-
1
-
-
84962966492
-
Global Report on Diabetes
-
World Health Organization
-
World Health Organization, Global Report on Diabetes., 2016, World Health Organization.
-
(2016)
-
-
World Health Organization1
-
2
-
-
0026488079
-
13C nuclear magnetic resonance study
-
13C nuclear magnetic resonance study. J. Clin. Invest. 90 (1992), 1323–1327.
-
(1992)
J. Clin. Invest.
, vol.90
, pp. 1323-1327
-
-
Magnusson, I.1
-
3
-
-
21344463062
-
Obesity and type 2 diabetes impair insulin-induced suppression of glycogenolysis as well as gluconeogenesis
-
Basu, R., et al. Obesity and type 2 diabetes impair insulin-induced suppression of glycogenolysis as well as gluconeogenesis. Diabetes 54 (2005), 1942–1948.
-
(2005)
Diabetes
, vol.54
, pp. 1942-1948
-
-
Basu, R.1
-
4
-
-
84922709227
-
Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes
-
Perry, R.J., et al. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell 160 (2015), 745–758.
-
(2015)
Cell
, vol.160
, pp. 745-758
-
-
Perry, R.J.1
-
5
-
-
0035011295
-
Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus
-
Boden, G., et al. Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus. Am. J. Physiol. Endocrinol. Metab. 280 (2001), E23–E30.
-
(2001)
Am. J. Physiol. Endocrinol. Metab.
, vol.280
, pp. E23-E30
-
-
Boden, G.1
-
6
-
-
9444262473
-
Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes
-
Krssak, M., et al. Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes. Diabetes 53 (2004), 3048–3056.
-
(2004)
Diabetes
, vol.53
, pp. 3048-3056
-
-
Krssak, M.1
-
7
-
-
0033673203
-
Mechanism by which metformin reduces glucose production in type 2 diabetes
-
Hundal, R.S., et al. Mechanism by which metformin reduces glucose production in type 2 diabetes. Diabetes 49 (2000), 2063–2069.
-
(2000)
Diabetes
, vol.49
, pp. 2063-2069
-
-
Hundal, R.S.1
-
8
-
-
14644435731
-
Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes
-
Petersen, K.F., et al. Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes. Diabetes 54 (2005), 603–608.
-
(2005)
Diabetes
, vol.54
, pp. 603-608
-
-
Petersen, K.F.1
-
9
-
-
57749183469
-
Prevalence and associated factors of non-alcoholic fatty liver disease in patients with type-2 diabetes mellitus
-
Leite, N.C., et al. Prevalence and associated factors of non-alcoholic fatty liver disease in patients with type-2 diabetes mellitus. Liver Int. 29 (2009), 113–119.
-
(2009)
Liver Int.
, vol.29
, pp. 113-119
-
-
Leite, N.C.1
-
10
-
-
34247605492
-
Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients
-
Targher, G., et al. Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients. Diabetes Care 30 (2007), 1212–1218.
-
(2007)
Diabetes Care
, vol.30
, pp. 1212-1218
-
-
Targher, G.1
-
11
-
-
0025002079
-
Liver pathology in morbidly obese patients with and without diabetes
-
Silverman, J.F., et al. Liver pathology in morbidly obese patients with and without diabetes. Am. J. Gastroenterol. 85 (1990), 1349–1355.
-
(1990)
Am. J. Gastroenterol.
, vol.85
, pp. 1349-1355
-
-
Silverman, J.F.1
-
12
-
-
0033231294
-
Association of nonalcoholic fatty liver disease with insulin resistance
-
Marchesini, G., et al. Association of nonalcoholic fatty liver disease with insulin resistance. Am. J. Med. 107 (1999), 450–455.
-
(1999)
Am. J. Med.
, vol.107
, pp. 450-455
-
-
Marchesini, G.1
-
13
-
-
30944455145
-
Insulin resistance: a metabolic pathway to chronic liver disease
-
Bugianesi, E., et al. Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology 42 (2005), 987–1000.
-
(2005)
Hepatology
, vol.42
, pp. 987-1000
-
-
Bugianesi, E.1
-
14
-
-
42949178538
-
Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects
-
Korenblat, K.M., et al. Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects. Gastroenterology 134 (2008), 1369–1375.
-
(2008)
Gastroenterology
, vol.134
, pp. 1369-1375
-
-
Korenblat, K.M.1
-
15
-
-
0036730974
-
Liver-fat accumulation and insulin resistance in obese women with previous gestational diabetes
-
Tiikkainen, M., et al. Liver-fat accumulation and insulin resistance in obese women with previous gestational diabetes. Obes. Res. 10 (2002), 859–867.
-
(2002)
Obes. Res.
, vol.10
, pp. 859-867
-
-
Tiikkainen, M.1
-
16
-
-
70349326750
-
Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity
-
Fabbrini, E., et al. Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc. Natl. Acad. Sci. U. S. A. 106 (2009), 15430–15435.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 15430-15435
-
-
Fabbrini, E.1
-
17
-
-
85027927359
-
Increased whole-body adiposity without a concomitant increase in liver fat is not associated with augmented metabolic dysfunction
-
Magkos, F., et al. Increased whole-body adiposity without a concomitant increase in liver fat is not associated with augmented metabolic dysfunction. Obesity (Silver Spring) 18 (2010), 1510–1515.
-
(2010)
Obesity (Silver Spring)
, vol.18
, pp. 1510-1515
-
-
Magkos, F.1
-
18
-
-
84962469252
-
Independent association between improvement of nonalcoholic fatty liver disease and reduced incidence of type 2 diabetes
-
Yamazaki, H., et al. Independent association between improvement of nonalcoholic fatty liver disease and reduced incidence of type 2 diabetes. Diabetes Care 38 (2015), 1673–1679.
-
(2015)
Diabetes Care
, vol.38
, pp. 1673-1679
-
-
Yamazaki, H.1
-
19
-
-
84995459787
-
Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance
-
Lotta, L.A., et al. Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance. Nat. Genet. 49 (2017), 17–26.
-
(2017)
Nat. Genet.
, vol.49
, pp. 17-26
-
-
Lotta, L.A.1
-
20
-
-
3543029821
-
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
-
Samuel, V.T., et al. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J. Biol. Chem. 279 (2004), 32345–32353.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 32345-32353
-
-
Samuel, V.T.1
-
22
-
-
0036114844
-
Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy
-
Petersen, K.F., et al. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J. Clin. Invest. 109 (2002), 1345–1350.
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 1345-1350
-
-
Petersen, K.F.1
-
23
-
-
84924778498
-
Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats
-
Perry, R.J., et al. Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats. Science 347 (2015), 1253–1256.
-
(2015)
Science
, vol.347
, pp. 1253-1256
-
-
Perry, R.J.1
-
24
-
-
84887432240
-
Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler
-
Perry, R.J., et al. Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler. Cell Metab. 18 (2013), 740–748.
-
(2013)
Cell Metab.
, vol.18
, pp. 740-748
-
-
Perry, R.J.1
-
25
-
-
0034708580
-
Mechanism of insulin resistance in A-ZIP/F-1 fatless mice
-
Kim, J.K., et al. Mechanism of insulin resistance in A-ZIP/F-1 fatless mice. J. Biol. Chem. 275 (2000), 8456–8460.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 8456-8460
-
-
Kim, J.K.1
-
26
-
-
84922080375
-
Niclosamide ethanolamine improves blood glycemic control and reduces hepatic steatosis in mice
-
Tao, H., et al. Niclosamide ethanolamine improves blood glycemic control and reduces hepatic steatosis in mice. Nat. Med. 20 (2014), 1263–1269.
-
(2014)
Nat. Med.
, vol.20
, pp. 1263-1269
-
-
Tao, H.1
-
27
-
-
0023834876
-
Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity
-
Takayama, S., et al. Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity. J. Biol. Chem. 263 (1988), 3440–3447.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 3440-3447
-
-
Takayama, S.1
-
28
-
-
0021733501
-
Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells
-
Takayama, S., et al. Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells. Proc. Natl. Acad. Sci. U. S. A. 81 (1984), 7797–7801.
-
(1984)
Proc. Natl. Acad. Sci. U. S. A.
, vol.81
, pp. 7797-7801
-
-
Takayama, S.1
-
29
-
-
0025123408
-
1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo
-
Turinsky, J., et al. 1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo. J. Biol. Chem. 265 (1990), 16880–16885.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 16880-16885
-
-
Turinsky, J.1
-
30
-
-
0027437753
-
Diacylglycerol/protein kinase C signalling: a mechanism for insulin resistance?
-
Shmueli, E., et al. Diacylglycerol/protein kinase C signalling: a mechanism for insulin resistance?. J. Intern. Med. 234 (1993), 397–400.
-
(1993)
J. Intern. Med.
, vol.234
, pp. 397-400
-
-
Shmueli, E.1
-
31
-
-
80053627289
-
Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
-
Kumashiro, N., et al. Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. Proc. Natl. Acad. Sci. U. S. A. 108 (2011), 16381–16385.
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 16381-16385
-
-
Kumashiro, N.1
-
32
-
-
84901944641
-
The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
-
Perry, R.J., et al. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature 510 (2014), 84–91.
-
(2014)
Nature
, vol.510
, pp. 84-91
-
-
Perry, R.J.1
-
33
-
-
84883167011
-
Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice
-
Camporez, J.P.G., et al. Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice. Endocrinology 154 (2013), 3099–3109.
-
(2013)
Endocrinology
, vol.154
, pp. 3099-3109
-
-
Camporez, J.P.G.1
-
34
-
-
84924530326
-
ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content
-
Camporez, J.P.G., et al. ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content. J. Lipid Res. 56 (2015), 526–536.
-
(2015)
J. Lipid Res.
, vol.56
, pp. 526-536
-
-
Camporez, J.P.G.1
-
35
-
-
84861647226
-
Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects
-
Magkos, F., et al. Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects. Gastroenterology 142 (2012), 1444–1446.e2.
-
(2012)
Gastroenterology
, vol.142
, pp. 1444-1446.e2
-
-
Magkos, F.1
-
36
-
-
84860497397
-
Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance
-
Jornayvaz, F.R., Shulman, G.I., Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance. Cell Metab. 15 (2012), 574–584.
-
(2012)
Cell Metab.
, vol.15
, pp. 574-584
-
-
Jornayvaz, F.R.1
Shulman, G.I.2
-
37
-
-
84959104290
-
Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease
-
Luukkonen, P.K., et al. Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease. J. Hepatol. 64 (2016), 1167–1175.
-
(2016)
J. Hepatol.
, vol.64
, pp. 1167-1175
-
-
Luukkonen, P.K.1
-
38
-
-
85020297753
-
Hepatic diacylglycerol-associated protein kinase Cε translocation links hepatic steatosis to hepatic insulin resistance in humans
-
(in press)
-
ter Horst, K.W., et al. Hepatic diacylglycerol-associated protein kinase Cε translocation links hepatic steatosis to hepatic insulin resistance in humans. Cell Rep., 2017 (in press).
-
(2017)
Cell Rep.
-
-
ter Horst, K.W.1
-
39
-
-
84874607649
-
Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance
-
Camporez, J.P.G., et al. Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance. Endocrinology 154 (2013), 1021–1028.
-
(2013)
Endocrinology
, vol.154
, pp. 1021-1028
-
-
Camporez, J.P.G.1
-
40
-
-
85020691232
-
A controlled-release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice
-
Published online March 22
-
Abulizi, A., et al. A controlled-release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice. FASEB J., 2017, 10.1096/fj.201700001R Published online March 22, 2017.
-
(2017)
FASEB J.
-
-
Abulizi, A.1
-
41
-
-
33644654777
-
Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2
-
Savage, D.B., et al. Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. J. Clin. Invest. 116 (2006), 817–824.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 817-824
-
-
Savage, D.B.1
-
42
-
-
79960969204
-
Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice
-
Birkenfeld, A.L., et al. Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice. Cell Metab. 14 (2011), 184–195.
-
(2011)
Cell Metab.
, vol.14
, pp. 184-195
-
-
Birkenfeld, A.L.1
-
43
-
-
70449927254
-
Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein
-
Erion, D.M., et al. Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein. Cell Metab. 10 (2009), 499–506.
-
(2009)
Cell Metab.
, vol.10
, pp. 499-506
-
-
Erion, D.M.1
-
44
-
-
33847404482
-
Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease
-
Samuel, V.T., et al. Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease. J. Clin. Invest. 117 (2007), 739–745.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 739-745
-
-
Samuel, V.T.1
-
45
-
-
80052538157
-
Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice
-
Raddatz, K., et al. Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice. Diabetologia 54 (2011), 1447–1456.
-
(2011)
Diabetologia
, vol.54
, pp. 1447-1456
-
-
Raddatz, K.1
-
46
-
-
84994613956
-
Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance
-
Petersen, M.C., et al. Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance. J. Clin. Invest. 126 (2016), 4361–4371.
-
(2016)
J. Clin. Invest.
, vol.126
, pp. 4361-4371
-
-
Petersen, M.C.1
-
47
-
-
27244440736
-
Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice
-
Neschen, S., et al. Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice. Cell Metab. 2 (2005), 55–65.
-
(2005)
Cell Metab.
, vol.2
, pp. 55-65
-
-
Neschen, S.1
-
48
-
-
34347238724
-
Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance
-
Nagle, C.A., et al. Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance. J. Biol. Chem. 282 (2007), 14807–14815.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 14807-14815
-
-
Nagle, C.A.1
-
49
-
-
79953194447
-
Endoplasmic reticulum stress promotes LIPIN2-dependent hepatic insulin resistance
-
Ryu, D., et al. Endoplasmic reticulum stress promotes LIPIN2-dependent hepatic insulin resistance. Diabetes 60 (2011), 1072–1081.
-
(2011)
Diabetes
, vol.60
, pp. 1072-1081
-
-
Ryu, D.1
-
50
-
-
60649114293
-
TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1
-
Ryu, D., et al. TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1. Cell Metab. 9 (2009), 240–251.
-
(2009)
Cell Metab.
, vol.9
, pp. 240-251
-
-
Ryu, D.1
-
51
-
-
34547946930
-
Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance
-
Choi, C.S., et al. Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance. J. Biol. Chem. 282 (2007), 22678–22688.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 22678-22688
-
-
Choi, C.S.1
-
52
-
-
34347235098
-
Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver
-
Monetti, M., et al. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab. 6 (2007), 69–78.
-
(2007)
Cell Metab.
, vol.6
, pp. 69-78
-
-
Monetti, M.1
-
53
-
-
79954996869
-
Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2
-
Jornayvaz, F.R., et al. Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2. Proc. Natl. Acad. Sci. U. S. A. 108 (2011), 5748–5752.
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 5748-5752
-
-
Jornayvaz, F.R.1
-
54
-
-
84939139499
-
Does diacylglycerol accumulation in fatty liver disease cause hepatic insulin resistance?
-
Finck, B.N., Hall, A.M., Does diacylglycerol accumulation in fatty liver disease cause hepatic insulin resistance?. Biomed. Res. Int., 2015, 2015, 104132.
-
(2015)
Biomed. Res. Int.
, vol.2015
, pp. 104132
-
-
Finck, B.N.1
Hall, A.M.2
-
55
-
-
84980368133
-
Activation of conventional and novel protein kinase C isozymes by different diacylglycerol molecular species
-
Kamiya, Y., et al. Activation of conventional and novel protein kinase C isozymes by different diacylglycerol molecular species. Biochem. Biophys. Rep. 7 (2016), 361–366.
-
(2016)
Biochem. Biophys. Rep.
, vol.7
, pp. 361-366
-
-
Kamiya, Y.1
-
56
-
-
0032547808
-
Distinct effects of fatty acids on translocation of gamma- and epsilon-subspecies of protein kinase C
-
Shirai, Y., et al. Distinct effects of fatty acids on translocation of gamma- and epsilon-subspecies of protein kinase C. J. Cell Biol. 143 (1998), 511–521.
-
(1998)
J. Cell Biol.
, vol.143
, pp. 511-521
-
-
Shirai, Y.1
-
57
-
-
78149346457
-
CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance
-
Brown, J.M., et al. CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance. J. Lipid Res. 51 (2010), 3306–3315.
-
(2010)
J. Lipid Res.
, vol.51
, pp. 3306-3315
-
-
Brown, J.M.1
-
58
-
-
84873178604
-
CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance
-
Cantley, J.L., et al. CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), 1869–1874.
-
(2013)
Proc. Natl. Acad. Sci. U. S. A.
, vol.110
, pp. 1869-1874
-
-
Cantley, J.L.1
-
59
-
-
53149101726
-
Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice
-
Minehira, K., et al. Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. J. Lipid Res. 49 (2008), 2038–2044.
-
(2008)
J. Lipid Res.
, vol.49
, pp. 2038-2044
-
-
Minehira, K.1
-
60
-
-
84903179316
-
Abrogating monoacylglycerol acyltransferase activity in liver improves glucose tolerance and hepatic insulin signaling in obese mice
-
Hall, A.M., et al. Abrogating monoacylglycerol acyltransferase activity in liver improves glucose tolerance and hepatic insulin signaling in obese mice. Diabetes 63 (2014), 2284–2296.
-
(2014)
Diabetes
, vol.63
, pp. 2284-2296
-
-
Hall, A.M.1
-
61
-
-
84889887123
-
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
-
Fullerton, M.D., et al. Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. Nat. Med. 19 (2013), 1649–1654.
-
(2013)
Nat. Med.
, vol.19
, pp. 1649-1654
-
-
Fullerton, M.D.1
-
62
-
-
84938569966
-
Targeted induction of ceramide degradation leads to improved systemic metabolism and reduced hepatic steatosis
-
Xia, J.Y., et al. Targeted induction of ceramide degradation leads to improved systemic metabolism and reduced hepatic steatosis. Cell Metab. 22 (2015), 266–278.
-
(2015)
Cell Metab.
, vol.22
, pp. 266-278
-
-
Xia, J.Y.1
-
63
-
-
84871908862
-
ARF1-regulated coatomer directs the steady-state localization of protein kinase C epsilon at the Golgi apparatus
-
Peterson, T.A., Stamnes, M., ARF1-regulated coatomer directs the steady-state localization of protein kinase C epsilon at the Golgi apparatus. Biochim. Biophys. Acta 1833 (2013), 487–493.
-
(2013)
Biochim. Biophys. Acta
, vol.1833
, pp. 487-493
-
-
Peterson, T.A.1
Stamnes, M.2
-
64
-
-
84870372459
-
Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases
-
Eichmann, T.O., et al. Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases. J. Biol. Chem. 287 (2012), 41446–41457.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 41446-41457
-
-
Eichmann, T.O.1
-
65
-
-
0021774491
-
The stereospecific activation of protein kinase C
-
Rando, R.R., Young, N., The stereospecific activation of protein kinase C. Biochem. Biophys. Res. Commun. 122 (1984), 818–823.
-
(1984)
Biochem. Biophys. Res. Commun.
, vol.122
, pp. 818-823
-
-
Rando, R.R.1
Young, N.2
-
66
-
-
84974683314
-
CrossTalk opposing view: intramyocellular ceramide accumulation does not modulate insulin resistance
-
Petersen, M.C., Jurczak, M.J., CrossTalk opposing view: intramyocellular ceramide accumulation does not modulate insulin resistance. J. Physiol. 594 (2016), 3171–3174.
-
(2016)
J. Physiol.
, vol.594
, pp. 3171-3174
-
-
Petersen, M.C.1
Jurczak, M.J.2
-
67
-
-
84974695650
-
CrossTalk proposal: intramyocellular ceramide accumulation does modulate insulin resistance
-
Summers, S.A., Goodpaster, B.H., CrossTalk proposal: intramyocellular ceramide accumulation does modulate insulin resistance. J. Physiol. 594 (2016), 3167–3170.
-
(2016)
J. Physiol.
, vol.594
, pp. 3167-3170
-
-
Summers, S.A.1
Goodpaster, B.H.2
-
68
-
-
0033588253
-
et al., Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate
-
Schmitz-Peiffer, C., et al., Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. J. Biol. Chem. 274 (1999), 24202–24210.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 24202-24210
-
-
Schmitz-Peiffer, C.1
-
69
-
-
84907978697
-
Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance
-
Turpin, S.M., et al. Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance. Cell Metab. 20 (2014), 678–686.
-
(2014)
Cell Metab.
, vol.20
, pp. 678-686
-
-
Turpin, S.M.1
-
70
-
-
84907984591
-
CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance
-
Raichur, S., et al. CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance. Cell Metab. 20 (2014), 687–695.
-
(2014)
Cell Metab.
, vol.20
, pp. 687-695
-
-
Raichur, S.1
-
71
-
-
84910147089
-
C16:0-ceramide signals insulin resistance
-
Hla, T., Kolesnick, R., C16:0-ceramide signals insulin resistance. Cell Metab. 20 (2014), 703–705.
-
(2014)
Cell Metab.
, vol.20
, pp. 703-705
-
-
Hla, T.1
Kolesnick, R.2
-
72
-
-
84878871217
-
Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding
-
Turner, N., et al. Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding. Diabetologia 56 (2013), 1638–1648.
-
(2013)
Diabetologia
, vol.56
, pp. 1638-1648
-
-
Turner, N.1
-
73
-
-
84876465920
-
Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding
-
Montgomery, M.K., et al. Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding. Diabetologia 56 (2013), 1129–1139.
-
(2013)
Diabetologia
, vol.56
, pp. 1129-1139
-
-
Montgomery, M.K.1
-
74
-
-
84987917179
-
Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: a beneficial role for very long-chain sphingolipid species
-
Montgomery, M.K., et al. Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: a beneficial role for very long-chain sphingolipid species. Biochim. Biophys. Acta 1861 (2016), 1828–1839.
-
(2016)
Biochim. Biophys. Acta
, vol.1861
, pp. 1828-1839
-
-
Montgomery, M.K.1
-
75
-
-
77956022194
-
Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption
-
Ussher, J.R., et al. Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption. Diabetes 59 (2010), 2453–2464.
-
(2010)
Diabetes
, vol.59
, pp. 2453-2464
-
-
Ussher, J.R.1
-
76
-
-
84881098074
-
Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo
-
Galbo, T., et al. Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), 12780–12785.
-
(2013)
Proc. Natl. Acad. Sci. U. S. A.
, vol.110
, pp. 12780-12785
-
-
Galbo, T.1
-
77
-
-
33847332202
-
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
-
Holland, W.L., et al. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab. 5 (2007), 167–179.
-
(2007)
Cell Metab.
, vol.5
, pp. 167-179
-
-
Holland, W.L.1
-
78
-
-
80055057797
-
Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance
-
Lee, H.-Y., et al. Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance. Hepatology 54 (2011), 1650–1660.
-
(2011)
Hepatology
, vol.54
, pp. 1650-1660
-
-
Lee, H.-Y.1
-
79
-
-
84943262988
-
Liver perilipin 5 expression worsens hepatosteatosis but not insulin resistance in high fat-fed mice
-
Trevino, M.B., et al. Liver perilipin 5 expression worsens hepatosteatosis but not insulin resistance in high fat-fed mice. Mol. Endocrinol. 29 (2015), 1414–1425.
-
(2015)
Mol. Endocrinol.
, vol.29
, pp. 1414-1425
-
-
Trevino, M.B.1
-
80
-
-
84904509368
-
Inhibition of ceramide de novo synthesis reduces liver lipid accumulation in rats with nonalcoholic fatty liver disease
-
Kurek, K., et al. Inhibition of ceramide de novo synthesis reduces liver lipid accumulation in rats with nonalcoholic fatty liver disease. Liver Int. 34 (2014), 1074–1083.
-
(2014)
Liver Int.
, vol.34
, pp. 1074-1083
-
-
Kurek, K.1
-
81
-
-
84861208352
-
Fenretinide prevents lipid-induced insulin resistance by blocking ceramide biosynthesis
-
Bikman, B.T., et al. Fenretinide prevents lipid-induced insulin resistance by blocking ceramide biosynthesis. J. Biol. Chem. 287 (2012), 17426–17437.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 17426-17437
-
-
Bikman, B.T.1
-
82
-
-
79955487247
-
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice
-
Holland, W.L., et al. Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J. Clin. Invest. 121 (2011), 1858–1870.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 1858-1870
-
-
Holland, W.L.1
-
83
-
-
22944434929
-
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
-
Yang, Q., et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 436 (2005), 356–362.
-
(2005)
Nature
, vol.436
, pp. 356-362
-
-
Yang, Q.1
-
84
-
-
0034903710
-
Prevention of fat-induced insulin resistance by salicylate
-
Kim, J.K., et al. Prevention of fat-induced insulin resistance by salicylate. J. Clin. Invest. 108 (2001), 437–446.
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 437-446
-
-
Kim, J.K.1
-
85
-
-
78651260799
-
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
-
Holland, W.L., et al. Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nat. Med. 17 (2011), 55–63.
-
(2011)
Nat. Med.
, vol.17
, pp. 55-63
-
-
Holland, W.L.1
-
86
-
-
84860482342
-
A ceramide-centric view of insulin resistance
-
Chavez, J.A., Summers, S.A., A ceramide-centric view of insulin resistance. Cell Metab. 15 (2012), 585–594.
-
(2012)
Cell Metab.
, vol.15
, pp. 585-594
-
-
Chavez, J.A.1
Summers, S.A.2
-
87
-
-
67650096801
-
Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome
-
Yang, G., et al. Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome. Am. J. Physiol. Endocrinol. Metab. 297 (2009), E211–E224.
-
(2009)
Am. J. Physiol. Endocrinol. Metab.
, vol.297
, pp. E211-E224
-
-
Yang, G.1
-
88
-
-
0342980927
-
Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells
-
Salinas, M., et al. Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells. Mol. Cell. Neurosci. 15 (2000), 156–169.
-
(2000)
Mol. Cell. Neurosci.
, vol.15
, pp. 156-169
-
-
Salinas, M.1
-
89
-
-
0034607914
-
Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473
-
Schubert, K.M., et al. Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473. J. Biol. Chem. 275 (2000), 13330–13335.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 13330-13335
-
-
Schubert, K.M.1
-
90
-
-
0032569026
-
Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis
-
Zhou, H., et al. Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis. J. Biol. Chem. 273 (1998), 16568–16575.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 16568-16575
-
-
Zhou, H.1
-
91
-
-
4344614649
-
Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B
-
Stratford, S., et al. Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B. J. Biol. Chem. 279 (2004), 36608–36615.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 36608-36615
-
-
Stratford, S.1
-
92
-
-
84886730615
-
PP2A inhibition results in hepatic insulin resistance despite Akt2 activation
-
Galbo, T., et al. PP2A inhibition results in hepatic insulin resistance despite Akt2 activation. Aging (Milano) 5 (2013), 770–781.
-
(2013)
Aging (Milano)
, vol.5
, pp. 770-781
-
-
Galbo, T.1
-
93
-
-
0022517504
-
Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes. Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activity
-
Caro, J.F., et al. Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes. Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activity. J. Clin. Invest. 78 (1986), 249–258.
-
(1986)
J. Clin. Invest.
, vol.78
, pp. 249-258
-
-
Caro, J.F.1
-
94
-
-
0024263777
-
Alteration of insulin-receptor kinase activity by high-fat feeding
-
Watarai, T., et al. Alteration of insulin-receptor kinase activity by high-fat feeding. Diabetes 37 (1988), 1397–1404.
-
(1988)
Diabetes
, vol.37
, pp. 1397-1404
-
-
Watarai, T.1
-
95
-
-
84856957894
-
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
-
Henao-Mejia, J., et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482 (2012), 179–185.
-
(2012)
Nature
, vol.482
, pp. 179-185
-
-
Henao-Mejia, J.1
-
96
-
-
79751512463
-
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
-
Vandanmagsar, B., et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat. Med. 17 (2011), 179–188.
-
(2011)
Nat. Med.
, vol.17
, pp. 179-188
-
-
Vandanmagsar, B.1
-
97
-
-
85010993660
-
Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis
-
Holland, W.L., et al. Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis. Mol. Metab. 6 (2017), 267–275.
-
(2017)
Mol. Metab.
, vol.6
, pp. 267-275
-
-
Holland, W.L.1
-
98
-
-
84942918965
-
Applying the Bradford Hill criteria in the 21st century: how data integration has changed causal inference in molecular epidemiology
-
Fedak, K.M., et al. Applying the Bradford Hill criteria in the 21st century: how data integration has changed causal inference in molecular epidemiology. Emerg. Themes Epidemiol., 12, 2015, 14.
-
(2015)
Emerg. Themes Epidemiol.
, vol.12
, pp. 14
-
-
Fedak, K.M.1
-
99
-
-
84900793058
-
Evolving concepts in the pathogenesis of NASH: beyond steatosis and inflammation
-
Peverill, W., et al. Evolving concepts in the pathogenesis of NASH: beyond steatosis and inflammation. Int. J. Mol. Sci. 15 (2014), 8591–8638.
-
(2014)
Int. J. Mol. Sci.
, vol.15
, pp. 8591-8638
-
-
Peverill, W.1
-
100
-
-
84860455885
-
The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance
-
Farese, R.V. Jr, et al. The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance. Cell Metab. 15 (2012), 570–573.
-
(2012)
Cell Metab.
, vol.15
, pp. 570-573
-
-
Farese, R.V.1
-
101
-
-
84983800999
-
Targeting ceramide metabolism in obesity
-
Aburasayn, H., et al. Targeting ceramide metabolism in obesity. Am. J. Physiol. Endocrinol. Metab. 311 (2016), E423–E435.
-
(2016)
Am. J. Physiol. Endocrinol. Metab.
, vol.311
, pp. E423-E435
-
-
Aburasayn, H.1
-
102
-
-
0025297310
-
Peripheral effects of insulin dominate suppression of fasting hepatic glucose production
-
Ader, M., Bergman, R.N., Peripheral effects of insulin dominate suppression of fasting hepatic glucose production. Am. J. Physiol. 258 (1990), E1020–E1032.
-
(1990)
Am. J. Physiol.
, vol.258
, pp. E1020-E1032
-
-
Ader, M.1
Bergman, R.N.2
-
103
-
-
0031851426
-
The direct and indirect effects of insulin on hepatic glucose production in vivo
-
Cherrington, A.D., The direct and indirect effects of insulin on hepatic glucose production in vivo. Diabetologia 41 (1998), 987–996.
-
(1998)
Diabetologia
, vol.41
, pp. 987-996
-
-
Cherrington, A.D.1
-
104
-
-
85020631152
-
Insulin's direct hepatic effect explains the inhibition of glucose production caused by insulin secretion
-
Edgerton, D.S., et al. Insulin's direct hepatic effect explains the inhibition of glucose production caused by insulin secretion. JCI Insight, 2, 2017, e91863.
-
(2017)
JCI Insight
, vol.2
, pp. e91863
-
-
Edgerton, D.S.1
-
105
-
-
84907386500
-
Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease
-
Shulman, G.I., Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease. N. Engl. J. Med. 371 (2014), 1131–1141.
-
(2014)
N. Engl. J. Med.
, vol.371
, pp. 1131-1141
-
-
Shulman, G.I.1
-
106
-
-
85009133022
-
2014 Diabetes Report Card
-
Centers For Disease Control
-
Centers For Disease Control, 2014 Diabetes Report Card., 2014, Centers For Disease Control.
-
(2014)
-
-
Centers For Disease Control1
-
107
-
-
36749082168
-
Mitochondrial dysfunction due to long-chain acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance
-
Zhang, D., et al. Mitochondrial dysfunction due to long-chain acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance. Proc. Natl. Acad. Sci. U. S. A. 104 (2007), 17075–17080.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 17075-17080
-
-
Zhang, D.1
-
108
-
-
77955296892
-
Resistance to high-fat diet-induced obesity and insulin resistance in mice with very long-chain acyl-CoA dehydrogenase deficiency
-
Zhang, D., et al. Resistance to high-fat diet-induced obesity and insulin resistance in mice with very long-chain acyl-CoA dehydrogenase deficiency. Cell Metab. 11 (2010), 402–411.
-
(2010)
Cell Metab.
, vol.11
, pp. 402-411
-
-
Zhang, D.1
-
109
-
-
78650851786
-
Adipose triglyceride lipase-null mice are resistant to high-fat diet-induced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation
-
Hoy, A.J., et al. Adipose triglyceride lipase-null mice are resistant to high-fat diet-induced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation. Endocrinology 152 (2011), 48–58.
-
(2011)
Endocrinology
, vol.152
, pp. 48-58
-
-
Hoy, A.J.1
-
110
-
-
79953787445
-
Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice
-
Turpin, S.M., et al. Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice. Diabetologia 54 (2011), 146–156.
-
(2011)
Diabetologia
, vol.54
, pp. 146-156
-
-
Turpin, S.M.1
-
111
-
-
84876718085
-
Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats
-
Kumashiro, N., et al. Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats. Hepatology 57 (2013), 1763–1772.
-
(2013)
Hepatology
, vol.57
, pp. 1763-1772
-
-
Kumashiro, N.1
-
112
-
-
84908191987
-
Inhibiting monoacylglycerol acyltransferase 1 ameliorates hepatic metabolic abnormalities but not inflammation and injury in mice
-
Soufi, N., et al. Inhibiting monoacylglycerol acyltransferase 1 ameliorates hepatic metabolic abnormalities but not inflammation and injury in mice. J. Biol. Chem. 289 (2014), 30177–30188.
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 30177-30188
-
-
Soufi, N.1
-
113
-
-
33747047885
-
Targeting Foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action
-
Samuel, V.T., et al. Targeting Foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action. Diabetes 55 (2006), 2042–2050.
-
(2006)
Diabetes
, vol.55
, pp. 2042-2050
-
-
Samuel, V.T.1
-
114
-
-
36749052873
-
Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity
-
Choi, C.S., et al. Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. Proc. Natl. Acad. Sci. U. S. A. 104 (2007), 16480–16485.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 16480-16485
-
-
Choi, C.S.1
-
115
-
-
34948904815
-
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance
-
Matsuzaka, T., et al. Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. Nat. Med. 13 (2007), 1193–1202.
-
(2007)
Nat. Med.
, vol.13
, pp. 1193-1202
-
-
Matsuzaka, T.1
-
116
-
-
59649089306
-
AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency
-
Jaworski, K., et al. AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency. Nat. Med. 15 (2009), 159–168.
-
(2009)
Nat. Med.
, vol.15
, pp. 159-168
-
-
Jaworski, K.1
-
117
-
-
78349242167
-
A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain
-
Jornayvaz, F.R., et al. A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain. Am. J. Physiol. Endocrinol. Metab. 299 (2010), E808–E815.
-
(2010)
Am. J. Physiol. Endocrinol. Metab.
, vol.299
, pp. E808-E815
-
-
Jornayvaz, F.R.1
-
118
-
-
84862907611
-
Thyroid hormone receptor-α gene knockout mice are protected from diet-induced hepatic insulin resistance
-
Jornayvaz, F.R., et al. Thyroid hormone receptor-α gene knockout mice are protected from diet-induced hepatic insulin resistance. Endocrinology 153 (2012), 583–591.
-
(2012)
Endocrinology
, vol.153
, pp. 583-591
-
-
Jornayvaz, F.R.1
-
119
-
-
84862908245
-
Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice
-
Jurczak, M.J., et al. Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice. J. Biol. Chem. 287 (2012), 2558–2567.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 2558-2567
-
-
Jurczak, M.J.1
-
120
-
-
84866296565
-
Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism
-
Brown, W.H., et al. Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism. Proc. Natl. Acad. Sci. U. S. A. 109 (2012), 14966–14971.
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. 14966-14971
-
-
Brown, W.H.1
-
121
-
-
84862025421
-
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration
-
Sun, Z., et al. Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nat. Med. 18 (2012), 934–942.
-
(2012)
Nat. Med.
, vol.18
, pp. 934-942
-
-
Sun, Z.1
-
122
-
-
84900561186
-
Estrogen signaling prevents diet-induced hepatic insulin resistance in male mice with obesity
-
Zhu, L., et al. Estrogen signaling prevents diet-induced hepatic insulin resistance in male mice with obesity. Am. J. Physiol. Endocrinol. Metab. 306 (2014), E1188–E1197.
-
(2014)
Am. J. Physiol. Endocrinol. Metab.
, vol.306
, pp. E1188-E1197
-
-
Zhu, L.1
-
123
-
-
84928723655
-
Fenofibrate insulates diacylglycerol in lipid droplet/ER and preserves insulin signaling transduction in the liver of high fat fed mice
-
Chan, S.M.H., et al. Fenofibrate insulates diacylglycerol in lipid droplet/ER and preserves insulin signaling transduction in the liver of high fat fed mice. Biochim. Biophys. Acta 1852 (2015), 1511–1519.
-
(2015)
Biochim. Biophys. Acta
, vol.1852
, pp. 1511-1519
-
-
Chan, S.M.H.1
-
124
-
-
84929675670
-
Analysis of the liver lipidome reveals insights into the protective effect of exercise on high-fat diet-induced hepatosteatosis in mice
-
Jordy, A.B., et al. Analysis of the liver lipidome reveals insights into the protective effect of exercise on high-fat diet-induced hepatosteatosis in mice. Am. J. Physiol. Endocrinol. Metab. 308 (2015), E778–E791.
-
(2015)
Am. J. Physiol. Endocrinol. Metab.
, vol.308
, pp. E778-E791
-
-
Jordy, A.B.1
-
125
-
-
84944393898
-
Dipeptidyl peptidase-4 inhibition ameliorates Western diet-induced hepatic steatosis and insulin resistance through hepatic lipid remodeling and modulation of hepatic mitochondrial function
-
Aroor, A.R., et al. Dipeptidyl peptidase-4 inhibition ameliorates Western diet-induced hepatic steatosis and insulin resistance through hepatic lipid remodeling and modulation of hepatic mitochondrial function. Diabetes 64 (2015), 1988–2001.
-
(2015)
Diabetes
, vol.64
, pp. 1988-2001
-
-
Aroor, A.R.1
-
126
-
-
84983803557
-
Duodenal–jejunal bypass surgery induces hepatic lipidomic alterations associated with ameliorated hepatic steatosis in mice
-
Shang, J., et al. Duodenal–jejunal bypass surgery induces hepatic lipidomic alterations associated with ameliorated hepatic steatosis in mice. Obesity (Silver Spring) 24 (2016), 1938–1945.
-
(2016)
Obesity (Silver Spring)
, vol.24
, pp. 1938-1945
-
-
Shang, J.1
-
127
-
-
84956932380
-
Hepatocyte-specific disruption of CD36 attenuates fatty liver and improves insulin sensitivity in HFD-fed mice
-
Wilson, C.G., et al. Hepatocyte-specific disruption of CD36 attenuates fatty liver and improves insulin sensitivity in HFD-fed mice. Endocrinology 157 (2016), 570–585.
-
(2016)
Endocrinology
, vol.157
, pp. 570-585
-
-
Wilson, C.G.1
-
128
-
-
84963934397
-
Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance
-
Popov, V.B., et al. Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance. FASEB J. 30 (2016), 1207–1217.
-
(2016)
FASEB J.
, vol.30
, pp. 1207-1217
-
-
Popov, V.B.1
|