Natural polyphenols: An overview

International Journal of Food Properties

Volumn 20, Issue 8, 2017, Pages 1689-1699

  Abbas, Munawar ^a   Saeed, Farhan ^a   Anjum, Faqir Muhammad ^a   Afzaal, Muhammad ^a   Tufail, Tabussam ^a   Bashir, Muhammad Shakeel ^b   Ishtiaq, Adnan ^b   Hussain, Shahzad ^c   Suleria, Hafiz Ansar Rasul ^c  

^a GOVERNMENT COLLEGE UNIVERSITY   (Pakistan)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Bioactive molecules; Flavonoids; Functional foods; Health benefits; Polyphenols

Indexed keywords

BIOACTIVITY; DISEASES; FLAVONOIDS; HEALTH; MOLECULES; ORGANIC ACIDS;

BIOACTIVE MOLECULES; CANCER PREVENTION; DISTRIBUTED GROUPS; HEALTH BENEFITS; HYDROXYCINNAMIC ACIDS; HYPERCHOLESTEROLEMIA; POLYPHENOLS; THERAPEUTIC POTENTIALS;

FUNCTIONAL FOOD;

EID: 85020256893     PISSN: 10942912     EISSN: 15322386     Source Type: Journal    
DOI: 10.1080/10942912.2016.1220393     Document Type: Review

References (94)

1. Dragovicuzelac, V.; Levaj, B.; Mrkic, V.; Bursac, D.; Boras, M., The Content of Polyphenols and Carotenoids in Three Apricot Cultivars Depending on Stage of Maturity and Geographical Region. Food Chemistry 2007, 102, 966–975.
2. Archivio, D.; Filesi, M.; Di Benedetto, C.; Gargiulo, R.; Giovannini, R.; Masella, C.R., Polyphenols, Dietary, Sources and Bioavailability. Annali-Istituto Superiore di Sanita 2007, 43, 348.
3. Scalbert, A.; Johnson, I.T.; Saltmarsh, M., Polyphenols:Antioxidants and Beyond. The American Journal of Clinical Nutrition 2005, 81, 215S–217S.
4. Marrugat, J.; Covas, M.-I.; Fitó, M.; Schröder, H.; Miró-Casas, E.; Gimeno, E.; López-Sabater, M.C.; de la Torre, R.; Farré, M., Effects of Differing Phenolic Content in Dietary Olive Oils on Lipids and LDL Oxidation. European Journal of Nutrition 2004, 43, 140–147.
5. Georgé, S.; Brat, P.; Alter, P.; Amiot, M.J., Rapid Determination of Polyphenols and Vitamin C in Plant-Derived Products. Journal of Agricultural and Food Chemistry 2005, 53, 1370–1373.
6. Lambert, J.D.; Hong, J.; Yang, G.-Y.; Liao, J.; Yang, C.S., Inhibition of Carcinogenesis by Polyphenols:Evidence from Laboratory Investigations. The American Journal of Clinical Nutrition 2005, 81, 284S–291S.
7. Hussain, T.; Gupta, S.; Adhami, V.M.; Mukhtar, H., Green Tea Constituent Epigallocatechin-3-Gallate Selectively Inhibits COX-2 Without Affecting COX-1 Expression in Human Prostate Carcinoma Cells. International Journal of Cancer 2004, 113, 660–669.
8. O’Leary, K.A.; Pascual-Tereasa, S.D.; Needs, P.W.; Bao, Y.-P.; O’Brien, N.M.; Williamson, G., Effect of Flavonoids and Vitamin E on Cyclooxygenase-2 (COX-2) Transcription. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 2004, 551, 245–254.
9. Tapiero, H.; Nguyen Ba, G.; Tew, K.D., Estrogens and Environmental, Estrogens. Biomedicine & Pharmacotherapy 2002, 56, 36–44.
10. Sadik, C.D.; Sies, H.; Schewe, T., Inhibition of 15-Lipoxygenases by Flavonoids:Structure–Activity Relations and Mode of Action. Biochemical Pharmacology 2003, 65, 773–781.
11. Schewe, T.; Sadik, C.; Klotz, L.-O.; Yoshimoto, T.; Kühn, H.; Sies, H., Polyphenols of Cocoa:Inhibition of Mammalian 15-Lipoxygenase. Biological Chemistry 2001, 382, 1687–1696.
12. Spencer, J.P.E., Modulation of Pro-Survival Akt/Protein Kinase B and ERK1/2 Signaling Cascades by Quercetin and Its in Vivo Metabolites Underlie Their Action on Neuronal Viability. Journal of Biological Chemistry 2003, 278, 34783–34793.
13. Leuzzi, U.; Caristi, C.; Panzera, V.; Licandro, G., Flavonoids in Pigmented Orange Juice and Second-Pressure Extracts. Journal of Agricultural and Food Chemistry 2000, 48, 5501–5506.
14. Manach, C.; Scalbert, A.; Morand, C.; Rémésy, C.; Jiménez, L., Polyphenols: Food, Sources and Bioavailability. The American Journal of Clinical Nutrition 2004, 79, 727–747.
15. Srini Srinivasan, V., Bioavailability of Ingredients in Dietary Supplements. In Pharmaceutical Dissolution Testing; Informa Healthcare:Cambridge, UK, 2005, 407–419.
16. Natsume, M.; Osakabe, N.; Oyama, M.; Sasaki, M.; Baba, S.; Nakamura, Y.; Osawa, T.; Terao, J., Structures of (−)-Epicatechin Glucuronide Identified from Plasma and Urine After Oral Ingestion of (−)-Epicatechin:Differences Between Human and Rat. Free Radical Biology and Medicine 2003, 34, 840–849.
17. Zhang, H.; Wang, L.; Deroles, S.; Bennett, R.; Davies, K., New Insight into the Structures and Formation of Anthocyanic Vacuolar Inclusions in Flower Petals. BMC Plant Biology 2006, 6, 29.
18. Purushotham, A.; Tian, M.; Belury, M.A., The Citrus Fruit Flavonoid Naringenin Suppresses Hepatic Glucose Production from Fao Hepatoma Cells. Molecular Nutrition & Food Research 2009, 53, 300–307.
19. Organization, W.H., Global Health Risks:Mortality and Burden of Disease Attributable to Selected Major Risks; World Health Organization, WHO Press:Geneva, Switzerland, 2009.
20. Kim, K.; Vance, T.M.; Chun, O.K., Greater Flavonoid Intake Is Associated with Improved CVD Risk Factors in US Adults. British Journal of Nutrition 2016, 115(8), 1481–1488.
21. Klinder, A.; Shen, Q.; Heppel, S.; Lovegrove, J.A.; Rowland, I.; Tuohy, K.M., Impact of Increasing Fruit and Vegetables and Flavonoid Intake on the Human Gut Microbiota. Food and Function 2016, 7(4),1788–1796.
22. Du, K.; McGill, M.R.; Xie, Y.; Bajt, M.L.; Jaeschke, H., Resveratrol Prevents Protein Nitration and Release of Endonucleases from Mitochondria During Acetaminophen Hepatotoxicity. Food and Chemical Toxicology 2015, 81, 62–70.
23. Mink, P.J.; Scrafford, C.G.; Barraj, L.M.; Harnack, L.; Hong, C.-P.; Nettleton, J.A.; Jacobs, D.R., Flavonoid, Intake and Cardiovascular Disease Mortality:A Prospective Study in Postmenopausal Women. The American Journal of Clinical Nutrition 2007, 85, 895–909.
24. Arts, I.C.; Hollman, P.C., Polyphenols and Disease Risk in Epidemiologic, Studies. The American Journal of Clinical Nutrition 2005, 81, 317S–325S.
25. Peters, U., Does Tea Affect Cardiovascular Disease? A Meta-Analysis. American Journal of Epidemiology 2001, 154, 495–503.
26. Hooper, L.; Kroon, P.A.; Rimm, E.B.; Cohn, J.S.; Harvey, I.; Le Cornu, K.A.; Ryder, J.J.; Hall, W.L.; Cassidy, A., Flavonoids, Flavonoid-Rich, Foods, and Cardiovascular Risk:A Meta-Analysis of Randomized Controlled Trials. The American Journal of Clinical Nutrition 2008, 88, 38–50.
27. Soliman, M.M.; Abdo Nassan, M.; Ismail, T.A., Immunohistochemical and Molecular Study on the Protective Effect of Curcumin Against Hepatic Toxicity Induced by Paracetamol Inwistar Rats. BMC Complementary and Alternative Medicine 2014, 14(57), 1–11.
28. Ozdal, T.; Sela, D.A.; Xiao, J.; Boyacioglu, D.; Chen, F.; Capanoglu, E., The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility. Nutrients 2016, 8, 78–113.
29. Erlund, I.; Koli, R.; Alfthan, G.; Marniemi, J.; Puukka, P.; Mustonen, P.; Mattila, P.; Jula, A., Favorable Effects of Berry Consumption on Platelet Function, Blood Pressure, and HDL Cholesterol. The American Journal of Clinical Nutrition 2008, 87, 323–331.
30. Desch, S.; Schmidt, J.; Kobler, D.; Sonnabend, M.; Eitel, I.; Sareban, M.; Rahimi, K.; Schuler, G.; Thiele, H., Effect of Cocoa Products on Blood Pressure:Systematic Review and Meta-Analysis. American Journal of Hypertension 2010, 23, 97–103.
31. Grassi, D.; Mulder, T.P.J.; Draijer, R.; Desideri, G.; Molhuizen, H.O.F.; Ferri, C., Black Tea Consumption Dose-Dependently Improves Flow-Mediated Dilation in Healthy Males. Journal of Hypertension 2009, 27, 774–781.
32. Heiss, C.; Finis, D.; Kleinbongard, P.; Hoffmann, A.; Rassaf, T.; Kelm, M.; Sies, H., Sustained Increase in Flow-Mediated Dilation After Daily Intake of High-Flavanol Cocoa Drink Over 1 Week. Journal of Cardiovascular Pharmacology 2007, 49, 74–80.
33. Keevil, J.G.; Osman, H.; Maalej, N.; Folts, J.D., Grape Juice Inhibits Human Ex Vivo Platelet Aggregation While Orange and Grapefruit Juices Do Not. Journal of the American College of Cardiology 1998, 31, 172.
34. Mathur, S.; Devaraj, S.; Grundy, S.M.; Jialal, I., Cocoa Products Decrease Low Density Lipoprotein Oxidative Susceptibility But Do Not Affect Biomarkers of Inflammation in Humans. The Journal of Nutrition 2002, 132, 3663–3667.
35. Schramm, D.D.; Karim, M.; Schrader, H.R.; Holt, R.R.; Kirkpatrick, N.J.; Polagruto, J.A.; Ensunsa, J.L.; Schmitz, H.H.; Keen, C.L., Food Effects on the Absorption and Pharmacokinetics of Cocoa Flavanols. Life Sciences 2003, 73, 857–869.
36. Valdés, L.; Cuervo, A.; Salazar, N.; Ruas-Madiedo, P.; Gueimonde, M.; González, S., The Relationship Between Phenolic Compounds from Diet and Microbiota:Impact on Human Health. Food & Function 2015, 6, 2424–2439.
37. Taubert, D.; Roesen, R.; Lehmann, C.; Jung, N.; Schömig, E., Effects of Low Habitual Cocoa Intake on Blood Pressure and Bioactive Nitric Oxide. JAMA 2007, 298, 49.
38. Yang, Y.-C.; Lu, F.-H.; Wu, J.-S.; Wu, C.-H.; Chang, C.-J., The Protective Effect of Habitual Tea Consumption on Hypertension. Archives of Internal Medicine 2004, 164, 1534.
39. Duffy, S.J.; Keaney, J.F.; Holbrook, M.; Gokce, N.; Swerdloff, P.L.; Frei, B.; Vita, J.A., Short- and Long-Term Black Tea Consumption Reverses Endothelial Dysfunction in Patients with Coronary Artery Disease. Circulation 2001, 104, 151–156.
40. Hodgson, J.M.; Puddey, I.B.; Burke, V.; Watts, G.F.; Beilin, L.J., Regular Ingestion of Black Tea Improves Brachial Artery Vasodilator Function. Clinical Science 2002, 102, 195–201.
41. Hodgson, J.M.; Burke, V.; Puddey, I.B., Acute Effects of Tea on Fasting and Postprandial Vascular Function and Blood Pressure in Humans. Journal of Hypertension 2005, 23, 47–54.
42. Whelan, A.P.; Sutherland, W.H.F.; McCormick, M.P.; Yeoman, D.J.; de Jong, S.A.; Williams, M.J.A., Effects of White and Red Wine on Endothelial Function in Subjects with Coronary Artery Disease. Internal Medicine Journal 2004, 34, 224–228.
43. Appeldoorn, M.M.; Venema, D.P.; Peters, T.H.F.; Koenen, M.E.; Arts, I.C.W.; Vincken, J.-P.; Gruppen, H.; Keijer, J.; Hollman, P.C.H., Some Phenolic Compounds Increase the Nitric Oxide Level in Endothelial Cells in Vitro. Journal of Agricultural and Food Chemistry 2009, 57, 7693–7699.
44. Schmitt, C.A.; Dirsch, V.M., Modulation of Endothelial Nitric Oxide by Plant-Derived Products. Nitric Oxide 2009, 21, 77–91.
45. Woodman, O.L.; Chan, E.C.H., Vascular and Anti-Oxidant Actions of Flavonols and Flavones. Clinical and Experimental Pharmacology and Physiology 2004, 31, 786–790.
46. Fitzpatrick, D.F.; Hirschfield, S.L.; Ricci, T.; Jantzen, P.; Coffey, R.G., Endothelium-Dependent Vasorelaxation Caused by Various Plant Extracts. Journal of Cardiovascular Pharmacology 1995, 26, 90–95.
47. Freedman, J.E.; Parker, C.; Li, L.; Perlman, J.A.; Frei, B.; Ivanov, V.; Deak, L.R.; Iafrati, M.D.; Folts, J.D., Select, Flavonoids and Whole Juice From Purple Grapes Inhibit Platelet Function and Enhance Nitric Oxide Release. Circulation 2001, 103, 2792–2798.
48. Kim, J.M.; Lee, E.K.; Kim, D.H.; Yu, B.P.; Chung, H.Y., Kaempferol Modulates Pro-Inflammatory NF-κB Activation by Suppressing Advanced Glycation Endproducts-Induced NADPH Oxidase. AGE 2010, 32, 197–208.
49. Hanahan, D.; Weinberg, R.A., The Hallmarks of Cancer. Cell 2000, 100, 57–70.
50. Guo, W.; Kong, E.; Meydani, M., Dietary Polyphenols, Inflammation, and Cancer. Nutrition and Cancer 2009, 61, 807–810.
51. Franceschi, S.; Parpinel, M.; Vecchia, C.L.; Favero, A.; Talamini, R.; Negri, E., Role of Different Types of Vegetables and Fruit in the Prevention of Cancer of the Colon, Rectum, and Breast. Epidemiology 1998, 9, 338–341.
52. La Vecchia, C.; Chatenoud, L.; Franceschi, S.; Soler, M.; Parazzini, F.; Negri, E., Vegetables and Fruit and Human Cancer:Update of An Italian Study. International Journal of Cancer 1999, 82, 151–152.
53. Benetou, V.; Orfanos, P.; Lagiou, P.; Trichopoulos, D.; Boffetta, P.; Trichopoulou, A., Vegetables and Fruits in Relation to Cancer Risk:Evidence from the Greek EPIC Cohort Study. Cancer Epidemiology Biomarkers & Prevention 2008, 17, 387–392.
54. González, C.A.; Pera, G.; Agudo, A.; Bueno-de-Mesquita, H.B.; Ceroti, M.; Boeing, H.; Schulz, M.; Del Giudice, G.; Plebani, M.; Carneiro, F.; Berrino, F.; Sacerdote, C.; Tumino, R.; Panico, S.; Berglund, G.; Simán, H.; Hallmans, G.; Stenling, R.; Martinez, C.; Dorronsoro, M.; Barricarte, A.; Navarro, C.; Quiros, J.R.; Allen, N.; Key, T.J.; Bingham, S.; Day, N.E.; Linseisen, J.; Nagel, G.; Overvad, K.; Jensen, M.K.; Olsen, A.; Tjønneland, A.; Büchner, F.L.; Peeters, P.H.M.; Numans, M.E.; Clavel-Chapelon, F.; Boutron-Ruault, M.-C.; Roukos, D.; Trichopoulou, A.; Psaltopoulou, T.; Lund, E.; Casagrande, C.; Slimani, N.; Jenab, M.; Riboli, E. Fruit, and Vegetable Intake and the Risk of Stomach and Oesophagus Adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC–EURGAST). International Journal of Cancer 2006, 118, 2559–2566.
55. Inoue, M.; Tajima, K.; Mizutani, M.; Iwata, H.; Iwase, T.; Miura, S.; Hirose, K.; Hamajima, N.; Tominaga, S., Regular Consumption of Green Tea and the Risk of Breast Cancer Recurrence:Follow-up Study from the Hospital-Based Epidemiologic Research Program at Aichi Cancer Center (HERPACC), Japan. Cancer Letters 2001, 167, 175–182.
56. Rieger-Christ, K.M.; Hanley, R.; Lodowsky, C.; Bernier, T.; Vemulapalli, P.; Roth, M.; Kim, J.; Yee, A.S.; Le, S.M.; Marie, P.J.; Libertino, J.A.; Summerhayes, I.C. The Green Tea Compound, (−)-Epigallocatechin-3-Gallate Downregulates n-Cadherin and Suppresses Migration of Bladder Carcinoma Cells. Journal of Cellular Biochemistry 2007, 102, 377–388.
57. Lee, J.-S.; Surh, Y.-J., Nrf2 As a Novel Molecular Target for Chemoprevention. Cancer Letters 2005, 224, 171–184.
58. Khan, S.G.; Katiyar, S.K.; Agarwal, R.; Mukhtar, H., Enhancement of Antioxidant and Phase II Enzymes by Oral Feeding of Green Tea Polyphenols in Drinking Water to SKH-1 Hairless Mice:Possible Role in Cancer Chemoprevention. Cancer Research 1992, 52, 4050–4052.
59. Motohashi, H.; Yamamoto, M., Nrf2–Keap1 Defines a Physiologically Important Stress Response Mechanism. Trends in Molecular Medicine 2004, 10, 549–557.
60. Gopalakrishnan, A.; Tony Kong, A.-N., Anticarcinogenesis by Dietary Phytochemicals:Cytoprotection by Nrf2 in Normal Cells and Cytotoxicity by Modulation of Transcription Factors NF-κB and AP-1 in Abnormal Cancer Cells. Food and Chemical Toxicology 2008, 46, 1257–1270.
61. Surh, Y.-J.; Na, H.-K., NF-κB and Nrf2 as Prime Molecular Targets for Chemoprevention and Cytoprotection with Anti-Inflammatory and Antioxidant Phytochemicals. Genes & Nutrition 2007, 2, 313–317.
62. Tusi, S.K.; Ansari, N.; Amini, M.; Amirabad, A.D.; Shafiee, A.; Khodagholi, F., Attenuation of NF-κB and Activation of Nrf2 Signaling by 1,2,4-Triazine Derivatives, Protects Neuron-Like PC12 Cells Against Apoptosis. Apoptosis 2010, 15, 738–751.
63. Karin, M.; Yamamoto, Y.; Wang, Q.M., The IKK NF-κB System:A Treasure Trove for Drug Development. Nature Reviews Drug Discovery 2004, 3, 17–26.
64. Flohé, L.; Brigelius-Flohé, R.; Saliou, C.; Traber, M.G.; Packer, L., Redox Regulation of NF-Kappa B Activation. Free Radical Biology and Medicine 1997, 22, 1115–1126.
65. Chen, C.; Kong, A.N.T., Dietary Chemopreventive Compounds and ARE/Epre Signaling. Free Radical Biology and Medicine 2004, 36, 1505–1516.
66. Karin, M.; Cao, Y.; Greten, F.R.; Li, Z.-W., NF-κB in Cancer:From Innocent Bystander to Major Culprit. Nature Reviews Cancer 2002, 2, 301–310.
67. Karin, M.; Greten, F.R., NF-κB:Linking Inflammation and Immunity to Cancer Development and Progression. Nature Reviews Immunology 2005, 5, 749–759.
68. Aggarwal, B.B.; Shishodia, S., Molecular Targets of Dietary Agents for Prevention and Therapy of Cancer. Biochemical Pharmacology 2006, 71, 1397–1421.
69. Yang, R.-C.; Chen, H.-W.; Lu, T.-S.; Hsu, C., Potential Protective Effect of NF-κB Activity on the Polymicrobial Sepsis of Rats Preconditioning Heat Shock Treatment. Clinica Chimica Acta 2000, 302, 11–22.
70. Valen, G., Signal Transduction Through Nuclear Factor Kappa B in Ischemia-Reperfusion and Heart Failure. Basic Research in Cardiology 2004, 99, 1–7.
71. Teoh, N., Hepatic Ischemic Preconditioning in Mice Is Associated with Activation of NF-κB, p38 Kinase, and Cell Cycle Entry. Hepatology 2002, 36, 94–102.
72. Blondeau, N.; Widmann, C.; Lazdunski, M.; Heurteaux, C., Activation of the Nuclear Factor-κB is a Key Event in Brain Tolerance. The Journal of Neuroscience 2001, 21, 4668–4677.
73. Hayakawa, M., Evidence that Reactive Oxygen Species Do Not Mediate NF- B Activation. The EMBO Journal 2003, 22, 3356–3366.
74. Paur, I.; Austenaa, L.M.; Blomhoff, R., Extracts of Dietary Plants Are Efficient Modulators of Nuclear Factor Kappa B. Food and Chemical Toxicology 2008, 46, 1288–1297.
75. Zhang, J.; Ping, P.; Vondriska, T.M.; Tang, X.-L.; Wang, G.-W.; Cardwell, E.M.; Bolli, R., Cardioprotection Involves Activation of NF-κB via PKC-Dependent Tyrosine and Serine Phosphorylation of IκB-α. American Journal of Physiology. Heart and Circulatory Physiology 2003, 285, H1753–H1758.
76. Bhamre, S.; Sahoo, D.; Tibshirani, R.; Dill, D.L.; Brooks, J.D., Gene Expression Changes Induced by Genistein in the Prostate Cancer Cell Line LNCaP. The Open Prostate Cancer Journal 2010, 3, 86–98.
77. Miller, N.J.; Ruiz-Larrea, M.B., Flavonoids and Other Plant Phenols in the Diet:Their Significance As Antioxidants. Journal of Nutritional and Environmental Medicine 2002, 12, 39–51.
78. Dinkova-Kostova, A.T.; Talalay, P., Direct and Indirect Antioxidant Properties of Inducers of Cytoprotective Proteins. Molecular Nutrition & Food Research 2008, 52(1), 128–138.
79. Duda-Chodak, A.; Tarko, T.; Satora, P.; Sroka, P., Interaction of Dietary Compounds, Especially Polyphenols, with the Intestinal Microbiota:A Review. European Journal of Nutrition 2015, 54, 325–341.
80. Dueñas, M.; Muñoz-González, I.; Cueva, C.; Jiménez-Girón, A.; Sánchez-Patán, F.; Santos-Buelga, C.; Moreno-Arribas, M.V.; Bartolome, B., A Survey of Modulation of Gut Microbiota by Dietary Polyphenols. BioMed Research International 2015, 2015, 1–15.
81. Li, Q.; Zhao, H.F.; Zhang, Z.F.; Liu, Z.G.; Pei, X.R.; Wang, J.B.; Cai, M.Y.; Li, Y., Long-Term Administration of Green Tea Catechins Prevents Age-Related Spatial Learning and Memory Decline in C57BL/6 J Mice by Regulating Hippocampal Cyclic Amp-Response Element Binding Protein Signaling Cascade. Neuroscience 2009, 159, 1208–1215.
82. Martínez, M.E., Primary Prevention of Colorectal Cancer:Lifestyle, Nutrition, Exercise. In Tumor Prevention and Genetics III; Springer Science/Business Media, Springer-Verlag:New York, USA, 2005, 177–211.
83. Dhillon, A.S.; Hagan, S.; Rath, O.; Kolch, W., MAP Kinase Signalling Pathways in Cancer. Oncogene 2007, 26, 3279–3290.
84. Hopfner, M., Growth Factor Receptors and Related Signalling Pathways As Targets for Novel Treatment Strategies of Hepatocellular Cancer. World Journal of Gastroenterology 2008, 14, 1.
85. Wang, W.; Wang, X.; Peng, L.; Deng, Q.; Liang, Y.; Qing, H.; Jiang, B., CD24-Dependent MAPK Pathway Activation Is Required for Colorectal Cancer Cell Proliferation. Cancer Science 2010, 101, 112–119.
86. Corona, G.; Spencer, J.; Dessi, M., Extra Virgin Olive Oil Phenolics:Absorption, Metabolism, and Biological Activities in the GI Tract. Toxicology and Industrial Health 2009, 25, 285–293.
87. Santaguida, P.L.; Balion, C.; Hunt, D., Diagnosis, Prognosis, and Treatment of Impaired Glucose Tolerance and Impaired Fasting Glucose. Evidence Report/Technology Assessment 2008, 12, 1–11.
88. Bahadoran, Z.; Tohidi, M.; Nazeri, P.; Mehran, M.; Azizi, F.; Mirmiran, P., Effect of Broccoli Sprouts on Insulin Resistance in Type 2 Diabetic Patients:A Randomized Double-Blind Clinical Trial. International Journal of Food Sciences and Nutrition 2012, 63, 767–771.
89. Hanhineva, K.; Torronen, R.; Bondia-Pons, I.; Pekkinen, J.; Kolehmainen, M.; Mykkanan, H.; Poutanen, K., Impact of Dietary Polyphenols on Carbohydrate Metabolism. International Journal of Molecular Science 2010, 11, 1365–1402.
90. Rodrigo, R.; Miranda, A.; Vergara, L., Modulation of Endogenous Antioxidant System by Wine Polyphenols in Human Disease. Clinical Chemica Acta 2011, 412, 410–424.
91. Stull, A.J.; Cash, C.K.; Johnson, W.D.; Champagne, C.M.; Cefalu, W.T., Bioactives in Blueberries Improve Insulin Sensitivity in Obese, Insulin-Resistant Men and Women. Journal of Nutrition 2010, 140, 1764–1768.
92. McDougall, G.J.; Shpiro, F.; Dobson, P.; Smith, P.; Blake, A.; Stewart, D., Different Polyphenolic Components of Soft Fruits Inhibit α-Amylase and α-Glucosidase. Journal of Agricultural and Food Chemistry 2005, 53, 2760–2766.
93. Boath, A.S.; Stewart, D.; McDougall, G.J., Berry Components Inhibit á-Glucosidase in Vitro:Synergies Between Acarbose and Polyphenols from Black Currant and Rowanberry. Food Chemistry 2012, 135, 929–936.
94. Takikawa, M.; Inoue, S.; Horio, F.; Tsuda, T., Dietary Anthocyanin-Rich Bilberry Extract Ameliorates Hyperglycemia and Insulin Sensitivity Via Activation of AMP-Activated Protein Kinase in Diabetic Mice. Journal of Nutrition 2010, 140, 527–533.