A controlled-release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice

FASEB Journal

Volumn 31, Issue 7, 2017, Pages 2916-2924

  Abulizi, Abudukadier ^a   Perry, Rachel J ^a   Camporez, João Paulo G ^a   Jurczak, Michael J ^a   Petersen, Kitt Falk ^a   Aspichueta, Patricia ^a,b,c   Shulman, Gerald I ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^c BIOCRUCES BIZKAIA HEALTH RESEARCH INSTITUTE   (Spain)

Author keywords

Insulin resistance; Mitochondrial uncoupling; NAFLD; NASH; Type 2 diabetes

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CASPASE 3; CD69 ANTIGEN; CONTROLLED RELEASE MITOCHONDRIAL PROTONOPHORE; DIACYLGLYCEROL; GLUCOSE; INSULIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; IRE-1ALPHA; PROTEIN KINASE C EPSILON; PROTEIN KINASE C THETA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN; DELAYED RELEASE FORMULATION; PROTON IONOPHORE;

ADIPOGENESIS; ADIPOSE TISSUE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE SEVERITY; ENERGY EXPENDITURE; ENZYME ACTIVATION; ENZYME ACTIVITY; FATTY LIVER; FOOD INTAKE; GLUCOSE TOLERANCE; HYPERINSULINEMIC-EUGLYCEMIC CLAMP TECHNIQUE; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPODYSTROPHY; LIVER; MALE; NONALCOHOLIC FATTY LIVER; NONHUMAN; OXIDATIVE PHOSPHORYLATION UNCOUPLING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKELETAL MUSCLE; TRANSCRIPTION REGULATION; UNFOLDED PROTEIN RESPONSE; ANIMAL; DELAYED RELEASE FORMULATION; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS; EATING; ENERGY METABOLISM; LIVER MITOCHONDRION; MOUSE; NON-ALCOHOLIC FATTY LIVER DISEASE; RANDOMIZATION;

ANIMALS; DELAYED-ACTION PREPARATIONS; DIABETES MELLITUS, TYPE 2; EATING; ENERGY METABOLISM; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; LIPODYSTROPHY; MALE; MICE; MITOCHONDRIA, LIVER; NON-ALCOHOLIC FATTY LIVER DISEASE; PROTON IONOPHORES; RANDOM ALLOCATION;

EID: 85020691232     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.201700001R     Document Type: Article

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