Impact of hematopoietic cyclooxygenase-1 deficiency on obesity-linked adipose tissue inflammation and metabolic disorders in mice

Metabolism: Clinical and Experimental

Volumn 62, Issue 11, 2013, Pages 1673-1685

  Saraswathi, Viswanathan ^a,c,d,e   Ramnanan, Christopher J ^a   Wilks, Anson W ^a   Desouza, Cyrus V ^c,e   Eller, Amy A ^c,e   Murali, Ganesan ^c,e   Ramalingam, Ramesh ^c,e   Milne, Ginger L ^b   Coate, Katie C ^a   Edgerton, Dale S ^a  

^a Biophysics Department of Molecular Physiology and Biophysics   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c Division of Diabetes Endocrinology and Metabolism   (United States)

^d UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^e VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

Author keywords

Dyslipidemia; Eicosanoids; Hyperglycemia; Obesity

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; CHOLESTEROL; CYCLOOXYGENASE 1; GLUCOSE; LEPTIN; MESSENGER RNA; THROMBOXANE B2; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; DISEASE MARKER; DYSLIPIDEMIA; FEMALE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HEMATOPOIETIC CELL; HOMEOSTASIS; HYPERGLYCEMIA; INFLAMMATION; LIPID TRANSPORT; LIPOGENESIS; METABOLIC DISORDER; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; REGULATORY MECHANISM;

3-HYDROXY-3-METHYL-GLUTARYL-COA REDUCTASE; 4′,6-DIAMIDINO-2-PHENYLINDOLE;F4/80, MURINE HOMOLOGUE OF EGF-LIKE MODULE-CONTAINING MUCIN-LIKE HORMONE RECEPTOR-LIKE 1; ADENOSINE MONOPHOSPHATE-ACTIVATED PROTEIN KINASE; ADIPOSE TISSUE; AMPK; APOE; APOLIPOPROTEIN E; AT; BMT; BONE MARROW TRANSPLANTATION; CARNITINE PALMITOYL TRANSFERASE-1; CC CHEMOKINE RECEPTOR-2; CC CHEMOKINE RECEPTOR-5; CCR2; CCR5; CD68; CLUSTER OF DIFFERENTIATION 68; COX; COX-1 KNOCK-OUT; COX-1+/+; COX-1-/-; CPT-1; CYCLOOXYGENASE; DAPI; DYSLIPIDEMIA; EICOSANOIDS; FASN; FATTY ACID SYNTHASE; FBP-1; FRUCTOSE 1,6 BISPHOSPHATASE; G6PC; GAPDH; GAS CHROMATOGRAPHY/MASS SPECTROMETRY; GC/MS; GLUCOSE TRANSPORTER-4; GLUCOSE-6-PHOSPHATASE; GLUT-4; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCOGEN SYNTHASE KINASE; GSK; HMGCR; HOMA-IR; HOMEOSTASIS MODEL ASSESSMENT OF INSULIN RESISTANCE; HYPERGLYCEMIA; IL; INTERLEUKIN; IR-Β; L-FABP; LDLR; LIVER FATTY ACID BINDING PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; MACROPHAGE GALACTOSE TYPE LECTIN; MACROPHAGE INFLAMMATORY PROTEIN-1Α; MATRIX METALLOPROTEINASE-12; MCP-1; MGL; MIP-1Α; MMP-12; MONOCYTE CHEMOATTRACTANT PROTEIN; NMR; NUCLEAR MAGNETIC RESONANCE; OBESITY; PCK-1 AND PEPCK; PCX; PG; PHOSPHO INSULIN RECEPTOR BETA; PHOSPHOENOL PYRUVATE CARBOXYKINASE; PROSTAGLANDIN; PYRUVATE CARBOXYLASE; SAA-3; SERUM AMYLOID A-3; SGLT-2; SODIUM GLUCOSE COTRANSPORTER-2; STROMAL VASCULAR CELLS; SVC; THROMBOXANE; TLR4; TNFΑ; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; TX; WILD TYPE;

ADIPONECTIN; ADIPOSE TISSUE; ANIMALS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CYCLOOXYGENASE 1; DIET, HIGH-FAT; EATING; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; INFLAMMATION; KIDNEY; LEPTIN; LIVER; MACROPHAGES; MICE; MICE, KNOCKOUT; OBESITY; REAL-TIME POLYMERASE CHAIN REACTION; WEIGHT GAIN;

EID: 84886396863     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2013.07.007     Document Type: Article

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