Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: A randomized double-blind clinical trial

International Journal of Food Sciences and Nutrition

Volumn 63, Issue 7, 2012, Pages 767-771

  Bahadoran, Zahra ^a   Tohidi, Maryam ^b   Nazeri, Pantea ^a   Mehran, Mahya ^a   Azizi, Fereidoun ^c   Mirmiran, Parvin ^d  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Broccoli sprouts; Insulin resistance; Sulphoraphane; Type 2 diabetes

Indexed keywords

ANTIOXIDANT; INSULIN; ISOTHIOCYANIC ACID DERIVATIVE; SULPHORAPHANE;

ADULT; ARTICLE; BLOOD; BRASSICA; CHEMISTRY; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIET THERAPY; DOUBLE BLIND PROCEDURE; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; HYPERINSULINISM; INSULIN RESISTANCE; IRAN; MALE; METABOLISM; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; PATIENT; PATIENT COMPLIANCE; PLANT; RANDOMIZED CONTROLLED TRIAL;

ADULT; ANTIOXIDANTS; BLOOD GLUCOSE; BRASSICA; DIABETES MELLITUS, TYPE 2; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPERGLYCEMIA; HYPERINSULINISM; INSULIN; INSULIN RESISTANCE; IRAN; ISOTHIOCYANATES; MALE; MIDDLE AGED; PATIENT COMPLIANCE; PATIENT DROPOUTS; PLANT SHOOTS;

EID: 84867474643     PISSN: 09637486     EISSN: 14653478     Source Type: Journal    
DOI: 10.3109/09637486.2012.665043     Document Type: Article

References (21)

1. Azar M, Sarkisian E. 1980. Food composition table of Iran National Nutrition and Food Research Institute. Shahid Beheshti University Press. Tehran: Iran.
2. Bahadoran Z, Mirmiran P, Hosseinpanah F, Hedayati M, Hosseinpour-Niazi S, Azizi F. 2011. Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial. Eur J Clin Nutr 65(8): 972-977.
3. Evans JL. 2007. Antioxidants: do they have a role in the treatment of insulin resistance? Indian J Med Res 125: 355-372.
4. Evans JL, Goldfine ID, Maddux BA, Grodsky GM. 2003. Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction? Diabetes 52(1): 1-8.
5. Fahey J, Talalay P. 1999. Antioxidant function of sulforaphane: a potent inducer of phase 2 detoxification enzymes. Food Chem Toxicol 37: 973-979.
6. Hanley AJ, Stern MP, Williams K, Haffner SM. 2002. Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovasculardisease. Diabetes Care 25: 1177-1184.
7. Henriksen EJ, Diamond-Stanic MK, Marchionne EM. 2011. Oxidative stress and the etiology of insulin resistance and type 2 diabetes. Free Radic Biol Med 51(5): 993-999.
8. Hoehn KL, Salmon AB, Hohnen-Behrens C, Turner N, Hoy AJ, Maghzal GJ, Stocker R. 2009. Insulin resistance is a cellular antioxidant defense mechanism. Proc Natl Acad Sci USA 106(42): 17787-17892.
9. Laakso M. 2001. Insulin resistance and its impact on the approach to therapy ofType 2 diabetes. Int J Clin Pract 121: 8-12.
10. Lebovitz HE. 2001. Insulin resistance: definition and consequences. Exp Clin Endocrinol Diabetes 109: S135-S148.
11. Lee SH, Park SA, Ko SH, Yim HW, Ahn YB, Yoon KH. 2010. Insulin resistance and inflammation may have an additional role in the link between cystatin C and cardiovascular disease in type 2 diabetes mellitus patients. Metabolism 59(2): 241-246.
12. Li J, Ichikawa T, Janicki JS, Cui T. 2009. Targeting the Nrf2 pathway against cardiovascular disease. Expert Opin Ther Targets 13: 785-794.
13. Nestle M. 1997. Broccoli sprouts as inducers of carcinogen-detoxifying enzyme systems: clinical, dietary, and policy implications. Proc Natl Acad Sci USA 94(21): 11149-11151.
14. Park K, Gross M, Lee DH, Holvoet P, Himes JH, Shikany JM, Jacobs DR. 2009. Oxidative stress and insulin resistance: the coronary artery risk development in young adults study. Diabetes Care 32(7): 1302-1307.
15. Reddy KJ, Singh M, Bangit JR, Batsell RR. 2010. The role of insulin resistance in the pathogenesis of atherosclerotic cardiovascular disease: an updated review. J Cardiovasc Med (Hagerstown) 11(9): 633-647.
16. Riedl MA, Saxon A, Diaz-Sanchez D. 2009. Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway. Clin Immunol 130(3): 244-251.
17. Silfen ME, Mavibo AM, McMahon DJ, Levine LS, Murphy AR, Oberfield SE. 2001. Fasting glucose to insulin ratio is a simple and useful measure of insulin resistance in young girls. J Clin Endocrinol Metab 86: 2863-2868.
18. Tan Y, Ichikawa T, Li J, Si Q, Yang H, Chen X. 2011. Diabetic down-regulation of Nrf2 activity via ERK contributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivo. Diabetes 60(2): 625-633.
19. Verkerk R, Schreiner M, Krumbein A. 2009. Glucosinolates in brassica vegetable: the influence of the food supply chain on intake, bioavailability and human health. Mol Nutr Food Res 53: S219-S266.
20. Wu L, Noyan MH, Facci M. 2004. Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardio-vascular system. Proc Natl Acad Sci 101(18): 7094-7099.
21. Xue M, Qian Q, Adaikalakoteswari A, Rabbani N, Babaei-Jadidi R, Thornalley PJ. 2008. Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease. Diabetes 57: 2809-2817.