Pharmacokinetic study of cinnamaldehyde in rats by GC-MS after oral and intravenous administration

Journal of Pharmaceutical and Biomedical Analysis

Volumn 89, Issue , 2014, Pages 150-157

  Zhao, Hang ^a,c   Xie, Yanhua ^a,c   Yang, Qian ^a,c   Cao, Yu ^a,c   Tu, Honghai ^b   Cao, Wei ^a,c   Wang, Siwang ^a,c  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b Xinjiang Military Command   (China)

^c The Cultivation Project of Collaborative Innovation Center for Chinese Medicine in QinBa Mountains   (China)

Author keywords

Bioavailability; Cinnamaldehyde; GC MS; Methyl cinnamate; Pharmacokinetic

Indexed keywords

CINNAMALDEHYDE; CINNAMIC ACID DERIVATIVE; CINNAMIC ACID METHYL ESTER; CINNAMYL ALCOHOL; DRUG METABOLITE; PROPIOPHENONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG FECES LEVEL; DRUG HALF LIFE; DRUG ISOLATION; DRUG METABOLISM; DRUG PURITY; DRUG STABILITY; DRUG STRUCTURE; DRUG URINE LEVEL; FREEZE THAWING; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MALE; MASS FRAGMENTOGRAPHY; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; PHARMACOKINETICS; PLASMA CLEARANCE; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; REPRODUCIBILITY; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION;

BIOAVAILABILITY; CINNAMALDEHYDE; GC-MS; METHYL CINNAMATE; PHARMACOKINETIC;

ACROLEIN; ADMINISTRATION, INTRAVENOUS; ADMINISTRATION, ORAL; ANIMALS; CALIBRATION; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HALF-LIFE; MALE; PROPANOLS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS;

EID: 84888423638     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2013.10.044     Document Type: Article

References (33)

1. Gruenwald J., Freder J., Armbruester N. Cinnamon and health. Crit. Rev. Food Sci. Nutr. 2010, 50:822-834.
2. National Commission of Chinese Pharmacopoeia Pharmacopoeia of the People's Republic of China 2010, 160-161. China Medical Science and Technology Press, Beijing.
3. Bickers D., Calow P., Greim H., Hanifin J.M.R.A. A toxicologic and dermatologic assessment of cinnamyl alcohol, cinnamaldehyde and cinnamic acid when used as fragrance ingredients. Food Chem. Toxicol. 2005, 43:799-836.
4. Blakemore W.M., Thompson H.C. Trace analysis of cinnamaldehyde in animal feed, human urine, and wastewater by electron capture gas chromatography. J. Agric. Food Chem. 1983, 31:1047-1052.
5. U.S.Production and Sales Synthetic Organic Chemicals 1978, U.S. International Trade Commission.
6. Ding Y., Qiu L., Zhao G., Xu J., Wang S. Influence of cinnamaldehyde on viral myocarditis in mice. Am. J. Med. Sci. 2010, 340:114-120.
7. Youn H.S., Lee J.K., Choi Y.J., Saitoh S.I., Miyake K., Hwang D.H., Lee J.Y. Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization. Biochem. Pharmacol. 2008, 75:494-502.
8. Lee S.H., Lee S.Y., Son D.J., Lee H., Yoo H.S., Song S., Oh K.W., Han D.C., Kwon B.M., Hong J.T. Inhibitory effect of 2'-hydroxycinnamaldehyde on nitric oxide production through inhibition of NF-kappa B activation in RAW 264.7 cells. Biochem. Pharmacol. 2005, 69:791-799.
9. Huang J., Wang S., Luo X., Xie Y., Shi X. Cinnamaldehyde reduction of platelet aggregation and thrombosis in rodents. Thromb. Res. 2007, 119:337-342.
10. Matsuda H., Matsuda R., Fukuda S., Shiomoto H., Kubo M. Anti-thrombic actions of 70% methanolic extract and cinnamic aldehyde from cinnamomi cortex. Chem. Pharm. Bull. 1987, 35:1275-1280.
11. Koivisto A., Hukkanen M., Saarnilehto M., Chapman H., Kuokkanen K., Wei H., Viisanen H., Akerman K.E., Lindstedt K., Pertovaara A. Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy. Pharmacol. Res. 2012, 65:149-158.
12. Anderson R.A. Chromium and polyphenols from cinnamon improve insulin sensitivity. Proc. Nutr. Soc. 2008, 67:48-53.
13. Koppikar S.J., Choudhari A.S., Suryavanshi S.A., Kumari S., Chattopadhyay S., Kaul-Ghanekar R. Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential. BMC Cancer 2010, 10:210.
14. Wu S.J., Ng L.T. MAPK inhibitors and pifithrin-alpha block cinnamaldehyde-induced apoptosis in human PLC/PRF/5 cells. Food Chem. Toxicol. 2007, 45:2446-2453.
15. Zhang Y., Cao W., Xie Y.H., Yang Q., Li X.Q., Liu X.X., Wang S.W. The comparison of alpha-bromo-4-chlorocinnamaldehyde and cinnamaldehyde on coxsackie virus B3-induced myocarditis and their mechanisms. Int. Immunopharmacol. 2012, 14:107-113.
16. Kang Y.H., Yang I.J., Morgan K.G., Shin H.M. Cinnamyl alcohol attenuates vasoconstriction by activation of K(+) channels via NO-cGMP-protein kinase G pathway and inhibition of Rho-kinase. Exp. Mol. Med. 2012, 44:749-755.
17. Chen Y.Y., Lee M.H., Hsu C.C., Wei C.L., Tsai Y.C. Methyl cinnamate inhibits adipocyte differentiation via activation of the CaMKK2-AMPK pathway in 3T3-L1 preadipocytes. J. Agric. Food Chem. 2012, 60:955-963.
18. Yuan J.H., Bucher J.R., Goehl T.J., Dieter M.P., Jameson C.W. Quantitation of cinnamaldehyde and cinnamic acid in blood by HPLC. J. Anal. Toxicol. 1992, 16:359-362.
19. Yuan J.H., Dieter M.P., Bucher J.R., Jameson C.W. Toxicokinetics of cinnamaldehyde in F344 rats. Food Chem. Toxicol. 1992, 30:997-1004.
20. Chen Y., Ma Y., Ma W. Pharmacokinetics and bioavailability of cinnamic acid after oral administration of Ramulus Cinnamomi in rats. Eur. J. Drug Metab. Pharmacokinet. 2009, 34:51-56.
21. Peters M.M., Caldwell J. Studies on trans-cinnamaldehyde. 1. The influence of dose size and sex on its disposition in the rat and mouse. Food Chem. Toxicol. 1994, 32:869-876.
22. Wisneski H.H., Yates R.L., Davis H.M. High-performance liquid chromatographic-fluorometric determination of cinnamaldehyde in perfume, cologne and toilet water. J. Chromatogr. 1984, 317:421-426.
23. Okamura N., Miki H., Orii H., Masaoka Y., Yamashita S., Kobayashi H., Yagi A. Simultaneous high-performance liquid chromatographic determination of puerarin, daidzin, paeoniflorin, liquiritin, cinnamic acid, cinnamaldehyde and glycyrrhizin in Kampo medicines. J. Pharm. Biomed. Anal. 1999, 19:603-612.
24. Yu B.S., Lai S.G., Tan Q.L. Simultaneous determination of cinnamaldehyde, eugenol and paeonol in traditional Chinese medicinal preparations by capillary GC-FID. Chem. Pharm. Bull. (Tokyo) 2006, 54:114-116.
25. Zhang W.G., Li X.L., Cai Z.N. Determination of cinnamaldehyde in cinnamon oil by gas chromatography. Zhong Yao Tong Bao 1988, 13:38-40. 60.
26. Shan B., Cai Y.Z., Brooks J.D., Corke H. Antibacterial properties and major bioactive components of cinnamon stick (Cinnamomum burmannii): activity against foodborne pathogenic bacteria. J. Agric. Food Chem. 2007, 55:5484-5490.
27. Cappiello A., Famiglini G., Termopoli V., Trufelli H., Zazzeroni R., Jacquoilleot S., Radici L., Saib O. Application of liquid chromatography-direct-electron ionization-MS in an in vitro dermal absorption study: quantitative determination of trans-cinnamaldehyde. Anal. Chem. 2011, 83:8537-8542.
28. Friedman M., Kozukue N., Harden L.A. Cinnamaldehyde content in foods determined by gas chromatography-mass spectrometry. J. Agric. Food Chem. 2000, 48:5702-5709.
29. Lv G.P., Huang W.H., Yang F.Q., Li J., Li S.P. Pressurized liquid extraction and GC-MS analysis for simultaneous determination of seven components in Cinnamomum cassia and the effect of sample preparation. J. Sep. Sci. 2010, 33:2341-2348.
30. Kumar S., Vasudeva N., Sharma S. GC-MS analysis and screening of antidiabetic, antioxidant and hypolipidemic potential of Cinnamomum tamala oil in streptozotocin induced diabetes mellitus in rats. Cardiovasc. Diabetol. 2012, 11:95.
31. Ding H., Liu Y., Zeng Z., Si H., Liu K., Liu Y., Yang F., Li Y., Zeng D. Pharmacokinetics of mequindox and one of its major metabolites in chickens after intravenous, intramuscular and oral administration. Res. Vet. Sci. 2012, 93:374-377.
32. Zhu Z., Zhao L., Liu X., Chen J., Zhang H., Zhang G., Chai Y. Comparative pharmacokinetics of baicalin and wogonoside by liquid chromatography-mass spectrometry after oral administration of Xiaochaihu Tang and Radix scutellariae extract to rats. J. Chromatogr. B 2010, 878:2184-2190.
33. Deng Y., Liao Q., Li S., Bi K., Pan B., Xie Z. Simultaneous determination of berberine, palmatine and jatrorrhizine by liquid chromatography-tandem mass spectrometry in rat plasma and its application in a pharmacokinetic study after oral administration of coptis-evodia herb couple. J. Chromatogr. B 2008, 863:195-205.