Studies on trans-cinnamaldehyde II: Mechanisms of cytotoxicity in rat isolated hepatocytes

Toxicology in Vitro

Volumn 10, Issue 1, 1996, Pages 37-42

  Swales, N J ^a   Caldwell, J ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; BUTHIONINE SULFOXIMINE; CINNAMALDEHYDE; CINNAMIC ACID; CINNAMYL ALCOHOL; CYANAMIDE; GLUTATHIONE; MALEIC ACID DIETHYL ESTER;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; LIVER CELL; MALE; NONHUMAN; RAT;

EID: 0029942470     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/0887-2333(95)00105-0     Document Type: Article

References (14)

1. Boyland E. and Chasseaud L. F. (1970) The effect of some carbonyl compounds on rat liver glutathione levels. Biochemical Pharmacology 19, 1526-1528.
2. Cotgreave I. A. and Moldéus P. (1986) Methodologies for the application of monobromobimane to the simultaneous analysis of soluble and protein thiol components of biological systems. Journal of Biological, Chemical and Biophysical Methods 13, 231-249.
3. Delbressine L. P. C., Klippert P. J. M., Reuvers J. T. A. and Seutter-Berlage F. (1981) Isolation and identification of mercapturic acids of cinnamyl aldehyde and cinnamyl alcohol from the urine of female rats. Archives of Toxicology 49, 57-64.
4. Dupuis G. and Benezera C. (1982) Allergic Contact Dermatitis to Simple Chemicals: A Molecular Approach. Marcel Dekker, New York.
5. Feron J. V., Til H. P., de Vrijer F., Woutersen R. A., Cassee F. R. and Van Bladeren P. J. (1991) Aldehydes: occurrence, carcinogenic potential, mechanism of action and risk assessment. Mutation Research 259, 363-385.
6. Goon D., Cheng X., Ruth J. A., Peterson D. R. and Ross D. (1992) Metabolism of trans, trans-muconaldehyde by aldehyde and alcohol dehydrogenases: identification of a novel metabolite. Toxicology and Applied Pharmacology 114, 147-155.
7. Gray T. J. B., Lake B. G., Beamand J. A., Foster J. R. and Gangolli S. D. (1983) Peroxisome proliferation in primary cultures of rat hepatocytes. Toxicology and Applied Pharmacology 67, 15-25.
8. Hoskins J. A. (1984) The metabolism of cinnamic acid by healthy and phenylketonuric adults: a kinetic study. Journal of Applied Toxicology 4, 283-292.
9. Jauregui H. O., Hayner N. T., Driscoll J. L., William-Hollan R., Lipsky M. H. and Galletti P. M. (1981) Trypan blue uptake and lactate dehydrogenase in adult rat hepatocytes - freshly isolated cells, cell suspensions and primary monolayer cultures. In Vitro 12, 1100-1110.
10. Marshall A. D. and Caldwell J. (1992) Influence of modulators of epoxide metabolism on the cytotoxicity of trans-anethole in freshly isolated rat hepatocytes. Food and Chemical Toxicology 30, 467-473.
11. Moldéus P. (1978) Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse. Biochemical Pharmacology 27, 2859-2863.
12. Peters M. M. C. G. (1993) Metabolic and mechanistic studies in the safety evaluation of trans-cinnamaldehyde. PhD thesis, Imperial College, London.
13. Peters M. M. C. G. and Caldwell J. (1994) Studies on trans-cinnamaldehyde I. The influence of dose size and sex upon its disposition in the rat and mouse. Food and Chemical Toxicology 32, 869-876.
14. Semna M., Fujiwari N., Sasaki S., Toyama M., Sakaguchi K. and Takaoka I. (1978) Studies on the cutaneous sensitisation reaction of guinea-pigs to purified aromatic chemicals. Acta Dermato-Venereologica 58, 121-124.