메뉴 건너뛰기




Volumn 130, Issue 18, 2016, Pages 1603-1614

Adipose tissue inflammation: A cause or consequence of obesity-related insulin resistance?

Author keywords

Adipocytes; Adipokines; Adipose tissue inflammation; Adipose tissue macrophages; Insulin resistance; Obesity

Indexed keywords

ACETYLCYSTEINE; ADIPOCYTOKINE; ADIPONECTIN; ANAKINRA; ANTIINFLAMMATORY AGENT; CANAKINUMAB; CHEMOKINE; CRYOPYRIN; CYTOKINE; CYTOKINE RECEPTOR; ETANERCEPT; GEVOKIZUMAB; GLUCOSE; INSULIN; INTERLEUKIN 1BETA; LENERCEPT; LEPTIN; LY 2189102; SALSALATE; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ANTIBODY; UNCLASSIFIED DRUG;

EID: 85014373529     PISSN: 01435221     EISSN: 14708736     Source Type: Journal    
DOI: 10.1042/CS20160005     Document Type: Article
Times cited : (216)

References (106)
  • 1
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil, G.S. (2006) Inflammation and metabolic disorders. Nature 444, 860-867.
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 3
    • 0001660570 scopus 로고
    • Zur Therapie des Diabetes mellitus, insbesondere über die Anwendung des salicylsauren Natron bei demselben
    • Ebstein, W. (1876) Zur Therapie des Diabetes mellitus, insbesondere über die Anwendung des salicylsauren Natron bei demselben. Berlöiner Klinische Wochenschrift 13, 337-340
    • (1876) Berlöiner Klinische Wochenschrift , vol.13 , pp. 337-340
    • Ebstein, W.1
  • 4
    • 0033562455 scopus 로고    scopus 로고
    • Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study
    • Schmidt, M.I., Duncan, B.B., Sharrett, A.R., Lindberg, G., Savage, P.J., Offenbacher, S., Azambuja, M.I., Tracy, R.P. and Heiss, G. (1999) Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. Lancet 353, 1649-1652.
    • (1999) Lancet , vol.353 , pp. 1649-1652
    • Schmidt, M.I.1    Duncan, B.B.2    Sharrett, A.R.3    Lindberg, G.4    Savage, P.J.5    Offenbacher, S.6    Azambuja, M.I.7    Tracy, R.P.8    Heiss, G.9
  • 5
    • 0035908632 scopus 로고    scopus 로고
    • C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus
    • Pradhan, A.D., Manson, J.E., Rifai, N., Buring, J.E. and Ridker, P.M. (2001) C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286, 327-334.
    • (2001) JAMA , vol.286 , pp. 327-334
    • Pradhan, A.D.1    Manson, J.E.2    Rifai, N.3    Buring, J.E.4    Ridker, P.M.5
  • 6
    • 0345700727 scopus 로고    scopus 로고
    • Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    • Spranger, J., Kroke, A., Möhlig, M., Hoffmann, K., Bergmann, M.M., Ristow, M., Boeing, H. and Pfeiffer, A.F. (2003) Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes 52, 812-817.
    • (2003) Diabetes , vol.52 , pp. 812-817
    • Spranger, J.1    Kroke, A.2    Möhlig, M.3    Hoffmann, K.4    Bergmann, M.M.5    Ristow, M.6    Boeing, H.7    Pfeiffer, A.F.8
  • 7
    • 0036140124 scopus 로고    scopus 로고
    • Leukocyte count, erythrocyte sedimentation rate, and diabetes incidence in a national sample of US adults
    • Ford, E.S. (2002) Leukocyte count, erythrocyte sedimentation rate, and diabetes incidence in a national sample of US adults. Am. J. Epidemiol. 155, 57-64.
    • (2002) Am. J. Epidemiol. , vol.155 , pp. 57-64
    • Ford, E.S.1
  • 12
    • 33646049670 scopus 로고    scopus 로고
    • Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance
    • Oberbach, A., Tönjes, A., Klöting, N., Fasshauer, M., Kratzsch, J., Busse, M.W., Paschke, R., Stumvoll, M. and Blüher, M. (2006) Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance. Eur. J. Endocrinol. 154, 577-585.
    • (2006) Eur. J. Endocrinol. , vol.154 , pp. 577-585
    • Oberbach, A.1    Tönjes, A.2    Klöting, N.3    Fasshauer, M.4    Kratzsch, J.5    Busse, M.W.6    Paschke, R.7    Stumvoll, M.8    Blüher, M.9
  • 14
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
    • Hotamisligil, G.S., Shargill, N.S. and Spiegelman, B.M. (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259, 87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 15
    • 84878532462 scopus 로고    scopus 로고
    • Adipose tissue dysfunction contributes to obesity related metabolic diseases
    • Blüher, M. (2013) Adipose tissue dysfunction contributes to obesity related metabolic diseases. Best Pract. Res. Clin. Endocrinol. Metab. 27, 163-177.
    • (2013) Best Pract. Res. Clin. Endocrinol. Metab. , vol.27 , pp. 163-177
    • Blüher, M.1
  • 16
    • 0028917432 scopus 로고
    • Weight gain as a risk factor for clinical diabetes mellitus in women
    • Colditz, G.A., Willett, W.C., Rotnitzky, A. and Manson, J.E. (1995) Weight gain as a risk factor for clinical diabetes mellitus in women. Ann. Intern. Med. 122, 481-486.
    • (1995) Ann. Intern. Med. , vol.122 , pp. 481-486
    • Colditz, G.A.1    Willett, W.C.2    Rotnitzky, A.3    Manson, J.E.4
  • 19
    • 84933676570 scopus 로고    scopus 로고
    • The genetics of lipid storage and human lipodystrophies
    • Robbins, A.L. and Savage, D.B. (2015) The genetics of lipid storage and human lipodystrophies. Trends Mol. Med. 21, 433-438.
    • (2015) Trends Mol. Med. , vol.21 , pp. 433-438
    • Robbins, A.L.1    Savage, D.B.2
  • 20
    • 33847637510 scopus 로고    scopus 로고
    • Improved glucose tolerance in mice receiving intraperitoneal transplantation of normal fat tissue
    • Konrad, D., Rudich, A. and Schoenle, E.J. (2007) Improved glucose tolerance in mice receiving intraperitoneal transplantation of normal fat tissue. Diabetologia 50, 833-839.
    • (2007) Diabetologia , vol.50 , pp. 833-839
    • Konrad, D.1    Rudich, A.2    Schoenle, E.J.3
  • 21
    • 42649144463 scopus 로고    scopus 로고
    • Beneficial effects of subcutaneous fat transplantation on metabolism
    • Tran, T.T., Yamamoto, Y., Gesta, S. and Kahn, C.R. (2008) Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab 7, 410-420.
    • (2008) Cell Metab , vol.7 , pp. 410-420
    • Tran, T.T.1    Yamamoto, Y.2    Gesta, S.3    Kahn, C.R.4
  • 22
    • 84865484612 scopus 로고    scopus 로고
    • The adipose organ at a glance
    • Cinti, S. (2012) The adipose organ at a glance. Dis. Model Mech. 5, 588-594.
    • (2012) Dis. Model Mech. , vol.5 , pp. 588-594
    • Cinti, S.1
  • 23
    • 84962076500 scopus 로고    scopus 로고
    • Brown and Beige fat: molecular parts of a thermogenic machine
    • Cohen, P. and Spiegelman, B.M. (2015) Brown and Beige fat: molecular parts of a thermogenic machine. Diabetes 64, 2346-2351.
    • (2015) Diabetes , vol.64 , pp. 2346-2351
    • Cohen, P.1    Spiegelman, B.M.2
  • 30
    • 23644450775 scopus 로고    scopus 로고
    • Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss
    • Cancello, R., Henegar, C., Viguerie, N., Taleb, S., Poitou, C., Rouault, C., Coupaye, M., Pelloux, V., Hugol, D., Bouillot, J.L. et al. (2005) Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes 54, 2277-2286.
    • (2005) Diabetes , vol.54 , pp. 2277-2286
    • Cancello, R.1    Henegar, C.2    Viguerie, N.3    Taleb, S.4    Poitou, C.5    Rouault, C.6    Coupaye, M.7    Pelloux, V.8    Hugol, D.9    Bouillot, J.L.10
  • 32
    • 84959506635 scopus 로고    scopus 로고
    • Obesogenic memory can confer long-term increases in adipose tissue but not liver inflammation and insulin resistance after weight loss
    • Schmitz, J., Evers, N., Awazawa, M., Nicholls, H.T., Brönneke, H.S., Dietrich, A., Mauer, J., Blüher, M. and Brüning, J.C. (2016) Obesogenic memory can confer long-term increases in adipose tissue but not liver inflammation and insulin resistance after weight loss. Mol. Metab. 5, 328-339.
    • (2016) Mol. Metab. , vol.5 , pp. 328-339
    • Schmitz, J.1    Evers, N.2    Awazawa, M.3    Nicholls, H.T.4    Brönneke, H.S.5    Dietrich, A.6    Mauer, J.7    Blüher, M.8    Brüning, J.C.9
  • 33
    • 84870058819 scopus 로고    scopus 로고
    • Adaptive immunity in obesity and insulin resistance
    • Sell, H., Habich, C. and Eckel, J. (2012) Adaptive immunity in obesity and insulin resistance. Nat. Rev. Endocrinol. 8, 709-716.
    • (2012) Nat. Rev. Endocrinol. , vol.8 , pp. 709-716
    • Sell, H.1    Habich, C.2    Eckel, J.3
  • 37
    • 84929515677 scopus 로고    scopus 로고
    • Evidence of early alterations in adipose tissue biology and function and its association with obesity-related inflammation and insulin resistance in children
    • Landgraf, K., Rockstroh, D., Wagner, I.V., Weise, S., Tauscher, R., Schwartze, J.T., Löffler, D., Bühligen, U., Wojan, M., Till, H. et al. (2015) Evidence of early alterations in adipose tissue biology and function and its association with obesity-related inflammation and insulin resistance in children. Diabetes 64, 1249-1261.
    • (2015) Diabetes , vol.64 , pp. 1249-1261
    • Landgraf, K.1    Rockstroh, D.2    Wagner, I.V.3    Weise, S.4    Tauscher, R.5    Schwartze, J.T.6    Löffler, D.7    Bühligen, U.8    Wojan, M.9    Till, H.10
  • 40
    • 84901920026 scopus 로고    scopus 로고
    • Targeting inflammation in the treatment of type 2 diabetes: time to start
    • Donath, M.Y. (2014) Targeting inflammation in the treatment of type 2 diabetes: time to start. Nat. Rev. Drug Discov. 13, 465-476.
    • (2014) Nat. Rev. Drug Discov. , vol.13 , pp. 465-476
    • Donath, M.Y.1
  • 41
    • 68849132248 scopus 로고    scopus 로고
    • Adipose tissue dysfunction in obesity
    • Blüher, M. (2009) Adipose tissue dysfunction in obesity. Exp. Clin. Endocrinol. Diabetes 117, 241-250.
    • (2009) Exp. Clin. Endocrinol. Diabetes , vol.117 , pp. 241-250
    • Blüher, M.1
  • 44
    • 0001362641 scopus 로고
    • The role of adipose cell size and adipose tissue insulin sensitivity in the carbohydrate intolerance of human obesity
    • Salans, L.B., Knittle, J.L. and Hirsch, J. (1968) The role of adipose cell size and adipose tissue insulin sensitivity in the carbohydrate intolerance of human obesity. J. Clin. Invest. 47, 153-165.
    • (1968) J. Clin. Invest. , vol.47 , pp. 153-165
    • Salans, L.B.1    Knittle, J.L.2    Hirsch, J.3
  • 45
    • 0015494227 scopus 로고
    • Adipose-cell size and immunoreactive insulin levels in obese and normal-weight adults
    • Stern, J.S., Batchelor, B.R., Hollander, N., Cohn, C.K. and Hirsch, J. (1972) Adipose-cell size and immunoreactive insulin levels in obese and normal-weight adults. Lancet 2, 948-951.
    • (1972) Lancet , vol.2 , pp. 948-951
    • Stern, J.S.1    Batchelor, B.R.2    Hollander, N.3    Cohn, C.K.4    Hirsch, J.5
  • 46
    • 33947502786 scopus 로고    scopus 로고
    • Relationship between adipocyte size and adipokine expression and secretion
    • Skurk, T., Alberti-Huber, C., Herder, C. and Hauner, H. (2007) Relationship between adipocyte size and adipokine expression and secretion. J. Clin. Endocrinol. Metab. 92, 1023-1033.
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , pp. 1023-1033
    • Skurk, T.1    Alberti-Huber, C.2    Herder, C.3    Hauner, H.4
  • 53
    • 2342644142 scopus 로고    scopus 로고
    • Comparison of proliferation and differentiation capacity of human adipocyte precursor cells from the omental and subcutaneous adipose tissue depot of obese subjects
    • Van Harmelen, V., Röhrig, K. and Hauner, H. (2004) Comparison of proliferation and differentiation capacity of human adipocyte precursor cells from the omental and subcutaneous adipose tissue depot of obese subjects. Metabolism 53, 632-637.
    • (2004) Metabolism , vol.53 , pp. 632-637
    • Van Harmelen, V.1    Röhrig, K.2    Hauner, H.3
  • 54
    • 0036068133 scopus 로고    scopus 로고
    • Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance
    • Blüher, M., Michael, M.D., Peroni, O.D., Ueki, K., Carter, N., Kahn, B.B. and Kahn, C.R. (2002) Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev. Cell 3, 25-38.
    • (2002) Dev. Cell , vol.3 , pp. 25-38
    • Blüher, M.1    Michael, M.D.2    Peroni, O.D.3    Ueki, K.4    Carter, N.5    Kahn, B.B.6    Kahn, C.R.7
  • 55
    • 77953226127 scopus 로고    scopus 로고
    • Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance
    • Mauer, J., Chaurasia, B., Plum, L., Quast, T., Hampel, B., Blüher, M., Kolanus, W., Kahn, C.R. and Brüning, J.C. (2010) Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance. PLoS Genet 6, e1000938.
    • (2010) PLoS Genet , vol.6
    • Mauer, J.1    Chaurasia, B.2    Plum, L.3    Quast, T.4    Hampel, B.5    Blüher, M.6    Kolanus, W.7    Kahn, C.R.8    Brüning, J.C.9
  • 56
    • 84872290190 scopus 로고    scopus 로고
    • Hypoxia and adipose tissue function and dysfunction in obesity
    • Trayhurn, P. (2013) Hypoxia and adipose tissue function and dysfunction in obesity. Physiol. Rev. 93, 1-21.
    • (2013) Physiol. Rev. , vol.93 , pp. 1-21
    • Trayhurn, P.1
  • 58
    • 84907481906 scopus 로고    scopus 로고
    • Macrophage HIF-2a ameliorates adipose tissue inflammation and insulin resistance in obesity
    • Choe, S.S., Shin, K.C., Ka, S., Lee, Y.K., Chun, J.S. and Kim, J.B. (2014) Macrophage HIF-2a ameliorates adipose tissue inflammation and insulin resistance in obesity. Diabetes 63, 3359-3371.
    • (2014) Diabetes , vol.63 , pp. 3359-3371
    • Choe, S.S.1    Shin, K.C.2    Ka, S.3    Lee, Y.K.4    Chun, J.S.5    Kim, J.B.6
  • 59
    • 34948911181 scopus 로고    scopus 로고
    • Adipose stress-sensing kinases: linking obesity to malfunction
    • Rudich, A., Kanety, H. and Bashan, N. (2007) Adipose stress-sensing kinases: linking obesity to malfunction. Trends Endocrinol. Metab. 18, 291-299.
    • (2007) Trends Endocrinol. Metab. , vol.18 , pp. 291-299
    • Rudich, A.1    Kanety, H.2    Bashan, N.3
  • 61
    • 57349101675 scopus 로고    scopus 로고
    • A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
    • Sabio, G., Das, M., Mora, A., Zhang, Z., Jun, J.Y., Ko, H.J., Barrett, T., Kim, J.K. and Davis, R.J. (2008) A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 322, 1539-1543.
    • (2008) Science , vol.322 , pp. 1539-1543
    • Sabio, G.1    Das, M.2    Mora, A.3    Zhang, Z.4    Jun, J.Y.5    Ko, H.J.6    Barrett, T.7    Kim, J.K.8    Davis, R.J.9
  • 62
    • 84872142459 scopus 로고    scopus 로고
    • JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation
    • Han, M.S., Jung, D.Y., Morel, C., Lakhani, S.A., Kim, J.K., Flavell, R.A. and Davis, R.J. (2013) JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science 339, 218-222.
    • (2013) Science , vol.339 , pp. 218-222
    • Han, M.S.1    Jung, D.Y.2    Morel, C.3    Lakhani, S.A.4    Kim, J.K.5    Flavell, R.A.6    Davis, R.J.7
  • 64
    • 0025310056 scopus 로고
    • Leaky gut hypothesis: a historical perspective
    • Fink, M.P. (1990) Leaky gut hypothesis: a historical perspective. Crit. Care Med. 18, 579-580.
    • (1990) Crit. Care Med. , vol.18 , pp. 579-580
    • Fink, M.P.1
  • 66
    • 84885849628 scopus 로고    scopus 로고
    • Tipping the inflammatory balance: inflammasome activation distinguishes metabolically unhealthy from healthy obesity
    • Stienstra, R. and Stefan, N. (2013) Tipping the inflammatory balance: inflammasome activation distinguishes metabolically unhealthy from healthy obesity. Diabetologia 56, 2343-2346.
    • (2013) Diabetologia , vol.56 , pp. 2343-2346
    • Stienstra, R.1    Stefan, N.2
  • 67
    • 34247361278 scopus 로고    scopus 로고
    • Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal
    • Grimsrud, P.A., Picklo, Sr, M.J., Griffin, T.J. and Bernlohr, D.A. (2007) Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal. Mol. Cell. Proteomics 6, 624-637.
    • (2007) Mol. Cell. Proteomics , vol.6 , pp. 624-637
    • Grimsrud, P.A.1    Picklo, M.J.2    Griffin, T.J.3    Bernlohr, D.A.4
  • 70
    • 84869184022 scopus 로고    scopus 로고
    • Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue
    • Kawasaki, N., Asada, R., Saito, A., Kanemoto, S. and Imaizumi, K. (2012) Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue. Sci. Rep. 2, 799.
    • (2012) Sci. Rep. , vol.2 , pp. 799
    • Kawasaki, N.1    Asada, R.2    Saito, A.3    Kanemoto, S.4    Imaizumi, K.5
  • 71
    • 84964599823 scopus 로고    scopus 로고
    • Small molecular allosteric activator of the Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) attenuates diabetes and metabolic disorders
    • Kang, S., Dahl, R., Hsieh, W., Shin, A., Zsebo, K.M., Buettner, C., Hajjar, R.J. and Lebeche, D. (2016) Small molecular allosteric activator of the Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) attenuates diabetes and metabolic disorders. J. Biol. Chem. 291, 5185-5198.
    • (2016) J. Biol. Chem. , vol.291 , pp. 5185-5198
    • Kang, S.1    Dahl, R.2    Hsieh, W.3    Shin, A.4    Zsebo, K.M.5    Buettner, C.6    Hajjar, R.J.7    Lebeche, D.8
  • 72
    • 84980395486 scopus 로고    scopus 로고
    • Regulatory role of natural killer T cells in diabetes
    • Tard, C., Rouxel, O. and Lehuen, A. (2015) Regulatory role of natural killer T cells in diabetes. Biomed. J. 38, 484-495.
    • (2015) Biomed. J. , vol.38 , pp. 484-495
    • Tard, C.1    Rouxel, O.2    Lehuen, A.3
  • 75
    • 84883494045 scopus 로고    scopus 로고
    • The immune cells in adipose tissue
    • Ferrante, Jr, A.W. (2013) The immune cells in adipose tissue. Diabetes Obes. Metab. 15 (Suppl. 3), 34-38.
    • (2013) Diabetes Obes. Metab , vol.15 , pp. 34-38
    • Ferrante, A.W.1
  • 76
    • 84925273129 scopus 로고    scopus 로고
    • Adipose tissue as an immunological organ
    • Grant, R.W. and Dixit, V.D. (2015) Adipose tissue as an immunological organ. Obesity (Silver Spring) 23, 512-518.
    • (2015) Obesity (Silver Spring) , vol.23 , pp. 512-518
    • Grant, R.W.1    Dixit, V.D.2
  • 80
    • 84904721826 scopus 로고    scopus 로고
    • Autophagy in adipose tissue and the beta cell: implications for obesity and diabetes
    • Stienstra, R., Haim, Y., Riahi, Y., Netea, M., Rudich, A. and Leibowitz, G. (2014) Autophagy in adipose tissue and the beta cell: implications for obesity and diabetes. Diabetologia 57, 1505-1516.
    • (2014) Diabetologia , vol.57 , pp. 1505-1516
    • Stienstra, R.1    Haim, Y.2    Riahi, Y.3    Netea, M.4    Rudich, A.5    Leibowitz, G.6
  • 82
    • 84962694280 scopus 로고    scopus 로고
    • Adipose tissue autophagy status in obesity: expression and flux-two faces of the picture
    • Soussi, H., Clément, K. and Dugail, I. (2016) Adipose tissue autophagy status in obesity: expression and flux-two faces of the picture. Autophagy 12, 588-589.
    • (2016) Autophagy , vol.12 , pp. 588-589
    • Soussi, H.1    Clément, K.2    Dugail, I.3
  • 87
    • 77957104739 scopus 로고    scopus 로고
    • Fas activation in adipocytes impairs insulin-stimulated glucose uptake by reducing Akt
    • Wueest, S., Rapold, R.A., Schoenle, E.J. and Konrad, D. (2010) Fas activation in adipocytes impairs insulin-stimulated glucose uptake by reducing Akt. FEBS Lett 584, 4187-4192.
    • (2010) FEBS Lett , vol.584 , pp. 4187-4192
    • Wueest, S.1    Rapold, R.A.2    Schoenle, E.J.3    Konrad, D.4
  • 88
    • 84871198269 scopus 로고    scopus 로고
    • Fas activates lipolysis in a Ca2+-CaMKII-dependent manner in 3T3-L1 adipocytes
    • Rapold, R.A., Wueest, S., Knoepfel, A., Schoenle, E.J. and Konrad, D. (2013) Fas activates lipolysis in a Ca2+-CaMKII-dependent manner in 3T3-L1 adipocytes. J. Lipid Res. 54, 63-70.
    • (2013) J. Lipid Res. , vol.54 , pp. 63-70
    • Rapold, R.A.1    Wueest, S.2    Knoepfel, A.3    Schoenle, E.J.4    Konrad, D.5
  • 89
    • 84881367782 scopus 로고    scopus 로고
    • Metabolic signaling in fuel-induced insulin secretion
    • Prentki, M., Matschinsky, F.M. and Madiraju, S.R. (2013) Metabolic signaling in fuel-induced insulin secretion. Cell Metab 18, 162-185.
    • (2013) Cell Metab , vol.18 , pp. 162-185
    • Prentki, M.1    Matschinsky, F.M.2    Madiraju, S.R.3
  • 94
    • 84858964200 scopus 로고    scopus 로고
    • Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders
    • Lehr, S., Hartwig, S. and Sell, H. (2012) Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders. Proteomics Clin. Appl. 6, 91-101.
    • (2012) Proteomics Clin. Appl. , vol.6 , pp. 91-101
    • Lehr, S.1    Hartwig, S.2    Sell, H.3
  • 95
    • 84897114276 scopus 로고    scopus 로고
    • Adipokines-removing road blocks to obesity and diabetes therapy
    • Blüher, M. (2014) Adipokines-removing road blocks to obesity and diabetes therapy. Mol. Metab. 3, 230-240.
    • (2014) Mol. Metab. , vol.3 , pp. 230-240
    • Blüher, M.1
  • 99
  • 101
    • 84895741552 scopus 로고    scopus 로고
    • RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance
    • Moraes-Vieira, P.M., Yore, M.M., Dwyer, P.M., Syed, I., Aryal, P. and Kahn, B.B. (2014) RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance. Cell Metab 19, 512-526.
    • (2014) Cell Metab , vol.19 , pp. 512-526
    • Moraes-Vieira, P.M.1    Yore, M.M.2    Dwyer, P.M.3    Syed, I.4    Aryal, P.5    Kahn, B.B.6
  • 104
    • 84925299420 scopus 로고    scopus 로고
    • Interleukin-1 receptor antagonist: friend or foe to the heart?
    • Herder, C. and Donath, M.Y. (2015) Interleukin-1 receptor antagonist: friend or foe to the heart? Lancet Diabetes Endocrinol. 3, 228-229
    • (2015) Lancet Diabetes Endocrinol. , vol.3 , pp. 228-229
    • Herder, C.1    Donath, M.Y.2
  • 105
    • 84931289926 scopus 로고    scopus 로고
    • Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice
    • Zhou, L., Park, S.Y., Xu, L., Xia, X., Ye, J., Su, L., Jeong, K.H., Hur, J.H., Oh, H., Tamori, Y. et al. (2015) Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice. Nat. Commun. 6, 5949.
    • (2015) Nat. Commun. , vol.6 , pp. 5949
    • Zhou, L.1    Park, S.Y.2    Xu, L.3    Xia, X.4    Ye, J.5    Su, L.6    Jeong, K.H.7    Hur, J.H.8    Oh, H.9    Tamori, Y.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.