Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 34, 2013, Pages 13827-13832

  McCord, Lauren A ^a   Liang, Wenguang G ^a   Dowdell, Evan ^b   Kalas, Vasilios ^a   Hoey, Robert J ^b   Koide, Akiko ^b   Koide, Shohei ^b   Tang, Wei Jen ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

M16 metalloprotease; Substrate recognition; X ray crystallography

Indexed keywords

AMYLOID; AMYLOID PROTEIN; INSULINASE; METALLOPROTEINASE;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTALLIZATION; ENZYME ACTIVE SITE; ENZYME DEGRADATION; HUMAN; INSULIN CLEARANCE; INSULIN CLIA KIT; MOLECULAR RECOGNITION; MUTATIONAL ANALYSIS; PHASE TRANSITION; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STABILITY; X RAY CRYSTALLOGRAPHY;

M16 METALLOPROTEASE; SUBSTRATE RECOGNITION; X-RAY CRYSTALLOGRAPHY;

AMYLOIDOGENIC PROTEINS; CATALYTIC DOMAIN; CRYSTALLIZATION; DNA MUTATIONAL ANALYSIS; ESCHERICHIA COLI; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; INSULYSIN; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEOLYSIS; SCATTERING, SMALL ANGLE; SURFACE PLASMON RESONANCE;

EID: 84882799287     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1304575110     Document Type: Article

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