메뉴 건너뛰기




Volumn 5, Issue 10, 2013, Pages 770-781

PP2A inhibition results in hepatic insulin resistance despite Akt2 activation

Author keywords

Akt; Glucose metabolism; Insulin resistance; PP2A

Indexed keywords

AKT2 PROTEIN, RAT; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, RAT; GLYCOGEN; NERVE PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2; PROTEIN KINASE B;

EID: 84886730615     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100611     Document Type: Article
Times cited : (37)

References (41)
  • 1
    • 84857861919 scopus 로고    scopus 로고
    • Mechanisms for insulin resistance:common threads and missing links
    • Samuel VT and Shulman GI. Mechanisms for insulin resistance:common threads and missing links. Cell. 2012;148:852-871.
    • (2012) Cell , vol.148 , pp. 852-871
    • Samuel, V.T.1    Shulman, G.I.2
  • 2
    • 78049259220 scopus 로고    scopus 로고
    • Pathogenesis of fasting and postprandial hyperglycemia in type 2 diabetes:implications for therapy
    • Rizza RA. Pathogenesis of fasting and postprandial hyperglycemia in type 2 diabetes:implications for therapy. Diabetes. 2010;59:2697-2707.
    • (2010) Diabetes , vol.59 , pp. 2697-2707
    • Rizza, R.A.1
  • 3
  • 8
    • 34548349302 scopus 로고    scopus 로고
    • Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver
    • Matsumoto M, Pocai A, Rossetti L, Depinho RA and Accili D. Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell metabolism. 2007;6:208-216.
    • (2007) Cell metabolism , vol.6 , pp. 208-216
    • Matsumoto, M.1    Pocai, A.2    Rossetti, L.3    Depinho, R.A.4    Accili, D.5
  • 10
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross DA, Alessi DR, Cohen P, Andjelkovich M and Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature. 1995;378:785-789.
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 11
    • 77956236967 scopus 로고    scopus 로고
    • Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases
    • Mistafa O, Ghalali A, Kadekar S, Hogberg J and Stenius U. Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases. The Journal of biological chemistry. 2010;285:27900-27910.
    • (2010) The Journal of biological chemistry , vol.285 , pp. 27900-27910
    • Mistafa, O.1    Ghalali, A.2    Kadekar, S.3    Hogberg, J.4    Stenius, U.5
  • 13
    • 33947528693 scopus 로고    scopus 로고
    • The 3D structure of protein phosphatase 2A:new insights into a ubiquitous regulator of cell signaling
    • Mumby M. The 3D structure of protein phosphatase 2A:new insights into a ubiquitous regulator of cell signaling. ACS chemical biology. 2007;2:99-103.
    • (2007) ACS chemical biology , vol.2 , pp. 99-103
    • Mumby, M.1
  • 14
    • 0035487315 scopus 로고    scopus 로고
    • A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate
    • Cazzolli R, Carpenter L, Biden TJ and Schmitz-Peiffer C. A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate. Diabetes. 2001;50:2210-2218.
    • (2001) Diabetes , vol.50 , pp. 2210-2218
    • Cazzolli, R.1    Carpenter, L.2    Biden, T.J.3    Schmitz-Peiffer, C.4
  • 15
    • 4344614649 scopus 로고    scopus 로고
    • Regulation of insulin action by ceramide:dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B
    • Stratford S, Hoehn KL, Liu F and Summers SA. Regulation of insulin action by ceramide:dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B. The Journal of biological chemistry. 2004;279:36608-36615.
    • (2004) The Journal of biological chemistry , vol.279 , pp. 36608-36615
    • Stratford, S.1    Hoehn, K.L.2    Liu, F.3    Summers, S.A.4
  • 16
    • 80455174428 scopus 로고    scopus 로고
    • Free fatty acid-induced PP2A hyperactivity selectively impairs hepatic insulin action on glucose metabolism
    • Galbo T, Olsen GS, Quistorff B and Nishimura E. Free fatty acid-induced PP2A hyperactivity selectively impairs hepatic insulin action on glucose metabolism. PloS one. 2011;6:e27424.
    • (2011) PloS one , vol.6
    • Galbo, T.1    Olsen, G.S.2    Quistorff, B.3    Nishimura, E.4
  • 17
    • 84860482342 scopus 로고    scopus 로고
    • A ceramide-centric view of insulin resistance
    • Chavez JA and Summers SA. A ceramide-centric view of insulin resistance. Cell metabolism. 2012;15:585-594.
    • (2012) Cell metabolism , vol.15 , pp. 585-594
    • Chavez, J.A.1    Summers, S.A.2
  • 19
    • 0027217027 scopus 로고
    • Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A
    • Honkanen RE. Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A. FEBS letters. 1993;330:283-286.
    • (1993) FEBS letters , vol.330 , pp. 283-286
    • Honkanen, R.E.1
  • 22
    • 0026040907 scopus 로고
    • Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats
    • Kraegen EW, Clark PW, Jenkins AB, Daley EA, Chisholm DJ and Storlien LH. Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats. Diabetes. 1991;40:1397-1403.
    • (1991) Diabetes , vol.40 , pp. 1397-1403
    • Kraegen, E.W.1    Clark, P.W.2    Jenkins, A.B.3    Daley, E.A.4    Chisholm, D.J.5    Storlien, L.H.6
  • 24
    • 80052968161 scopus 로고    scopus 로고
    • Regulation of FOXO protein stability via ubiquitination and proteasome degradation
    • Huang H and Tindall DJ. Regulation of FOXO protein stability via ubiquitination and proteasome degradation. Biochimica et biophysica acta. 2011;1813:1961-1964.
    • (2011) Biochimica et biophysica acta , vol.1813 , pp. 1961-1964
    • Huang, H.1    Tindall, D.J.2
  • 25
    • 0020565637 scopus 로고
    • Protein phosphatases:properties and role in cellular regulation
    • Ingebritsen TS and Cohen P. Protein phosphatases:properties and role in cellular regulation. Science. 1983;221:331-338.
    • (1983) Science , vol.221 , pp. 331-338
    • Ingebritsen, T.S.1    Cohen, P.2
  • 26
    • 0020641117 scopus 로고
    • The protein phosphatases involved in cellular regulation.6. Measurement of type-1 and type-2 protein phosphatases in extracts of mammalian tissues;an assessment of their physiological roles
    • Ingebritsen TS, Stewart AA and Cohen P. The protein phosphatases involved in cellular regulation. 6. Measurement of type-1 and type-2 protein phosphatases in extracts of mammalian tissues;an assessment of their physiological roles. European journal of biochemistry/FEBS. 1983;132:297-307.
    • (1983) European journal of biochemistry/FEBS , vol.132 , pp. 297-307
    • Ingebritsen, T.S.1    Stewart, A.A.2    Cohen, P.3
  • 27
    • 0032533162 scopus 로고    scopus 로고
    • Specific features of glycogen metabolism in the liver
    • Bollen M, Keppens S and Stalmans W. Specific features of glycogen metabolism in the liver. The Biochemical journal. 1998;336:19-31.
    • (1998) The Biochemical journal , vol.336 , pp. 19-31
    • Bollen, M.1    Keppens, S.2    Stalmans, W.3
  • 28
    • 20844451123 scopus 로고    scopus 로고
    • AMP-activated protein kinase:ancient energy gauge provides clues to modern understanding of metabolism
    • Kahn BB, Alquier T, Carling D and Hardie DG. AMP-activated protein kinase:ancient energy gauge provides clues to modern understanding of metabolism. Cell metabolism. 2005;1:15-25.
    • (2005) Cell metabolism , vol.1 , pp. 15-25
    • Kahn, B.B.1    Alquier, T.2    Carling, D.3    Hardie, D.G.4
  • 29
    • 45549090182 scopus 로고    scopus 로고
    • Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation
    • Dong XC, Copps KD, Guo S, Li Y, Kollipara R, DePinho RA and White MF. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell metabolism. 2008;8:65-76.
    • (2008) Cell metabolism , vol.8 , pp. 65-76
    • Dong, X.C.1    Copps, K.D.2    Guo, S.3    Li, Y.4    Kollipara, R.5    DePinho, R.A.6    White, M.F.7
  • 31
    • 0037707890 scopus 로고    scopus 로고
    • Inactivation of phosphorylase is a major component of the mechanism by which insulin stimulates hepatic glycogen synthesis
    • Aiston S, Coghlan MP and Agius L. Inactivation of phosphorylase is a major component of the mechanism by which insulin stimulates hepatic glycogen synthesis. European journal of biochemistry/FEBS. 2003;270:2773-2781.
    • (2003) European journal of biochemistry/FEBS , vol.270 , pp. 2773-2781
    • Aiston, S.1    Coghlan, M.P.2    Agius, L.3
  • 33
    • 84864397831 scopus 로고    scopus 로고
    • Hyperactivation of protein phosphatase 2A in models of glucolipotoxicity and diabetes:Potential mechanisms and functional consequences
    • Kowluru A and Matti A. Hyperactivation of protein phosphatase 2A in models of glucolipotoxicity and diabetes:Potential mechanisms and functional consequences. Biochemical pharmacology. 2012;84:591-597.
    • (2012) Biochemical pharmacology , vol.84 , pp. 591-597
    • Kowluru, A.1    Matti, A.2
  • 37
    • 34248199965 scopus 로고    scopus 로고
    • Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase
    • Wu Y, Song P, Xu J, Zhang M and Zou MH. Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase. The Journal of biological chemistry. 2007;282:9777-9788.
    • (2007) The Journal of biological chemistry , vol.282 , pp. 9777-9788
    • Wu, Y.1    Song, P.2    Xu, J.3    Zhang, M.4    Zou, M.H.5
  • 38
    • 0344665680 scopus 로고    scopus 로고
    • Transgenic and knockout models of PP2A
    • Gotz J and Schild A. Transgenic and knockout models of PP2A. Methods in enzymology. 2003;366:390-403.
    • (2003) Methods in enzymology , vol.366 , pp. 390-403
    • Gotz, J.1    Schild, A.2
  • 39
    • 0017101039 scopus 로고
    • Preparation of isolated rat liver cells
    • Seglen PO. Preparation of isolated rat liver cells. Methods in cell biology. 1976;13:29-83.
    • (1976) Methods in cell biology , vol.13 , pp. 29-83
    • Seglen, P.O.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.