-
1
-
-
0030890811
-
Cloning, sequencing and expression of rat liver 3-phosphoglycerate dehydrogenase
-
Achouri, Y., M.H. Rider, E.V. Schaftingen, and M. Robbi. 1997. Cloning, sequencing and expression of rat liver 3-phosphoglycerate dehydrogenase. Biochem. J. 323:365-370. http://dx.doi.org/10.1042/bj3230365.
-
(1997)
Biochem. J
, vol.323
, pp. 365-370
-
-
Achouri, Y.1
Rider, M.H.2
Schaftingen, E.V.3
Robbi, M.4
-
2
-
-
84908242138
-
Neu-Laxova syndrome is a heterogeneous metabolic disorder caused by defects in enzymes of the L-serine biosynthesis pathway
-
Acuna-Hidalgo, R., D. Schanze, A. Kariminejad, A. Nordgren, M.H. Kariminejad, P. Conner, G. Grigelioniene, D. Nilsson, M. Nordenskjöld, A. Wedell, et al. 2014. Neu-Laxova syndrome is a heterogeneous metabolic disorder caused by defects in enzymes of the L-serine biosynthesis pathway. Am. J. Hum. Genet. 95:285-293. http://dx.doi.org/10.1016/j.ajhg.2014.07.012.
-
(2014)
Am. J. Hum. Genet
, vol.95
, pp. 285-293
-
-
Acuna-Hidalgo, R.1
Schanze, D.2
Kariminejad, A.3
Nordgren, A.4
Kariminejad, M.H.5
Conner, P.6
Grigelioniene, G.7
Nilsson, D.8
Nordenskjöld, M.9
Wedell, A.10
-
3
-
-
34447121352
-
Role of the transcription factor ATF4 in the anabolic actions of insulin and the anti-anabolic actions of glucocorticoids
-
Adams, C.M. 2007. Role of the transcription factor ATF4 in the anabolic actions of insulin and the anti-anabolic actions of glucocorticoids. J. Biol. Chem. 282:16744-16753. http://dx.doi.org/10.1074/jbc.M610510200.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 16744-16753
-
-
Adams, C.M.1
-
4
-
-
84866842363
-
Pyruvate kinase M2. activators promote tetramer formation and suppress tumorigenesis
-
Anastasiou, D., Y. Yu, W.J. Israelsen, J.K. Jiang, M.B. Boxer, B.S. Hong, W. Tempel, S. Dimov, M. Shen, A. Jha, et al. 2012. Pyruvate kinase M2. activators promote tetramer formation and suppress tumorigenesis. Nat. Chem. Biol. 8:839-847. http://dx.doi.org/10.1038/nchembio.1060.
-
(2012)
Nat. Chem. Biol
, vol.8
, pp. 839-847
-
-
Anastasiou, D.1
Yu, Y.2
Israelsen, W.J.3
Jiang, J.K.4
Boxer, M.B.5
Hong, B.S.6
Tempel, W.7
Dimov, S.8
Shen, M.9
Jha, A.10
-
5
-
-
84975247161
-
Mitochondrial dysfunction remodels one-carbon metabolism in human cells
-
Bao, X.R., S.E. Ong, O. Goldberger, J. Peng, R. Sharma, D.A. Thompson, S.B. Vafai, A.G. Cox, E. Marutani, F. Ichinose, et al. 2016. Mitochondrial dysfunction remodels one-carbon metabolism in human cells. eLife. 5:5. http://dx.doi.org/10.7554/eLife.10575.
-
(2016)
eLife
, vol.5
, pp. 5
-
-
Bao, X.R.1
Ong, S.E.2
Goldberger, O.3
Peng, J.4
Sharma, R.5
Thompson, D.A.6
Vafai, S.B.7
Cox, A.G.8
Marutani, E.9
Ichinose, F.10
-
6
-
-
84957899529
-
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
-
Ben-Sahra, I., G. Hoxhaj, S.J. Ricoult, J.M. Asara, and B.D. Manning. 2016. mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle. Science. 351:728-733. http://dx.doi.org/10.1126/science.aad0489.
-
(2016)
Science
, vol.351
, pp. 728-733
-
-
Ben-Sahra, I.1
Hoxhaj, G.2
Ricoult, S.J.3
Asara, J.M.4
Manning, B.D.5
-
7
-
-
77249119762
-
The landscape of somatic copy-number alteration across human cancers
-
Beroukhim, R., C.H. Mermel, D. Porter, G. Wei, S. Raychaudhuri, J. Donovan, J. Barretina, J.S. Boehm, J. Dobson, M. Urashima, et al. 2010. The landscape of somatic copy-number alteration across human cancers. Nature. 463:899-905. http://dx.doi.org/10.1038/nature08822.
-
(2010)
Nature
, vol.463
, pp. 899-905
-
-
Beroukhim, R.1
Mermel, C.H.2
Porter, D.3
Wei, G.4
Raychaudhuri, S.5
Donovan, J.6
Barretina, J.7
Boehm, J.S.8
Dobson, J.9
Urashima, M.10
-
8
-
-
79251517382
-
Regulation of cancer cell metabolism
-
Cairns, R.A., I.S. Harris, and T.W. Mak. 2011. Regulation of cancer cell metabolism. Nat. Rev. Cancer. 11:85-95. http://dx.doi.org/10.1038/nrc2981.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 85-95
-
-
Cairns, R.A.1
Harris, I.S.2
Mak, T.W.3
-
9
-
-
84869082905
-
Serine is a natural ligand and allosteric activator of pyruvate kinase M2
-
Chaneton, B., P. Hillmann, L. Zheng, A.C. Martin, O.D. Maddocks, A. Chokkathukalam, J.E. Coyle, A. Jankevics, F.P. Holding, K.H. Vousden, et al. 2012. Serine is a natural ligand and allosteric activator of pyruvate kinase M2. Nature. 491:458-462. http://dx.doi.org/10.1038/nature11540.
-
(2012)
Nature
, vol.491
, pp. 458-462
-
-
Chaneton, B.1
Hillmann, P.2
Zheng, L.3
Martin, A.C.4
Maddocks, O.D.5
Chokkathukalam, A.6
Coyle, J.E.7
Jankevics, A.8
Holding, F.P.9
Vousden, K.H.10
-
10
-
-
84891913582
-
Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth
-
Chen, J., F. Chung, G. Yang, M. Pu, H. Gao, W. Jiang, H. Yin, V. Capka, S. Kasibhatla, B. Laffitte, et al. 2013. Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth. Oncotarget. 4:2502-2511. http://dx.doi.org/10.18632/oncotarget.1540.
-
(2013)
Oncotarget
, vol.4
, pp. 2502-2511
-
-
Chen, J.1
Chung, F.2
Yang, G.3
Pu, M.4
Gao, H.5
Jiang, W.6
Yin, H.7
Capka, V.8
Kasibhatla, S.9
Laffitte, B.10
-
11
-
-
0014470830
-
The effects of dietary protein on the hepatic enzymes of serine metabolism in the rabbit
-
Cheung, G.P., J.P. Cotropia, and H.J. Sallach. 1969. The effects of dietary protein on the hepatic enzymes of serine metabolism in the rabbit. Arch. Biochem. Biophys. 129:672-682. http://dx.doi.org/10.1016/0003-9861(69)90227-6.
-
(1969)
Arch. Biochem. Biophys
, vol.129
, pp. 672-682
-
-
Cheung, G.P.1
Cotropia, J.P.2
Sallach, H.J.3
-
12
-
-
40749163248
-
The M2. splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
-
Christofk, H.R., M.G. Vander Heiden, M.H. Harris, A. Ramanathan, R.E. Gerszten, R. Wei, M.D. Fleming, S.L. Schreiber, and L.C. Cantley. 2008a. The M2. splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature. 452:230-233. http://dx.doi.org/10.1038/nature06734.
-
(2008)
Nature
, vol.452
, pp. 230-233
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Harris, M.H.3
Ramanathan, A.4
Gerszten, R.E.5
Wei, R.6
Fleming, M.D.7
Schreiber, S.L.8
Cantley, L.C.9
-
13
-
-
40749099894
-
Pyruvate kinase M2 is a phosphotyrosine-binding protein
-
Christofk, H.R., M.G. Vander Heiden, N. Wu, J.M. Asara, and L.C. Cantley. 2008b. Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature. 452:181-186. http://dx.doi.org/10.1038/nature06667.
-
(2008)
Nature
, vol.452
, pp. 181-186
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Wu, N.3
Asara, J.M.4
Cantley, L.C.5
-
14
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang, L., D.W. White, S. Gross, B.D. Bennett, M.A. Bittinger, E.M. Driggers, V.R. Fantin, H.G. Jang, S. Jin, M.C. Keenan, et al. 2009. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 462:739-744. http://dx.doi.org/10.1038/nature08617.
-
(2009)
Nature
, vol.462
, pp. 739-744
-
-
Dang, L.1
White, D.W.2
Gross, S.3
Bennett, B.D.4
Bittinger, M.A.5
Driggers, E.M.6
Fantin, V.R.7
Jang, H.G.8
Jin, S.9
Keenan, M.C.10
-
15
-
-
84958138936
-
Environment impacts the metabolic dependencies of Rasdriven non-small cell lung cancer
-
Davidson, S.M., T. Papagiannakopoulos, B.A. Olenchock, J.E. Heyman, M.A. Keibler, A. Luengo, M.R. Bauer, A.K. Jha, J.P. O'Brien, K.A. Pierce, et al. 2016. Environment impacts the metabolic dependencies of Rasdriven non-small cell lung cancer. Cell Metab. 23:517-528. http://dx.doi.org/10.1016/j.cmet.2016.01.007.
-
(2016)
Cell Metab
, vol.23
, pp. 517-528
-
-
Davidson, S.M.1
Papagiannakopoulos, T.2
Olenchock, B.A.3
Heyman, J.E.4
Keibler, M.A.5
Luengo, A.6
Bauer, M.R.7
Jha, A.K.8
O'Brien, J.P.9
Pierce, K.A.10
-
16
-
-
0014887484
-
Two enzymes of serine metabolism in rat liver and hepatomas
-
Davis, J.L., H.J. Fallon, and H.P. Morris. 1970. Two enzymes of serine metabolism in rat liver and hepatomas. Cancer Res. 30:2917-2920.
-
(1970)
Cancer Res
, vol.30
, pp. 2917-2920
-
-
Davis, J.L.1
Fallon, H.J.2
Morris, H.P.3
-
17
-
-
75149148563
-
Q's next: The diverse functions of glutamine in metabolism, cell biology and cancer
-
DeBerardinis, R.J., and T. Cheng. 2010. Q's next: The diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene. 29:313-324. http://dx.doi.org/10.1038/onc.2009.358.
-
(2010)
Oncogene
, vol.29
, pp. 313-324
-
-
DeBerardinis, R.J.1
Cheng, T.2
-
18
-
-
84949102276
-
NRF2 regulates serine biosynthesis in non-small cell lung cancer
-
DeNicola, G.M., P.H. Chen, E. Mullarky, J.A. Sudderth, Z. Hu, D. Wu, H. Tang, Y. Xie, J.M. Asara, K.E. Huffman, et al. 2015. NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nat. Genet. 47:1475-1481. http://dx.doi.org/10.1038/ng.3421.
-
(2015)
Nat. Genet
, vol.47
, pp. 1475-1481
-
-
DeNicola, G.M.1
Chen, P.H.2
Mullarky, E.3
Sudderth, J.A.4
Hu, Z.5
Wu, D.6
Tang, H.7
Xie, Y.8
Asara, J.M.9
Huffman, K.E.10
-
19
-
-
17644426079
-
D-3-phosphoglycerate dehydrogenase from Mycobacterium tuberculosis is a link between the Escherichia coli and mammalian enzymes
-
Dey, S., Z. Hu, X.L. Xu, J.C. Sacchettini, and G.A. Grant. 2005. D-3-phosphoglycerate dehydrogenase from Mycobacterium tuberculosis is a link between the Escherichia coli and mammalian enzymes. J. Biol. Chem. 280:14884-14891. http://dx.doi.org/10.1074/jbc.M414488200.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 14884-14891
-
-
Dey, S.1
Hu, Z.2
Xu, X.L.3
Sacchettini, J.C.4
Grant, G.A.5
-
20
-
-
84889684498
-
The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation
-
Ding, J., T. Li, X. Wang, E. Zhao, J.H. Choi, L. Yang, Y. Zha, Z. Dong, S. Huang, J.M. Asara, et al. 2013. The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation. Cell Metab. 18:896-907. http://dx.doi.org/10.1016/j.cmet.2013.11.004.
-
(2013)
Cell Metab
, vol.18
, pp. 896-907
-
-
Ding, J.1
Li, T.2
Wang, X.3
Zhao, E.4
Choi, J.H.5
Yang, L.6
Zha, Y.7
Dong, Z.8
Huang, S.9
Asara, J.M.10
-
21
-
-
84975455372
-
Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway
-
Ducker, G.S., L. Chen, R.J. Morscher, J.M. Ghergurovich, M. Esposito, X. Teng, Y. Kang, and J.D. Rabinowitz. 2016. Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway. Cell Metab. 23:1140-1153. http://dx.doi.org/10.1016/j.cmet.2016.04.016.
-
(2016)
Cell Metab
, vol.23
, pp. 1140-1153
-
-
Ducker, G.S.1
Chen, L.2
Morscher, R.J.3
Ghergurovich, J.M.4
Esposito, M.5
Teng, X.6
Kang, Y.7
Rabinowitz, J.D.8
-
22
-
-
0019493184
-
The role of serine hydroxymethyltransferase in cell proliferation: DNA synthesis from serine following mitogenic stimulation of lymphocytes
-
Eichler, H.G., R. Hubbard, and K. Snell. 1981. The role of serine hydroxymethyltransferase in cell proliferation: DNA synthesis from serine following mitogenic stimulation of lymphocytes. Biosci. Rep. 1:101-106. http://dx.doi.org/10.1007/BF01117006.
-
(1981)
Biosci. Rep
, vol.1
, pp. 101-106
-
-
Eichler, H.G.1
Hubbard, R.2
Snell, K.3
-
23
-
-
0020958437
-
Structural and kinetic differences between the M2 type pyruvate kinases from lung and various tumors
-
Eigenbrodt, E., S. Leib, W. Kramer, R.R. Friis, and W. Schoner. 1983. Structural and kinetic differences between the M2 type pyruvate kinases from lung and various tumors. Biomed. Biochim. Acta. 42:S278-S282.
-
(1983)
Biomed. Biochim. Acta
, vol.42
, pp. S278-S282
-
-
Eigenbrodt, E.1
Leib, S.2
Kramer, W.3
Friis, R.R.4
Schoner, W.5
-
24
-
-
84964994281
-
Serine biosynthesis and transport defects
-
El-Hattab, A.W. 2016. Serine biosynthesis and transport defects. Mol. Genet. Metab. 118:153-159. http://dx.doi.org/10.1016/j.ymgme.2016.04.010.
-
(2016)
Mol. Genet. Metab
, vol.118
, pp. 153-159
-
-
El-Hattab, A.W.1
-
25
-
-
84902332213
-
Quantitative flux analysis reveals folate-dependent NAD PH production
-
Fan, J., J. Ye, J.J. Kamphorst, T. Shlomi, C.B. Thompson, and J.D. Rabinowitz. 2014. Quantitative flux analysis reveals folate-dependent NAD PH production. Nature. 510:298-302. http://dx.doi.org/10.1038/nature13236.
-
(2014)
Nature
, vol.510
, pp. 298-302
-
-
Fan, J.1
Ye, J.2
Kamphorst, J.J.3
Shlomi, T.4
Thompson, C.B.5
Rabinowitz, J.D.6
-
26
-
-
84923350269
-
Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate
-
Fan, J., X. Teng, L. Liu, K.R. Mattaini, R.E. Looper, M.G. Vander Heiden, and J.D. Rabinowitz. 2015. Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate. ACS Chem. Biol. 10:510-516. http://dx.doi.org/10.1021/cb500683c
-
(2015)
ACS Chem. Biol
, vol.10
, pp. 510-516
-
-
Fan, J.1
Teng, X.2
Liu, L.3
Mattaini, K.R.4
Looper, R.E.5
Vander Heiden, M.G.6
Rabinowitz, J.D.7
-
27
-
-
84874274833
-
Allosteric regulation of PKM2 allows cellular adaptation to different physiological states
-
Gui, D.Y., C.A. Lewis, and M.G. Vander Heiden. 2013. Allosteric regulation of PKM2 allows cellular adaptation to different physiological states. Sci. Signal. 6:pe7. http://dx.doi.org/10.1126/scisignal.2003925.
-
(2013)
Sci. Signal
, vol.6
-
-
Gui, D.Y.1
Lewis, C.A.2
Vander Heiden, M.G.3
-
28
-
-
84958120328
-
Metabolic heterogeneity in human lung tumors
-
Hensley, C.T., B. Faubert, Q. Yuan, N. Lev-Cohain, E. Jin, J. Kim, L. Jiang, B. Ko, R. Skelton, L. Loudat, et al. 2016. Metabolic heterogeneity in human lung tumors. Cell. 164:681-694. http://dx.doi.org/10.1016/j.cell.2015.12.034.
-
(2016)
Cell
, vol.164
, pp. 681-694
-
-
Hensley, C.T.1
Faubert, B.2
Yuan, Q.3
Lev-Cohain, N.4
Jin, E.5
Kim, J.6
Jiang, L.7
Ko, B.8
Skelton, R.9
Loudat, L.10
-
29
-
-
0037064008
-
Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses
-
Herbig, K., E.P. Chiang, L.R. Lee, J. Hills, B. Shane, and P.J. Stover. 2002. Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses. J. Biol. Chem. 277:38381-38389. http://dx.doi.org/10.1074/jbc.M205000200.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 38381-38389
-
-
Herbig, K.1
Chiang, E.P.2
Lee, L.R.3
Hills, J.4
Shane, B.5
Stover, P.J.6
-
30
-
-
77449131347
-
Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth
-
Hitosugi, T., S. Kang, M.G. Vander Heiden, T.W. Chung, S. Elf, K. Lythgoe, S. Dong, S. Lonial, X. Wang, G.Z. Chen, et al. 2009. Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Sci. Signal. 2:ra73. http://dx.doi.org/10.1126/scisignal.2000431.
-
(2009)
Sci. Signal
, vol.2
-
-
Hitosugi, T.1
Kang, S.2
Vander Heiden, M.G.3
Chung, T.W.4
Elf, S.5
Lythgoe, K.6
Dong, S.7
Lonial, S.8
Wang, X.9
Chen, G.Z.10
-
31
-
-
84959280789
-
Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells
-
Hosios, A.M., V.C. Hecht, L.V. Danai, M.O. Johnson, J.C. Rathmell, M.L. Steinhauser, S.R. Manalis, and M.G. Vander Heiden. 2016. Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells. Dev. Cell. 36:540-549. http://dx.doi.org/10.1016/j.devcel.2016.02.012.
-
(2016)
Dev. Cell
, vol.36
, pp. 540-549
-
-
Hosios, A.M.1
Hecht, V.C.2
Danai, L.V.3
Johnson, M.O.4
Rathmell, J.C.5
Steinhauser, M.L.6
Manalis, S.R.7
Vander Heiden, M.G.8
-
32
-
-
80053902441
-
Imaging cytosolic NADH-NAD(+) redox state with a genetically encoded fluorescent biosensor
-
Hung, Y.P., J.G. Albeck, M. Tantama, and G. Yellen. 2011. Imaging cytosolic NADH-NAD(+) redox state with a genetically encoded fluorescent biosensor. Cell Metab. 14:545-554. http://dx.doi.org/10.1016/j.cmet.2011.08.012.
-
(2011)
Cell Metab
, vol.14
, pp. 545-554
-
-
Hung, Y.P.1
Albeck, J.G.2
Tantama, M.3
Yellen, G.4
-
33
-
-
0017261388
-
Inhibition of chicken pyruvate kinases by amino acids
-
Ibsen, K.H., and S.W. Marles. 1976. Inhibition of chicken pyruvate kinases by amino acids. Biochemistry. 15:1073-1079. http://dx.doi.org/10.1021/bi00650a018.
-
(1976)
Biochemistry
, vol.15
, pp. 1073-1079
-
-
Ibsen, K.H.1
Marles, S.W.2
-
34
-
-
0000796646
-
Pathway of serine formation from carbohydrate in rat liver
-
Ichihara, A., and D.M. Greenberg. 1955. Pathway of serine formation from carbohydrate in rat liver. Proc. Natl. Acad. Sci. USA. 41:605-609. http://dx.doi.org/10.1073/pnas.41.9.605.
-
(1955)
Proc. Natl. Acad. Sci. USA
, vol.41
, pp. 605-609
-
-
Ichihara, A.1
Greenberg, D.M.2
-
35
-
-
84948094800
-
Pyruvate kinase: Function, regulation and role in cancer
-
Israelsen, W.J., and M.G. Vander Heiden. 2015. Pyruvate kinase: Function, regulation and role in cancer. Semin. Cell Dev. Biol. 43:43-51. http://dx.doi.org/10.1016/j.semcdb.2015.08.004.
-
(2015)
Semin. Cell Dev. Biol
, vol.43
, pp. 43-51
-
-
Israelsen, W.J.1
Vander Heiden, M.G.2
-
36
-
-
84885589840
-
PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells
-
Israelsen, W.J., T.L. Dayton, S.M. Davidson, B.P. Fiske, A.M. Hosios, G. Bellinger, J. Li, Y. Yu, M. Sasaki, J.W. Horner, et al. 2013. PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell. 155:397-409. http://dx.doi.org/10.1016/j.cell.2013.09.025.
-
(2013)
Cell
, vol.155
, pp. 397-409
-
-
Israelsen, W.J.1
Dayton, T.L.2
Davidson, S.M.3
Fiske, B.P.4
Hosios, A.M.5
Bellinger, G.6
Li, J.7
Yu, Y.8
Sasaki, M.9
Horner, J.W.10
-
37
-
-
84861420588
-
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation
-
Jain, M., R. Nilsson, S. Sharma, N. Madhusudhan, T. Kitami, A.L. Souza, R. Kafri, M.W. Kirschner, C.B. Clish, and V.K. Mootha. 2012. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science. 336:1040-1044. http://dx.doi.org/10.1126/science.1218595.
-
(2012)
Science
, vol.336
, pp. 1040-1044
-
-
Jain, M.1
Nilsson, R.2
Sharma, S.3
Madhusudhan, N.4
Kitami, T.5
Souza, A.L.6
Kafri, R.7
Kirschner, M.W.8
Clish, C.B.9
Mootha, V.K.10
-
38
-
-
84888236467
-
Expression and clinical significance of phosphoglycerate dehydrogenase and squamous cell carcinoma antigen in cervical cancer
-
Jing, Z., W. Heng, D. Aiping, Q. Yafei, and Z. Shulan. 2013. Expression and clinical significance of phosphoglycerate dehydrogenase and squamous cell carcinoma antigen in cervical cancer. Int. J. Gynecol. Cancer. 23:1465-1469. http://dx.doi.org/10.1097/IGC.0b013e3182a0c068.
-
(2013)
Int. J. Gynecol. Cancer
, vol.23
, pp. 1465-1469
-
-
Jing, Z.1
Heng, W.2
Aiping, D.3
Yafei, Q.4
Shulan, Z.5
-
39
-
-
84928395993
-
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
-
Kim, D., B.P. Fiske, K. Birsoy, E. Freinkman, K. Kami, R.L. Possemato, Y. Chudnovsky, M.E. Pacold, W.W. Chen, J.R. Cantor, et al. 2015. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. 520:363-367. http://dx.doi.org/10.1038/nature14363.
-
(2015)
Nature
, vol.520
, pp. 363-367
-
-
Kim, D.1
Fiske, B.P.2
Birsoy, K.3
Freinkman, E.4
Kami, K.5
Possemato, R.L.6
Chudnovsky, Y.7
Pacold, M.E.8
Chen, W.W.9
Cantor, J.R.10
-
40
-
-
84964670673
-
Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor
-
Krall, A.S., S. Xu, T.G. Graeber, D. Braas, and H.R. Christofk. 2016. Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. Nat. Commun. 7:11457. http://dx.doi.org/10.1038/ncomms11457.
-
(2016)
Nat. Commun
, vol.7
, pp. 11457
-
-
Krall, A.S.1
Xu, S.2
Graeber, T.G.3
Braas, D.4
Christofk, H.R.5
-
41
-
-
84866697915
-
Small molecule activation of PKM2 in cancer cells induces serine auxotrophy
-
Kung, C., J. Hixon, S. Choe, K. Marks, S. Gross, E. Murphy, B. DeLaBarre, G. Cianchetta, S. Sethumadhavan, X. Wang, et al. 2012. Small molecule activation of PKM2 in cancer cells induces serine auxotrophy. Chem. Biol. 19:1187-1198. http://dx.doi.org/10.1016/j.chembiol.2012.07.021.
-
(2012)
Chem. Biol
, vol.19
, pp. 1187-1198
-
-
Kung, C.1
Hixon, J.2
Choe, S.3
Marks, K.4
Gross, S.5
Murphy, E.6
DeLaBarre, B.7
Cianchetta, G.8
Sethumadhavan, S.9
Wang, X.10
-
42
-
-
84901263663
-
Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells
-
Labuschagne, C.F., N.J. van den Broek, G.M. Mackay, K.H. Vousden, and O.D. Maddocks. 2014. Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells. Cell Reports. 7:1248-1258. http://dx.doi.org/10.1016/j.celrep.2014.04.045.
-
(2014)
Cell Reports
, vol.7
, pp. 1248-1258
-
-
Labuschagne, C.F.1
van den Broek, N.J.2
Mackay, G.M.3
Vousden, K.H.4
Maddocks, O.D.5
-
44
-
-
84904504373
-
Tracing compartmentalized NAD PH metabolism in the cytosol and mitochondria of mammalian cells
-
Lewis, C.A., S.J. Parker, B.P. Fiske, D. McCloskey, D.Y. Gui, C.R. Green, N.I. Vokes, A.M. Feist, M.G. Vander Heiden, and C.M. Metallo. 2014. Tracing compartmentalized NAD PH metabolism in the cytosol and mitochondria of mammalian cells. Mol. Cell. 55:253-263. http://dx.doi.org/10.1016/j.molcel.2014.05.008.
-
(2014)
Mol. Cell
, vol.55
, pp. 253-263
-
-
Lewis, C.A.1
Parker, S.J.2
Fiske, B.P.3
McCloskey, D.4
Gui, D.Y.5
Green, C.R.6
Vokes, N.I.7
Feist, A.M.8
Vander Heiden, M.G.9
Metallo, C.M.10
-
45
-
-
84880425659
-
Phosphoglycerate dehydrogenase induces glioma cells proliferation and invasion by stabilizing forkhead box M1
-
Liu, J., S. Guo, Q. Li, L. Yang, Z. Xia, L. Zhang, Z. Huang, and N. Zhang. 2013. Phosphoglycerate dehydrogenase induces glioma cells proliferation and invasion by stabilizing forkhead box M1. J. Neurooncol. 111:245-255. http://dx.doi.org/10.1007/s11060-012-1018-x
-
(2013)
J. Neurooncol
, vol.111
, pp. 245-255
-
-
Liu, J.1
Guo, S.2
Li, Q.3
Yang, L.4
Xia, Z.5
Zhang, L.6
Huang, Z.7
Zhang, N.8
-
46
-
-
84881177291
-
Serine, glycine and one-carbon units: Cancer metabolism in full circle
-
Locasale, J.W. 2013. Serine, glycine and one-carbon units: Cancer metabolism in full circle. Nat. Rev. Cancer. 13:572-583. http://dx.doi.org/10.1038/nrc3557.
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 572-583
-
-
Locasale, J.W.1
-
47
-
-
80052258995
-
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
-
Locasale, J.W., A.R. Grassian, T. Melman, C.A. Lyssiotis, K.R. Mattaini, A.J. Bass, G. Heffron, C.M. Metallo, T. Muranen, H. Sharfi, et al. 2011. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat. Genet. 43:869-874. http://dx.doi.org/10.1038/ng.890.
-
(2011)
Nat. Genet
, vol.43
, pp. 869-874
-
-
Locasale, J.W.1
Grassian, A.R.2
Melman, T.3
Lyssiotis, C.A.4
Mattaini, K.R.5
Bass, A.J.6
Heffron, G.7
Metallo, C.M.8
Muranen, T.9
Sharfi, H.10
-
48
-
-
80054046029
-
Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation
-
Lunt, S.Y., and M.G. Vander Heiden. 2011. Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation. Annu. Rev. Cell Dev. Biol. 27:441-464. http://dx.doi.org/10.1146/annurev-cellbio-092910-154237.
-
(2011)
Annu. Rev. Cell Dev. Biol
, vol.27
, pp. 441-464
-
-
Lunt, S.Y.1
Vander Heiden, M.G.2
-
49
-
-
84920447418
-
Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation
-
Lunt, S.Y., V. Muralidhar, A.M. Hosios, W.J. Israelsen, D.Y. Gui, L. Newhouse, M. Ogrodzinski, V. Hecht, K. Xu, P.N. Acevedo, et al. 2015. Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation. Mol. Cell. 57:95-107. http://dx.doi.org/10.1016/j.molcel.2014.10.027.
-
(2015)
Mol. Cell
, vol.57
, pp. 95-107
-
-
Lunt, S.Y.1
Muralidhar, V.2
Hosios, A.M.3
Israelsen, W.J.4
Gui, D.Y.5
Newhouse, L.6
Ogrodzinski, M.7
Hecht, V.8
Xu, K.9
Acevedo, P.N.10
-
50
-
-
84872905650
-
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
-
Maddocks, O.D., C.R. Berkers, S.M. Mason, L. Zheng, K. Blyth, E. Gottlieb, and K.H. Vousden. 2013. Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature. 493:542-546. http://dx.doi.org/10.1038/nature11743.
-
(2013)
Nature
, vol.493
, pp. 542-546
-
-
Maddocks, O.D.1
Berkers, C.R.2
Mason, S.M.3
Zheng, L.4
Blyth, K.5
Gottlieb, E.6
Vousden, K.H.7
-
51
-
-
84957427247
-
Serine metabolism supports the methionine cycle and DNA/RNA methylation through de novo ATP synthesis in cancer cells
-
Maddocks, O.D., C.F. Labuschagne, P.D. Adams, and K.H. Vousden. 2016. Serine metabolism supports the methionine cycle and DNA/RNA methylation through de novo ATP synthesis in cancer cells. Mol. Cell. 61:210-221. http://dx.doi.org/10.1016/j.molcel.2015.12.014.
-
(2016)
Mol. Cell
, vol.61
, pp. 210-221
-
-
Maddocks, O.D.1
Labuschagne, C.F.2
Adams, P.D.3
Vousden, K.H.4
-
52
-
-
84948117747
-
An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation
-
Mattaini, K.R., E.J. Brignole, M. Kini, S.M. Davidson, B.P. Fiske, C.L. Drennan, and M.G. Vander Heiden. 2015. An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation. Cancer Metab. 3:5. http://dx.doi.org/10.1186/s40170-015-0131-7.
-
(2015)
Cancer Metab
, vol.3
, pp. 5
-
-
Mattaini, K.R.1
Brignole, E.J.2
Kini, M.3
Davidson, S.M.4
Fiske, B.P.5
Drennan, C.L.6
Vander Heiden, M.G.7
-
53
-
-
84923186422
-
Famine versus feast: Understanding the metabolism of tumors in vivo
-
Mayers, J.R., and M.G. Vander Heiden. 2015. Famine versus feast: Understanding the metabolism of tumors in vivo. Trends Biochem. Sci. 40:130-140. http://dx.doi.org/10.1016/j.tibs.2015.01.004.
-
(2015)
Trends Biochem. Sci
, vol.40
, pp. 130-140
-
-
Mayers, J.R.1
Vander Heiden, M.G.2
-
54
-
-
81955167417
-
PHG DH amplification and altered glucose metabolism in human melanoma
-
Mullarky, E., K.R. Mattaini, M.G. Vander Heiden, L.C. Cantley, and J.W. Locasale. 2011. PHG DH amplification and altered glucose metabolism in human melanoma. Pigment Cell Melanoma Res. 24:1112-1115. http://dx.doi.org/10.1111/j.1755-148X.2011.00919.x
-
(2011)
Pigment Cell Melanoma Res
, vol.24
, pp. 1112-1115
-
-
Mullarky, E.1
Mattaini, K.R.2
Vander Heiden, M.G.3
Cantley, L.C.4
Locasale, J.W.5
-
55
-
-
84959449345
-
Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers
-
Mullarky, E., N.C. Lucki, R. Beheshti Zavareh, J.L. Anglin, A.P. Gomes, B.N. Nicolay, J.C. Wong, S. Christen, H. Takahashi, P.K. Singh, et al. 2016. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proc. Natl. Acad. Sci. USA. 113:1778-1783. http://dx.doi.org/10.1073/pnas.1521548113.
-
(2016)
Proc. Natl. Acad. Sci. USA
, vol.113
, pp. 1778-1783
-
-
Mullarky, E.1
Lucki, N.C.2
Beheshti Zavareh, R.3
Anglin, J.L.4
Gomes, A.P.5
Nicolay, B.N.6
Wong, J.C.7
Christen, S.8
Takahashi, H.9
Singh, P.K.10
-
56
-
-
0034854417
-
ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini
-
Muthuswamy, S.K., D. Li, S. Lelievre, M.J. Bissell, and J.S. Brugge. 2001. ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nat. Cell Biol. 3:785-792. http://dx.doi.org/10.1038/ncb0901-785.
-
(2001)
Nat. Cell Biol
, vol.3
, pp. 785-792
-
-
Muthuswamy, S.K.1
Li, D.2
Lelievre, S.3
Bissell, M.J.4
Brugge, J.S.5
-
57
-
-
84859261025
-
Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis
-
Nilsson, L.M., T.Z. Forshell, S. Rimpi, C. Kreutzer, W. Pretsch, G.W. Bornkamm, and J.A. Nilsson. 2012. Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis. PLoS Genet. 8:e1002573. http://dx.doi.org/10.1371/journal.pgen.1002573.
-
(2012)
PLoS Genet
, vol.8
-
-
Nilsson, L.M.1
Forshell, T.Z.2
Rimpi, S.3
Kreutzer, C.4
Pretsch, W.5
Bornkamm, G.W.6
Nilsson, J.A.7
-
58
-
-
84897414311
-
Metabolic enzyme expression highlights a key role for MTH FD2 and the mitochondrial folate pathway in cancer
-
Nilsson, R., M. Jain, N. Madhusudhan, N.G. Sheppard, L. Strittmatter, C. Kampf, J. Huang, A. Asplund, and V.K. Mootha. 2014. Metabolic enzyme expression highlights a key role for MTH FD2 and the mitochondrial folate pathway in cancer. Nat. Commun. 5:3128. http://dx.doi.org/10.1038/ncomms4128.
-
(2014)
Nat. Commun
, vol.5
, pp. 3128
-
-
Nilsson, R.1
Jain, M.2
Madhusudhan, N.3
Sheppard, N.G.4
Strittmatter, L.5
Kampf, C.6
Huang, J.7
Asplund, A.8
Mootha, V.K.9
-
59
-
-
84964216448
-
A PHG DH inhibitor reveals coordination of serine synthesis and one-carbon unit fate
-
Pacold, M.E., K.R. Brimacombe, S.H. Chan, J.M. Rohde, C.A. Lewis, L.J.Y.M. Swier, R. Possemato, W.W. Chen, L.B. Sullivan, B.P. Fiske, et al. 2016. A PHG DH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat. Chem. Biol. 12:452-458. http://dx.doi.org/10.1038/nchembio.2070.
-
(2016)
Nat. Chem. Biol
, vol.12
, pp. 452-458
-
-
Pacold, M.E.1
Brimacombe, K.R.2
Chan, S.H.3
Rohde, J.M.4
Lewis, C.A.5
Swier, L.J.Y.M.6
Possemato, R.7
Chen, W.W.8
Sullivan, L.B.9
Fiske, B.P.10
-
60
-
-
84977661252
-
Targeting MTH FD2 in acute myeloid leukemia
-
Pikman, Y., A. Puissant, G. Alexe, A. Furman, L.M. Chen, S.M. Frumm, L. Ross, N. Fenouille, C.F. Bassil, C.A. Lewis, et al. 2016. Targeting MTH FD2 in acute myeloid leukemia. J. Exp. Med. 213:1285-1306. http://dx.doi.org/10.1084/jem.20151574.
-
(2016)
J. Exp. Med
, vol.213
, pp. 1285-1306
-
-
Pikman, Y.1
Puissant, A.2
Alexe, G.3
Furman, A.4
Chen, L.M.5
Frumm, S.M.6
Ross, L.7
Fenouille, N.8
Bassil, C.F.9
Lewis, C.A.10
-
61
-
-
84946903513
-
Oxidative stress inhibits distant metastasis by human melanoma cells
-
Piskounova, E., M. Agathocleous, M.M. Murphy, Z. Hu, S.E. Huddlestun, Z. Zhao, A.M. Leitch, T.M. Johnson, R.J. DeBerardinis, and S.J. Morrison. 2015. Oxidative stress inhibits distant metastasis by human melanoma cells. Nature. 527:186-191. http://dx.doi.org/10.1038/nature15726.
-
(2015)
Nature
, vol.527
, pp. 186-191
-
-
Piskounova, E.1
Agathocleous, M.2
Murphy, M.M.3
Hu, Z.4
Huddlestun, S.E.5
Zhao, Z.6
Leitch, A.M.7
Johnson, T.M.8
DeBerardinis, R.J.9
Morrison, S.J.10
-
62
-
-
0000008924
-
The pathway and control of serine biosynthesis in Escherichia coli
-
Pizer, L.I. 1963. The pathway and control of serine biosynthesis in Escherichia coli. J. Biol. Chem. 238:3934-3944.
-
(1963)
J. Biol. Chem
, vol.238
, pp. 3934-3944
-
-
Pizer, L.I.1
-
63
-
-
78650996423
-
Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis
-
Pollari, S., S.M. Käkönen, H. Edgren, M. Wolf, P. Kohonen, H. Sara, T. Guise, M. Nees, and O. Kallioniemi. 2011. Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis. Breast Cancer Res. Treat. 125:421-430. http://dx.doi.org/10.1007/s10549-010-0848-5.
-
(2011)
Breast Cancer Res. Treat
, vol.125
, pp. 421-430
-
-
Pollari, S.1
Käkönen, S.M.2
Edgren, H.3
Wolf, M.4
Kohonen, P.5
Sara, H.6
Guise, T.7
Nees, M.8
Kallioniemi, O.9
-
64
-
-
80051923932
-
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
-
Possemato, R., K.M. Marks, Y.D. Shaul, M.E. Pacold, D. Kim, K. Birsoy, S. Sethumadhavan, H.K. Woo, H.G. Jang, A.K. Jha, et al. 2011. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature. 476:346-350. http://dx.doi.org/10.1038/nature10350.
-
(2011)
Nature
, vol.476
, pp. 346-350
-
-
Possemato, R.1
Marks, K.M.2
Shaul, Y.D.3
Pacold, M.E.4
Kim, D.5
Birsoy, K.6
Sethumadhavan, S.7
Woo, H.K.8
Jang, H.G.9
Jha, A.K.10
-
65
-
-
84913285138
-
Evidence for a specific alanine-hydroxypyruvic transaminase
-
W.D. McElroy, and B. Glass, editors. Johns Hopkins, Baltimore
-
Sallach, H.J. 1955. Evidence for a specific alanine-hydroxypyruvic transaminase. In Amino Acid Metabolism. W.D. McElroy, and B. Glass, editors. Johns Hopkins, Baltimore. 782-796.
-
(1955)
Amino Acid Metabolism
, pp. 782-796
-
-
Sallach, H.J.1
-
66
-
-
69949101473
-
Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
-
Schafer, Z.T., A.R. Grassian, L. Song, Z. Jiang, Z. Gerhart-Hines, H.Y. Irie, S. Gao, P. Puigserver, and J.S. Brugge. 2009. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature. 461:109-113. http://dx.doi.org/10.1038/nature08268.
-
(2009)
Nature
, vol.461
, pp. 109-113
-
-
Schafer, Z.T.1
Grassian, A.R.2
Song, L.3
Jiang, Z.4
Gerhart-Hines, Z.5
Irie, H.Y.6
Gao, S.7
Puigserver, P.8
Brugge, J.S.9
-
67
-
-
0021191196
-
Enzymes of serine metabolism in normal, developing and neoplastic rat tissues
-
Snell, K. 1984. Enzymes of serine metabolism in normal, developing and neoplastic rat tissues. Adv. Enzyme Regul. 22:325-400. http://dx.doi.org/10.1016/0065-2571(84)90021-9.
-
(1984)
Adv. Enzyme Regul
, vol.22
, pp. 325-400
-
-
Snell, K.1
-
68
-
-
0022643088
-
Enzymic imbalance in serine metabolism in rat hepatomas
-
Snell, K., and G. Weber. 1986. Enzymic imbalance in serine metabolism in rat hepatomas. Biochem. J. 233:617-620. http://dx.doi.org/10.1042/bj2330617.
-
(1986)
Biochem. J
, vol.233
, pp. 617-620
-
-
Snell, K.1
Weber, G.2
-
69
-
-
0023655502
-
The modulation of serine metabolism in hepatoma 3924A during different phases of cellular proliferation in culture
-
Snell, K., Y. Natsumeda, and G. Weber. 1987. The modulation of serine metabolism in hepatoma 3924A during different phases of cellular proliferation in culture. Biochem. J. 245:609-612. http://dx.doi.org/10.1042/bj2450609.
-
(1987)
Biochem. J
, vol.245
, pp. 609-612
-
-
Snell, K.1
Natsumeda, Y.2
Weber, G.3
-
70
-
-
0014164744
-
A view of the comparison of the regulation of enzymes in mammalian and microbial systems
-
Suda, M. 1967. A view of the comparison of the regulation of enzymes in mammalian and microbial systems. Adv. Enzyme Regul. 5:181-209. http://dx.doi.org/10.1016/0065-2571(67)90016-7.
-
(1967)
Adv. Enzyme Regul
, vol.5
, pp. 181-209
-
-
Suda, M.1
-
71
-
-
84938234308
-
Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells
-
Sullivan, L.B., D.Y. Gui, A.M. Hosios, L.N. Bush, E. Freinkman, and M.G. Vander Heiden. 2015. Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells. Cell. 162:552-563. http://dx.doi.org/10.1016/j.cell.2015.07.017.
-
(2015)
Cell
, vol.162
, pp. 552-563
-
-
Sullivan, L.B.1
Gui, D.Y.2
Hosios, A.M.3
Bush, L.N.4
Freinkman, E.5
Vander Heiden, M.G.6
-
72
-
-
77955616558
-
Compartmentalization of mammalian folate-mediated one-carbon metabolism
-
Tibbetts, A.S., and D.R. Appling. 2010. Compartmentalization of mammalian folate-mediated one-carbon metabolism. Annu. Rev. Nutr. 30:57-81. http://dx.doi.org/10.1146/annurev.nutr.012809.104810.
-
(2010)
Annu. Rev. Nutr
, vol.30
, pp. 57-81
-
-
Tibbetts, A.S.1
Appling, D.R.2
-
73
-
-
50549185131
-
The biosynthetic pathway of serine in Salmonella typhimurium
-
Umbarger, H.E., and M.A. Umbarger. 1962. The biosynthetic pathway of serine in Salmonella typhimurium. Biochim. Biophys. Acta. 62:193-195. http://dx.doi.org/10.1016/0006-3002(62)90515-2.
-
(1962)
Biochim. Biophys. Acta
, vol.62
, pp. 193-195
-
-
Umbarger, H.E.1
Umbarger, M.A.2
-
74
-
-
84880239424
-
An update on serine deficiency disorders
-
van der Crabben, S.N., N.M. Verhoeven-Duif, E.H. Brilstra, L. Van Maldergem, T. Coskun, E. Rubio-Gozalbo, R. Berger, and T.J. de Koning. 2013. An update on serine deficiency disorders. J. Inherit. Metab. Dis. 36:613-619. http://dx.doi.org/10.1007/s10545-013-9592-4.
-
(2013)
J. Inherit. Metab. Dis
, vol.36
, pp. 613-619
-
-
van der Crabben, S.N.1
Verhoeven-Duif, N.M.2
Brilstra, E.H.3
Van Maldergem, L.4
Coskun, T.5
Rubio-Gozalbo, E.6
Berger, R.7
de Koning, T.J.8
-
75
-
-
80052242132
-
Targeting cancer metabolism: A therapeutic window opens
-
Vander Heiden, M.G. 2011. Targeting cancer metabolism: A therapeutic window opens. Nat. Rev. Drug Discov. 10:671-684. http://dx.doi.org/10.1038/nrd3504.
-
(2011)
Nat. Rev. Drug Discov
, vol.10
, pp. 671-684
-
-
Vander Heiden, M.G.1
-
76
-
-
77649305610
-
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting a-ketoglutarate to 2-hydroxyglutarate
-
Ward, P.S., J. Patel, D.R. Wise, O. Abdel-Wahab, B.D. Bennett, H.A. Coller, J.R. Cross, V.R. Fantin, C.V. Hedvat, A.E. Perl, et al. 2010. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting a-ketoglutarate to 2-hydroxyglutarate. Cancer Cell. 17:225-234. http://dx.doi.org/10.1016/j.ccr.2010.01.020.
-
(2010)
Cancer Cell
, vol.17
, pp. 225-234
-
-
Ward, P.S.1
Patel, J.2
Wise, D.R.3
Abdel-Wahab, O.4
Bennett, B.D.5
Coller, H.A.6
Cross, J.R.7
Fantin, V.R.8
Hedvat, C.V.9
Perl, A.E.10
-
77
-
-
84885357137
-
Exploiting the bad eating habits of Ras-driven cancers
-
White, E. 2013. Exploiting the bad eating habits of Ras-driven cancers. Genes Dev. 27:2065-2071. http://dx.doi.org/10.1101/gad.228122.113.
-
(2013)
Genes Dev
, vol.27
, pp. 2065-2071
-
-
White, E.1
-
78
-
-
84860793042
-
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
-
Ye, J., A. Mancuso, X. Tong, P.S. Ward, J. Fan, J.D. Rabinowitz, and C.B. Thompson. 2012. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proc. Natl. Acad. Sci. USA. 109:6904-6909. http://dx.doi.org/10.1073/pnas.1204176109.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 6904-6909
-
-
Ye, J.1
Mancuso, A.2
Tong, X.3
Ward, P.S.4
Fan, J.5
Rabinowitz, J.D.6
Thompson, C.B.7
-
79
-
-
84915746768
-
Serine catabolism regulates mitochondrial redox control during hypoxia
-
Ye, J., J. Fan, S. Venneti, Y.W. Wan, B.R. Pawel, J. Zhang, L.W. Finley, C. Lu, T. Lindsten, J.R. Cross, et al. 2014. Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov. 4:1406-1417. http://dx.doi.org/10.1158/2159-8290.CD-14-0250.
-
(2014)
Cancer Discov
, vol.4
, pp. 1406-1417
-
-
Ye, J.1
Fan, J.2
Venneti, S.3
Wan, Y.W.4
Pawel, B.R.5
Zhang, J.6
Finley, L.W.7
Lu, C.8
Lindsten, T.9
Cross, J.R.10
-
80
-
-
9144270452
-
Targeted disruption of the mouse 3-phosphoglycerate dehydrogenase gene causes severe neurodevelopmental defects and results in embryonic lethality
-
Yoshida, K., S. Furuya, S. Osuka, J. Mitoma, Y. Shinoda, M. Watanabe, N. Azuma, H. Tanaka, T. Hashikawa, S. Itohara, and Y. Hirabayashi. 2004. Targeted disruption of the mouse 3-phosphoglycerate dehydrogenase gene causes severe neurodevelopmental defects and results in embryonic lethality. J. Biol. Chem. 279:3573-3577. http://dx.doi.org/10.1074/jbc.C300507200.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 3573-3577
-
-
Yoshida, K.1
Furuya, S.2
Osuka, S.3
Mitoma, J.4
Shinoda, Y.5
Watanabe, M.6
Azuma, N.7
Tanaka, H.8
Hashikawa, T.9
Itohara, S.10
Hirabayashi, Y.11
-
81
-
-
0029671184
-
A novel alpha-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria
-
Zhao, G., and M.E. Winkler. 1996. A novel alpha-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria. J. Bacteriol. 178:232-239.
-
(1996)
J. Bacteriol
, vol.178
, pp. 232-239
-
-
Zhao, G.1
Winkler, M.E.2
-
82
-
-
84919797513
-
Phosphoglycerate dehydrogenase: Potential therapeutic target and putative metabolic oncogene
-
Zogg, C.K. 2014. Phosphoglycerate dehydrogenase: Potential therapeutic target and putative metabolic oncogene. J. Oncol. 2014:524101. http://dx.doi.org/10.1155/2014/524101.
-
(2014)
J. Oncol
, vol.2014
-
-
Zogg, C.K.1
|