified ribonucleotides on two-dimensional cellulose thin-layer chromatography
-
Keith, G. Mobilities of modified ribonucleotides on two-dimensional cellulose thin-layer chromatography. Biochimie 77, 142-144 (1995).
-
(1995)
Biochimie
, vol.77
, pp. 142-144
-
-
Keith, G.1
-
32
-
-
84890107723
-
High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis
-
Schwartz, S. et al. High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Cell 155, 1409-1421 (2013).
-
(2013)
Cell
, vol.155
, pp. 1409-1421
-
-
Schwartz, S.1
-
33
-
-
84888423912
-
6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA
-
6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA. RNA 19, 1848-1856 (2013).
-
(2013)
RNA
, vol.19
, pp. 1848-1856
-
-
Liu, N.1
-
34
-
-
0025193111
-
6-methyladenosine residues in an intron-specific region of prolactin pre-mRNA
-
6- methyladenosine residues in an intron-specific region of prolactin pre-mRNA. Mol. Cell. Biol. 10, 4456-4465 (1990).
-
(1990)
Mol. Cell. Biol.
, vol.10
, pp. 4456-4465
-
-
Carroll, S.M.1
Narayan, P.2
Rottman, F.M.3
-
37
-
-
84875649230
-
Analysis of RNA base modification and structural rearrangement by single-molecule realtime detection of reverse transcription
-
Vilfan, I. D. et al. Analysis of RNA base modification and structural rearrangement by single-molecule realtime detection of reverse transcription. J. Nanobiotechnol. 11, 8 (2013).
-
(2013)
J. Nanobiotechnol.
, vol.11
, pp. 8
-
-
Vilfan, I.D.1
-
40
-
-
84897110592
-
6-adenosine methylation
-
6-adenosine methylation. Nature Chem. Biol. 10, 93-95 (2014).
-
(2014)
Nature Chem. Biol.
, vol.10
, pp. 93-95
-
-
Liu, J.1
-
42
-
-
84893310526
-
6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells
-
6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. Nature Cell Biol. 16, 191-198 (2014).
-
(2014)
Nature Cell Biol.
, vol.16
, pp. 191-198
-
-
Wang, Y.1
-
43
-
-
0036795285
-
Tw o proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA
-
Alexandrov, A., Martzen, M. R. & Phizicky, E. M. Tw o proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. RNA 8, 1253-1266 (2002).
-
(2002)
RNA
, vol.8
, pp. 1253-1266
-
-
Alexandrov, A.1
Martzen, M.R.2
Phizicky, E.M.3
-
44
-
-
84869768792
-
Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs
-
Chujo, T. & Suzuki, T. Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs. RNA 18, 2269-2276 (2012).
-
(2012)
RNA
, vol.18
, pp. 2269-2276
-
-
Chujo, T.1
Suzuki, T.2
-
45
-
-
23644456550
-
The bipartite structure of the tRNA m1A58 methyltransferase from S. Cerevisiae is conserved in humans
-
Ozanick, S., Krecic, A., Andersland, J. & Anderson, J. T. The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. RNA 11, 1281-1290 (2005).
-
(2005)
RNA
, vol.11
, pp. 1281-1290
-
-
Ozanick, S.1
Krecic, A.2
Andersland, J.3
Anderson, J.T.4
-
46
-
-
37549067728
-
7G methylation complex
-
7G methylation complex. Structure 16, 52-61 (2008).
-
(2008)
Structure
, vol.16
, pp. 52-61
-
-
Leulliot, N.1
-
47
-
-
57749089784
-
MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor
-
Zhong, S. et al. MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor. Plant Cell 20, 1278-1288 (2008).
-
(2008)
Plant Cell
, vol.20
, pp. 1278-1288
-
-
Zhong, S.1
-
48
-
-
84864037029
-
RNA methylation by the MIS complex regulates a cell fate decision in yeast
-
Agarwala, S. D., Blitzblau, H. G., Hochwagen, A. & Fink, G. R. RNA methylation by the MIS complex regulates a cell fate decision in yeast. PLoS Genet. 8, e1002732 (2012).
-
(2012)
PLoS Genet.
, vol.8
-
-
Agarwala, S.D.1
Blitzblau, H.G.2
Hochwagen, A.3
Fink, G.R.4
-
49
-
-
0034703394
-
Identification of WTAP, a novel Wilms' tumour 1-associating protein
-
Little, N. A., Hastie, N. D. & Davies, R. C. Identification of WTAP, a novel Wilms' tumour 1-associating protein. Hum. Mol. Genet. 9, 2231-2239 (2000).
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 2231-2239
-
-
Little, N.A.1
Hastie, N.D.2
Davies, R.C.3
-
50
-
-
84893746230
-
6- methyladenosine methyltransferase
-
6-methyladenosine methyltransferase. Cell Res. 24, 177-189 (2014).
-
(2014)
Cell Res.
, vol.24
, pp. 177-189
-
-
Ping, X.L.1
-
51
-
-
84887833997
-
Identification of Wilms' Tumor 1-associating protein complex and its role in alternative splicing and the cell cycle
-
Horiuchi, K. et al. Identification of Wilms' Tumor 1-associating protein complex and its role in alternative splicing and the cell cycle. J. Biol. Chem. 288, 33292-33302 (2013).
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 33292-33302
-
-
Horiuchi, K.1
-
52
-
-
84891485596
-
Adenosine methylation in Arabidopsis mRNA is associated with the 3 end and reduced levels cause developmental defects
-
Bodi, Z. et al. Adenosine methylation in Arabidopsis mRNA is associated with the 3? end and reduced levels cause developmental defects. Front. Plant Sci. 3, 48 (2012).
-
(2012)
Front. Plant Sci.
, vol.3
, pp. 48
-
-
Bodi, Z.1
-
53
-
-
80052601644
-
Drosophila Inducer of MEiosis 4 (IME4) is required for Notch signaling during oogenesis
-
Hongay, C. F. & Orr-Weaver, T. L. Drosophila Inducer of MEiosis 4 (IME4) is required for Notch signaling during oogenesis. Proc. Natl Acad. Sci. USA 108, 14855-14860 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 14855-14860
-
-
Hongay, C.F.1
Orr-Weaver, T.L.2
-
54
-
-
0032886705
-
Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation
-
Peters, T., Ausmeier, K. & Ruther, U. Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation. Mamm. Genome 10, 983-986 (1999).
-
(1999)
Mamm. Genome
, vol.10
, pp. 983-986
-
-
Peters, T.1
Ausmeier, K.2
Ruther, U.3
-
55
-
-
34249777814
-
Variation in F to contributes to childhood obesity and severe adult obesity
-
Dina, C. et al. Variation in F TO contributes to childhood obesity and severe adult obesity. Nature Genet. 39, 724-726 (2007).
-
(2007)
Nature Genet.
, vol.39
, pp. 724-726
-
-
Dina, C.1
-
56
-
-
34248594090
-
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
-
Frayling, T. M. et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316, 889-894 (2007).
-
(2007)
Science
, vol.316
, pp. 889-894
-
-
Frayling, T.M.1
-
57
-
-
34547625955
-
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
-
Scuteri, A. et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 3, e115 (2007).
-
(2007)
PLoS Genet.
, vol.3
-
-
Scuteri, A.1
-
58
-
-
36749041363
-
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
-
Gerken, T. et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 318, 1469-1472 (2007).
-
(2007)
Science
, vol.318
, pp. 1469-1472
-
-
Gerken, T.1
-
59
-
-
67349211789
-
Inactivation of the Fto gene protects from obesity
-
Fischer, J. et al. Inactivation of the Fto gene protects from obesity. Nature 458, 894-898 (2009).
-
(2009)
Nature
, vol.458
, pp. 894-898
-
-
Fischer, J.1
-
60
-
-
78649459183
-
Overexpression of Fto leads to increased food intake and results in obesity
-
Church, C. et al. Overexpression of Fto leads to increased food intake and results in obesity. Nature Genet. 42, 1086-1092 (2010).
-
(2010)
Nature Genet.
, vol.42
, pp. 1086-1092
-
-
Church, C.1
-
61
-
-
67649875640
-
Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations
-
Boissel, S. et al. Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. Am. J. Hum. Genet. 85, 106-111 (2009).
-
(2009)
Am. J. Hum. Genet.
, vol.85
, pp. 106-111
-
-
Boissel, S.1
-
62
-
-
80052495940
-
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA
-
He, Y. F. et al. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science 333, 1303-1307 (2011).
-
(2011)
Science
, vol.333
, pp. 1303-1307
-
-
He, Y.F.1
-
63
-
-
80052461558
-
Te t proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
-
Ito, S. et al. Te t proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 333, 1300-1303 (2011).
-
(2011)
Science
, vol.333
, pp. 1300-1303
-
-
Ito, S.1
-
64
-
-
66149146320
-
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
-
Tahiliani, M. et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324, 930-935 (2009).
-
(2009)
Science
, vol.324
, pp. 930-935
-
-
Tahiliani, M.1
-
65
-
-
54849381000
-
Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO
-
Jia, G. et al. Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett. 582, 3313-3319 (2008).
-
(2008)
FEBS Lett.
, vol.582
, pp. 3313-3319
-
-
Jia, G.1
-
66
-
-
84880916638
-
The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry
-
Hess, M. E. et al. The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nature Neurosci. 16, 1042-1048 (2013).
-
(2013)
Nature Neurosci.
, vol.16
, pp. 1042-1048
-
-
Hess, M.E.1
-
67
-
-
84873735640
-
Role for the obesity-related FTO gene in the cellular sensing of amino acids
-
Gulati, P. et al. Role for the obesity-related FTO gene in the cellular sensing of amino acids. Proc. Natl Acad. Sci. USA 110, 2557-2562 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 2557-2562
-
-
Gulati, P.1
-
68
-
-
77951623073
-
Crystal structure of the FTO protein reveals basis for its substrate specificity
-
Han, Z. et al. Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature 464, 1205-1209 (2010).
-
(2010)
Nature
, vol.464
, pp. 1205-1209
-
-
Han, Z.1
-
69
-
-
84894599601
-
Sprouts of RNA epigenetics: The discovery of mammalian RNA demethylases
-
Zheng, G. et al. Sprouts of RNA epigenetics: the discovery of mammalian RNA demethylases. RNA Biol. 10, 915-918 (2013).
-
(2013)
RNA Biol.
, vol.10
, pp. 915-918
-
-
Zheng, G.1
-
70
-
-
84861997955
-
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts
-
Baltz, A. G. et al. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46, 674-690 (2012).
-
(2012)
Mol. Cell
, vol.46
, pp. 674-690
-
-
Baltz, A.G.1
-
71
-
-
84877750692
-
6-formyladenosine in mammalian RNA
-
6-formyladenosine in mammalian RNA. Nature Commun. 4, 1798 (2013).
-
(2013)
Nature Commun.
, vol.4
, pp. 1798
-
-
Fu, Y.1
-
72
-
-
79956322553
-
Global quantification of mammalian gene expression control
-
Schwanhausser, B. et al. Global quantification of mammalian gene expression control. Nature 473, 337-342 (2011).
-
(2011)
Nature
, vol.473
, pp. 337-342
-
-
Schwanhausser, B.1
-
73
-
-
79955768436
-
Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells
-
Rabani, M. et al. Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells. Nature Biotech. 29, 436-442 (2011).
-
(2011)
Nature Biotech.
, vol.29
, pp. 436-442
-
-
Rabani, M.1
-
74
-
-
38649130998
-
The FTO gene, implicated in human obesity, is found only in vertebrates and marine algae
-
Robbens, S. et al. The FTO gene, implicated in human obesity, is found only in vertebrates and marine algae. J. Mol. Evol. 66, 80-84 (2008).
-
(2008)
J. Mol. Evol.
, vol.66
, pp. 80-84
-
-
Robbens, S.1
-
75
-
-
66749152204
-
Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids
-
Iyer, L. M., Tahiliani, M., Rao, A. & Aravind, L. Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids. Cell Cycle 8, 1698-1710 (2009).
-
(2009)
Cell Cycle
, vol.8
, pp. 1698-1710
-
-
Iyer, L.M.1
Tahiliani, M.2
Rao, A.3
Aravind, L.4
-
76
-
-
84892372347
-
6-methyladenosine-dependent regulation of messenger RNA stability
-
6-methyladenosine-dependent regulation of messenger RNA stability. Nature 505, 117-120 (2014).
-
(2014)
Nature
, vol.505
, pp. 117-120
-
-
Wang, X.1
-
77
-
-
84858446718
-
Regulation of cytoplasmic mRNA decay
-
Schoenberg, D. R. & Maquat, L. E. Regulation of cytoplasmic mRNA decay. Nature Rev. Genet. 13, 246-259 (2012).
-
(2012)
Nature Rev. Genet.
, vol.13
, pp. 246-259
-
-
Schoenberg, D.R.1
Maquat, L.E.2
-
78
-
-
49949105213
-
The multiple lives of NMD factors: Balancing roles in gene and genome regulation
-
Isken, O. & Maquat, L. E. The multiple lives of NMD factors: balancing roles in gene and genome regulation. Nature Rev. Genet. 9, 699-712 (2008).
-
(2008)
Nature Rev. Genet.
, vol.9
, pp. 699-712
-
-
Isken, O.1
Maquat, L.E.2
-
79
-
-
0037968357
-
Decapping and decay of messenger RNA occur in cytoplasmic processing bodies
-
Sheth, U. & Parker, R. Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300, 805-808 (2003).
-
(2003)
Science
, vol.300
, pp. 805-808
-
-
Sheth, U.1
Parker, R.2
-
80
-
-
68049110633
-
IRE1α kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates
-
Han, D. et al. IRE1α kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell 138, 562-575 (2009).
-
(2009)
Cell
, vol.138
, pp. 562-575
-
-
Han, D.1
-
81
-
-
54149091257
-
Metabolism and regulation of canonical histone mRNAs: Life without a poly(A) tail
-
Marzluff, W. F., Wagner, E. J. & Duronio, R. J. Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail. Nature Rev. Genet. 9, 843-854 (2008).
-
(2008)
Nature Rev. Genet.
, vol.9
, pp. 843-854
-
-
Marzluff, W.F.1
Wagner, E.J.2
Duronio, R.J.3
-
82
-
-
84858440814
-
The importance of CELF control: Molecular and biological roles of the CUG-BP, Elav-like family of RNA-binding proteins
-
Dasgupta, T. & Ladd, A. N. The importance of CELF control: molecular and biological roles of the CUG-BP, Elav-like family of RNA-binding proteins. Wiley Interdiscip. Rev. RNA 3, 104-121 (2012).
-
(2012)
Wiley Interdiscip. Rev. RNA
, vol.3
, pp. 104-121
-
-
Dasgupta, T.1
Ladd, A.N.2
-
83
-
-
2442419461
-
Endonuclease-mediated mRNA decay involves the selective targeting of PMR1 to polyribosome-bound substrate mRNA
-
Yang, F. & Schoenberg, D. R. Endonuclease-mediated mRNA decay involves the selective targeting of PMR1 to polyribosome-bound substrate mRNA. Mol. Cell 14, 435-445 (2004).
-
(2004)
Mol. Cell
, vol.14
, pp. 435-445
-
-
Yang, F.1
Schoenberg, D.R.2
-
84
-
-
84857770525
-
RNA decay modulates gene expression and controls its fidelity
-
Ghosh, S. & Jacobson, A. RNA decay modulates gene expression and controls its fidelity. Wiley Interdiscip. Rev. RNA 1, 351-361 (2010).
-
(2010)
Wiley Interdiscip. Rev. RNA
, vol.1
, pp. 351-361
-
-
Ghosh, S.1
Jacobson, A.2
-
85
-
-
3042767202
-
MicroRNAs: Small RNAs with a big role in gene regulation
-
He, L. & Hannon, G. J. MicroRNAs: small RNAs with a big role in gene regulation. Nature Rev. Genet. 5, 522-531 (2004).
-
(2004)
Nature Rev. Genet.
, vol.5
, pp. 522-531
-
-
He, L.1
Hannon, G.J.2
-
87
-
-
33746005932
-
Selective elimination of messenger RNA prevents an incidence of untimely meiosis
-
Harigaya, Y. et al. Selective elimination of messenger RNA prevents an incidence of untimely meiosis. Nature 442, 45-50 (2006).
-
(2006)
Nature
, vol.442
, pp. 45-50
-
-
Harigaya, Y.1
-
88
-
-
23844464444
-
Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA
-
Kariko, K., Buckstein, M., Ni, H. & Weissman, D. Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity 23, 165-175 (2005).
-
(2005)
Immunity
, vol.23
, pp. 165-175
-
-
Kariko, K.1
Buckstein, M.2
Ni, H.3
Weissman, D.4
-
89
-
-
56549116047
-
Toll-like receptor and RIG-I-like receptor signaling
-
Kawai, T. & Akira, S. Toll-like receptor and RIG-I-like receptor signaling. Ann. NY Acad. Sci. 1143, 1-20 (2008).
-
(2008)
Ann. NY Acad. Sci.
, vol.1143
, pp. 1-20
-
-
Kawai, T.1
Akira, S.2
-
90
-
-
0036896469
-
Sculpting of the spliceosomal branch site recognition motif by a conserved pseudouridine
-
Newby, M. I. & Greenbaum, N. L. Sculpting of the spliceosomal branch site recognition motif by a conserved pseudouridine. Nature Struct. Biol. 9, 958-965 (2002).
-
(2002)
Nature Struct. Biol.
, vol.9
, pp. 958-965
-
-
Newby, M.I.1
Greenbaum, N.L.2
-
91
-
-
79960929333
-
Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR
-
Lebedeva, S. et al. Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR. Mol. Cell 43, 340-352 (2011).
-
(2011)
Mol. Cell
, vol.43
, pp. 340-352
-
-
Lebedeva, S.1
-
92
-
-
79960918737
-
Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability
-
Mukherjee, N. et al. Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability. Mol. Cell 43, 327-339 (2011).
-
(2011)
Mol. Cell
, vol.43
, pp. 327-339
-
-
Mukherjee, N.1
-
93
-
-
79960904961
-
UneCLIPsing HuR nuclear function
-
Srikantan, S. & Gorospe, M. UneCLIPsing HuR nuclear function. Mol. Cell 43, 319-321 (2011).
-
(2011)
Mol. Cell
, vol.43
, pp. 319-321
-
-
Srikantan, S.1
Gorospe, M.2
-
94
-
-
84884126014
-
HuR and miR-1192 regulate myogenesis by modulating the translation of HMGB1 mRNA
-
Dormoy-Raclet, V. et al. HuR and miR-1192 regulate myogenesis by modulating the translation of HMGB1 mRNA. Nature Commun. 4, 2388 (2013).
-
(2013)
Nature Commun.
, vol.4
, pp. 2388
-
-
Dormoy-Raclet, V.1
-
95
-
-
84888438314
-
Changes in cellular mRNA stability, splicing, and polyadenylation through HuR protein sequestration by a cytoplasmic RNA virus
-
Barnhart, M. D., Moon, S. L., Emch, A. W., Wilusz, C. J. & Wilusz, J. Changes in cellular mRNA stability, splicing, and polyadenylation through HuR protein sequestration by a cytoplasmic RNA virus. Cell Rep. 5, 909-917 (2013).
-
(2013)
Cell Rep.
, vol.5
, pp. 909-917
-
-
Barnhart, M.D.1
Moon, S.L.2
Emch, A.W.3
Wilusz, C.J.4
Wilusz, J.5
-
97
-
-
4644309196
-
The functions of animal microRNAs
-
Ambros, V. The functions of animal microRNAs. Nature 431, 350-355 (2004).
-
(2004)
Nature
, vol.431
, pp. 350-355
-
-
Ambros, V.1
-
98
-
-
33846283385
-
The evolution of gene regulation by transcription factors and microRNAs
-
Chen, K. & Rajewsky, N. The evolution of gene regulation by transcription factors and microRNAs. Nature Rev. Genet. 8, 93-103 (2007).
-
(2007)
Nature Rev. Genet.
, vol.8
, pp. 93-103
-
-
Chen, K.1
Rajewsky, N.2
-
99
-
-
38349169664
-
Mechanisms of post-transcriptional regulation by microRNAs: Are the answers in sight? Nature Rev
-
Filipowicz, W., Bhattacharyya, S. N. & Sonenberg, N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nature Rev. Genet. 9, 102-114 (2008).
-
(2008)
Genet.
, vol.9
, pp. 102-114
-
-
Filipowicz, W.1
Bhattacharyya, S.N.2
Sonenberg, N.3
-
100
-
-
33847417585
-
P bodies and the control of mRNA translation and degradation
-
Parker, R. & Sheth, U. P bodies and the control of mRNA translation and degradation. Mol. Cell 25, 635-646 (2007).
-
(2007)
Mol. Cell
, vol.25
, pp. 635-646
-
-
Parker, R.1
Sheth, U.2
-
101
-
-
34250735674
-
RNA regulons: Coordination of post-transcriptional events
-
Keene, J. D. RNA regulons: coordination of post-transcriptional events. Nature Rev. Genet. 8, 533-543 (2007).
-
(2007)
Nature Rev. Genet.
, vol.8
, pp. 533-543
-
-
Keene, J.D.1
-
102
-
-
33847779219
-
Post-translational modifications regulate the ticking of the circadian clock
-
Gallego, M. & Virshup, D. M. Post-translational modifications regulate the ticking of the circadian clock. Nature Rev. Mol. Cell Biol. 8, 139-148 (2007).
-
(2007)
Nature Rev. Mol. Cell Biol.
, vol.8
, pp. 139-148
-
-
Gallego, M.1
Virshup, D.M.2
-
103
-
-
33845809231
-
P bodies: At the crossroads of post-transcriptional pathways
-
Eulalio, A., Behm-Ansmant, I. & Izaurralde, E. P bodies: at the crossroads of post-transcriptional pathways. Nature Rev. Mol. Cell Biol. 8, 9-22 (2007).
-
(2007)
Nature Rev. Mol. Cell Biol.
, vol.8
, pp. 9-22
-
-
Eulalio, A.1
Behm-Ansmant, I.2
Izaurralde, E.3
-
104
-
-
84887875528
-
RNA-methylation-dependent RNA processing controls the speed of the circadian clock
-
Fustin, J. M. et al. RNA-methylation-dependent RNA processing controls the speed of the circadian clock. Cell 155, 793-806 (2013).
-
(2013)
Cell
, vol.155
, pp. 793-806
-
-
Fustin, J.M.1
-
105
-
-
84888838351
-
Primate transcript and protein expression levels evolve under compensatory selection pressures
-
Khan, Z. et al. Primate transcript and protein expression levels evolve under compensatory selection pressures. Science 342, 1100-1104 (2013).
-
(2013)
Science
, vol.342
, pp. 1100-1104
-
-
Khan, Z.1
-
106
-
-
84879879014
-
Variation and genetic control of protein abundance in humans
-
Wu, L. et al. Variation and genetic control of protein abundance in humans. Nature 499, 79-82 (2013).
-
(2013)
Nature
, vol.499
, pp. 79-82
-
-
Wu, L.1
-
107
-
-
85027958937
-
The birth of the epitranscriptome: Deciphering the function of RNA modifications
-
Saletore, Y. et al. The birth of the epitranscriptome: deciphering the function of RNA modifications. Genome Biol. 13, 175 (2012).
-
(2012)
Genome Biol.
, vol.13
, pp. 175
-
-
Saletore, Y.1
-
108
-
-
79959284255
-
Converting nonsense codons into sense codons by targeted pseudouridylation
-
Karijolich, J. & Yu, Y. T. Converting nonsense codons into sense codons by targeted pseudouridylation. Nature 474, 395-398 (2011).
-
(2011)
Nature
, vol.474
, pp. 395-398
-
-
Karijolich, J.1
Yu, Y.T.2
-
109
-
-
84881477474
-
Unusual base pairing during the decoding of a stop codon by the ribosome
-
Fernandez, I. S. et al. Unusual base pairing during the decoding of a stop codon by the ribosome. Nature 500, 107-110 (2013).
-
(2013)
Nature
, vol.500
, pp. 107-110
-
-
Fernandez, I.S.1
-
110
-
-
84875514519
-
RNA pseudouridylation: New insights into an old modification
-
Ge, J. & Yu, Y. T. RNA pseudouridylation: new insights into an old modification. Trends Biochem. Sci. 38, 210-218 (2013).
-
(2013)
Trends Biochem. Sci.
, vol.38
, pp. 210-218
-
-
Ge, J.1
Yu, Y.T.2
-
112
-
-
84888791449
-
Characterizing 5-methylcytosine in the mammalian epitranscriptome
-
Hussain, S., Aleksic, J., Blanco, S., Dietmann, S. & Frye, M. Characterizing 5-methylcytosine in the mammalian epitranscriptome. Genome Biol. 14, 215 (2013).
-
(2013)
Genome Biol.
, vol.14
, pp. 215
-
-
Hussain, S.1
Aleksic, J.2
Blanco, S.3
Dietmann, S.4
Frye, M.5
-
113
-
-
84860751168
-
Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA
-
Squires, J. E. et al. Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA. Nucleic Acids Res. 40, 5023-5033 (2012).
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. 5023-5033
-
-
Squires, J.E.1
-
114
-
-
2442691791
-
Missense mutation in pseudouridine synthase 1 (PUS1) causes mitochondrial myopathy and sideroblastic anemia (MLASA)
-
Bykhovskaya, Y., Casas, K., Mengesha, E., Inbal, A. & Fischel-Ghodsian, N. Missense mutation in pseudouridine synthase 1 (PUS1) causes mitochondrial myopathy and sideroblastic anemia (MLASA). Am. J. Hum. Genet. 74, 1303-1308 (2004).
-
(2004)
Am. J. Hum. Genet.
, vol.74
, pp. 1303-1308
-
-
Bykhovskaya, Y.1
Casas, K.2
Mengesha, E.3
Inbal, A.4
Fischel-Ghodsian, N.5
-
115
-
-
21244449941
-
Mitochondrial myopathy and sideroblastic anemia (MLASA): Missense mutation in the pseudouridine synthase 1 (PUS1) gene is associated with the loss of tRNA pseudouridylation
-
Patton, J. R., Bykhovskaya, Y., Mengesha, E., Bertolotto, C. & Fischel-Ghodsian, N. Mitochondrial myopathy and sideroblastic anemia (MLASA): missense mutation in the pseudouridine synthase 1 (PUS1) gene is associated with the loss of tRNA pseudouridylation. J. Biol. Chem. 280, 19823-19828 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 19823-19828
-
-
Patton, J.R.1
Bykhovskaya, Y.2
Mengesha, E.3
Bertolotto, C.4
Fischel-Ghodsian, N.5
-
116
-
-
44349191455
-
Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar RNA cluster
-
Sahoo, T. et al. Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar RNA cluster. Nature Genet. 40, 719-721 (2008).
-
(2008)
Nature Genet.
, vol.40
, pp. 719-721
-
-
Sahoo, T.1
-
117
-
-
0742305875
-
Repairing DNA-methylation damage
-
Sedgwick, B. Repairing DNA-methylation damage. Nature Rev. Mol. Cell Biol. 5, 148-157 (2004).
-
(2004)
Nature Rev. Mol. Cell Biol.
, vol.5
, pp. 148-157
-
-
Sedgwick, B.1
-
118
-
-
33644639463
-
Direct reversal of DNA alkylation damage
-
Mishina, Y., Duguid, E. M. & He, C. Direct reversal of DNA alkylation damage. Chem. Rev. 106, 215-232 (2006).
-
(2006)
Chem. Rev.
, vol.106
, pp. 215-232
-
-
Mishina, Y.1
Duguid, E.M.2
He, C.3
-
119
-
-
78449233126
-
The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA
-
Fu, Y. et al. The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA. Angew. Chem. Int. Ed Engl. 49, 8885-8888 (2010).
-
(2010)
Angew. Chem. Int. Ed Engl.
, vol.49
, pp. 8885-8888
-
-
Fu, Y.1
-
120
-
-
79551582659
-
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA
-
van den Born, E. et al. ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA. Nature Commun. 2, 172 (2011).
-
(2011)
Nature Commun.
, vol.2
, pp. 172
-
-
Van Den Born, E.1
-
121
-
-
84898832234
-
6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation
-
6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation. Nucleic Acids Res. http://dx.doi. org/10.1093/nar/gku085 (2014).
-
(2014)
Nucleic Acids Res
-
-
Aik, W.1
-
122
-
-
84896078447
-
Crystal structure of the RNA demethylase ALKBH5 from zebrafish
-
Chen, W. et al. Crystal structure of the RNA demethylase ALKBH5 from zebrafish. FEBS Lett. 588, 892-898 (2014).
-
(2014)
FEBS Lett.
, vol.588
, pp. 892-898
-
-
Chen, W.1
|