A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

Nature Chemical Biology

Volumn 12, Issue 6, 2016, Pages 452-458

  Pacold, Michael E ^a,b,c,d   Brimacombe, Kyle R ^e   Chan, Sze Ham ^a,b,c,d   Rohde, Jason M ^e   Lewis, Caroline A ^c   Swier, Lotteke J Y M ^a,b,c   Possemato, Richard ^f   Chen, Walter W ^a,b,c   Sullivan, Lucas B ^c   Fiske, Brian P ^c   Cho, Steve ^a,b,c   Freinkman, Elizaveta ^a   Birsoy, Klvanç ^g   Abu Remaileh, Monther ^a,b,c   Shaul, Yoav D ^h   Liu, Chieh Min ^a,b,c   Zhou, Minerva ^a,b,c   Koh, Min Jung ^a,b,c   Chung, Haeyoon ^a,b,c   Davidson, Shawn M ^c   Luengo, Alba ^c   Wang, Amy Q ^e   Xu, Xin ^e   Yasgar, Adam ^e   Liu, Li ^e   Rai, Ganesha ^e   Westover, Kenneth D ⁱ   Vander Heiden, Matthew G ^c   Shen, Min ^e   Gray, Nathanael S ^d   Boxer, Matthew B ^e   Sabatini, David M ^a,b,c   more..

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c KOCH INSTITUTE FOR INTEGRATIVE CANCER RESEARCH   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

^f NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^g ROCKEFELLER UNIVERSITY   (United States)

^h HEBREW UNIVERSITY   (Israel)

ⁱ UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CARBON; NCT 502; NCT 503; NUCLEOTIDE; OXIDOREDUCTASE INHIBITOR; SERINE; UNCLASSIFIED DRUG; ENZYME INHIBITOR; MOLECULAR LIBRARY; PHOSPHOGLYCERATE DEHYDROGENASE; PURINE; PURINE DERIVATIVE; THYMIDINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG SYNTHESIS; EC50; GLYCOLYSIS; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME; MAXIMUM PLASMA CONCENTRATION; MELTING POINT; METABOLIC STABILITY; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; TUMOR XENOGRAFT; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; ENZYMOLOGY; FEMALE; HUMAN; MAMMARY NEOPLASMS, EXPERIMENTAL; METABOLISM; MOLECULAR LIBRARY; PATHOLOGY; PHARMACOLOGY; STRUCTURE ACTIVITY RELATION; TUMOR CELL CULTURE;

ANIMALS; CARBON; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; GLYCOLYSIS; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MOLECULAR STRUCTURE; PHOSPHOGLYCERATE DEHYDROGENASE; PURINES; SERINE; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDINE; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84964216448     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.2070     Document Type: Article

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