메뉴 건너뛰기




Volumn 25, Issue 3, 2005, Pages 201-205

Insulysin: An allosteric enzyme as a target for Alzheimer's disease

Author keywords

amyloid peptide clearance; Allosteric enzyme; Enzyme activation; Insulin degrading enzyme; Insulysin

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN[25-35]; GLYCINE; HISTIDINE; INSULIN; INSULINASE; METALLOPROTEINASE; PEPTIDE DERIVATIVE; PHENYLALANINE; ZINC; AMYLOID BETA PROTEIN;

EID: 22244456767     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:25:3:201     Document Type: Article
Times cited : (27)

References (16)
  • 1
    • 0034711206 scopus 로고    scopus 로고
    • Degradation of amylin by insulin-degrading enzyme
    • Bennett R. G., Duckworth W. C., and Hamel F. G. (2000) Degradation of amylin by insulin-degrading enzyme. J. Biol. Chem. 275, 36621-36625.
    • (2000) J. Biol. Chem. , vol.275 , pp. 36621-36625
    • Bennett, R.G.1    Duckworth, W.C.2    Hamel, F.G.3
  • 3
    • 0032831757 scopus 로고    scopus 로고
    • Deposition of soluble amyloid-beta onto amyloid templates: With application for the identification of amyloid fibril extension inhibitors
    • Esler W.P, Stimson E. R., Mantyh P. W., and Maggio J. E. (1999) Deposition of soluble amyloid-beta onto amyloid templates: with application for the identification of amyloid fibril extension inhibitors. Methods Enzymol. 309, 350-374.
    • (1999) Methods Enzymol. , vol.309 , pp. 350-374
    • Esler, W.P.1    Stimson, E.R.2    Mantyh, P.W.3    Maggio, J.E.4
  • 4
    • 0037390039 scopus 로고    scopus 로고
    • Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo
    • Farris W., Mansourian S., Chang Y., Lindsley L., Eckman E. A., Frosch M. P., et al. (2003) Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc. Natl. Acad. Sci. U. S. A. 100, 4162-4167.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 4162-4167
    • Farris, W.1    Mansourian, S.2    Chang, Y.3    Lindsley, L.4    Eckman, E.A.5    Frosch, M.P.6
  • 5
    • 0024454036 scopus 로고
    • An evolutionarily conserved enzyme degrades transforming growth factor-alpha as well as insulin
    • Garcia V., Gehm B. D., and Rosner M. R. (1989) An evolutionarily conserved enzyme degrades transforming growth factor-alpha as well as insulin. J. Cell Biol. 109, 1301-1307.
    • (1989) J. Cell Biol. , vol.109 , pp. 1301-1307
    • Garcia, V.1    Gehm, B.D.2    Rosner, M.R.3
  • 6
    • 0025809406 scopus 로고
    • Regulation of insulin, epidermal growth factor, and transforming growth factor-alpha levels by growth factor-degrading enzymes
    • Gehm B. D. and Rosner M. R. (1991) Regulation of insulin, epidermal growth factor, and transforming growth factor-alpha levels by growth factor-degrading enzymes. Endocrinology 128, 1603-1610
    • (1991) Endocrinology , vol.128 , pp. 1603-1610
    • Gehm, B.D.1    Rosner, M.R.2
  • 7
    • 0037242768 scopus 로고    scopus 로고
    • Peptidases, proteases and amyloid beta-peptide catabolism
    • Hersh L. B. (2003) Peptidases, proteases and amyloid beta-peptide catabolism. Curr. Pharm. Des. 9, 449-454.
    • (2003) Curr. Pharm. Des. , vol.9 , pp. 449-454
    • Hersh, L.B.1
  • 8
    • 0021111565 scopus 로고
    • A high molecular weight metalloendoprotease from the cytosol of mammalian cells
    • Kirschner R. J. and Goldberg A. L. (1983) A high molecular weight metalloendoprotease from the cytosol of mammalian cells. J. Biol. Chem. 258, 967-976.
    • (1983) J. Biol. Chem. , vol.258 , pp. 967-976
    • Kirschner, R.J.1    Goldberg, A.L.2
  • 9
    • 0028176821 scopus 로고
    • Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme
    • Kurochkin V. and Goto S. (1994) Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme. FEBS Lett. 345, 33-37
    • (1994) FEBS Lett. , vol.345 , pp. 33-37
    • Kurochkin, V.1    Goto, S.2
  • 10
    • 0031044352 scopus 로고    scopus 로고
    • Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: Involvement of insulin-degrading enzyme
    • McDermott J. R. and Gibson A. M. (1997) Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme. Neurochem. Res. 22, 49-56
    • (1997) Neurochem. Res. , vol.22 , pp. 49-56
    • McDermott, J.R.1    Gibson, A.M.2
  • 12
    • 0036813533 scopus 로고    scopus 로고
    • Regulation of amyloid beta-peptide levels by enzymatic degradation
    • Mukherjee A. and Hersh L. B. (2002) Regulation of amyloid beta-peptide levels by enzymatic degradation. J. Alzheimer's Dis. 4, 341-348.
    • (2002) J. Alzheimer's Dis. , vol.4 , pp. 341-348
    • Mukherjee, A.1    Hersh, L.B.2
  • 13
    • 0034551718 scopus 로고    scopus 로고
    • Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques
    • Mukherjee A., Song E., Kihiko-Ehmann M., Goodman J. P. Jr., Pyrek J. S., Estus S., and Hersh L. B. (2000) Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques. J. Neurosci. 20, 8745-8749.
    • (2000) J. Neurosci. , vol.20 , pp. 8745-8749
    • Mukherjee, A.1    Song, E.2    Kihiko-Ehmann, M.3    Goodman Jr., J.P.4    Pyrek, J.S.5    Estus, S.6    Hersh, L.B.7
  • 14
    • 0025987157 scopus 로고
    • Atrial natriuretic peptide (ANP) is a high-affinity substrate for rat insulin-degrading enzyme
    • Muller D., Baumeister H., Buck F., and Richter D. (1991) Atrial natriuretic peptide (ANP) is a high-affinity substrate for rat insulin-degrading enzyme. Eur. J. Biochem. 202, 285-292.
    • (1991) Eur. J. Biochem. , vol.202 , pp. 285-292
    • Muller, D.1    Baumeister, H.2    Buck, F.3    Richter, D.4
  • 15
    • 0026471959 scopus 로고
    • Rat insulin-degrading enzyme: Cleavage pattern of the natriuretic peptide hormones ANP, BNP, and CNP revealed by HPLC and mass spectrometry
    • Muller D., Schulze C., Baumeister H., Buck F., and Richter D. (1992) Rat insulin-degrading enzyme: cleavage pattern of the natriuretic peptide hormones ANP, BNP, and CNP revealed by HPLC and mass spectrometry. Biochemistry 31, 11138-11143
    • (1992) Biochemistry , vol.31 , pp. 11138-11143
    • Muller, D.1    Schulze, C.2    Baumeister, H.3    Buck, F.4    Richter, D.5
  • 16
    • 0029843563 scopus 로고    scopus 로고
    • Identification of gamma-endorphin-generating enzyme as insulin-degrading enzyme
    • Safavi A., Miller B. C., Cottam L., and Hersh L. B. (1996) Identification of gamma-endorphin-generating enzyme as insulin-degrading enzyme. Biochemistry 35, 14318-14325.
    • (1996) Biochemistry , vol.35 , pp. 14318-14325
    • Safavi, A.1    Miller, B.C.2    Cottam, L.3    Hersh, L.B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.