메뉴 건너뛰기




Volumn 122, Issue , 2017, Pages 78-89

Cinnamaldehyde in diabetes: A review of pharmacology, pharmacokinetics and safety

Author keywords

Cinnamaldehyde; Diabetes; Obesity; Pharmacokinetics; Pharmacology; Safety

Indexed keywords

ADENYLATE KINASE; AMYLASE; CINNAMALDEHYDE; CINNAMIC ACID; CINNAMYL ALCOHOL; GHRELIN; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE PHOSPHATASE 1B; RETINOL BINDING PROTEIN 4; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR NRF2; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; ACROLEIN; ANTIDIABETIC AGENT;

EID: 85020129944     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2017.05.019     Document Type: Review
Times cited : (227)

References (122)
  • 1
    • 85035060712 scopus 로고    scopus 로고
    • Recent advanceson cinnamaldehyde
    • Zhou, M., Chen, Z., Shen, S., Recent advanceson cinnamaldehyde. J. Econ. Anim. 19 (2015), 1–5.
    • (2015) J. Econ. Anim. , vol.19 , pp. 1-5
    • Zhou, M.1    Chen, Z.2    Shen, S.3
  • 4
    • 84859985695 scopus 로고
    • Organic chemistry research −on cinnamon oil, the hippuric acid and sebacic acid
    • Dumas, J.P.E., Organic chemistry research −on cinnamon oil, the hippuric acid and sebacic acid. Annales de chimie et de physique 57 (1834), 305–334.
    • (1834) Annales de chimie et de physique , vol.57 , pp. 305-334
    • Dumas, J.P.E.1
  • 5
    • 84974586039 scopus 로고
    • Sur la production artificielle de ĺessence de cannelle [on the artificial production of cinnamon oil]
    • Chiozza, L., Sur la production artificielle de ĺessence de cannelle [on the artificial production of cinnamon oil]. Comptes rendus (in French) 42 (1856), 222–227.
    • (1856) Comptes rendus (in French) , vol.42 , pp. 222-227
    • Chiozza, L.1
  • 7
    • 77952951962 scopus 로고    scopus 로고
    • Insulinotropic effect of cinnamaldehyde on transcriptional regulation of pyruvate kinase, phosphoenolpyruvate carboxykinase, and glut4 translocation in experimental diabetic rats
    • Anand, P., Murali, K.Y., Tandon, V., Murthy, P.S., Chandra, R., Insulinotropic effect of cinnamaldehyde on transcriptional regulation of pyruvate kinase, phosphoenolpyruvate carboxykinase, and glut4 translocation in experimental diabetic rats. Chem. Biol. Interact. 186 (2010), 72–81.
    • (2010) Chem. Biol. Interact. , vol.186 , pp. 72-81
    • Anand, P.1    Murali, K.Y.2    Tandon, V.3    Murthy, P.S.4    Chandra, R.5
  • 8
    • 58149360797 scopus 로고    scopus 로고
    • Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus
    • Zhang, W., Xu, Y.C., Guo, F.J., Meng, Y., Li, M.L., Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus. Chin. Med. J.-Peking 121 (2008), 2124–2128.
    • (2008) Chin. Med. J.-Peking , vol.121 , pp. 2124-2128
    • Zhang, W.1    Xu, Y.C.2    Guo, F.J.3    Meng, Y.4    Li, M.L.5
  • 9
    • 84878251816 scopus 로고    scopus 로고
    • Chemical composition and hypoglycemic and pancreas-protective effect of leaf essential oil from indigenous cinnamon (cinnamomum osmophloeum kanehira)
    • Lee, S.C., Xu, W.X., Lin, L.Y., Yang, J.J., Liu, C.T., Chemical composition and hypoglycemic and pancreas-protective effect of leaf essential oil from indigenous cinnamon (cinnamomum osmophloeum kanehira). J. Agric. Food Chem. 61 (2013), 4905–4913.
    • (2013) J. Agric. Food Chem. , vol.61 , pp. 4905-4913
    • Lee, S.C.1    Xu, W.X.2    Lin, L.Y.3    Yang, J.J.4    Liu, C.T.5
  • 10
    • 80053562178 scopus 로고    scopus 로고
    • Cinnamaldehyde protects from the hypertension associated with diabetes
    • El-Bassossy, H.M., Fahmy, A., Badawy, D., Cinnamaldehyde protects from the hypertension associated with diabetes. Food Chem. Toxicol. 49 (2011), 3007–3012.
    • (2011) Food Chem. Toxicol. , vol.49 , pp. 3007-3012
    • El-Bassossy, H.M.1    Fahmy, A.2    Badawy, D.3
  • 11
    • 75149176702 scopus 로고    scopus 로고
    • Effects of cinnamaldehyde on the expression levels of irs-1 and p85 alpha in gastrocnemius of type 2 diabetic rats
    • (723–726 = 731)
    • Li, M., Xu, Y., Zhang, W., Effects of cinnamaldehyde on the expression levels of irs-1 and p85 alpha in gastrocnemius of type 2 diabetic rats. Med. J. Wuhan Univ., 30, 2009 (723–726 = 731).
    • (2009) Med. J. Wuhan Univ. , vol.30
    • Li, M.1    Xu, Y.2    Zhang, W.3
  • 12
    • 84864812822 scopus 로고    scopus 로고
    • Gc-ms analysis and screening of antidiabetic, antioxidant and hypolipidemic potential of cinnamomum tamala oil in streptozotocin induced diabetes mellitus in rats
    • Kumar, S., Vasudeva, N., Sharma, S., Gc-ms analysis and screening of antidiabetic, antioxidant and hypolipidemic potential of cinnamomum tamala oil in streptozotocin induced diabetes mellitus in rats. Cardiovasc. Diabetol., 11, 2012, 95.
    • (2012) Cardiovasc. Diabetol. , vol.11 , pp. 95
    • Kumar, S.1    Vasudeva, N.2    Sharma, S.3
  • 13
    • 84923100458 scopus 로고    scopus 로고
    • Anti-obesity and anti-hyperglycemic effects of cinnamaldehyde via altered ghrelin secretion and functional impact on food intake and gastric emptying
    • Camacho, S., Michlig, S., de Senarclens-Bezencon, C., Meylan, J., Meystre, J., Pezzoli, M., Markram, H., le Coutre, J., Anti-obesity and anti-hyperglycemic effects of cinnamaldehyde via altered ghrelin secretion and functional impact on food intake and gastric emptying. Sci. Rep., 5, 2015, 7919.
    • (2015) Sci. Rep. , vol.5 , pp. 7919
    • Camacho, S.1    Michlig, S.2    de Senarclens-Bezencon, C.3    Meylan, J.4    Meystre, J.5    Pezzoli, M.6    Markram, H.7    le Coutre, J.8
  • 14
    • 84872725565 scopus 로고    scopus 로고
    • The c57bl/6j mouse strain background modifies the effect of a mutation in bcl2l2
    • Navarro, S.J., Trinh, T., Lucas, C.A., Ross, A.J., Waymire, K.G., Macgregor, G.R., The c57bl/6j mouse strain background modifies the effect of a mutation in bcl2l2. G3 2 (2012), 99–102.
    • (2012) G3 , vol.2 , pp. 99-102
    • Navarro, S.J.1    Trinh, T.2    Lucas, C.A.3    Ross, A.J.4    Waymire, K.G.5    Macgregor, G.R.6
  • 16
    • 80855145712 scopus 로고    scopus 로고
    • All (c57bl/6) mice are not created equal
    • Kiselycznyk, C., Holmes, A., All (c57bl/6) mice are not created equal. Front. Neurosci., 5, 2011, 10.
    • (2011) Front. Neurosci. , vol.5 , pp. 10
    • Kiselycznyk, C.1    Holmes, A.2
  • 17
    • 84979234536 scopus 로고    scopus 로고
    • Differential insulin secretion of high-fat diet-fed c57bl/6nn and c57bl/6nj mice: implications of mixed genetic background in metabolic studies
    • Attane, C., Peyot, M.L., Lussier, R., Zhang, D., Joly, E., Madiraju, S.R., Prentki, M., Differential insulin secretion of high-fat diet-fed c57bl/6nn and c57bl/6nj mice: implications of mixed genetic background in metabolic studies. PLoS One, 11, 2016, e0159165.
    • (2016) PLoS One , vol.11 , pp. e0159165
    • Attane, C.1    Peyot, M.L.2    Lussier, R.3    Zhang, D.4    Joly, E.5    Madiraju, S.R.6    Prentki, M.7
  • 19
    • 77950226497 scopus 로고    scopus 로고
    • Singh Ishar MP. Ameliorative effect of the cinnamon oil from cinnamomum zeylanicum upon early stage diabetic nephropathy
    • Mishra, A., Bhatti, R., Singh, A., Singh Ishar MP. Ameliorative effect of the cinnamon oil from cinnamomum zeylanicum upon early stage diabetic nephropathy. Planta Med. 76 (2010), 412–417.
    • (2010) Planta Med. , vol.76 , pp. 412-417
    • Mishra, A.1    Bhatti, R.2    Singh, A.3
  • 20
    • 77955050877 scopus 로고    scopus 로고
    • Antidiabetic effects of cinnamon oil in diabetic kk-ay mice
    • Ping, H., Zhang, G., Ren, G., Antidiabetic effects of cinnamon oil in diabetic kk-ay mice. Food Chem. Toxicol. 48 (2010), 2344–2349.
    • (2010) Food Chem. Toxicol. , vol.48 , pp. 2344-2349
    • Ping, H.1    Zhang, G.2    Ren, G.3
  • 21
    • 84964258887 scopus 로고    scopus 로고
    • Cinnamic acid exerts anti-diabetic activity by improving glucose tolerance in vivo and by stimulating insulin secretion in vitro
    • Hafizur, R.M., Hameed, A., Shukrana, M., Raza, S.A., Chishti, S., Kabir, N., Siddiqui, R.A., Cinnamic acid exerts anti-diabetic activity by improving glucose tolerance in vivo and by stimulating insulin secretion in vitro. Phytomedicine 22 (2015), 297–300.
    • (2015) Phytomedicine , vol.22 , pp. 297-300
    • Hafizur, R.M.1    Hameed, A.2    Shukrana, M.3    Raza, S.A.4    Chishti, S.5    Kabir, N.6    Siddiqui, R.A.7
  • 23
    • 84862150176 scopus 로고    scopus 로고
    • Ingestion of cinnamaldehyde, a trpa1 agonist, reduces visceral fats in mice fed a high-fat and high-sucrose diet
    • Tamura, Y., Iwasaki, Y., Narukawa, M., Watanabe, T., Ingestion of cinnamaldehyde, a trpa1 agonist, reduces visceral fats in mice fed a high-fat and high-sucrose diet. J. Nutr. Sci. Vitaminol. 58 (2012), 9–13.
    • (2012) J. Nutr. Sci. Vitaminol. , vol.58 , pp. 9-13
    • Tamura, Y.1    Iwasaki, Y.2    Narukawa, M.3    Watanabe, T.4
  • 24
    • 80052007192 scopus 로고    scopus 로고
    • Cinnamon intake lowers fasting blood glucose: meta-analysis
    • Davis, P.A., Yokoyama, W., Cinnamon intake lowers fasting blood glucose: meta-analysis. J. Med. Food 14 (2011), 884–889.
    • (2011) J. Med. Food , vol.14 , pp. 884-889
    • Davis, P.A.1    Yokoyama, W.2
  • 25
    • 84906551942 scopus 로고    scopus 로고
    • Effects of the polyphenol content on the anti-diabetic activity of cinnamomum zeylanicum extracts
    • Im, K., Issac, A., Nm, J., Ninan, E., Maliakel, B., Kuttan, R., Effects of the polyphenol content on the anti-diabetic activity of cinnamomum zeylanicum extracts. Food Funct. 5 (2014), 2208–2220.
    • (2014) Food Funct. , vol.5 , pp. 2208-2220
    • Im, K.1    Issac, A.2    Nm, J.3    Ninan, E.4    Maliakel, B.5    Kuttan, R.6
  • 26
    • 84863092148 scopus 로고    scopus 로고
    • Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in chinese patients with type 2 diabetes
    • Lu, T., Sheng, H., Wu, J., Cheng, Y., Zhu, J., Chen, Y., Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in chinese patients with type 2 diabetes. Nutr. Res. 32 (2012), 408–412.
    • (2012) Nutr. Res. , vol.32 , pp. 408-412
    • Lu, T.1    Sheng, H.2    Wu, J.3    Cheng, Y.4    Zhu, J.5    Chen, Y.6
  • 28
    • 16244397279 scopus 로고    scopus 로고
    • Tagami H, panel Re A toxicologic and dermatologic assessment of cinnamyl alcohol, cinnamaldehyde and cinnamic acid when used as fragrance ingredients
    • Bickers, D., Calow, P., Greim, H., Hanifin, J.M., Rogers, A.E., Saurat, J.H., Sipes, I.G., Smith, R.L., Tagami H, panel Re A toxicologic and dermatologic assessment of cinnamyl alcohol, cinnamaldehyde and cinnamic acid when used as fragrance ingredients. Food Chem. Toxicol. 43 (2005), 799–836.
    • (2005) Food Chem. Toxicol. , vol.43 , pp. 799-836
    • Bickers, D.1    Calow, P.2    Greim, H.3    Hanifin, J.M.4    Rogers, A.E.5    Saurat, J.H.6    Sipes, I.G.7    Smith, R.L.8
  • 30
    • 84937709355 scopus 로고    scopus 로고
    • Cinnamaldehyde in a novel intravenous submicrometer emulsion: pharmacokinetics, tissue distribution, antitumor efficacy, and toxicity
    • Zhao, H., Yuan, J., Yang, Q., Xie, Y., Cao, W., Wang, S., Cinnamaldehyde in a novel intravenous submicrometer emulsion: pharmacokinetics, tissue distribution, antitumor efficacy, and toxicity. J. Agric. Food Chem. 63 (2015), 6386–6392.
    • (2015) J. Agric. Food Chem. , vol.63 , pp. 6386-6392
    • Zhao, H.1    Yuan, J.2    Yang, Q.3    Xie, Y.4    Cao, W.5    Wang, S.6
  • 31
    • 84992200343 scopus 로고    scopus 로고
    • Adipose tissue (p)rr regulates insulin sensitivity, fat mass and body weight
    • Shamansurova, Z., Tan, P., Ahmed, B., Pepin, E., Seda, O., Lavoie, J.L., Adipose tissue (p)rr regulates insulin sensitivity, fat mass and body weight. Mol. Metab. 5 (2016), 959–969.
    • (2016) Mol. Metab. , vol.5 , pp. 959-969
    • Shamansurova, Z.1    Tan, P.2    Ahmed, B.3    Pepin, E.4    Seda, O.5    Lavoie, J.L.6
  • 33
    • 84954546692 scopus 로고    scopus 로고
    • Gsalpha deficiency in adipose tissue improves glucose metabolism and insulin sensitivity without an effect on body weight
    • Li, Y.Q., Shrestha, Y.B., Chen, M., Chanturiya, T., Gavrilova, O., Weinstein, L.S., Gsalpha deficiency in adipose tissue improves glucose metabolism and insulin sensitivity without an effect on body weight. Proc. Natl. Acad. Sci. U. S. A. 113 (2016), 446–451.
    • (2016) Proc. Natl. Acad. Sci. U. S. A. , vol.113 , pp. 446-451
    • Li, Y.Q.1    Shrestha, Y.B.2    Chen, M.3    Chanturiya, T.4    Gavrilova, O.5    Weinstein, L.S.6
  • 34
    • 84994424500 scopus 로고    scopus 로고
    • beige adipose tissue: therapy for obesity and its comorbidities
    • Mulya, A., Brown, Kirwan J.P., beige adipose tissue: therapy for obesity and its comorbidities. Endocrinol. Metab. Clin. North Am. 45 (2016), 605–621.
    • (2016) Endocrinol. Metab. Clin. North Am. , vol.45 , pp. 605-621
    • Mulya, A.1    Brown, K.J.P.2
  • 35
    • 84985961967 scopus 로고    scopus 로고
    • Exercise regulation of adipose tissue
    • Stanford, K.I., Goodyear, L.J., Exercise regulation of adipose tissue. Adipocyte 5 (2016), 153–162.
    • (2016) Adipocyte , vol.5 , pp. 153-162
    • Stanford, K.I.1    Goodyear, L.J.2
  • 36
    • 84950310236 scopus 로고    scopus 로고
    • Food compounds activating thermosensitive trp channels in asian herbal and medicinal foods
    • Watanabe, T., Terada, Y., Food compounds activating thermosensitive trp channels in asian herbal and medicinal foods. J. Nutr. Sci. Vitaminol. 61:Suppl (2015), S86–S88.
    • (2015) J. Nutr. Sci. Vitaminol. , vol.61 , pp. S86-S88
    • Watanabe, T.1    Terada, Y.2
  • 38
    • 79955025463 scopus 로고    scopus 로고
    • Cinnamaldehyde prevents adipocyte differentiation and adipogenesis via regulation of peroxisome proliferator-activated receptor-gamma (ppargamma) and amp-activated protein kinase (ampk) pathways
    • Huang, B., Yuan, H.D., Kim, D.Y., Quan, H.Y., Chung, S.H., Cinnamaldehyde prevents adipocyte differentiation and adipogenesis via regulation of peroxisome proliferator-activated receptor-gamma (ppargamma) and amp-activated protein kinase (ampk) pathways. J. Agric. Food Chem. 59 (2011), 3666–3673.
    • (2011) J. Agric. Food Chem. , vol.59 , pp. 3666-3673
    • Huang, B.1    Yuan, H.D.2    Kim, D.Y.3    Quan, H.Y.4    Chung, S.H.5
  • 40
    • 84881248414 scopus 로고    scopus 로고
    • Diminished acyl-coa synthetase isoform 4 activity in ins 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion
    • Klett, E.L., Chen, S., Edin, M.L., Li, L.O., Ilkayeva, O., Zeldin, D.C., Newgard, C.B., Coleman, R.A., Diminished acyl-coa synthetase isoform 4 activity in ins 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion. J. Biol. Chem. 288 (2013), 21618–21629.
    • (2013) J. Biol. Chem. , vol.288 , pp. 21618-21629
    • Klett, E.L.1    Chen, S.2    Edin, M.L.3    Li, L.O.4    Ilkayeva, O.5    Zeldin, D.C.6    Newgard, C.B.7    Coleman, R.A.8
  • 43
    • 67049154139 scopus 로고    scopus 로고
    • Intragastric administration of trpv1, trpv3, trpm8, and trpa1 agonists modulates autonomic thermoregulation in different manners in mice
    • Masamoto, Y., Kawabata, F., Fushiki, T., Intragastric administration of trpv1, trpv3, trpm8, and trpa1 agonists modulates autonomic thermoregulation in different manners in mice. Biosci. Biotechnol. Biochem. 73 (2009), 1021–1027.
    • (2009) Biosci. Biotechnol. Biochem. , vol.73 , pp. 1021-1027
    • Masamoto, Y.1    Kawabata, F.2    Fushiki, T.3
  • 44
    • 84885868900 scopus 로고    scopus 로고
    • Recent advances in understanding the anti-diabetic actions of dietary flavonoids
    • Babu, P.V., Liu, D., Gilbert, E.R., Recent advances in understanding the anti-diabetic actions of dietary flavonoids. J. Nutr. Biochem. 24 (2013), 1777–1789.
    • (2013) J. Nutr. Biochem. , vol.24 , pp. 1777-1789
    • Babu, P.V.1    Liu, D.2    Gilbert, E.R.3
  • 45
    • 85014373529 scopus 로고    scopus 로고
    • Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance
    • Bluher, M., Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance. Clin. Sci. 130 (2016), 1603–1614.
    • (2016) Clin. Sci. , vol.130 , pp. 1603-1614
    • Bluher, M.1
  • 46
    • 84973160954 scopus 로고    scopus 로고
    • Importance of adipocyte cyclooxygenase-2 and prostaglandin e2-prostaglandin e receptor 3 signaling in the development of obesity-induced adipose tissue inflammation and insulin resistance
    • Chan, P.C., Hsiao, F.C., Chang, H.M., Wabitsch, M., Hsieh, P.S., Importance of adipocyte cyclooxygenase-2 and prostaglandin e2-prostaglandin e receptor 3 signaling in the development of obesity-induced adipose tissue inflammation and insulin resistance. FASEB J. 30 (2016), 2282–2297.
    • (2016) FASEB J. , vol.30 , pp. 2282-2297
    • Chan, P.C.1    Hsiao, F.C.2    Chang, H.M.3    Wabitsch, M.4    Hsieh, P.S.5
  • 48
    • 77149154977 scopus 로고    scopus 로고
    • An increase in the circulating concentration of monocyte chemoattractant protein-1 elicits systemic insulin resistance irrespective of adipose tissue inflammation in mice
    • Tateya, S., Tamori, Y., Kawaguchi, T., Kanda, H., Kasuga, M., An increase in the circulating concentration of monocyte chemoattractant protein-1 elicits systemic insulin resistance irrespective of adipose tissue inflammation in mice. Endocrinology 151 (2010), 971–979.
    • (2010) Endocrinology , vol.151 , pp. 971-979
    • Tateya, S.1    Tamori, Y.2    Kawaguchi, T.3    Kanda, H.4    Kasuga, M.5
  • 49
    • 84862854070 scopus 로고    scopus 로고
    • Protective effects of salvianolic acid b on schwann cells apoptosis induced by high glucose
    • Sun, L.Q., Zhao, J., Zhang, T.T., Qu, L., Wang, X., Xue, B., Li, X.J., Mu, Y.M., Lu, J.M., Protective effects of salvianolic acid b on schwann cells apoptosis induced by high glucose. Neurochem. Res. 37 (2012), 996–1010.
    • (2012) Neurochem. Res. , vol.37 , pp. 996-1010
    • Sun, L.Q.1    Zhao, J.2    Zhang, T.T.3    Qu, L.4    Wang, X.5    Xue, B.6    Li, X.J.7    Mu, Y.M.8    Lu, J.M.9
  • 50
    • 84937872658 scopus 로고    scopus 로고
    • Impaired adipogenesis in adipose tissue associated with hepatic lipid deposition induced by chronic inflammation in mice with chew diet
    • Yang, S., Zhang, W., Zhen, Q., Gao, R., Du, T., Xiao, X., Wang, Z., Ge, Q., Hu, J., Ye, P., Zhu, Q., Li, Q., Impaired adipogenesis in adipose tissue associated with hepatic lipid deposition induced by chronic inflammation in mice with chew diet. Life Sci. 137 (2015), 7–13.
    • (2015) Life Sci. , vol.137 , pp. 7-13
    • Yang, S.1    Zhang, W.2    Zhen, Q.3    Gao, R.4    Du, T.5    Xiao, X.6    Wang, Z.7    Ge, Q.8    Hu, J.9    Ye, P.10    Zhu, Q.11    Li, Q.12
  • 51
    • 79954480208 scopus 로고    scopus 로고
    • Carnitine palmitoyltransferase 1a prevents fatty acid-induced adipocyte dysfunction through suppression of c-jun n-terminal kinase
    • Gao, X., Li, K., Hui, X., Kong, X., Sweeney, G., Wang, Y., Xu, A., Teng, M., Liu, P., Wu, D., Carnitine palmitoyltransferase 1a prevents fatty acid-induced adipocyte dysfunction through suppression of c-jun n-terminal kinase. Biochem. J. 435 (2011), 723–732.
    • (2011) Biochem. J. , vol.435 , pp. 723-732
    • Gao, X.1    Li, K.2    Hui, X.3    Kong, X.4    Sweeney, G.5    Wang, Y.6    Xu, A.7    Teng, M.8    Liu, P.9    Wu, D.10
  • 52
    • 84930674014 scopus 로고    scopus 로고
    • Tonebp suppresses adipogenesis and insulin sensitivity by blocking epigenetic transition of ppargamma2
    • Lee, J.H., Lee, H.H., Ye, B.J., Lee-Kwon, W., Choi, S.Y., Kwon, H.M., Tonebp suppresses adipogenesis and insulin sensitivity by blocking epigenetic transition of ppargamma2. Sci. Rep., 5, 2015, 10937.
    • (2015) Sci. Rep. , vol.5 , pp. 10937
    • Lee, J.H.1    Lee, H.H.2    Ye, B.J.3    Lee-Kwon, W.4    Choi, S.Y.5    Kwon, H.M.6
  • 53
    • 58149170595 scopus 로고    scopus 로고
    • Improved insulin resistance and lipid metabolism by cinnamon extract through activation of peroxisome proliferator-activated receptors
    • Sheng, X., Zhang, Y., Gong, Z., Huang, C., Zang, Y.Q., Improved insulin resistance and lipid metabolism by cinnamon extract through activation of peroxisome proliferator-activated receptors. PPAR Res., 2008, 2008, 581348.
    • (2008) PPAR Res. , vol.2008 , pp. 581348
    • Sheng, X.1    Zhang, Y.2    Gong, Z.3    Huang, C.4    Zang, Y.Q.5
  • 54
    • 84944316269 scopus 로고    scopus 로고
    • The glycaemic outcomes of cinnamon, a review of the experimental evidence and clinical trials
    • Medagama, A.B., The glycaemic outcomes of cinnamon, a review of the experimental evidence and clinical trials. Nutr. J., 14, 2015, 108.
    • (2015) Nutr. J. , vol.14 , pp. 108
    • Medagama, A.B.1
  • 55
  • 56
    • 33749240737 scopus 로고    scopus 로고
    • Regulation of glucose transporters by insulin and extracellular glucose in c2c12 myotubes
    • Nedachi, T., Kanzaki, M., Regulation of glucose transporters by insulin and extracellular glucose in c2c12 myotubes. Am. J. Physiol. Endocrinol. Metab. 291 (2006), E817–828.
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.291 , pp. E817-828
    • Nedachi, T.1    Kanzaki, M.2
  • 57
    • 0019762341 scopus 로고
    • The effect of insulin on the disposal of intravenous glucose: results from indirect calorimetry and hepatic and femoral venous catheterization
    • DeFronzo, R.A., Jacot, E., Jequier, E., Maeder, E., Wahren, J., Felber, J.P., The effect of insulin on the disposal of intravenous glucose: results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 30 (1981), 1000–1007.
    • (1981) Diabetes , vol.30 , pp. 1000-1007
    • DeFronzo, R.A.1    Jacot, E.2    Jequier, E.3    Maeder, E.4    Wahren, J.5    Felber, J.P.6
  • 59
    • 84944340046 scopus 로고    scopus 로고
    • Trans-cinnamaldehyde stimulates mitochondrial biogenesis through pgc-1alpha and pparbeta/delta leading to enhanced glut4 expression
    • Gannon, N.P., Schnuck, J.K., Mermier, C.M., Conn, C.A., Vaughan, R.A., Trans-cinnamaldehyde stimulates mitochondrial biogenesis through pgc-1alpha and pparbeta/delta leading to enhanced glut4 expression. Biochimie 119 (2015), 45–51.
    • (2015) Biochimie , vol.119 , pp. 45-51
    • Gannon, N.P.1    Schnuck, J.K.2    Mermier, C.M.3    Conn, C.A.4    Vaughan, R.A.5
  • 60
    • 84944340046 scopus 로고    scopus 로고
    • Trans-cinnamaldehyde stimulates mitochondrial biogenesis through pgc-1α and pparβ/δ leading to enhanced glut4 expression
    • Nicholas, P.G., Schnuckc, J.K., Mermierd, C.M., Conne, C.A., Vaughanc, R.A., Trans-cinnamaldehyde stimulates mitochondrial biogenesis through pgc-1α and pparβ/δ leading to enhanced glut4 expression. Biochimie 119 (2015), 45–51.
    • (2015) Biochimie , vol.119 , pp. 45-51
    • Nicholas, P.G.1    Schnuckc, J.K.2    Mermierd, C.M.3    Conne, C.A.4    Vaughanc, R.A.5
  • 61
    • 58149360797 scopus 로고    scopus 로고
    • Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus
    • Zhang, W., Xu, Y.C., Guo, F.J., Meng, Y., Li, M.L., Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus. Chin. Med. J. (Engl.) 121 (2008), 2124–2128.
    • (2008) Chin. Med. J. (Engl.) , vol.121 , pp. 2124-2128
    • Zhang, W.1    Xu, Y.C.2    Guo, F.J.3    Meng, Y.4    Li, M.L.5
  • 62
    • 23644448924 scopus 로고    scopus 로고
    • Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle
    • Bandyopadhyay, G.K., Yu, J.G., Ofrecio, J., Olefsky, J.M., Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle. Diabetes 54 (2005), 2351–2359.
    • (2005) Diabetes , vol.54 , pp. 2351-2359
    • Bandyopadhyay, G.K.1    Yu, J.G.2    Ofrecio, J.3    Olefsky, J.M.4
  • 63
    • 84979294074 scopus 로고    scopus 로고
    • Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus
    • Hesselink, M.K., Schrauwen-Hinderling, V., Schrauwen, P., Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus. Nat. Rev. Endocrinol. 12 (2016), 633–645.
    • (2016) Nat. Rev. Endocrinol. , vol.12 , pp. 633-645
    • Hesselink, M.K.1    Schrauwen-Hinderling, V.2    Schrauwen, P.3
  • 67
    • 0034907655 scopus 로고    scopus 로고
    • Effect of garlic oil on the levels of various enzymes in the serum and tissue of streptozotocin diabetic rats
    • Ohaeri, O.C., Effect of garlic oil on the levels of various enzymes in the serum and tissue of streptozotocin diabetic rats. Biosci. Rep. 21 (2001), 19–24.
    • (2001) Biosci. Rep. , vol.21 , pp. 19-24
    • Ohaeri, O.C.1
  • 68
    • 84958824717 scopus 로고    scopus 로고
    • Assessment of neutrophil gelatinase-associated lipocalin (ngal) and retinol-binding protein 4 (rbp4) in type 2 diabetic patients with nephropathy
    • Mahfouz, M.H., Assiri, A.M., Mukhtar, M.H., Assessment of neutrophil gelatinase-associated lipocalin (ngal) and retinol-binding protein 4 (rbp4) in type 2 diabetic patients with nephropathy. Biomarker Insights 11 (2016), 31–40.
    • (2016) Biomarker Insights , vol.11 , pp. 31-40
    • Mahfouz, M.H.1    Assiri, A.M.2    Mukhtar, M.H.3
  • 69
    • 84900462011 scopus 로고    scopus 로고
    • Lower fetuin-a, retinol binding protein 4 and several metabolites after gastric bypass compared to sleeve gastrectomy in patients with type 2 diabetes
    • Jullig, M., Yip, S., Xu, A., Smith, G., Middleditch, M., Booth, M., Babor, R., Beban, G., Murphy, R., Lower fetuin-a, retinol binding protein 4 and several metabolites after gastric bypass compared to sleeve gastrectomy in patients with type 2 diabetes. PLoS One, 9, 2014, e96489.
    • (2014) PLoS One , vol.9 , pp. e96489
    • Jullig, M.1    Yip, S.2    Xu, A.3    Smith, G.4    Middleditch, M.5    Booth, M.6    Babor, R.7    Beban, G.8    Murphy, R.9
  • 70
    • 84893126393 scopus 로고    scopus 로고
    • Beneficial antioxidative and antiperoxidative effect of cinnamaldehyde protect streptozotocin-induced pancreatic beta-cells damage in wistar rats
    • Subash-Babu, P., Alshatwi, A.A., Ignacimuthu, S., Beneficial antioxidative and antiperoxidative effect of cinnamaldehyde protect streptozotocin-induced pancreatic beta-cells damage in wistar rats. Biomol. Ther. 22 (2014), 47–54.
    • (2014) Biomol. Ther. , vol.22 , pp. 47-54
    • Subash-Babu, P.1    Alshatwi, A.A.2    Ignacimuthu, S.3
  • 71
  • 73
    • 55049139230 scopus 로고    scopus 로고
    • Trpa1 agonists-allyl isothiocyanate and cinnamaldehyde-induce adrenaline secretion
    • Iwasaki, Y., Tanabe, M., Kobata, K., Watanabe, T., Trpa1 agonists-allyl isothiocyanate and cinnamaldehyde-induce adrenaline secretion. Biosci. Biotechnol. Biochem. 72 (2008), 2608–2614.
    • (2008) Biosci. Biotechnol. Biochem. , vol.72 , pp. 2608-2614
    • Iwasaki, Y.1    Tanabe, M.2    Kobata, K.3    Watanabe, T.4
  • 74
    • 84855986409 scopus 로고    scopus 로고
    • Inhibiting trpa1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: sustained activation of the trpa1 channel contributes to the pathogenesis of peripheral diabetic neuropathy
    • Koivisto, A., Hukkanen, M., Saarnilehto, M., Chapman, H., Kuokkanen, K., Wei, H., Viisanen, H., Akerman, K.E., Lindstedt, K., Pertovaara, A., Inhibiting trpa1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: sustained activation of the trpa1 channel contributes to the pathogenesis of peripheral diabetic neuropathy. Pharmacol. Res. 65 (2012), 149–158.
    • (2012) Pharmacol. Res. , vol.65 , pp. 149-158
    • Koivisto, A.1    Hukkanen, M.2    Saarnilehto, M.3    Chapman, H.4    Kuokkanen, K.5    Wei, H.6    Viisanen, H.7    Akerman, K.E.8    Lindstedt, K.9    Pertovaara, A.10
  • 75
    • 83255193988 scopus 로고    scopus 로고
    • Influence of a long-term high-fat diet on ghrelin secretion and ghrelin-induced food intake in rats
    • Gomez, G., Han, S., Englander, E.W., Greeley, G.H. Jr., Influence of a long-term high-fat diet on ghrelin secretion and ghrelin-induced food intake in rats. Regul. Pept. 173 (2012), 60–63.
    • (2012) Regul. Pept. , vol.173 , pp. 60-63
    • Gomez, G.1    Han, S.2    Englander, E.W.3    Greeley, G.H.4
  • 76
    • 84904462479 scopus 로고    scopus 로고
    • Modulation of orexigenic and anorexigenic peptides gene expression in the rat dvc and hypothalamus by acute immobilization stress
    • Chigr, F., Rachidi, F., Tardivel, C., Najimi, M., Moyse, E., Modulation of orexigenic and anorexigenic peptides gene expression in the rat dvc and hypothalamus by acute immobilization stress. Front. Cell. Neurosci., 8, 2014, 198.
    • (2014) Front. Cell. Neurosci. , vol.8 , pp. 198
    • Chigr, F.1    Rachidi, F.2    Tardivel, C.3    Najimi, M.4    Moyse, E.5
  • 77
    • 84898029980 scopus 로고    scopus 로고
    • Crf and urocortin peptides as modulators of energy balance and feeding behavior during stress
    • Stengel, A., Tache, Y., Crf and urocortin peptides as modulators of energy balance and feeding behavior during stress. Front. Neurosci., 8, 2014, 52.
    • (2014) Front. Neurosci. , vol.8 , pp. 52
    • Stengel, A.1    Tache, Y.2
  • 79
    • 77950064310 scopus 로고    scopus 로고
    • Cinnamaldehyde impairs high glucose-induced hypertrophy in renal interstitial fibroblasts
    • Chao, L.K., Chang, W.T., Shih, Y.W., Huang, J.S., Cinnamaldehyde impairs high glucose-induced hypertrophy in renal interstitial fibroblasts. Toxicol. Appl. Pharmacol. 244 (2010), 174–180.
    • (2010) Toxicol. Appl. Pharmacol. , vol.244 , pp. 174-180
    • Chao, L.K.1    Chang, W.T.2    Shih, Y.W.3    Huang, J.S.4
  • 80
    • 80755168858 scopus 로고    scopus 로고
    • Therapeutic potential of nrf2 activators in streptozotocin-induced diabetic nephropathy
    • Zheng, H., Whitman, S.A., Wu, W., Wondrak, G.T., Wong, P.K., Fang, D., Zhang, D.D., Therapeutic potential of nrf2 activators in streptozotocin-induced diabetic nephropathy. Diabetes 60 (2011), 3055–3066.
    • (2011) Diabetes , vol.60 , pp. 3055-3066
    • Zheng, H.1    Whitman, S.A.2    Wu, W.3    Wondrak, G.T.4    Wong, P.K.5    Fang, D.6    Zhang, D.D.7
  • 81
    • 80755168955 scopus 로고    scopus 로고
    • Nrf2 activators as attractive therapeutics for diabetic nephropathy
    • de Haan, J.B., Nrf2 activators as attractive therapeutics for diabetic nephropathy. Diabetes 60 (2011), 2683–2684.
    • (2011) Diabetes , vol.60 , pp. 2683-2684
    • de Haan, J.B.1
  • 82
    • 84929908347 scopus 로고    scopus 로고
    • Cinnamaldehyde prevents endothelial dysfunction induced by high glucose by activating nrf2
    • Wang, F., Pu, C., Zhou, P., Wang, P., Liang, D., Wang, Q., Hu, Y., Li, B., Hao, X., Cinnamaldehyde prevents endothelial dysfunction induced by high glucose by activating nrf2. Cell. Physiol. Biochem. 36 (2015), 315–324.
    • (2015) Cell. Physiol. Biochem. , vol.36 , pp. 315-324
    • Wang, F.1    Pu, C.2    Zhou, P.3    Wang, P.4    Liang, D.5    Wang, Q.6    Hu, Y.7    Li, B.8    Hao, X.9
  • 83
    • 84906690102 scopus 로고    scopus 로고
    • Effect of redox modulating nrf2 activators on chronic kidney disease
    • Choi, B.-h., Kang, K.-S., Kwak, M.-K., Effect of redox modulating nrf2 activators on chronic kidney disease. Molecules 19 (2014), 12727–12759.
    • (2014) Molecules , vol.19 , pp. 12727-12759
    • Choi, B.-H.1    Kang, K.-S.2    Kwak, M.-K.3
  • 85
    • 84927664254 scopus 로고    scopus 로고
    • Xenobiotics and human health: a new view of their pharma-nutritional role
    • Visioli, F., Xenobiotics and human health: a new view of their pharma-nutritional role. PharmaNutrition 3 (2015), 60–64.
    • (2015) PharmaNutrition , vol.3 , pp. 60-64
    • Visioli, F.1
  • 87
    • 84958552684 scopus 로고    scopus 로고
    • Alterations in glucose metabolism on cognition: a possible link between diabetes and dementia
    • Gonzalez-Reyes, R.E., Aliev, G., Avila-Rodrigues, M., Barreto, G.E., Alterations in glucose metabolism on cognition: a possible link between diabetes and dementia. Curr. Pharm. Des. 22 (2016), 812–818.
    • (2016) Curr. Pharm. Des. , vol.22 , pp. 812-818
    • Gonzalez-Reyes, R.E.1    Aliev, G.2    Avila-Rodrigues, M.3    Barreto, G.E.4
  • 88
    • 84974530398 scopus 로고    scopus 로고
    • Reversal of diabetes-induced behavioral and neurochemical deficits by cinnamaldehyde
    • Jawale, A., Datusalia, A.K., Bishnoi, M., Sharma, S.S., Reversal of diabetes-induced behavioral and neurochemical deficits by cinnamaldehyde. Phytomedicine 23 (2016), 923–930.
    • (2016) Phytomedicine , vol.23 , pp. 923-930
    • Jawale, A.1    Datusalia, A.K.2    Bishnoi, M.3    Sharma, S.S.4
  • 89
    • 84914128937 scopus 로고    scopus 로고
    • High-resolution alpha-amylase assay combined with high-performance liquid chromatography-solid-phase extraction-nuclear magnetic resonance spectroscopy for expedited identification of alpha-amylase inhibitors: proof of concept and alpha-amylase inhibitor in cinnamon
    • Okutan, L., Kongstad, K.T., Jager, A.K., Staerk, D., High-resolution alpha-amylase assay combined with high-performance liquid chromatography-solid-phase extraction-nuclear magnetic resonance spectroscopy for expedited identification of alpha-amylase inhibitors: proof of concept and alpha-amylase inhibitor in cinnamon. J. Agric. Food Chem. 62 (2014), 11465–11471.
    • (2014) J. Agric. Food Chem. , vol.62 , pp. 11465-11471
    • Okutan, L.1    Kongstad, K.T.2    Jager, A.K.3    Staerk, D.4
  • 90
    • 84939652973 scopus 로고    scopus 로고
    • Natural products for the treatment of type 2 diabetes mellitus
    • Rios, J.L., Francini, F., Schinella, G.R., Natural products for the treatment of type 2 diabetes mellitus. Planta Med. 81 (2015), 975–994.
    • (2015) Planta Med. , vol.81 , pp. 975-994
    • Rios, J.L.1    Francini, F.2    Schinella, G.R.3
  • 91
    • 0037183497 scopus 로고    scopus 로고
    • Peptidyl aldehydes as reversible covalent inhibitors of protein tyrosine phosphatases
    • Fu, H., Park, J., Pei, D., Peptidyl aldehydes as reversible covalent inhibitors of protein tyrosine phosphatases. Biochemistry 41 (2002), 10700–10709.
    • (2002) Biochemistry , vol.41 , pp. 10700-10709
    • Fu, H.1    Park, J.2    Pei, D.3
  • 92
    • 84882847585 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase 1b inhibitory activity of indonesian herbal medicines and constituents of cinnamomum burmannii and zingiber aromaticum
    • Saifudin, A., Kadota, S., Tezuka, Y., Protein tyrosine phosphatase 1b inhibitory activity of indonesian herbal medicines and constituents of cinnamomum burmannii and zingiber aromaticum. J. Nat. Med. 67 (2013), 264–270.
    • (2013) J. Nat. Med. , vol.67 , pp. 264-270
    • Saifudin, A.1    Kadota, S.2    Tezuka, Y.3
  • 94
    • 84992756789 scopus 로고    scopus 로고
    • Structural basis of fullerene derivatives as novel potent inhibitors of protein tyrosine phosphatase 1b: insight into the inhibitory mechanism through molecular modeling studies
    • Qian, M., Shan, Y., Guan, S., Zhang, H., Wang, S., Han, W., Structural basis of fullerene derivatives as novel potent inhibitors of protein tyrosine phosphatase 1b: insight into the inhibitory mechanism through molecular modeling studies. J. Chem. Inf. Model., 2016.
    • (2016) J. Chem. Inf. Model.
    • Qian, M.1    Shan, Y.2    Guan, S.3    Zhang, H.4    Wang, S.5    Han, W.6
  • 97
    • 84888423638 scopus 로고    scopus 로고
    • Pharmacokinetic study of cinnamaldehyde in rats by gc-ms after oral and intravenous administration
    • Zhao, H., Xie, Y., Yang, Q., Cao, Y., Tu, H., Cao, W., Wang, S., Pharmacokinetic study of cinnamaldehyde in rats by gc-ms after oral and intravenous administration. J. Pharm. Biomed. Anal. 89 (2014), 150–157.
    • (2014) J. Pharm. Biomed. Anal. , vol.89 , pp. 150-157
    • Zhao, H.1    Xie, Y.2    Yang, Q.3    Cao, Y.4    Tu, H.5    Cao, W.6    Wang, S.7
  • 98
    • 0027460802 scopus 로고
    • Tissue distribution and excretion of 14c-labelled cinnamic aldehyde following single and multiple oral administration in male fischer 344 rats
    • Sapienza, P.P., Ikeda, G.J., Warr, P.I., Plummer, S.L., Dailey, R.E., Lin, C.S., Tissue distribution and excretion of 14c-labelled cinnamic aldehyde following single and multiple oral administration in male fischer 344 rats. Food Chem. Toxicol. 31 (1993), 253–261.
    • (1993) Food Chem. Toxicol. , vol.31 , pp. 253-261
    • Sapienza, P.P.1    Ikeda, G.J.2    Warr, P.I.3    Plummer, S.L.4    Dailey, R.E.5    Lin, C.S.6
  • 99
    • 0028171295 scopus 로고
    • Studies on trans-cinnamaldehyde: 1The influence of dose size and sex on its disposition in the rat and mouse
    • Peters, M.M., Caldwell, J., Studies on trans-cinnamaldehyde: 1The influence of dose size and sex on its disposition in the rat and mouse. Food Chem. Toxicol. 32 (1994), 869–876.
    • (1994) Food Chem. Toxicol. , vol.32 , pp. 869-876
    • Peters, M.M.1    Caldwell, J.2
  • 101
    • 65649117769 scopus 로고    scopus 로고
    • Pharmacokinetics and bioavailability of cinnamic acid after oral administration of ramulus cinnamomi in rats
    • Chen, Y., Ma, Y., Ma, W., Pharmacokinetics and bioavailability of cinnamic acid after oral administration of ramulus cinnamomi in rats. Eur. J. Drug Metab. Pharmacokinet. 34 (2009), 51–56.
    • (2009) Eur. J. Drug Metab. Pharmacokinet. , vol.34 , pp. 51-56
    • Chen, Y.1    Ma, Y.2    Ma, W.3
  • 105
    • 85013806370 scopus 로고    scopus 로고
    • Cinnamic acid and its derivatives: mechanisms for prevention and management of diabetes and its complications
    • Adisakwattana, S., Cinnamic acid and its derivatives: mechanisms for prevention and management of diabetes and its complications. Nutrients, 9, 2017.
    • (2017) Nutrients , vol.9
    • Adisakwattana, S.1
  • 106
    • 84963677749 scopus 로고    scopus 로고
    • Muralidhara Neurorestorative effects of eugenol, a spice bioactive: evidence in cell model and its efficacy as an intervention molecule to abrogate brain oxidative dysfunctions in the streptozotocin diabetic rat
    • Prasad, S.N., Bharath, M.M., Muralidhara Neurorestorative effects of eugenol, a spice bioactive: evidence in cell model and its efficacy as an intervention molecule to abrogate brain oxidative dysfunctions in the streptozotocin diabetic rat. Neurochem. Int. 95 (2016), 24–36.
    • (2016) Neurochem. Int. , vol.95 , pp. 24-36
    • Prasad, S.N.1    Bharath, M.M.2
  • 107
    • 33846703632 scopus 로고    scopus 로고
    • Cinnamon extract and polyphenols affect the expression of tristetraprolin, insulin receptor, and glucose transporter 4 in mouse 3t3-l1 adipocytes
    • Cao, H., Polansky, M.M., Anderson, R.A., Cinnamon extract and polyphenols affect the expression of tristetraprolin, insulin receptor, and glucose transporter 4 in mouse 3t3-l1 adipocytes. Arch. Biochem. Biophys. 459 (2007), 214–222.
    • (2007) Arch. Biochem. Biophys. , vol.459 , pp. 214-222
    • Cao, H.1    Polansky, M.M.2    Anderson, R.A.3
  • 108
    • 41849141611 scopus 로고    scopus 로고
    • Cinnamon bark proanthocyanidins as reactive carbonyl scavengers to prevent the formation of advanced glycation endproducts
    • Peng, X., Cheng, K.W., Ma, J., Chen, B., Ho, C.T., Lo, C., Chen, F., Wang, M., Cinnamon bark proanthocyanidins as reactive carbonyl scavengers to prevent the formation of advanced glycation endproducts. J. Agric. Food Chem. 56 (2008), 1907–1911.
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 1907-1911
    • Peng, X.1    Cheng, K.W.2    Ma, J.3    Chen, B.4    Ho, C.T.5    Lo, C.6    Chen, F.7    Wang, M.8
  • 109
    • 84885101185 scopus 로고    scopus 로고
    • Identification of compounds from the water soluble extract of cinnamomum cassia barks and their inhibitory effects against high-glucose-induced mesangial cells
    • Luo, Q., Wang, S.M., Lu, Q., Luo, J., Cheng, Y.X., Identification of compounds from the water soluble extract of cinnamomum cassia barks and their inhibitory effects against high-glucose-induced mesangial cells. Molecules 18 (2013), 10930–10943.
    • (2013) Molecules , vol.18 , pp. 10930-10943
    • Luo, Q.1    Wang, S.M.2    Lu, Q.3    Luo, J.4    Cheng, Y.X.5
  • 110
    • 36549071060 scopus 로고    scopus 로고
    • From type 2 diabetes to antioxidant activity: a systematic review of the safety and efficacy of common and cassia cinnamon bark
    • Dugoua, J.J., Seely, D., Perri, D., Cooley, K., Forelli, T., Mills, E., Koren, G., From type 2 diabetes to antioxidant activity: a systematic review of the safety and efficacy of common and cassia cinnamon bark. Can. J. Physiol. Pharmacol. 85 (2007), 837–847.
    • (2007) Can. J. Physiol. Pharmacol. , vol.85 , pp. 837-847
    • Dugoua, J.J.1    Seely, D.2    Perri, D.3    Cooley, K.4    Forelli, T.5    Mills, E.6    Koren, G.7
  • 111
    • 85027432971 scopus 로고    scopus 로고
    • Safety assessment of food flavor −cinnamaldehyde
    • Gowder, S.J.T., Safety assessment of food flavor −cinnamaldehyde. Biosafety, 2014, 3.
    • (2014) Biosafety , pp. 3
    • Gowder, S.J.T.1
  • 113
    • 0029942470 scopus 로고    scopus 로고
    • Studies on trans-cinnamaldehyde ii: mechanisms of cytotoxicity in rat isolated hepatocytes
    • Swales, N.J., Caldwell, J., Studies on trans-cinnamaldehyde ii: mechanisms of cytotoxicity in rat isolated hepatocytes. Toxicol. In Vitro 10 (1996), 37–42.
    • (1996) Toxicol. In Vitro , vol.10 , pp. 37-42
    • Swales, N.J.1    Caldwell, J.2
  • 114
    • 0030837693 scopus 로고    scopus 로고
    • Inhibition of the genotoxic effects of heterocyclic amines in human derived hepatoma cells by dietary bioantimutagens
    • Sanyal, R., Darroudi, F., Parzefall, W., Nagao, M., Knasmuller, S., Inhibition of the genotoxic effects of heterocyclic amines in human derived hepatoma cells by dietary bioantimutagens. Mutagenesis 12 (1997), 297–303.
    • (1997) Mutagenesis , vol.12 , pp. 297-303
    • Sanyal, R.1    Darroudi, F.2    Parzefall, W.3    Nagao, M.4    Knasmuller, S.5
  • 116
    • 84987887522 scopus 로고    scopus 로고
    • Distribution, quantification and toxicity of cinnamaldehyde in electronic cigarette refill fluids and aerosols
    • Behar, R.Z., Luo, W., Lin, S.C., Wang, Y., Valle, J., Pankow, J.F., Talbot, P., Distribution, quantification and toxicity of cinnamaldehyde in electronic cigarette refill fluids and aerosols. Tob. Control, 2016.
    • (2016) Tob. Control
    • Behar, R.Z.1    Luo, W.2    Lin, S.C.3    Wang, Y.4    Valle, J.5    Pankow, J.F.6    Talbot, P.7
  • 117
    • 84929744287 scopus 로고    scopus 로고
    • Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde
    • Isaac-Renton, M., Li, M.K., Parsons, L.M., Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde. Dermatitis 26 (2015), 116–121.
    • (2015) Dermatitis , vol.26 , pp. 116-121
    • Isaac-Renton, M.1    Li, M.K.2    Parsons, L.M.3
  • 118
    • 84907992110 scopus 로고    scopus 로고
    • Somatosensory and vasomotor manifestations of individual and combined stimulation of trpm8 and trpa1 using topical l-menthol and trans-cinnamaldehyde in healthy volunteers
    • Olsen, R.V., Andersen, H.H., Moller, H.G., Eskelund, P.W., Arendt-Nielsen, L., Somatosensory and vasomotor manifestations of individual and combined stimulation of trpm8 and trpa1 using topical l-menthol and trans-cinnamaldehyde in healthy volunteers. Eur. J. Pain 18 (2014), 1333–1342.
    • (2014) Eur. J. Pain , vol.18 , pp. 1333-1342
    • Olsen, R.V.1    Andersen, H.H.2    Moller, H.G.3    Eskelund, P.W.4    Arendt-Nielsen, L.5
  • 120
    • 0034331402 scopus 로고    scopus 로고
    • Human skin absorption and metabolism of the contact allergens, cinnamic aldehyde, and cinnamic alcohol
    • Smith, C.K., Moore, C.A., Elahi, E.N., Smart, A.T., Hotchkiss, S.A., Human skin absorption and metabolism of the contact allergens, cinnamic aldehyde, and cinnamic alcohol. Toxicol. Appl. Pharmacol. 168 (2000), 189–199.
    • (2000) Toxicol. Appl. Pharmacol. , vol.168 , pp. 189-199
    • Smith, C.K.1    Moore, C.A.2    Elahi, E.N.3    Smart, A.T.4    Hotchkiss, S.A.5
  • 121
    • 0035123292 scopus 로고    scopus 로고
    • Dermal exposure to cinnamaldehyde alters lymphocyte subpopulations, number of interferon-gamma-producing cells, and expression of b7 costimulatory molecules and cytokine messenger rnas in auricular lymph nodes of b6c3f1 mice
    • Karrow, N.A., Leffel, E.K., Guo, T.L., Zhang, L.X., McCay, J.A., Germolec, D.R., White, K.L. Jr., Dermal exposure to cinnamaldehyde alters lymphocyte subpopulations, number of interferon-gamma-producing cells, and expression of b7 costimulatory molecules and cytokine messenger rnas in auricular lymph nodes of b6c3f1 mice. Am. J. Contact Dermatol. 12 (2001), 6–17.
    • (2001) Am. J. Contact Dermatol. , vol.12 , pp. 6-17
    • Karrow, N.A.1    Leffel, E.K.2    Guo, T.L.3    Zhang, L.X.4    McCay, J.A.5    Germolec, D.R.6    White, K.L.7
  • 122
    • 13844308480 scopus 로고
    • The genetic toxicology of cinnamaldehyde
    • Neudecker, T., The genetic toxicology of cinnamaldehyde. Mutat. Res. 277 (1992), 173–185.
    • (1992) Mutat. Res. , vol.277 , pp. 173-185
    • Neudecker, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.