Toward allosterically increased catalytic activity of insulin-degrading enzyme against amyloid peptides

Biochemistry

Volumn 56, Issue 1, 2017, Pages 228-239

  Kurochkin, Igor V ^a,d   Guarnera, Enrico ^a   Wong, Jin H ^a   Eisenhaber, Frank ^a,b,c   Berezovsky, Igor N ^a,b  

^a BIOINFORMATICS INSTITUTE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^d SYSMEX CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME ACTIVITY; FREE ENERGY; GLYCOPROTEINS; INSULIN; INTEGRODIFFERENTIAL EQUATIONS; NEURODEGENERATIVE DISEASES; PEPTIDES; SUBSTRATES;

ACTIVITY REGULATION; ALLOSTERIC MODULATION; ALZHEIMER'S DISEASE; AMYLOID PEPTIDES; FREE-ENERGY CALCULATIONS; HYPERACTIVATION; INSULIN-DEGRADING ENZYMES; PHYSIOLOGICAL ROLES;

CATALYST ACTIVITY;

AMYLOID BETA PROTEIN; AMYLOID PROTEIN; INSULINASE;

ALLOSTERISM; AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CONTROLLED STUDY; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; QUANTITATIVE ANALYSIS; RESIDUE ANALYSIS; STRUCTURE ACTIVITY RELATION; UPREGULATION; ALGORITHM; ALZHEIMER DISEASE; BIOCATALYSIS; BIOLOGY; CHEMISTRY; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; HUMAN; KINETICS; METABOLISM; MISSENSE MUTATION; MOLECULAR MODEL; PROCEDURES; PROTEIN DOMAIN; THERMODYNAMICS;

ALGORITHMS; ALLOSTERIC REGULATION; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOIDOGENIC PROTEINS; BIOCATALYSIS; CATALYTIC DOMAIN; COMPUTATIONAL BIOLOGY; ENZYME ASSAYS; HUMANS; INSULYSIN; KINETICS; MODELS, MOLECULAR; MUTATION, MISSENSE; PROTEIN DOMAINS; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 85020325128     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.6b00783     Document Type: Article

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