An extended polyanion activation surface in insulin degrading enzyme

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Song, Eun Suk ^a   Ozbil, Mehmet ^b,e   Zhang, Tingting ^b   Sheetz, Michael ^c   Lee, David ^d   Tran, Danny ^d   Li, Sheng ^d   Prabhakar, Rajeev ^b   Hersh, Louis B ^a   Rodgers, David W ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b University of Miami   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMYLIN; AMYLOID BETA PROTEIN; ANION; ARGININE; ATRIAL NATRIURETIC FACTOR; GLUCAGON; INSULIN; INSULINASE; LYSINE; PEPTIDE; POLYANION; DEUTERIUM; HYDROGEN; POLYANIONS; POLYMER; PROTEIN BINDING;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG TARGETING; ENZYME DEGRADATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; INSULIN METABOLISM; KINETICS; MATHEMATICAL ANALYSIS; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MUTAGENESIS; MUTATION; POLYANION BINDING SURFACE; PROTEIN DEGRADATION; AMINO ACID SEQUENCE; CHEMISTRY; CONFORMATION; GENETICS; METABOLISM; MOLECULAR GENETICS;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; BINDING SITES; DEUTERIUM; HYDROGEN; INSULYSIN; MOLECULAR CONFORMATION; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTATION; POLYMERS; PROTEIN BINDING;

EID: 84941342094     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0133114     Document Type: Article

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